Sialic acid utilization by bacterial pathogens. অনুযায়ী Severi, E, Hood, D, Thomas, G

“…In this mini-review we will summarize recent findings relating to sialic acid transport, modification of sialic acid by O-acetylation, and the mechanisms of sialic acid-mediated complement resistance.…”

Synthesis and assessment of [11C]acetylhomotaurine as an imaging agent for the study of the pharmacodynamic properties of acamprosate by positron emission tomography. অনুযায়ী Courtyn, J, Cornelissen, B, Oltenfreiter, R, Vandecapelle, M, Slegers, G, Strijckmans, K

“…Acetylhomotaurine was labeled with (11)C via N-acetylation with [(11)C]acetyl chloride. The synthesis yielded 48.2+/-3.8%, decay corrected to end of bombardment. …”

Epigenetic protein families: a new frontier for drug discovery. অনুযায়ী Arrowsmith, C, Bountra, C, Fish, P, Lee, K, Schapira, M

“…Here, we review the key protein families that mediate epigenetic signalling through the acetylation and methylation of histones, including histone deacetylases, protein methyltransferases, lysine demethylases, bromodomain-containing proteins and proteins that bind to methylated histones. …”

A transcription cofactor required for the heat-shock response. অনুযায়ী Xu, D, Zalmas, L, La Thangue, N

“…A chromatin-associated complex involving heat-shock factor 1 (HSF1), Strap and the p300 coactivator assembles on the heat-shock protein 70 (hsp70) promoter, and Strap augments HSF1 binding and chromatin acetylation in Hsp genes, most probably through the p300 histone acetyltransferase. …”

Epigenetic protein families: A new frontier for drug discovery অনুযায়ী Arrowsmith, C, Bountra, C, Fish, P, Lee, K, Schapira, M

“…Here, we review the key protein families that mediate epigenetic signalling through the acetylation and methylation of histones, including histone deacetylases, protein methyltransferases, lysine demethylases, bromodomain-containing proteins and proteins that bind to methylated histones. …”

Position-Dependent Silencing of Germline V beta Segments on TCR beta Alleles Containing Preassembled V beta DJ beta C beta 1 Genes অনুযায়ী Brady, Brenna L., Oropallo, Michael A., Yang-lott, Katherine S., Serwold, Thomas, Hochedlinger, Konrad, Jaenisch, Rudolf, Weissman, Irving L., Bassing, Craig H.

“…This allele-dependent and developmental stage-specific silencing of Vβ10 correlated with increased CpG methylation and decreased histone acetylation over the Vβ10 promoter and coding region. …”
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Differential effects of cocaine on histone posttranslational modifications in identified populations of striatal neurons অনুযায়ী Heiman, Myriam, Jordi, Emmanuelle, Marion-Poll, Lucile, Guermonprez, Pierre, Cheng, Shuk Kei, Nairn, Angus C., Greengard, Paul, Girault, Jean-Antoine

“…Fluorescence in nucleoli was used to sort nuclei from D1R- or D2R-expressing neurons and to quantify by flow cytometry the cocaine-induced changes in histone acetylation and methylation specifically in these two types of nuclei. …”
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The role of histone modification in DNA double-strand break repair in Schizosaccharomyces pombe অনুযায়ী Deegan, R

“…Methylation of H3K36 by Set2, which peaks in G1, promotes NHEJ whereas acetylation of H3K36 by Gcn5, which peaks in S phase, promotes HR.…”

THEEFFECTOF ACETICACIDON PROPERTIESOF COCONUTSHELLFILLEDLOW DENSITYPOLYETHYLENECOMPOSITES অনুযায়ী Perpustakaan UGM, i-lib

“…The effect of surface treatment of coconut shell (CS) with acetic acid (acetylation) on mechanical properties, thermal properties and morphology were studied. …”

HDAC inhibitors in cancer biology: emerging mechanisms and clinical applications. অনুযায়ী Khan, O, La Thangue, N

“…Reversible acetylation mediated by histone deacetylases (HDACs) influences a broad repertoire of physiological processes, many of which are aberrantly controlled in tumor cells. …”

Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk অনুযায়ী Huber, K, Knapp, S, Fedorov, O

“…Bromodomain-containing proteins of the BET family recognize histone lysine acetylation and mediate transcriptional activation of target genes such as the MYC oncogene. …”

Bromodomain-peptide displacement assays for interactome mapping and inhibitor discovery. অনুযায়ী Philpott, M, Yang, J, Tumber, T, Fedorov, O, Uttarkar, S, Filippakopoulos, P, Picaud, S, Keates, T, Felletar, I, Ciulli, A, Knapp, S, Heightman, T

“…Histone lysine acetylation is a key component of epigenetic regulation of gene transcription. …”

Live-cell studies of p300/CBP histone acetyltransferase activity and inhibition. অনুযায়ী Dancy, B, Crump, N, Peterson, D, Mukherjee, C, Bowers, E, Ahn, Y, Yoshida, M, Zhang, J, Mahadevan, L, Meyers, D, Boeke, J, Cole, P

“…Here we present the application of a FRET-based reporter, Histac, in live-cell studies of p300/CBP HAT inhibition, by both genetic and pharmacologic disruption. shRNA knockdown of p300/CBP led to increased Histac FRET, thus suggesting a role for p300/CBP in the acetylation of the histone H4 tail. Additionally, we describe a new p300/CBP HAT inhibitor, C107, and show that it can also increase cellular Histac FRET. …”

PTMs in Conversation: Activity and Function of Deubiquitinating Enzymes Regulated via Post-Translational Modifications অনুযায়ী Kessler, B, Edelmann, M

“…This review is focused on the role of PTMs including monoubiquitination, sumoylation, acetylation, and phosphorylation as characterized and putative regulative factors of DUB function. …”

PTMs in conversation: activity and function of deubiquitinating enzymes regulated via post-translational modifications. অনুযায়ী Kessler, B, Edelmann, M

“…This review is focused on the role of PTMs including monoubiquitination, sumoylation, acetylation, and phosphorylation as characterized and putative regulative factors of DUB function. …”

Bromodomain-peptide displacement assays for interactome mapping and inhibitor discovery. অনুযায়ী Philpott, M, Yang, J, Tumber, T, Fedorov, O, Uttarkar, S, Filippakopoulos, P, Picaud, S, Keates, T, Felletar, I, Ciulli, A, Knapp, S, Heightman, T

“…Histone lysine acetylation is a key component of epigenetic regulation of gene transcription. …”

Mechanism of Polycomb recruitment to CpG islands revealed by inherited disease-associated mutation অনুযায়ী Caputo, VS, Costa, JR, Makarona, K, Georgiou, E, Layton, DM, Roberts, I, Karadimitris, A

“…By exploiting a CpG island (CGI) point mutation causing a Mendelian disease, we show that DNA binding of activating transcription factor (TF) determines histone acetylation and nucleosomal depletion commensurate with Polycomb exclusion from the target promoter. …”

HDAC inhibitor-based therapies and haematological malignancy. অনুযায়ী Stimson, L, Wood, V, Khan, O, Fotheringham, S, La Thangue, N

“…Reversible acetylation mediated by histone deacetylase (HDAC) influences a broad repertoire of physiological processes, many of which are aberrantly controlled in tumour cells. …”

Strong cation exchange (SCX) based analytical methods for the targeted analysis of protein post-translational modifications. অনুযায়ী Mohammed, S, Heck, A

“…Here, we describe how in particular SCX chromatography can be used for the targeted analysis of important post-translational modifications, such as phosphorylation and N-terminal acetylation. Compared to other methods, SCX is less labor-intensive and more robust, and therefore likely more easily adaptable to main-stream research laboratories.…”

Quantitative Analysis of Histone Modifications: Formaldehyde Is a Source of Pathological N6-Formyllysine That Is Refractory to Histone Deacetylases অনুযায়ী Edrissi, Bahar, Taghizadeh, Koli, Dedon, Peter C.

“…Recent studies have identified a chemical homolog of lysine acetylation, N[superscript 6]-formyllysine, as an abundant modification of histone and chromatin proteins, one possible source of which is the reaction of lysine with 3′-formylphosphate residues from DNA oxidation. …”
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