Epigenetic modification of the frataxin gene for the treatment of Friedreich’s ataxia by Vilema Enriquez, MG

“…</p> <p>In this thesis, first HDAC3 and G9a were targeted by siRNA-mediated knockdown to increase overall acetylation and reduce methylation and promote transcription of FXN. …”

Phytochemical and bioactivities of Malaysian Artocarpus lowii king, A. Scortechinii king and A. Teysmanii MIQ. by Jamil, Shajarahtunnur

“…Methylation of artonin E gave artonin E trimethyl ether while acetylation of artonin E afforded artonin E tetraacetate. …”
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Role of hypoxia-inducible factors in epigenetic regulation via histone demethylases. by Yang, J, Ledaki, I, Turley, H, Gatter, K, Montero, J, Li, J, Harris, A

“…Eukaryotic chromatin is subject to multiple posttranslational histone modifications such as acetylation, methylation, phosphorylation, and ubiquitination. …”

C/EBPs: recipients of extracellular signals through proteome modulation. by Nerlov, C

“…Post-translational modification may also control the interaction between C/EBPs and chromatin modifiers, as exemplified by decreased HDAC1-C/EBPbeta interaction upon GCN5-mediated lysine acetylation, and the ability of sumoylation to inhibit C/EBPalpha-SWI/SNF interaction. …”

Cohesin: a catenase with separate entry and exit gates? by Nasmyth, K

“…Establishment of cohesion during S phase involves neutralization of releasin through acetylation of Smc3 at a site close to the putative exit gate of DNA, which locks rings shut until opened irreversibly by kleisin cleavage through the action of separase, an event that triggers the metaphase to anaphase transition.…”

Advances in hypoxia-inducible factor biology by Choudhry, H, Harris, A

“…Hypoxia, in part through HIF-dependent mechanisms, influences epigenetic factors, including DNA methylation and histone acetylation, which modulate hypoxia-responsive gene expression in cells. …”

The switching mechanism of the bacterial rotary motor combines tight regulation with inherent flexibility by Afanzar, O, Di Paolo, D, Eisenstein, M, Levi, K, Plochowietz, A, Kapanidis, AN, Berry, RM, Eisenbach, M

“…Here, we resolved the functions of each of the three CheY-binding sites at the switch in E. coli, as well as their different dependencies on phosphorylation and acetylation of CheY. Based on this, we propose that CheY motor switching activity is potentiated upon binding to the first site. …”

An approach to identifying novel substrates of bacterial arylamine N-acetyltransferases. by Brooke, E, Davies, S, Mulvaney, A, Pompeo, F, Sim, E, Vickers, R

“…Arylamine N-acetyltransferases (NATs) catalyse the acetylation of arylamine, arylhydrazine and arylhydroxylamine substrates by acetyl Coenzyme A. …”

Accurate calculation of the absolute free energy of binding for drug molecules by Aldeghi, M, Heifetz, A, Bodkin, M, Knapp, S, Biggin, P

“…Bromodomains are epigenetic mark readers that recognize acetylation motifs and regulate gene transcription, and are currently being investigated as therapeutic targets for cancer and inflammation. …”

Interplay of histone marks with serine ADP-ribosylation by Bartlett, E, Bonfiglio, J, Prokhorova, E, Colby, T, Zobel, F, Ahel, I, Matic, I

“…Here, we show that specific canonical histone marks interfere with Ser-ADPr of neighboring residues and vice versa. Most notably, acetylation, but not methylation of H3K9, is mutually exclusive with ADPr of H3S10 in vitro and in vivo. …”

Sister DNA entrapment between juxtaposed Smc heads and kleisin of the cohesin complex by Chapard, C, Jones, R, van Oepen, T, Scheinost, J, Nasmyth, K

“…We show that K compartments of either E or J type can entrap single DNAs, that acetylation of Smc3 during S phase is associated with J heads, and that sister DNAs are entrapped in J-K compartments.…”

Secondary metabolites from two garcinia species and their biological activities. by Ee, Gwendoline Cheng Lian, Yuen, Lin Cheow

“…Their structures were derived based on spectroscopic evidence, mainly 1D and 2D NMR spectroscopy. Acetylation reaction was carried out on rubraxanthone to yield triacetate rubraxanthone. …”
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Chemical constituents from Garcinia maingayi and Garcinia parvifolia (Guttiferae) and their biological activities by Ee, Gwendoline Cheng Lian, Cheow, Yuen Lin

“…Their structures were derived based on spectroscopic evidence, mainly ID and 2D NMR spectroscopy. Acetylation reaction was carried out on rubraxanthone to yield triacetate rubraxanthone. …”

Reaction-Based Probes for Imaging Mobile Zinc in Live Cells and Tissues by Zastrow, Melissa L., Radford, Robert John, Chyan, Wen, Anderson, Charles T., Zhang, Daniel Y., Loas, Andrei Ioan, Tzounopoulos, Thanos, Lippard, Stephen J.

“…An acetylated blue coumarin-based sensor was used to carry out detailed analyses of metal binding and metal-promoted acetyl hydrolysis. …”
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A Selective HDAC 1/2 Inhibitor Modulates Chromatin and Gene Expression in Brain and Alters Mouse Behavior in Two Mood-Related Tests by Schroeder, Frederick A., Lewis, Michael C., Fass, Daniel M., Wagner, Florence F., Zhang, Yan-Ling, Hennig, Krista M., Gale, Jennifer, Zhao, Wen-Ning, Reis, Surya, Barker, Douglas D., Berry-Scott, Erin, Kim, Sung Won, Clore, Elizabeth L., Hooker, Jacob M., Holson, Edward B., Haggarty, Stephen J., Petryshen, Tracey

“…HDAC inhibition in brain was confirmed by increased histone acetylation both globally and, using chromatin immunoprecipitation, at the promoter regions of upregulated transcripts, a finding consistent with in vivo engagement of HDAC targets. …”
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SYNTHESISOF FLAVANONE-6-CARBOXYLICACID DERIVATIVES FROMSALICYLIC ACID DERIVATIVE by Perpustakaan UGM, i-lib

“…The acidcatalyzed- acetylation of the product using acetic anhydride gave methyl 4-acetoxybenzoate in 75% yield. …”

Epigenetic regulation of sensory axon regeneration after spinal cord injury by Finelli, M, Wong, J, Zou, H

“…When neurons are triggered into a growth state, as in the conditioning lesion paradigm, H4 acetylation is restored, and RAG transcription is initiated. …”

A chemical toolbox for the study of bromodomains and epigenetic signaling by Wu, Q, Heidenreich, D, Zhou, S, Ackloo, S, Krämer, A, Nakka, K, Lima-Fernandes, E, Deblois, G, Duan, S, Vellanki, R, Li, F, Vedadi, M, Dilworth, J, Lupien, M, Brennan, P, Arrowsmith, C, Müller, S, Fedorov, O, Filippakopoulos, P, Knapp, S

“…Bromodomains (BRDs) are conserved protein interaction modules which recognize (read) acetyl-lysine modifications, however their role(s) in regulating cellular states and their potential as targets for the development of targeted treatment strategies is poorly understood. …”

Structure and function of cohesin's Scc3/SA regulatory subunit by Roig, M, Löwe, J, Chan, K, Beckouët, F, Metson, J, Nasmyth, K

“…Scc3 turns over in G2/M while maintaining cohesin's association with chromosomes and it promotes de-acetylation of Smc3 upon Scc1 cleavage.…”

Interactome rewiring following pharmacological targeting of BET bromodomains by Lambert, J-P, Picaud, SS, Fujisawa, T, Hou, H, Savitsky, P, Uusküla-Reimand, L, Gupta, G, Lin, ZY, Tucholska, M, Knight, JDR, Gonzalez-Badillo, B, St-Denis, N, Newman, JA, Stucki, M, Pelletier, L, Bandeira, N, Wilson, MD, Filippakopoulos, P, Gingras, AC

“…A group of proteins associate in a JQ1-sensitive manner with BET BRDs through canonical and new binding modes, while two classes of extra-terminal (ET)-domain binding motifs mediate acetylation-independent interactions. Last, we identify an unexpected increase in several interactions following JQ1 treatment that define negative functions for BRD3 in the regulation of rRNA synthesis and potentially RNAPII-dependent gene expression that result in decreased cell proliferation. …”