Structure and function of cohesin's Scc3/SA regulatory subunit by Roig, M, Löwe, J, Chan, K, Beckouët, F, Metson, J, Nasmyth, K

“…Scc3 turns over in G2/M while maintaining cohesin's association with chromosomes and it promotes de-acetylation of Smc3 upon Scc1 cleavage.…”

Interactome rewiring following pharmacological targeting of BET bromodomains by Lambert, J-P, Picaud, SS, Fujisawa, T, Hou, H, Savitsky, P, Uusküla-Reimand, L, Gupta, G, Lin, ZY, Tucholska, M, Knight, JDR, Gonzalez-Badillo, B, St-Denis, N, Newman, JA, Stucki, M, Pelletier, L, Bandeira, N, Wilson, MD, Filippakopoulos, P, Gingras, AC

“…A group of proteins associate in a JQ1-sensitive manner with BET BRDs through canonical and new binding modes, while two classes of extra-terminal (ET)-domain binding motifs mediate acetylation-independent interactions. Last, we identify an unexpected increase in several interactions following JQ1 treatment that define negative functions for BRD3 in the regulation of rRNA synthesis and potentially RNAPII-dependent gene expression that result in decreased cell proliferation. …”

Strap: a versatile transcription co-factor. by Xu, D, La Thangue, N

“…A chromatin-associated complex involving heat-shock factor 1 (HSF1), Strap and the p300 co-activator assembles on the HSP70 gene promoter, and Strap augments HSF1 binding and chromatin acetylation in HSP genes, most probably through recruiting p300 acetyltransferase. …”

Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit. by Fish, P, Filippakopoulos, P, Bish, G, Brennan, P, Bunnage, M, Cook, A, Federov, O, Gerstenberger, B, Jones, H, Knapp, S, Marsden, B, Nocka, K, Owen, DR, Philpott, M, Picaud, S, Primiano, M, Ralph, M, Sciammetta, N, Trzupek, J

“…The posttranslational modification of chromatin through acetylation at selected histone lysine residues is governed by histone acetyltransferases (HATs) and histone deacetylases (HDACs). …”

Insights into histone code syntax from structural and biochemical studies of CARM1 methyltransferase. by Yue, W, Hassler, M, Roe, S, Thompson-Vale, V, Pearl, L

“…Kinetic analysis shows Arg17 methylation is potentiated by pre-acetylation of Lys18, and this is reflected in k(cat) rather than K(m). …”

Stability of histone modifications across mammalian genomes: implications for 'epigenetic' marking. by Lee, B, Mahadevan, L

“…In light of such studies, which show highly dynamic methylation, acetylation and phosphorylation of histone H3 during gene transcription, we consider the extent to which genome-wide maps of chromatin state could be interpreted as 'snapshots' of heterogeneous profiles deriving from dynamic modification processes. …”

Development and pre-clinical testing of a novel hypoxia-activated KDAC inhibitor by Skwarska, A, Calder, E, Sneddon, D, Bolland, H, Odyniec, M, Mistry, I, Martin, J, Folkes, L, Conway, S, Hammond, E

“…Treatment of cells grown in both 2D and 3D with NI-Pano increased acetylation of histone H3 at lysine 9, induced apoptosis and decreased clonogenic survival. …”

Epigenetic control of macrophage polarisation and soluble mediator gene expression during inflammation by Kapellos, T, Iqbal, A

“…Changes in methylation and acetylation of histones by methyltransferases, demethylases, acetyltransferases, and deacetylases can all impact how macrophage phenotypes are generated. …”

Comprehensive identification of RNA-binding domains in human cells by Castello, A, Fischer, B, Frese, CK, Horos, R, Alleaume, A-M, Foehr, S, Curk, T, Krijgsveld, J, Hentze, MW

“…RNA-binding sites represent hot spots for defined posttranslational modifications such as lysine acetylation and tyrosine phosphorylation, suggesting metabolic and signal-dependent regulation of RBP function. …”

THE DISPOSITION AND METABOLISM OF SULPHASALAZINE (SALICYLAZOSULFAPYRIDINE) IN MAN by Khan, A, Truelove, S, Aronson, J

“…Of the 5-ASA released in the colon at least 25% is absorbed and rapidly eliminated in the urine after acetylation. At least 50% is eliminated in the faeces. …”

Comprehensive identification of RNA-binding domains in human cells by Castello, A, Fischer, B, Frese, C, Horos, R, Alleaume, A, Foehr, S, Curk, T, Krijgsveld, J, Hentze, M

“…RNA-binding sites represent hot spots for defined posttranslational modifications such as lysine acetylation and tyrosine phosphorylation, suggesting metabolic and signal-dependent regulation of RBP function. …”

The PWWP2A histone deacetylase complex represses intragenic spurious transcription initiation in mESCs by Wei, G, Brockdorff, N, Zhang, T

“…Loss of PWWP2A/B enhances spurious initiation from intragenic sites present in wild-type mESCs, and this effect is associated with increased levels of initiating Pol-II and histone acetylation. Spurious initiation events in Pwwp2a/b DKO mESCs do not overlap in genomic location or chromatin features with spurious sites that arise in Dnmt3b KO mESCs, previously reported to function in the suppression of intragenic transcriptional initiation, suggesting these pathways function cooperatively in maintaining the fidelity of transcription initiation in metazoans.…”

Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins. by Ahel, I, Ahel, D, Matsusaka, T, Clark, A, Pines, J, Boulton, S, West, S

“…PTM can be mediated by the addition of functional groups (for example, acetylation or phosphorylation), peptides (for example, ubiquitylation or sumoylation), or nucleotides (for example, poly(ADP-ribosyl)ation). …”

Tissue-specific histone modification and transcription factor binding in alpha globin gene expression. by De Gobbi, M, Anguita, E, Hughes, J, Sloane-Stanley, J, Sharpe, J, Koch, C, Dunham, I, Gibbons, R, Wood, W, Higgs, D

“…This un-biased, comprehensive analysis of transcription factor binding and histone modifications (acetylation and methylation) described here not only identified all known cis-acting regulatory elements in the human alpha globin cluster but also demonstrated that there are no additional erythroid-specific regulatory elements in the 220-kb region tested. …”

The effect of food deprivation on the rate of sulfamethazine elimination in goats by Abdullah, A.S., Baggot, J.D.

“…Because of the analytical method used to measure sulfamethazine concentrations in plasma and urine, no conclusion could be drawn as to whether the rates of hydroxylation or of acetylation, or both metabolic pathways were decreased in the starved condition.…”
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Xanthones and xanthone derivatives from Garcinia nitida by Ee, Gwendoline Cheng Lian, Lim, Che Kiong, Yap, Taufiq Yun Hin, Md. Sukari, Mohd Aspollah, Rahmani, Mawardi

“…The structures of these compounds were established using mainly 1D and 2D NMR spectrocopy. Acetylation of rubraxanthone resulted in two new compounds, rubraxanthone monoacetate (6) and rubraxanthone diacetate (7) with rubraxanthone triacetate (8).…”
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Some aspects of terpenoid chemistry by Weston, R, Weston, Roderick James

“…The 7andalpha;,8andalpha;-epoxide (2) was rearranged with boron trifluoride and acetylation of the product gave methyl 3andalpha;,7andalpha;-diacetoxyapotirucall-14-en-21-oate (3).…”

Investigating effects of histone tail modification on chromatin compaction in nucleosome arrays by Abdollah Allahverdi

“…Histone tails are subject to a range of post-translational modifications, the most common of which, acetylation of the lysine ε-amino group, neutralizes the positive charge will induce decondensation of chromatin. …”
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LAPORAN BARU: SPESIES LALAT BUAH TERPIKAT 4-(4-HIDROKSI-FENIL)-2-BUTANON by Pranowo, Deni, Martono, Edhi, Taufiq Arminudin, Ahmad, Suputa, Suputa

“…Acetylation of 4-(4-hydrory-penyl)-3-butene-2-one by anhydride of acetic acid catalyzed by sulphuric acid results in 4-(4-acetoxy-phenyl)-3-butene-2-one compound, and 4-(4-hydroxy-phenyl)-2-butanone compound as a by product. …”
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Nuclear PtdIns5P as a transducer of stress signaling: an in vivo role for PIP4Kbeta. by Jones, DR, Bultsma, Y, Keune, W, Halstead, JR, Elouarrat, D, Mohammed, S, Heck, A, D'Santos, C, Divecha, N

“…Inhibitor of growth protein-2 (ING2) is a nuclear adaptor protein that can regulate p53 and histone acetylation in response to cellular stress and contains a PHD (plant homeodomain) finger that can interact with phosphatidylinositol-5-phosphate (PtdIns5P). …”