The HDAC inhibitor zabadinostat is a systemic regulator of adaptive immunity מאת Liu, G, Barczak, W, Lee, LN, Shrestha, A, Provine, NM, Albayrak, G, Zhu, H, Hutchings, C, Klenerman, P, La Thangue, NB

"...<p>Protein acetylation plays a key role in regulating cellular processes and is subject to aberrant control in diverse pathologies. ..."

The synthesis and biological characterisation of high affinity, selective macrocyclic ligands targeting the CREBBP/p300 bromodomains מאת Boyd, AM

"...Lysine acetylation of histone tails is a post-translational modification recognised by epigenetic “reader” domains, otherwise known as bromodomains. ..."

Deacetylation inhibition reverses PABPN1-dependent muscle wasting מאת Olie, C, Riaz, M, Konietzny, R, Charles, P, Pinto-Fernandez, A, Kielbasa, S, Aartsma-Rus, A, Goeman, J, Kessler, B, Raz, V

"...Protein accumulation in the shPab proteome was concomitant with reduced proteasomal activity. Notably, protein acetylation appeared to be decreased in shPab versus control proteomes (63%). ..."

A generic mechanism in Neisseria meningitidis for enhanced resistance against bactericidal antibodies. מאת Uria, M, Zhang, Q, Li, Y, Chan, A, Exley, R, Gollan, B, Chan, H, Feavers, I, Yarwood, A, Abad, R, Borrow, R, Fleck, R, Mulloy, B, Vazquez, J, Tang, C

"...The increased resistance was not caused by changes either in lipopolysaccharide sialylation or acetylation of the alpha2-9-linked polysialic acid capsule. ..."

Deletion of the major GATA1 enhancer HS 1 does not affect eosinophil GATA1 expression and eosinophil differentiation. מאת Guyot, B, Valverde-Garduno, V, Porcher, C, Vyas, P

"...Chromatin isolated from eosinophils and encompassing HS 1 is weakly enriched for acetylated histones H3/H4. HS 1 deletion does not alter eosinophil GATA1 locus histone acetylation. ..."

Leukemogenic MLL fusion proteins bind across a broad region of the Hox a9 locus, promoting transcription and multiple histone modifications. מאת Milne, T, Martin, M, Brock, H, Slany, R, Hess, J

"...Induction of MLL fusion protein activity is associated with increased levels of histone acetylation and Lys(4) methylation at Hox target genes. ..."

REVERBa couples the circadian clock to hepatic glucocorticoid action מאת Caratti, G, Iqbal, M, Hunter, L, Kim, D, Wang, P, Vonslow, RM, Begley, N, Tetley, AJ, Woodburn, JL, Pariollaud, M, Maidstone, R, Donaldson, IJ, Zhang, Z, Ince, LM, Kitchen, G, Baxter, M, Poolman, TM, Daniels, DA, Stirling, DR, Brocker, C, Gonzalez, F, Loudon, AS, Bechtold, DA, Rattray, M, Matthews, LC, Ray, DW

"...REVERBa promoted efficient GR recruitment to chromatin during the day, acting in part by maintaining histone acetylation, with REVERBa-dependent GC responses providing segregation of carbohydrate and lipid metabolism. ..."

Reactivation of a developmentally silenced embryonic globin gene מאת King, AJ, Songdej, D, Downes, DJ, Beagrie, RA, Liu, S, Buckley, M, Hua, P, Suciu, MC, Marieke Oudelaar, A, Hanssen, LLP, Jeziorska, D, Roberts, N, Carpenter, SJ, Francis, H, Telenius, J, Olijnik, A-A, Sharpe, JA, Sloane-Stanley, J, Eglinton, J, Kassouf, MT, Orkin, SH, Pennacchio, LA, Davies, JOJ, Hughes, JR, Higgs, DR, Babbs, C

"...The ζ-gene can be partially re-activated by acetylation and inhibition of histone de-acetylases. ..."

The HIF complex recruits the histone methyltransferase SET1B to activate specific hypoxia-inducible genes מאת Ortmann, BM, Burrows, N, Lobb, IT, Arnaiz, E, Wit, N, Bailey, PSJ, Jordon, LH, Lombardi, O, Peñalver, A, McCaffrey, J, Seear, R, Mole, DR, Ratcliffe, PJ, Maxwell, PH, Nathan, JA

"...The selective induction of H3K4 trimethylation at HIF target loci is both HIF- and SET1B-dependent and, when impaired, correlates with decreased promoter acetylation and gene expression. Together, these findings show SET1B as a determinant of site-specific histone methylation and provide insight into how HIF target genes are differentially regulated...."

Androgen receptor deregulation drives bromodomain-mediated chromatin alterations in prostate cancer. מאת Urbanucci, A, Barfeld, S, Kytölä, V, Itkonen, H, Coleman, I, Vodák, D, Sjöblom, L, Sheng, X, Tolonen, T, Minner, S, Burdelski, C, Kivinummi, K, Kohvakka, A, Kregel, S, Takhar, M, Alshalalfa, M, Davicioni, E, Erho, N, Lloyd, P, Karnes, R, Ross, A, Schaeffer, E, Vander Griend, D, Knapp, S, Corey, E, Feng, F, Nelson, P, Saatcioglu, F, Knudsen, K, Tammela, T, Sauter, G, Schlomm, T, Nykter, M, Visakorpi, T, Mills, I

"...In addition, histone acetylation readers such as bromodomain-containing protein 4 (BRD4) have been shown to associate with these TFs and contribute to aggressive cancers including prostate cancer (PC). ..."

A positively charged channel within the Smc1/Smc3 hinge required for sister chromatid cohesion. מאת Kurze, A, Michie, K, Dixon, SE, Mishra, A, Itoh, T, Khalid, S, Strmecki, L, Shirahige, K, Haering, C, Löwe, J, Nasmyth, K

"...Our finding that neutralization reduces acetylation of Smc3, which normally occurs during replication and is essential for cohesion, suggests that the positively charged channel is involved in a major conformational change during S phase...."

Regulation of E2F-1 by methylation and NEDDylation מאת Loftus, S, Sarah Loftus

"...One of the ways E2F-1 activity is controlled is by direct modification by post translational modifications such as acetylation, ubiquitination and phosphorylation. Here it was demonstrated that E2F-1 is targeted by two novel modifications, namely methylation by Set7/9 and NEDDylation, both within the DNA binding and heterodimerisation domain of the protein. ..."

Drug Insight: histone deacetylase inhibitor-based therapies for cutaneous T-cell lymphomas. מאת Khan, O, La Thangue, N

"...Reversible acetylation is mediated by histone deacetylase (HDAC), which is involved in regulating a broad repertoire of physiological processes, many of which are under aberrant control in tumor cells. ..."

Physical and mechanical properties of rubberwood particleboard made with furfuryl alcohol added urea formaldehyde resin מאת Sek, Bih Fang

"...Chemical modification on the rubberwood particleboard such as acetylation and furfurylation are great in improving the dimensional of particleboard. ..."
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The delta opioid receptor influences circadian rhythms in human N/TERT-1 keratinocytes through the β-arrestin pathway מאת Junnarkar, Seetanshu Bharat

"...Coupled with this finding, β-arrestin1 was found to regulate the transcription of its target genes, including Per2, by facilitating histone 4 acetylation. Taken together, we propose that activation of DOPr leads to a phase shift in Per2 expression via β-arrestin1 facilitated chromatin remodelling. ..."
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Drug target discovery in human malaria; inhibition of histone deacetylases (HDAC) in Plasmodium falciparum. מאת Chua, Rui Jing.

"...The two HDAC inhibitors used in this study were apicidin (API) and Trichostatin A (TSA); both HDAC inhibitors have shown to affect the level of acetylation on H3 and H4 modification. Interestingly, the level of methylated H3K4 and H4K20 seems to be altered by API and TSA. ..."
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Synthesis Of 3,4-Dimethqxy Isoamyl Cinnamic As The Sunscreen Compound From Clove Oil And Fusel Oil = Sintesis Senyawa Tabir Surya 3,4-dlmetoksi lsoamll Sinamat clad Bahan Dasar Min... מאת Perpustakaan UGM, i-lib

"...From the fusel oil, we isolate isoamyl alcohol and modified by acetylation into isoamyl acetic. The final product could be produce by C/a issen's condensation of isoamyl acetic and veratraldehyde to give 3,4-dimethoxy isoamyl cinnamic. ..."

Genetic predisposition to chronic lymphocytic leukemia is mediated by a BMF super-enhancer polymorphism. מאת Kandaswamy, R, Sava, G, Speedy, H, Beà, S, Martín-Subero, J, Studd, J, Migliorini, G, Law, P, Puente, X, Martín-García, D, Salaverria, I, Gutiérrez-Abril, J, López-Otín, C, Catovsky, D, Allan, J, Campo, E, Houlston, R

"...SNP rs539846 C&gt;A, the most highly associated variant (p = 1.42 × 10(-13), odds ratio = 1.35), localizes to a super-enhancer defined by extensive histone H3 lysine 27 acetylation in intron 3 of B cell lymphoma 2 (BCL2)-modifying factor (BMF). ..."

Family with sequence similarity 60A (FAM60A) protein is a cell cycle-fluctuating regulator of the SIN3-HDAC1 histone deacetylase complex. מאת Muñoz, I, MacArtney, T, Sanchez-Pulido, L, Ponting, C, Rocha, S, Rouse, J

"...Cells depleted of FAM60A show increased histone acetylation at the cyclin D1 promoter and elevated levels of cyclin D1 mRNA and protein. ..."

Reaction engineering for protein modification: tools for chemistry and biology מאת Chalker, J

"...Dehydroalanine is used as a general precursor to several post-translational modifications and glycosylation, polyprenylation, phosphorylation, and lysine methylation and acetylation are all accessible. These modifications and their mimics were explored on multiple proteins, including histone proteins. ..."