Globin gene activation during haemopoiesis is driven by protein complexes nucleated by GATA-1 and GATA-2. by Anguita, E, Hughes, J, Heyworth, C, Blobel, G, Wood, W, Higgs, D

“…Changes in protein/DNA binding are accompanied by sequential alterations in long-range histone acetylation and methylation. The recruitment of polymerase II, which ultimately leads to a rapid increase in alpha-globin transcription, occurs late in maturation. …”

Specialized transcription factories. by Bartlett, J, Blagojevic, J, Carter, D, Eskiw, C, Fromaget, M, Job, C, Shamsher, M, Trindade, I, Xu, M, Cook, P

“…Because a promoter can diffuse approximately 100 nm in 15 s, one lying near a factory is likely to initiate; moreover, when released at termination, it will still lie near a factory, and the movement and modifications (e.g. acetylation) accompanying elongation will leave it in an 'open' conformation. …”

Regulatory T cells: hypes and limitations. by Schiopu, A, Wood, K

“…The level of expression and the extent of posttranslational acetylation of the regulatory T-cell specific transcription factor Foxp3 are important modulators of their suppressive activity. …”

Transcriptional and epigenetic basis for restoration of G6PD enzymatic activity in human G6PD-deficient cells. by Makarona, K, Caputo, V, Costa, J, Liu, B, O'Connor, D, Iskander, D, Roper, D, Robertson, L, Bhatnagar, N, Terpos, E, Georgiou, E, Papaioannou, M, Layton, D, Luzzatto, L, Roberts, I, Karadimitris, A

“…This requires enhanced recruitment of the generic transcription factor Sp1, with commensurate recruitment of histone acetyltransferases and deacetylases, increased histone acetylation, and polymerase II recruitment to G6PD. …”

Synthesis and anticancer activities of 6-amino amonafide derivatives. by Norton, J, Witschi, M, Luong, L, Kawamura, A, Ghosh, S, Stack, MS, Sim, E, Avram, M, Appella, D, Huang, S

“…Amonafide contains a free arylamine, which causes it to be metabolized in humans by N-acetyl transferase-2 (NAT2) into a toxic form. To eliminate the NAT2 acetylation of amonafide while retaining the anticancer properties, we have synthesized nine derivatives that are structurally similar to amonafide that should not be acetylated. …”

Protein arginine methylation: a prominent modification and its demethylation by Wesche, J, Kühn, S, Kessler, B, Salton, M, Wolf, A

“…Prominent histone modifications like lysine acetylation and lysine methylation are reversible. Enzyme family pairs have been identified, with each pair of lysine acetyltransferases/deacetylases and lysine methyltransferases/demethylases operating complementarily to generate or erase lysine modifications. …”

DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation by Godfrey, L, Crump, N, Thorne, R, Lau, I, Repapi, E, Dimou, D, Smith, A, Harman, J, Telenius, J, Oudelaar, A, Downes, D, Vyas, P, Hughes, J, Milne, T

“…Using the DOT1L inhibitor EPZ-5676 in MLL-AF4 leukemia cells, we show that H3K79me2/3 is required for maintaining chromatin accessibility, histone acetylation and transcription factor binding specifically at KEEs but not non-KEE enhancers. …”

Controlling intramolecular interactions in the design of selective, high-affinity, ligands for the CREBBP Bromodomain by Brand, M, Clayton, J, Moroglu, M, Schiedel, M, Picaud, S, Buck, J, Skwarska, A, Bolland, H, Chan, A, Laurin, C, Scorah, A, See, L, Rooney, T, Andrews, K, Fedorov, O, Perell, G, Kalra, P, Vinh, K, Cortopassi, W, Heitel, P, Christensen, K, Cooper, R, Paton, R, Pomerantz, W, Biggin, P, Hammond, E, Filippakopoulos, P, Conway, S

“…The bromodomains of CREBBP and EP300 enable binding of acetylated lysine residues from histones, and a number of other important proteins, including p53, p73, E2F and GATA1. …”

Kenaf/Glass Hybrid Composites: Preparation, Characterization And Properties by Abdul Malek Ya’acob, Abdul Malek

“…Kenaf treatment was done using sodium hydroxide and acetylation process to modify the surface of the kenaf fibers. …”
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Kenaf/Glass Hybrid Composites: Preparation, Characterization And Properties by Ya’acob, Abdul Malek

“…Kenaf treatment was done using sodium hydroxide and acetylation process to modify the surface of the kenaf fibers. …”
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Synthesis of several bisabolane sesquiterpenoids from xanthorrhizol isolated from C. Xanthorrhiza by Ngai, Mun Hong

“…Fremy’s salt oxidation of xanthorrhizol gave curcuhydroquinone in 60% yield, which was successfully reduced with sodium dithionite to curcuhydroquinone in 100% yield. Sequential acetylation and Sharpless asymmetric dihydroxylation on curcuhydroquinone led to the diacetate derivative of helibisabonol A. …”
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Metabolism in mood disorder across the gut-liver-brain axis by Radford-Smith, DE

“…Serum triglycerides, VLDL, isoleucine, and the inflammatory biomarker of glycoprotein acetylation were key metabolites increased in patients with recent depressive symptoms. …”

Sororin actively maintains sister chromatid cohesion by Ladurner, Rene, Kreidl, Emanuel, Ivanov, Miroslav P., Ekker, Heinz, Idarraga‐Amado, Maria H., Busslinger, Georg A., Wutz, Gordana, Cisneros, David A., Peters, Jan‐Michael

“…Cohesion is mediated by cohesin, but also depends on cohesin acetylation and sororin. Sororin contributes to cohesion by stabilizing cohesin on DNA. …”
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Investigating the functions and signaling properties of kindlins by Tan, Hui Foon

“…Mechanistically, it involves the Akt/ GSK3β / Histone deacetylase 6 (HDAC6) or/and Paxillin/ HDAC6 signaling pathway that modulates the acetylation of α-tubulin, a post-translational modification that stabilizes microtubules. …”
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Maintenance of muscle myosin levels in adult C. elegans requires both the double bromodomain protein BET-1 and sumoylation. by Fisher, K, Gee, F, Wang, S, Xue, F, Knapp, S, Philpott, M, Wells, C, Rodriguez, M, Snoek, L, Kammenga, J, Poulin, G

“…BET-1 is a conserved double bromodomain protein that recognises acetyl-lysines on histone tails and maintains the stable fate of various lineages. …”

Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming by Ebrahimi, A, Sevinç, K, Sevinç, G, Cribbs, A, Philpott, M, Uyulur, F, Morova, T, Dunford, J, Göklemez, S, Arı, Ş, Oppermann, U, Onder, T

“…CBP/EP300 bromodomain inhibition decreases somatic-specific gene expression, histone H3 lysine 27 acetylation (H3K27Ac) and chromatin accessibility at target promoters and enhancers. …”

Deleterious effects of obesity upon the hormonal and molecular mechanisms controlling spermatogenesis and male fertility by Davidson, L, Millar, K, Jones, C, Fatum, M, Coward, K

“…More recent investigations into trans-generational epigenetic inheritance further suggest that molecular changes in sperm that arise from obesity-related impaired spermatogenesis, such as modified sperm RNA levels, DNA methylation, protamination and histone acetylation, can impact upon the development of offspring. …”

BRD3 and BRD4 BET bromodomain proteins differentially regulate skeletal myogenesis by Roberts, T, Etxaniz, U, Dall'Agnese, A, Wu, S, Chiang, C, Brennan, P, Wood, M, Puri, P

“…These molecules target Bromodomain and Extra Terminal domain (BET) proteins, which are epigenetic readers of acetylated histone lysine tail residues. BETi-mediated anti-myogenic effects were also observed in a model of MYOD1-mediated myogenic conversion of human fibroblasts, and in primary mouse and human myoblasts. …”

Benzoisoquinolinediones as potent and selective inhibitors of BRPF2 and TAF1/TAF1L bromodomains by Bouché, L, Christ, C, Siegel, S, Fernández-Montalván, A, Holton, S, Fedorov, O, Ter Laak, A, Sugawara, T, Stöckigt, D, Tallant, C, Bennett, J, Monteiro, O, Díaz-Sáez, L, Siejka, P, Meier, J, Pütter, V, Weiske, J, Müller, S, Huber, K, Hartung, I, Haendler, B

“…Bromodomains (BD) are readers of lysine acetylation marks present in numerous proteins associated with chromatin. …”

Perturbation of the yeast N-acetyltransferase NatB induces elevation of protein phosphorylation levels. by Helbig, A, Rosati, S, Pijnappel, P, van Breukelen, B, Timmers, M, Mohammed, S, Slijper, M, Heck, A

“… BACKGROUND: The addition of an acetyl group to protein N-termini is a widespread co-translational modification. …”