3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands. od Hewings, D, Wang, M, Philpott, M, Fedorov, O, Uttarkar, S, Filippakopoulos, P, Picaud, S, Vuppusetty, C, Marsden, B, Knapp, S, Conway, S, Heightman, T

“…Bromodomains bind acetylated lysines, acting as readers of the histone-acetylation code. …”

Dissecting the role of CBP/P300-mediated acetylation in enhancer function od Jackson, N

“…However, the extent to which histone acetylation is important for enhancer function is not fully elucidated. …”

3-Acetyl-2-methyl-4-phenylquinolin-1-ium chloride od Tan, Kong Wai, Tiekink, E.R.T., Kiran, K., Sarveswari, S., Vijayakumar, V.

“…The quinolin-1-ium residue is almost planar (r.m.s. deviation = 0.020 A) but both the acetyl group [O-C-C-C torsion angle = 62.73 (17)degrees] and adjacent benzene ring [C-C-C-C torsion angle = -104.06 (14)degrees] are twisted out of this plane; the acetyl and benzene substituents are non-parallel [dihedral angle = 66.16 (7)degrees]. …”
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5-Acetyl goniothalamin, a styryl dihydropyrone from Goniothalamus uvaroides od Badruddin Ahmad, Fasihuddin, Tukol, Wan Ahmad, Omar, Siraj, Mohd. Sharif, Atan

“…However, 5-acetyl goniothalamin has never been reported before. …”
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Spectroscopic data of 3-O-acetyl-betulinic acid: an antitumor reagent od Ahmad @ Amat, Faujan, Ghaffari-Moghaddam, Mansour, Basri, Mahiran, Abdul Rahman, Mohd Basyaruddin

“…In this paper, the spectroscopic data of the 3-O-acetyl betulinic acid is reported. This compound was prepared by enzymatic reaction of betulinic acid and acetic anhydride in the presence of lipase from Candida antarctica (Novozem® 435) at 54oC for 20 h in 79.3 % yield.…”
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Decay threshold of acetylated rattan (Calamus manan) against soft rot od Hamid, Norul Hisham, Hale, Mike

“…We investigated the resistance of acetylated rattan against soft rot and other soil inhabiting micro-organisms in comparison with wood of beech and Scots pine. …”
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Synthesis of acetylated glucose esters of palm fatty acids and their properties as surfactants od Obaje, Olobo Jonathan

“…The reactions leading to the fonnation of the mono- and di-substituted acetylated glucose fatty esters were found to follow zero-order kinetics. …”
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Determinants within the C-Terminal Domain of Streptomyces lividans Acetyl-CoA Synthetase that Block Acetylation of Its Active Site Lysine In Vitro by the Protein Acetyltransferase (Pat) Enzyme od Tucker, Alex C., Escalante-Semerena, Jorge C.

“…Reversible lysine acetylation (RLA) is a widespread regulatory mechanism that modulates the function of proteins involved in diverse cellular processes. …”
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Histone H4 acetylation regulates behavioral inter-individual variability in zebrafish od Román, Angel-Carlos, Vicente-Page, Julián, Carvajal-González, Jose M, Fernández-Salguero, Pedro M, de Polavieja, Gonzalo G, Carvajal-González, Jose M., Fernández-Salguero, Pedro M., de Polavieja, Gonzalo G., Perez Escudero, Alfonso

“…Individuals with high levels of histone H4 acetylation, and specifically H4K12, behave similarly to the average of the population, but those with low levels deviate from it. …”
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Distinct and Predictive Histone Lysine Acetylation Patterns at Promoters, Enhancers, and Gene Bodies od Rajagopal, Nisha, Kellis, Manolis, Ernst, Jason, Ray, Pradipta, Wu, Jie, Zhang, Michael, Ren, Bing

“…In eukaryotic cells, histone lysines are frequently acetylated. However, unlike modifications such as methylations, histone acetylation modifications are often considered redundant. …”
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Influence of histone tails and H4 tail acetylations on nucleosome–nucleosome interactions od Liu, Ying, Lu, Chenning, Yang, Ye, Fan, Yanping, Yang, Renliang, Liu, Chuan Fa, Korolev, Nikolay, Nordenskiöld, Lars

“…In addition, the histone construct with the single H4K16 acetylation was investigated. Acetylated histones were prepared by a semisynthetic native chemical ligation method. …”
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Acetylated bovine serum albumin differentially inhibits polymerase chain reaction in microdevices od Ramalingam, Naveen, Warkiani, Majid Ebrahimi, Gong, Thomas Hai-Qing

“…BSA is available commercially in two types: either acetylated or non-acetylated. A survey of literature indicates that both types of BSA are used in PCR-based microfluidic devices. …”
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Characterisation of in-situ modified bacterial cellulose using 2-acetyl-1-pyrroline od Pa'e, Norhayati

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Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium. od van Noort, V, Seebacher, J, Bader, S, Mohammed, S, Vonkova, I, Betts, M, Kühner, S, Kumar, R, Maier, T, O'Flaherty, M, Rybin, V, Schmeisky, A, Yus, E, Stülke, J, Serrano, L, Russell, R, Heck, A, Bork, P, Gavin, A

“…The results imply previously unreported hidden layers of post-transcriptional regulation intertwining phosphorylation with lysine acetylation and other mechanisms that define the functional state of a cell.…”

N-terminal cysteine acetylation and oxidation patterns may define protein stability od Heathcote, KC, Keeley, TP, Myllykoski, M, Lundekvam, M, McTiernan, N, Akter, S, Masson, N, Ratcliffe, PJ, Arnesen, T, Flashman, E

“…This could be because alternative modifications of N-terminal cysteine residues, including acetylation, prevent ADO-catalysed oxidation. Here we investigate the relationship between ADO-catalysed oxidation and NatA-catalysed acetylation of a broad range of protein sequences with N-terminal cysteines. …”

Building sister chromatid cohesion: smc3 acetylation counteracts an antiestablishment activity. od Rowland, B, Roig, M, Nishino, T, Kurze, A, Uluocak, P, Mishra, A, Beckouët, F, Underwood, P, Metson, J, Imre, R, Mechtler, K, Katis, V, Nasmyth, K

“…We describe here smc3, scc3, pds5, and rad61 mutations that permit yeast cell proliferation and entrapment of sister DNAs by cohesin rings in the absence of Eco1, an acetyl transferase normally essential for establishing sister chromatid cohesion. …”

Functional and structural characterization of a thermostable acetyl esterase from Thermotoga maritima. od Levisson, M, Han, G, Deller, M, Xu, Q, Biely, P, Hendriks, S, Ten Eyck, L, Flensburg, C, Roversi, P, Miller, MD, McMullan, D, von Delft, F, Kreusch, A, Deacon, A, van der Oost, J, Lesley, SA, Elsliger, M, Kengen, S, Wilson, I

“…No activity was detected on xylan or acetylated xylan, which implies that TM0077 is an acetyl esterase and not an acetyl xylan esterase as currently annotated. …”

Acetylation of L12 increases interactions in the Escherichia coli ribosomal stalk complex. od Gordiyenko, Y, Deroo, S, Zhou, M, Videler, H, Robinson, C

“…For cells grown in minimal medium, L12 acetylation and processing is altered, resulting in deficient removal of N-terminal methionine in approximately 50% of the L12 population, while processed L12 is almost 100% acetylated. …”

Functional and structural characterization of a thermostable acetyl esterase from Thermotoga maritima od Levisson, M, Han, G, Deller, M, Xu, Q, Biely, P, Hendriks, S, Ten Eyck, L, Flensburg, C, Roversi, P, Miller, MD, McMullan, D, von Delft, F, Kreusch, A, Deacon, A, van der Oost, J, Lesley, SA, Elsliger, M, Kengen, S, Wilson, I

“…No activity was detected on xylan or acetylated xylan, which implies that TM0077 is an acetyl esterase and not an acetyl xylan esterase as currently annotated. …”

Progress in the development and application of small molecule inhibitors of bromodomain-acetyl-lysine interactions. od Hewings, D, Rooney, T, Jennings, L, Hay, D, Schofield, C, Brennan, P, Knapp, S, Conway, S

“…Bromodomains, protein modules that recognize and bind to acetylated lysine, are emerging as important components of cellular machinery. …”