The value of machine perfusion perfusate biomarkers for predicting kidney transplant outcome. מאת Moers, C, Varnav, O, van Heurn, E, Jochmans, I, Kirste, G, Rahmel, A, Leuvenink, H, Squifflet, J, Paul, A, Pirenne, J, van Oeveren, W, Rakhorst, G, Ploeg, R

"... BACKGROUND: Retrospective evidence suggests that lactate dehydrogenase, aspartate aminotransferase, total glutathione-S-transferase (GST), alanine-aminopeptidase, N-acetyl-β-D-glucosaminidase (NAG), and heart-type fatty acid binding protein (H-FABP) measured during kidney machine perfusion (MP) could have predictive value for posttransplant outcome. ..."

Genetic engineering of the primary/secondary metabolic interface in tobacco BY-2 cells מאת Hall-Ponselè, A

"...This was achieved by genetically engineering increased activity of mitochondrial citrate synthase, an enzyme of the tricarboxylic acid (TCA) cycle that is involved in the provision of cytosolic acetyl coenzyme A, the primary metabolite precursor to sterols. ..."

Asymmetric synthesis of the loline alkaloids מאת Linsdall, SM

"...</p> <p><b>Chapter 5</b> describes the synthesis of four loline alkaloids (loline, norloline, N-acetyl loline and N-methyl loline) from (+)-norloline dihydrochloride, which was followed by comparison of their spectroscopic data with those previously reported in the literature...."

Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains מאת Hay, D, Fedorov, O, Martin, S, Singleton, D, Tallant, C, Wells, C, Picaud, S, Philpott, M, Monteiro, O, Rogers, C, Conway, S, Rooney, T, Tumber, A, Yapp, C, Filippakopoulos, P, Bunnage, M, Müller, S, Knapp, S, Schofield, C, Brennan, P

"...Here, we describe highly potent and selective ligands for the bromodomain module of the human lysine acetyl transferase CBP/p300, developed from a series of 5-isoxazolyl-benzimidazoles. ..."

Orphan macrodomain protein (human C6orf130) is an O-acyl-ADP-ribose deacylase: solution structure and catalytic properties. מאת Peterson, F, Chen, D, Lytle, B, Rossi, M, Ahel, I, Denu, J, Volkman, B

"...We demonstrate that C6orf130 catalyzes the efficient deacylation of O-acetyl-ADP-ribose, O-propionyl-ADP-ribose, and O-butyryl-ADP-ribose to produce ADP-ribose (ADPr) and acetate, propionate, and butyrate, respectively. ..."

Polymorphisms and colorectal tumor risk. מאת Houlston, R, Tomlinson, I

"...For tumor protein 53 (TP53), N-acetyl transferase 1 (NAT1), NAT2, glutathione-S transferase Mu (GSTM1), glutathione-S transferase Theta (GSTT1), and glutathione-S transferase Pi (GSTP1) polymorphisms, the best estimates are sufficient to exclude a 1.7-fold increase in risk of colorectal cancer. ..."

Accommodation of a central arginine in a transmembrane peptide by changing the placement of anchor residues. מאת Vostrikov, V, Hall, B, Sansom, MS, Koeppe, R

"...Derivatives of the designed peptide GWALP23, acetyl-GGALW(5)LALALALALALALW(19)LAGA-amide, with single Trp anchors, have proven useful for characterizing such interactions. ..."

Alterations in receptor binding properties of recent human influenza H3N2 viruses are associated with reduced natural killer cell lysis of infected cells. מאת Owen, R, Yamada, E, Thompson, C, Phillipson, L, Thompson, C, Taylor, E, Zambon, M, Osborn, H, Barclay, W, Borrow, P

"...The SA binding properties of H3N2 influenza viruses have been observed to change during circulation in humans: recent isolates are unable to agglutinate chicken red blood cells and show reduced affinity for synthetic glycopolymers representing SA-alpha-2,3-lactose (3'SL-PAA) and SA-alpha-2,6-N-acetyl lactosamine (6'SLN-PAA) carbohydrates. Here, NK lysis of cells infected with human H3N2 influenza viruses isolated between 1969 and 2003 was analyzed. ..."

Investigating the role of lysine demethylase UTX-1 in lifespan regulation of C. elegans מאת Guillermo, A

"...Overall, the work in this thesis, which also includes analysis of <em>cbp-1</em> (H3K27 acetyl transferase), suggests that lifespan regulation due to H3K27 modification is incredibly complex and that longevity is mediated differentially as a consequence of different doses of modifier, and in specific tissues, likely due to transcriptional changes mediated by the demethylase function of UTX-1...."

Salmonella Typhi Vi capsule prime-boost vaccination induces convergent and functional antibody responses מאת Dahora, LC, Verheul, MK, Williams, KL, Jin, C, Stockdale, L, Pollard, AJ, Cavet, G, Giladi, E, Hill, J, Kim, D, Leung, Y, Bobay, BG, Spicer, LD, Sawant, S, Rijpkema, S, Dennison, SM, Alam, SM, Tomaras, GD

"...We identified antibodies induced by prime and boost vaccines that recognized subdominant epitopes, indicated by binding to the de–O-acetylated Vi backbone. These antibodies also mediated Fc-dependent functions, such as complement deposition and monocyte phagocytosis. ..."

Deficiency of PPARalpha disturbs the response of lipogenic flux and of lipogenic and cholesterogenic gene expression to dietary cholesterol in mouse white adipose tissue. מאת Islam, K, Knight, B, Frayn, K, Patel, D, Gibbons, G

"...The increased lipogenesis in the chow-fed PPARalpha-null mice was accompanied paradoxically by lower mRNA expression of SREBP-1c and its target genes, acetyl-CoA carboxylase and fatty acid synthase. Consumption of a high-cholesterol diet increased the mRNA expression of these genes in the PPARalpha-deficient mice but not in the wild-type. ..."

Chemical constituents of Croton laevifolius Blume bark / Ahmad Nazif Aziz מאת Aziz, Ahmad Nazif

"...Subsequently, the hexane extract yielded laevifin B, three oleanane triterpenes: P-amyrin, (3-amyrone (MS) = Main Supervisor (CS) = Co Supervisor and acetyl aleuritolic acid; one steroid (p-sitostenone) and one flavonoid named pachypodol…..."
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Synthesis of 3,4-fused y-lactone-y-lactam and y-lactonepyrrolidine bicyclic systems / Nur Aini Azib מאת Azib, Nur Aini

"...The y-lactam ring moiety underwent C-alkylation reaction at the C3-position via insertion of the ethyl acetyl functionality by utilizing TBAF as the base. ..."
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Identification of metabolites in the normal ovary and their transformation in primary and metastatic ovarian cancer מאת Fong, M.Y., McDunn, J., Kakar, S.S.

"...We have also identified novel metabolites in the ovary, specifically N-acetylasparate and N-acetyl-aspartyl-glutamate, whose role in ovarian physiology has yet to be determined. ..."

Modulation of major histocompatibility complex (MHC) class i heavy chain gene expression by naringenin in cells that express human papillomavirus (HPV) E6 and E7 genes מאת Yusof, Rohana, Yim, Yong Hoi, Mohd, Mustafa Ali, Blair, G Eric

"...Treatment of control 3Y1 cells and cells co-transfected with high or low risk HPV E6 and E7 plasmids with 300µg/ml of Naringenin for 24 hours led to an increase in H-2Kb-driven CAT (chloramphenicol acetyl transferase) reporter gene activity. Thus, Naringenin retained the ability to increase H-2Kb promoter activity in the presence of either E6 or E7 expression constructs, indicating that Naringenin can over-ride the transcriptional repressor effects of HPV oncoproteins and may therefore have some potential immunostimulatory properties in HPV-associated malignancy...."
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Analysis of pyrrolizidine alkaloids in stingless bee honey and identification of a botanical source as Ageratum conyzoides מאת Hungerford, Natasha L., Zawawi, Norhasnida, Zhu, Tianqi, Carter, Steve J., Melksham, Kevin J., Fletcher, Mary T.

"...The evaluation of this weed provided a PA profile matching that of the SBH of H. itama produced nearby, and included supinine, supinine N-oxide (or isomers) and acetylated derivatives. These PAs lacking a hydroxyl group at C7 are thought to be less hepatoxic. ..."
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Analysis of pyrrolizidine alkaloids in stingless bee honey and identification of a botanical source as Ageratum conyzoides מאת Hungerford, Natasha L., Zawawi, Norhasnida, Zhu, Tianqi, Carter, Steve J., Melksham, Kevin J., Fletcher, Mary T.

"...The evaluation of this weed provided a PA profile matching that of the SBH of H. itama produced nearby, and included supinine, supinine N-oxide (or isomers) and acetylated derivatives. These PAs lacking a hydroxyl group at C7 are thought to be less hepatoxic. ..."

Metabolic engineered Escherichia coli to enhance polyhydroxyalkanoates production מאת Mohamed Biran, Nurhajirah, Mohd Yusoff, Mohd Zulkhairi, Maeda, Toshinari, Zakaria @ Mamat, Mohd Rafein, Hassan, Mohd Ali

"...Biosynthesis of PHA consists of three enzymes which are acetyl-CoA acetyltransferase (phaA), acetoacetyl-CoA reductase (phaB) and PHA synthase (phaC). ..."
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Isolation and Characterization of a Gene Coding for Chitinase in Developing Winged Bean Seed (Psophocarpus Tetragonolubus ) מאת Sekeli, Rogayah

"...Chitinase, which catalyse the hydrolysis of the β-1,4-N-acetyl-D-glucosamine linkages of the fungal cell wall polymer chitin, is involved in inducible defences of plants. ..."
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Anti-aging and antioxidant of four traditional Malaysian plants using simplex centroid mixture design approach מאת Ranneh, Yazan, Abu Bakar, Mohd Fadzelly, Ismail, Nur Amalina, Kormin, Faridah, Mohamed, Maryati, Md Akim, Abdah, Isha, Azizul

"...After selecting the optimal formulations based on desirability function of antioxidant activity (DPPḢ, ABTṠ+ and FRAP), they were further examined against the activity of aging-related-enzymes (collagenase, tyrosinase, acetyl- and butyrylcholinesterase). The single extracts of C. palala, U. micrantha and the binary mixture of C. palala and U. micrantha were the optimal formulations with high antioxidant activities. ..."