Methylation-directed acetylation of histone H3 regulates developmental sensitivity to histone deacetylase inhibition מאת Huang, L-Y, Hsu, D-W, Pears, CJ

"...Treatment of cells with hydroxamates such as trichostatin A (TSA) leads to rapid preferential acetylation of histone H3 already trimethylated on lysine 4 (H3K4me3), although the importance of this H3K4me3-directed acetylation in the biological consequences of KDACi treatment is not known. ..."

Acetylated alpha-tubulin in Physarum: immunological characterization of the isotype and its usage in particular microtubular organelles. מאת Sasse, R, Glyn, M, Birkett, C, Gull, K

"...We have used monoclonal antibodies specific for acetylated and unacetylated alpha-tubulin to characterize the acetylated alpha-tubulin isotype of Physarum polycephalum, its expression in the life cycle, and its localization in particular microtubular organelles. ..."

Profiling of N-acetylated protein termini provides in-depth insights into the N-terminal nature of the proteome. מאת Helbig, A, Gauci, S, Raijmakers, R, van Breukelen, B, Slijper, M, Mohammed, S, Heck, A

"...Our multiprotease approach led to the identification of 1391 acetylated human protein N termini in HEK293 cells and revealed that the role of the penultimate position on the cleavage efficiency by the methionine aminopeptidases is essentially conserved from Escherichia coli to human. ..."

Regulation of transcription through acetylation of H3K122 on the lateral surface of the histone octamer. מאת Tropberger, P, Pott, S, Keller, C, Kamieniarz-Gdula, K, Caron, M, Richter, F, Li, G, Mittler, G, Liu, E, Bühler, M, Margueron, R, Schneider, R

"...Collectively, this suggests that transcriptional regulators elicit their effects not only via signaling to histone tails but also via direct structural perturbation of nucleosomes by directing acetylation to their lateral surface...."

Associations between diffusion and perfusion parameters, N-acetyl aspartate, and lactate in acute ischemic stroke. מאת Cvoro, V, Wardlaw, J, Marshall, I, Armitage, P, Rivers, C, Bastin, M, Carpenter, T, Wartolowska, K, Farrall, A, Dennis, MS

"...We used spectroscopic imaging to measure N-acetyl aspartate (NAA, a marker of normal neurons) and lactate (a marker of ischemia) to compare with diffusion and perfusion values in the diffusion lesion in acute ischemic stroke. ..."

Citrullination-acetylation interplay guides E2F-1 activity during the inflammatory response מאת la Thangue, N, Ghari, F, Munro, S, Quirke, A, Kawalkowska, A, Picaud, S, McGouran, J, Williams, R, Kessler, B, Fillipakopoulos, P, Knapp, S, Venables, P, Subramian, V, Muth, A, Thompson, P

"...Our results shed light on a new E2F-dependent pathway that mediates the inflammatory effect of PAD4 and, for the first time, establish the interplay between citrullination and acetylation as a regulatory interface for driving inflammatory gene expression...."

Acetyl-CoA carboxylase-1 is a critical regulator of beta cell size and proliferation מאת Cantley, J, Whitworth, P, Davenport, A, Hoehn, K, James, D, Biden, T

KAT2-mediated PLK4 acetylation contributes to genomic stability by preserving centrosome number מאת Fournier, M, Tora, L

"...We have recently identified the first human lysine (K) acetyltransferase 2A and 2B (called KAT2A/2B; known also as GCN5/PCAF, respectively)-dependent acetylome and revealed a mechanism by which KAT2A/2B-mediated acetylation of serine/threonine polo-like kinase 4 (PLK4) maintains correct centrosome number in human cells, therefore contributing to the maintenance of genome stability...."

3-Acetyl-5-methyl-1-(4-methylphenyl)-1H-pyrazole-4-carboxamide מאת Abdel-Aziz, H.A., Bari, A., Ng, S.W.

N-Acetyl-2-hydroxy-N'-[methoxy(1-methylindol-2-yl)methyl]benzohydrazide מאת Yehye, W.A., Rahman, N.A., Ariffin, A., Ng, Seik Weng

"...In the crystal structure of the title Schiff-base, C(20)H(21)N(3)O(4), the amino group forms an N-H⋯O hydrogen bond to the acetyl group of an adjacent mol-ecule, forming a zigzag chain. ..."
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N-acetyl-2-hydroxy-N'-[methoxy(1-methylindol-2-yl)methyl]benzohydrazide מאת Ariffin, Azhar, Ng, S.W., Yehye, W.A., Rahman, N.A.

"...In the crystal structure of the title Schiff-base, C(20)H(21)N(3)O(4), the amino group forms an N-H center dot center dot center dot O hydrogen bond to the acetyl group of an adjacent molecule, forming a zigzag chain. ..."
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Development of sulfonated carbon-based catalysts derived from palm kernel shell for acetylation of glycerol מאת Usman Idris, Nda-Umar

"...The carbon-based catalysts were deployed in glycerol acetylation and the product was analyzed using gas chromatography coupled with mass spectrometer (GC-MS), gas chromatograph equipped with flame ionization detector (GC-FID), FTIR and NMR. ..."
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Improving acetyl-CoA biosynthesis in Saccharomyces cerevisiae via the overexpression of pantothenate kinase and PDH bypass מאת Liu, Wenshan, Zhang, Bo, Jiang, Rongrong

נושאים: קבל טקסט מלא
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A dual role of linker histone H1.4 Lys 34 acetylation in transcriptional activation. מאת Kamieniarz, K, Izzo, A, Dundr, M, Tropberger, P, Ozretic, L, Kirfel, J, Scheer, E, Tropel, P, Wisniewski, JR, Tora, L, Viville, S, Buettner, R, Schneider, R

"...We provide here the first functional characterization of H1 acetylation. We show that H1.4K34 acetylation (H1.4K34ac) is mediated by GCN5 and is preferentially enriched at promoters of active genes, where it stimulates transcription by increasing H1 mobility and recruiting a general transcription factor. ..."

Dolichyl-Phosphate Alpha-N-Acetyl Glucosaminyl Transferase (DPAGT1); A Target Enabling Package מאת Carpenter, E

"...The ER integral membrane enzyme dolichyl-phosphate alpha-N-acetyl glucosaminyl phosphotransferase (DPAGT1) catalyses the first step in the synthesis of the oligosaccharide-P-P-dolichol unit which provides the glycans structure for N-glycosylation of proteins. ..."

Dolichyl-Phosphate Alpha-N-Acetyl Glucosaminyl Transferase (DPAGT1); A Target Enabling Package מאת Chu, A

"...The ER integral membrane enzyme dolichyl-phosphate alpha-N-acetyl glucosaminyl phosphotransferase (DPAGT1) catalyses the first step in the synthesis of the oligosaccharide-P-P-dolichol unit which provides the glycans structure for N-glycosylation of proteins. ..."

Identification of a conserved erythroid specific domain of histone acetylation across the a globin gene cluster. מאת Anguita, E, Jonhson, C, Wood, W, Turner, B, Higgs, D

Dolichyl-Phosphate Alpha-N-Acetyl Glucosaminyl Transferase (DPAGT1); A Target Enabling Package מאת Dong, Y

"...The ER integral membrane enzyme dolichyl-phosphate alpha-N-acetyl glucosaminyl phosphotransferase (DPAGT1) catalyses the first step in the synthesis of the oligosaccharide-P-P-dolichol unit which provides the glycans structure for N-glycosylation of proteins. ..."

KAT2-mediated acetylation switches the mode of PALB2 chromatin association to safeguard genome integrity מאת Fournier, M, Rodrigue, A, Milano, L, Bleuyard, J-Y, Couturier, AM, Wall, J, Ellins, J, Hester, S, Smerdon, SJ, Tora, L, Masson, J-Y, Esashi, F

"...In unperturbed cells, the 7K-patch is targeted for KAT2A/2B-mediated acetylation, which in turn enhances the direct association of PALB2 with nucleosomes. ..."

An anecdotal report by an Oxford basic neuroscientist: effects of acetyl-dl-leucine on cognitive function and mobility in the elderly מאת Platt, F, Strupp, M