Investigation and validation of the functional role of sMEK1 acetylation in DNA damage repair and HDACi-mediated radiosensitisation by Yeo, X

“…Reciprocal co-immunoprecipitations using anti-acetyl lysine and anti-HA antibodies confirmed the acetylation status of sMEK1 following PAN treatment. …”

Anatomy of a simple acyl intermediate in enzyme catalysis: combined biophysical and modeling studies on ornithine acetyl transferase. by Iqbal, A, Clifton, I, Bagonis, M, Kershaw, N, Domene, C, Claridge, T, Wharton, C, Schofield, C

“…We have carried out biophysical analyses on ornithine acetyl transferase (OAT2), both in solution and in the crystalline state. …”

Effect of acetylation on the physical and static bending properties of cultivated Rotan Manau (Calamus manan) grown in Peninsular Malaysia by Hamid, Norul Hisham, Mike, Hale

“…The static bending properties varied by rattan age, which the modulus of rupture (MoR), modulus of elasticity (MoE) and maximum load (ML), was not significantly different by reaction period for both ages, except for the MoR of the older acetylated rattan. The acetylation of rattan, performed at 110°C for prolong reaction period, did not impair the static bending properties.…”
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Synthesis of 2-acetyl-5,8-dihydro-1,4-dihydroxy-3-methyl naphthalene: a product from the isomerisation of Diels-Alder adducts of both 5-methyl- and 6-methyl-2-acetyl-1,4-benzoquinone with 1,3-butadiene by Ahmad, Faujan, Bruce, J. Malcolm

“…2-Acetyl-5,8-dihydro-1,4-dihydroxy-3-methyl-naphthalene was synthesised via Diels-Alder addition of 2-acetyl-3-methyl-1,4-benzoquinone to buta-1,3-diene followed by enolisation. …”
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SIRT2 Ablation Has No Effect on Tubulin Acetylation in Brain, Cholesterol Biosynthesis or the Progression of Huntington's Disease Phenotypes In Vivo by Bobrowska, Anna, Donmez Yalcin, Gizem, Weiss, Andreas, Guarente, Leonard Pershing, Bates, Gillian P.

“…Surprisingly we found that reduction or loss of SIRT2 had no effect on the acetylation of α-tubulin or H4K16 or on cholesterol biosynthesis in the brains of wild type mice. …”
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Acetylation at lysine 183 of progesterone receptor by p300 accelerates DNA binding kinetics and transactivation of direct target genes by Sze, Siu Kwan, Chung, Hwa Hwa, Tay, Alvin Shun Long, Lin, Valerie Chun Ling

“…In vivo acetylation and mutagenesis experiments revealed that Lys-183 is a primary site of progesterone receptor (PR) acetylation. …”
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Investigating the effect of soy isoflavone daidzein on the histone acetylation status of MDA-MB-231 breast cancer cell line by Quek, Su-An

“…The objective of this project was to investigate the effect of Daidzein in increasing Histone acetylation on MDA-MB-231 breast cancer cells. Results from Western Immunoblotting show that acetylation of Histone H3K9 of MDAMB-231 cells increased when treated with Daidzein as compared to the untreated control cells. …”
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Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass by Cantley, J, Davenport, A, Vetterli, L, Nemes, N, Whitworth, P, Boslem, E, Thai, L, Mellett, N, Meikle, P, Hoehn, K, James, D, Biden, T

“…However, it also feeds mitochondrial anaplerotic pathways, driving citrate export and cytosolic malonyl-CoA production by the acetyl-CoA carboxylase 1 (ACC1) enzyme. This pathway has been proposed as an alternative glucose-sensing mechanism, supported mainly by in vitro data. …”

Biofilm formation at the air-liquid interface by the Pseudomonas fluorescens SBW25 wrinkly spreader requires an acetylated form of cellulose

“…Both polar and non-polar mutations in the sixth gene of the wss operon ( wssF ) or adjacent downstream genes ( wssGHIJ ) generated mutants that overproduce non-acetylated cellulose, thus implicating WssFGHIJ in acetylation of cellulose. …”

RESOLUTION OF THE CHIRAL IRON ACETYL COMPLEX [(C5H5)FE(CO)(PPH3)COCH3] by Baker, R, Davies, S

Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP. by Crump, N, Hazzalin, C, Bowers, E, Alani, R, Cole, P, Mahadevan, L

“…Furthermore, dynamic acetylation targeted to H3K4me3 is mediated by the same lysine acetyltransferase, p300/cAMP response element binding (CREB)-binding protein (CBP), in both mouse and fly cells. …”

The NK1 receptor antagonist N-acetyl-l-tryptophan reduces dyskinesia in a hemi-parkinsonian rodent model by Thornton, E, Hassall, M, Corrigan, F, Vink, R

“…At day 21, daily administration commenced of either l-DOPA (6mg/kg plus 15mg/kg of benseraside), l-DOPA with the NK1 antagonist N-acetyl- l-tryptophan (NAT) or equal volume of saline. …”

Purified recombinant hARD1 does not catalyse acetylation of Lys532 of HIF-1alpha fragments in vitro. by Murray-Rust, T, Oldham, N, Hewitson, K, Schofield, C

“…However, recombinant hARD1 from Escherichia coli was produced with partial N-terminal acetylation and was observed to undergo slow self-mediated N-terminal acetylation. …”

Tolerance to acetyl-salicylic acid in NSAID-exacerbated respiratory disease after biological therapies with benralizumab, dupilumab, mepolizumab or omalizumab by López, J, Garcia, E, Alvarez, AMC, Buendía, J-A, Sanchez, J

Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer’s human brains by Klein, Hans-Ulrich, McCabe, Cristin, Gjoneska, Elizabeta, Sullivan, Sarah E, Kaskow, Belinda J, Tang, Anna, Smith, Robert V, Xu, Jishu, Pfenning, Andreas R, Bernstein, Bradley E, Meissner, Alexander, Schneider, Julie A, Mostafavi, Sara, Tsai, Li-Huei, Young-Pearse, Tracy L, Bennett, David A, De Jager, Philip L

“…We conducted an epigenome-wide association study using the histone 3 lysine 9 acetylation (H3K9ac) mark in 669 aged human prefrontal cortices; in contrast with amyloid-β, tau protein burden had a broad effect on the epigenome, affecting 5,990 of 26,384 H3K9ac domains. …”
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Correction: SIRT2 Ablation Has No Effect on Tubulin Acetylation in Brain, Cholesterol Biosynthesis or the Progression of Huntington’s Disease Phenotypes In Vivo by Bobrowska, Anna, Donmez, Gizem, Weiss, Andreas, Guarente, Leonard, Bates, Gillian

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Crystallographic Snapshots of Cyanide- and Water-Bound C-Clusters from Bifunctional Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase by Kung, Yan, Doukov, Tzanko I., Seravalli, Javier, Ragsdale, Stephen W., Drennan, Catherine L

“…To determine whether this bridging sulfide is catalytically relevant and to further explore the mechanism of the C-cluster, we obtained crystal structures of the 310 kDa bifunctional CODH/acetyl-CoA synthase complex from Moorella thermoacetica bound both with a substrate H2O/OH− molecule and with a cyanide inhibitor. …”
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N-acetyl-beta-D-glucopyranosylamine: a potent T-state inhibitor of glycogen phosphorylase. A comparison with alpha-D-glucose. by Oikonomakos, N, Kontou, M, Zographos, SE, Watson, K, Johnson, L, Bichard, C, Fleet, G, Acharya, K

“…The best inhibitor in the class of N-acyl derivatives of beta-D-glucopyranosylamine, N-acetyl-beta-D-glucopyranosylamine (1-GlcNAc), has been characterized by kinetic, ultracentrifugation, and crystallographic studies. 1-GlcNAc acts as a competitive inhibitor for both the b (Ki = 32 microM) and the a (Ki = 35 microM) forms of the enzyme with respect to glucose 1-phosphate and in synergism with caffeine, mimicking the binding of glucose. …”

Novel lipopolysaccharide biosynthetic genes containing tetranucleotide repeats in Haemophilus influenzae, identification of a gene for adding O-acetyl groups. by Fox, K, Yildirim, H, Deadman, M, Schweda, E, Moxon, E, Hood, D

“…These results provide genetic and structural evidence that H. influenzae oafA is required for phase variable O-acetylation of LPS and functional evidence to support the role of O-acetylation of LPS in pathogenesis.…”

Dynamic acetylation of lysine-4-trimethylated histone H3 and H3 variant biology in a simple multicellular eukaryote. by Hsu, D, Chubb, JR, Muramoto, T, Pears, C, Mahadevan, L

“…Dynamic acetylation of all lysine-4-trimethylated histone H3 is a complex phenomenon involved in Immediate-early gene induction in metazoan eukaryotes. …”