Characterization of cholinesterases present in brain and muscle tissues of juvenile blue shark (<i>Prionace glauca</i>) by Luís Miguel Fonseca Alves, Sara Calçada Novais

“…Introduction</b> Acetylcholinesterase (AChE) is a vital enzyme for the normal functioning of the neuromuscular system, where it is responsible for the hydrolysis of acetylcholine into choline and acetic acid, thus preventing continuous nervous impulses (Murphy, 1986; Walker and Thompson, 1991). …”
Get full text

Apigetrin-enriched Pulmeria alba extract prevents assault of STZ on pancreatic β-cells and neuronal oxidative stress with concomitant attenuation of tissue damage and suppression o... by Tawakaltu Abdulrasheed-Adeleke, Bashir Lawal, Eyuwa Ignatius Agwupuye, Yucheng Kuo, Amarachi Mary Eni, Okwukwe Faith Ekoh, Halimat Yusuf Lukman, Amos S. Onikanni, Femi Olawale, Sani Saidu, Yunusa O. Ibrahim, Maliha Abdullah Saleh Al Ghamdi, Sarah S. Aggad, Abdulrahman A. Alsayegh, Nada H. Aljarba, Gaber El-Saber Batiha, Alexander T.H. Wu, Hsu-Shan Huang

“…This was evidenced by increased levels of antioxidants enzymes (superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH)), and decreased malondialdehyde (MDA), proinflammatory markers (cyclooxygenase 2 (COX2), nuclear factor (NF)-κB and nitric oxide (NOx)), and acetylcholinesterase (AChE) activities in the brain of PAm-treated rats compared to the STZ-induced diabetic controls. …”
Get full text

Deciphering gut pathology, oxidative stress, metabolome and microbiome alterations in javanese medaka fish (Oryzias javanicus Bleeker, 1854) exposed to polystyrene microplastics by Usman, Sunusi

“…In the brain, a significant increase in oxidative stress [CAT activity, Control (16±3), MPHIGH (6 ±1) and T-SOD activity (Control (67 ± 18), MP-HIGH (38 ± 5)], oxidant damage measured using MDA in ng/mL [Control (30.8 ± 2), MP-LOW(47 ± 2), MPMED (55 ± 3), MP-HIGH (38.8 ± 50)], and neurotoxicity by inhibition of acetylcholinesterase in ng/mL [Control (8 ± 0.1), MP-MED (6 ± 1), MP-HIGH (5 ± 1)] was elicited. …”
Get full text

Roles of anti-neuroinflammation and anti-oxidative Properties of a standardised andrographis paniculata burm.Nees aqueous extract in improving cognition in wistar Rats (embargo) by Sani, Dahiru

“…It was also demonstrated that LPS administration caused increased production of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6), oxidative stress markers (reactive oxygen species (ROS), thiobarbituric acid reactive substances (TBARS), cholinesterase (acetylcholinesterase (AChE), butyrylcholinesterase (BChE) activities and decreased antioxidant enzymes superoxide dismutase (SOD), catalase (CAT) activities and depletion of antioxidant glutathione (GSH) level in the hippocampal region of the brain. …”
Get full text

The screening for marine fungal strains with high potential in alkaloids production by in situ colony assay and LC-MS/MS based secondary metabolic profiling by Tiantian Lu, Yayue Liu, Yayue Liu, Yayue Liu, Longjian Zhou, Longjian Zhou, Longjian Zhou, Qingnan Liao, Yingying Nie, Xingyuan Wang, Xiaoling Lei, Xiaoling Lei, Xiaoling Lei, Pengzhi Hong, Pengzhi Hong, Pengzhi Hong, Yan Feng, Xueqiong Hu, Xueqiong Hu, Xueqiong Hu, Yi Zhang, Yi Zhang, Yi Zhang

“…In bioassays, the crude extracts of ACD-5 in Czapek–dox broth and brown rice medium showed moderate antioxidant, acetylcholinesterase inhibitory, anti-neuroinflammatory, and anti-β aggregation activities. …”
Get full text

Insights into environmental caffeine contamination in ecotoxicological biomarkers and potential health effects of Danio rerio by Bárbara S. Diogo, Sara C. Antunes, Ivo Pinto, João Amorim, Cláudia Teixeira, Luís Oliva Teles, Oksana Golovko, Vladimír Žlábek, António Paulo Carvalho, Sara Rodrigues

“…Lactate dehydrogenase activity decreased in all the concentrations tested, while acetylcholinesterase activity was only affected by the highest concentrations tested (19.23 and 50 μg/L). …”
Get full text

Hizikia fusiforme functional oil (HFFO) prevents neuroinflammation and memory deficits evoked by lipopolysaccharide/aluminum trichloride in zebrafish by Ying-Ying Nie, Ying-Ying Nie, Long-Jian Zhou, Long-Jian Zhou, Yan-Mei Li, Wen-Cong Yang, Ya-Yue Liu, Ya-Yue Liu, Zhi-You Yang, Xiao-Xiang Ma, Yong-Ping Zhang, Peng-Zhi Hong, Peng-Zhi Hong, Yi Zhang, Yi Zhang

“…Previously, we had reported that the Hizikia fusiforme functional oil (HFFO) contains arachidonic acid, 11,14,17-eicosatrienoic acid, phytol, and other molecules displaying in vitro acetylcholinesterase inhibitory and nitroxide scavenging activity; however, the in vivo effect remains unclear. …”
Get full text

Presence of cholinesterases in Echinococcus granulosus protoscolices by Giménez-Pardo C., Ros Moreno R.M., De Armas-Serra C., Rodriguez-Caabeiro F.

“…To characterize these activities as acetylcholinesterases or pseudocholinesterases, BW284C51 and the organophosphate anthelmintic Neguvón® were assayed as specific inhibitors of acetylcholinesterases, while Iso-OMPA was employed as specific inhibitor of pseudocholinesterases. …”
Get full text

AChE-rich magnopyramidal neurons have a left-right size asymmetry in Broca's area. by García, R, Montiel, J, Villalón, A, Gatica, M, Aboitiz, F

“…Acetylcholinesterase-rich neurons (AChERN) are a particular group of pyramidal neurons, displaying a specific laminar and ontogenetic pattern in the cerebral cortex of human and nonhuman primates. …”

Modulation by 5-hydroxytryptamine of nicotinic acetylcholine responses recorded from an identified cockroach (Periplaneta americana) motoneuron. by Butt, S, Pitman, R

“…The amines also modulated responses to nicotine or carbachol (each of which resists hydrolysis by acetylcholinesterases), indicating that the amines did not act by accelerating ACh degradation. …”

Proteomic Investigation of Cape Cobra (<i>Naja nivea</i>) Venom Reveals First Evidence of Quaternary Protein Structures by Lewis O. McFarlane, Tara L. Pukala

“…Additionally, cysteine-rich secretory proteins (CRISPs), vespryns (VESPs), cobra venom factors (CVFs), 5′-nucleotidases (5′NUCs), nerve growth factors (NGFs), phospholipase A2s (PLA₂), acetylcholinesterases (AChEs), Kunitz-type serine protease inhibitor (KUN), phosphodiesterases (PDEs), L-amino acid oxidases (LAAOs), hydrolases (HYDs), snake venom metalloproteinases (SVMPs), and snake venom serine protease (SVSP) toxins were also identified in decreasing order of abundance. …”
Get full text

Proteomic Deep Mining the Venom of the Red-Headed Krait, Bungarus flaviceps by Alex Chapeaurouge, Andreza Silva, Paulo Carvalho, Ryan J. R. McCleary, Cassandra Marie Modahl, Jonas Perales, R. Manjunatha Kini, Stephen P. Mackessy

“…Abundant protein families comprise 3FTxs (22.3%), KSPIs (19%), acetylcholinesterases (12.6%), PLA2s (11.9%), venom endothelial growth factors (VEGFs, 8.4%), nucleotidases (4.3%), and C-type lectin-like proteins (snaclecs, 3.3%); an additional 11 toxin families are present at significantly lower concentrations, including complement depleting factors, a family not previously detected in Bungarus venoms. …”
Get full text

Cholinesterase activities in cerebrospinal fluid of patients with senile dementia of Alzheimer type. by Appleyard, M, Smith, A, Berman, P, Wilcock, G, Esiri, M, Neary, D, Bowen, D

“…Acetylcholinesterase (AChE) and nonspecific cholinesterase (nsChE) activities of lumbar ceresbrospinal fluid (CSF) from patients with a clinical or histological diagnosis of Alzheimer's disease have been compared with those of normal age-matched control patients and patients with dementia of non-Alzheimer aetiology. …”

Bio-Potency and Molecular Docking Studies of Isolated Compounds from <i>Grewia optiva</i> J.R. Drumm. ex Burret by Wasim Ul Bari, Najeeb Ur Rehman, Ajmal Khan, Sobia Ahsan Halim, Ye Yuan, Mark A.T. Blaskovich, Zyta M. Ziora, Muhammad Zahoor, Sumaira Naz, Riaz Ullah, Amal Alotaibi, Ahmed Al-Harrasi

“…All the isolated compounds exhibited a moderate-to-good degree of activity against acetylcholinesterases (AChE) and butyrylcholinesterase (BChE). …”
Get full text