In silico and in vitro screening of pyrrole-based Hydrazide-Hydrazones as novel acetylcholinesterase inhibitors by Emilio Mateev, Ali Irfan, Alexandrina Mateeva, Magdalena Kondeva-Burdina, Maya Georgieva, Alexander Zlatkov

“…The aim of this work was to apply consensus docking, molecular mechanics/generalized Born surface area (MM/GBSA) free binding energy recalculations, and in vitro evaluations on an in-house dataset of recently synthesized pyrrole-based hydrazide-hydrazones in the search for novel acetylcholinesterase (AChE) inhibitors. Two licensed softwares – GOLD 5.3 and Glide, were employed for the virtual screenings, and several chemotherapeutic potential hits were identified. …”
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Isolation of Pleurotus florida derived acetylcholinesterase inhibitor for the treatment of cognitive dysfunction in mice by Kudrat Randhawa, Varinder Singh, Sanimardeep Kaur, Ravinder Kaur, Suresh Kumar, Richa Shri

Subjects: “…Acetylcholinesterase inhibitor…”
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MAPLE Assembled Acetylcholinesterase–Polyethylenimine Hybrid and Multilayered Interfaces for Toxic Gases Detection by Valentina Dinca, Cristian Viespe, Simona Brajnicov, Izabela Constantinoiu, Antoniu Moldovan, Anca Bonciu, Constantin Nicolae Toader, Raluca Elena Ginghina, Nicoleta Grigoriu, Maria Dinescu, Nicu Doinel Scarisoreanu

“…The MAPLE fabrication consisted of the simultaneous alternating evaporation of layers of polyethylenimine (PEI) and acetylcholinesterase (AchE) in order to obtain active surfaces as both hybrid PEI-AchE and a PEI/AchE layered coating, respectively. …”
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Natural acetylcholinesterase inhibitors: A multi-targeted therapeutic potential in Alzheimer's disease by Kumar Gajendra, G.K. Pratap, D.V. Poornima, Manjula Shantaram, G. Ranjita

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TSPO Expression Modulatory Effect of Acetylcholinesterase Inhibitor in the Ischemic Stroke Rat Model by Yoo Sung Song, Sang Hee Lee, Jae Ho Jung, In Ho Song, Hyun Soo Park, Byung Seok Moon, Sang Eun Kim, Byung Chul Lee

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In vivo effects of metals on the acetylcholinesterase activity of the Perna perna mussel’s digestive gland by Afonso Celso Dias Bainy, Marisa Helena Gennari de Medeiros, Paolo Di Mascio, Eduardo Alves de Almeida

Subjects: “…Acetylcholinesterase…”
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Effect of Gallic Acid on Reactivation of Acetylcholinesterase and Butyrylcholinesterase Inhibited by Diazinon in Vitro and in Vivo by Farzaneh Sadat Motafeghi, Mohammad Ali Ebrahimzadeh, Pegah Karbalaei, Hamidreza Mohammadi

“…Background and purpose: Diazinon is an organophosphate insecticide that binds to the acetylcholinesterase enzyme after metabolization causing its inactivation. …”
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Acetylcholinesterase Biosensor Based on Functionalized Renewable Carbon Platform for Detection of Carbaryl in Food by Erik W. Nunes, Martin K. L. Silva, Jesús Rascón, Damaris Leiva-Tafur, Rainer M. L. Lapa, Ivana Cesarino

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In Silico Investigation of Novel Compounds as Inhibitors of Acetylcholinesterase Enzyme for the Treatment of Alzheimer’s Diseases by Kassim Adebambo, Oghenekevwe (Claudia) Ojoh

“…A very useful receptor for this study was PDB-1DX6, a cocrystallized galantamine inhibitor of acetylcholinesterase enzyme. The molecular docking analysis (using ligand interactions) and molecular dynamic analysis (root mean square deviation (RMSD) and root mean square fluctuation (RMSF)) showed that the two peptide molecules CHEMBL-1240685 and Zoladex gave the best binding energy and stability when compared to the FDA-approved drugs (donepezil and galantamine). …”
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Identification of a Novel Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase: In Vitro and In Silico Studies by Raquel B. M. de Almeida, Deyse B. Barbosa, Mayra R. do Bomfim, Jéssika A. O. Amparo, Bruno S. Andrade, Silvia L. Costa, Joaquín M. Campos, Jorddy N. Cruz, Cleydson B. R. Santos, Franco H. A. Leite, Mariana B. Botura

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Non-Neuronal Acetylcholinesterase Activity Shows Limited Utility for Early Detection of Sepsis by Aleksandar R. Zivkovic, Karsten Schmidt, Stefan Hofer, Thorsten Brenner, Markus A. Weigand, Sebastian O. Decker

“…The cholinergic system has been implicated in modulating the inflammatory response. Acetylcholinesterase (AChE), an enzyme primarily responsible for the hydrolysis of acetylcholine, has been proposed as a potential early indicator of sepsis onset. …”
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Acetylcholinesterase Inhibitory Activities of Essential Oils from Vietnamese Traditional Medicinal Plants by Nguyen Huy Hung, Pham Minh Quan, Prabodh Satyal, Do Ngoc Dai, Vo Van Hoa, Ngo Gia Huy, Le Duc Giang, Nguyen Thi Ha, Le Thi Huong, Vu Thi Hien, William N. Setzer

“…Furthermore, they are also of interest as aromatherapeutic agents in the treatment of Alzheimer’s disease, and inhibition of the enzyme acetylcholinesterase (AChE) has been evaluated as an important mechanism. …”
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Novel Lawsone–Quinoxaline Hybrids as New Dual Binding Site Acetylcholinesterase Inhibitors by Paptawan Suwanhom, Teerapat Nualnoi, Pasarat Khongkow, Varomyalin Tipmanee, Luelak Lomlim

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2-Hydroxy-<i>N</i>-phenylbenzamides and Their Esters Inhibit Acetylcholinesterase and Butyrylcholinesterase by Martin Krátký, Šárka Štěpánková, Neto-Honorius Houngbedji, Rudolf Vosátka, Katarína Vorčáková, Jarmila Vinšová

Subjects: “…acetylcholinesterase…”
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Synthesis and biological evaluation of lycorine derivatives as dual inhibitors of human acetylcholinesterase and butyrylcholinesterase by Wang Yue-Hu, Wan Qin-Li, Gu Cheng-Ding, Luo Huai-Rong, Long Chun-Lin

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Can Activation of Acetylcholinesterase by β-Amyloid Peptide Decrease the Effectiveness of Cholinesterase Inhibitors? by Irina V. Zueva, Elmira A. Vasilieva, Gulnara A. Gaynanova, Andrey V. Moiseenko, Anna D. Burtseva, Konstantin M. Boyko, Lucia Ya. Zakharova, Konstantin A. Petrov

“…The main class of drugs currently used for the treatment of AD are the acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. …”
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In silico and in vitro studies confirm Ondansetron as a novel acetylcholinesterase and butyrylcholinesterase inhibitor by Asma Gholami, Dariush Minai-Tehrani, Leif A. Eriksson

“…Studies show that a lack of acetylcholine and butyrylcholine due to the overexpression of enzymes Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE) may lead to reduced communication between neuron cells. …”
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A galantamine–curcumin hybrid lacks the depressant side effect of acetylcholinesterase inhibitors by Ivanka Kostadinova, Mariyana Atanasova, Georgi Stavrakov, Irena Philipova, Irini Doytchinova

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Nanomaterials - Acetylcholinesterase Enzyme Matrices for Organophosphorus Pesticides Electrochemical Sensors: A Review by Shen-Ming Chen, Arun Prakash Periasamy, Yogeswaran Umasankar

Subjects: “…acetylcholinesterase…”
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Computational Approaches to Evaluate the Acetylcholinesterase Binding Interaction with Taxifolin for the Management of Alzheimer’s Disease by Varish Ahmad, Ibrahim Alotibi, Anwar A. Alghamdi, Aftab Ahmad, Qazi Mohammad Sajid Jamal, Supriya Srivastava

“…Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are enzymes that break down and reduce the level of the neurotransmitter acetylcholine (ACh). …”
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