Preclinical evaluation of the effect of periodontal regeneration by carbonate apatite in a canine one-wall intrabony defect model by Shunsuke Takeuchi, Shunsuke Fukuba, Munehiro Okada, Kohei Nohara, Ryo Sato, Daichi Yamaki, Takanori Matsuura, Shu Hoshi, Kazuhiro Aoki, Takanori Iwata

“…Results: No ankylosis, infection, or acute inflammation was observed at any of the experimental sites. …”
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Cardiovascular Magnetic Resonance Demonstrates Myocardial Inflammation of Differing Etiologies and Acuities in Patients with Genetic and Inflammatory Myopathies by George Markousis-Mavrogenis, Antonios Belegrinos, Aikaterini Giannakopoulou, Antigoni Papavasiliou, Vasiliki Koulouri, Nikolaos Marketos, Eleftheria Patsilinakou, Fotini Lazarioti, Flora Bacopoulou, Clio P. Mavragani, George P. Chrousos, Sophie I. Mavrogeni

“…The vast majority of symptomatic patients with inflammatory myopathies and normal echocardiography show evidence of acute myocardial inflammation. In contrast, acute inflammation is rare in patients with genetic myopathies, who show evidence of chronic low-grade inflammation.…”
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Pentoxifylline-induced protein expression change in RAW 264.7 cells as determined by immunoprecipitation-based high performance liquid chromatography. by Mi Hyun Seo, Dae Won Kim, Yeon Sook Kim, Suk Keun Lee

“…The present study explored the effect of low dose 10 μg/mL PTX (therapeutic dose) compared to high dose 300 μg/mL PTX (experimental dose) in RAW 264.7 cells through immunoprecipitation-based high performance liquid chromatography (IP-HPLC), immunohistochemistry, and western blot. 10 μg/mL PTX increased the expression of proliferation (Ki-67, PCNA, cyclin D2, cdc25A), epigenetic modification (KDM4D, PCAF, HMGB1), protein translation (DOHH, DHPS, eIF5A1), RAS signaling (KRAS, pAKT1/2/3, PI3K), NFkB signaling (NFkB, GADD45, p38), protection (HSP70, SOD1, GSTO1/2), survival (pAKT1/2/3, SP1, sirtuin 6), neuromuscular differentiation (NSEγ, myosin-1a, desmin), osteoblastic differentiation (BMP2, RUNX2, osterix), acute inflammation (TNFα, IL-1, CXCR4), innate immunity (β-defensin 1, lactoferrin, TLR-3, -4), cell-mediated immunity (CD4, CD8, CD80), while decreased the expression of ER stress (eIF2α, eIF2AK3, ATF6α), fibrosis (FGF2, CTGF, collagen 3A1), and chronic inflammation (CD68, MMP-2, -3, COX2) versus the untreated controls. …”
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Multimodal Identification by Transcriptomics and Multiscale Bioassays of Active Components in Xuanfeibaidu Formula to Suppress Macrophage-Mediated Immune Response by Lu Zhao, Hao Liu, Yingchao Wang, Shufang Wang, Dejin Xun, Yi Wang, Yiyu Cheng, Boli Zhang

“…Thus, we examined the anti-inflammation activity of XFBD in a lipopolysaccharide-induced acute inflammation mice model. XFBD significantly alleviated pulmonary inflammation and decreased the level of serum proinflammatory cytokines. …”
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Efficacy of the Endolysin-Based Antibacterial Gel for Treatment of Anaerobic Infection Caused by <i>Fusobacterium necrophorum</i> by Daria V. Vasina, Nataliia P. Antonova, Aleksei M. Vorobev, Aleksei I. Laishevtsev, Andrei V. Kapustin, Eldar R. Zulkarneev, Svetlana S. Bochkareva, Irina A. Kiseleva, Mariia N. Anurova, Andrei V. Aleshkin, Artem P. Tkachuk, Vladimir A. Gushchin

“…The administration of the investigated gel twice per day for 5 days resulted in less acute inflammation, with decreased leukocytes and segmented neutrophils in the blood, retardation of infection progression, and an almost two-fold increase in the lifespan of the animals compared to the placebo group. …”
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Potential Antioxidant and Anti-Inflammatory Properties of Serum from Healthy Adolescents with Optimal Mediterranean Diet Adherence: Findings from DIMENU Cross-Sectional Study by Giuseppina Augimeri, Angelo Galluccio, Giovanna Caparello, Ennio Avolio, Daniele La Russa, Daniela De Rose, Catia Morelli, Ines Barone, Stefania Catalano, Sebastiano Andò, Cinzia Giordano, Diego Sisci, Daniela Bonofiglio

“…Finally, using lipopolysaccharide-stimulated human macrophages, as an in vitro model of acute inflammation, we found a reduced secretion of pro-inflammatory cytokines upon serum treatment from adolescents with optimal respect to medium and poor MD adherence. …”
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Less Severe Lipopolysaccharide-Induced Inflammation in Conditional <i>mgmt</i>-Deleted Mice with LysM-Cre System: The Loss of DNA Repair in Macrophages by Wilasinee Saisorn, Pornpimol Phuengmaung, Jiraphorn Issara-Amphorn, Jiradej Makjaroen, Peerapat Visitchanakun, Kritsanawan Sae-khow, Atsadang Boonmee, Salisa Benjaskulluecha, Aleksandra Nita-Lazar, Tanapat Palaga, Asada Leelahavanichkul

“…The transcriptomic profiling of epigenetic enzymes from wild-type macrophages after single and double LPS stimulation, representing acute inflammation and LPS tolerance, respectively, was performed. …”
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Src/NF-κB-Targeted Anti-Inflammatory Effects of <i>Potentilla glabra</i> var. Mandshurica (Maxim.) Hand.-Mazz. Ethanol Extract by Haeyeop Kim, Kon Kuk Shin, Han Gyung Kim, Minkyeong Jo, Jin Kyeong Kim, Jong Sub Lee, Eui Su Choung, Wan Yi Li, Sang Woo Lee, Kyung-Hee Kim, Byong Chul Yoo, Jae Youl Cho

“…Inflammation is a complex protective response of body tissues to harmful stimuli. Acute inflammation can progress to chronic inflammation, which can lead to severe disease. …”
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In vivo characterization of 123/125I-2-iodo-L-phenylalanine in an R1M rhabdomyosarcoma athymic mouse model as a potential tumor tracer for SPECT. by Kersemans, V, Cornelissen, B, Kersemans, K, Bauwens, M, Achten, E, Dierckx, R, Mertens, J, Slegers, G

“…The characteristics of 125I-2-iodo-L-phenylalanine were examined in vivo in R1M tumor-bearing athymic mice and in acute inflammation-bearing NMRI mice. The uptake of 123/125I-2-iodo-L-phenylalanine in tumor and other organs of interest was measured by dynamic planar imaging (DPI) and gamma-counting after dissection. …”

Characterization of the anti-inflammatory and antinociceptive activities of Erythroxylum cuneatum (Miq.) Kurz / Siti Rohani Saleh by Saleh, Siti Rohani

“…ECAE (400 mg/kg, p.o.) significantly reduced paw edema volume after carrageenan injection in acute inflammation study. Significant increase in TNF-a was observed after 4 h of treatment with ECAE (400 mg/kg, p.o.). …”
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Nickel(II) Complex of Polyhydroxybenzaldehyde N4-Thiosemicarbazone Exhibits Anti-Inflammatory Activity by Inhibiting NF-κB Transactivation by Shawish, H.B., Wong, W.Y., Wong, Y.L., Loh, S.W., Looi, C.Y., Hassandarvish, P., Phan, A.Y.L., Wong, W.F., Wang, H., Paterson, I.C., Kwee, C.

“…The active compound was further evaluated on its ability to suppress carrageenan-induced acute inflammation in vivo. A potential binding target of the active compound was also predicted by molecular docking analysis. …”
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The uptake of [18F]-fluorodeoxyglucose by the renal allograft correlates with the acute Banff scores of cortex inflammation but not with the 1-year graft outcomes by Hélène Fank, Laurent Weekers, Pierre Lovinfosse, Hans Pottel, Laurence Seidel, Alexandre Jadoul, Antoine Bouquegneau, Catherine Bonvoisin, Christophe Bovy, Christophe Bovy, Stephanie Grosch, Stephanie Grosch, Pauline Erpicum, Pauline Erpicum, Roland Hustinx, François Jouret

“…PET/CT-based scores of acute inflammation remains unknown, as does the prognostic performance of [18F]FDG PET/CT at one year post suspected AR.MethodsFrom 2012 to 2019, 114 [18F]FDG-PET/CTs were prospectively performed in 105 adult KTRs who underwent per cause transplant biopsies. …”
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EP4 Antagonism by E7046 diminishes Myeloid immunosuppression and synergizes with Treg-reducing IL-2-Diphtheria toxin fusion protein in restoring anti-tumor immunity by Diana I. Albu, Zichun Wang, Kuan-Chun Huang, Jiayi Wu, Natalie Twine, Sarah Leacu, Christy Ingersoll, Lana Parent, Winnie Lee, Diana Liu, Renee Wright-Michaud, Namita Kumar, Galina Kuznetsov, Qian Chen, Wanjun Zheng, Kenichi Nomoto, Mary Woodall-Jappe, Xingfeng Bao

“…In the TME, E7046 and E7777 markedly increased ratios of CD8+granzymeB+ cytotoxic T cells (CTLs)/live Tregs and of M1-like/M2TAM, and converted a chronic inflammation phenotype into acute inflammation, shown by substantial induction of STAT1/IRF-1 and IFNγ-controlled genes. …”
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Oxidation of HMGB1 Is a Dynamically Regulated Process in Physiological and Pathological Conditions by Michele Ferrara, Ginevra Chialli, Ginevra Chialli, Lorena Maria Ferreira, Elena Ruggieri, Elena Ruggieri, Giorgia Careccia, Giorgia Careccia, Alessandro Preti, Rosanna Piccirillo, Marco Emilio Bianchi, Marco Emilio Bianchi, Giovanni Sitia, Emilie Venereau

“…Acute inflammation is a complex biological response of tissues to harmful stimuli, such as pathogens or cell damage, and is essential for immune defense and proper healing. …”
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Expression of FIBCD1 by intestinal epithelial cells alleviates inflammation-driven tumorigenesis in a mouse model of colorectal cancer by Vahid Khaze Shahgoli, Vahid Khaze Shahgoli, Magdalena Dubik, Bartosz Pilecki, Sofie Skallerup, Sandra Gaedt Schmidt, Sönke Detlefsen, Sönke Detlefsen, Grith L. Sorensen, Uffe Holmskov, Behzad Baradaran, Jesper B. Moeller, Jesper B. Moeller

“…Furthermore, we identify a soluble variant of FIBCD1 that is significantly increased in feces during acute inflammation. Finally, we demonstrate increased expression of FIBCD1 by immunohistochemistry in human CRC specimens at more developed tumor stages. …”
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Neuroprotective Effect of <i>Abelmoschus manihot</i> Flower Extracts against the H₂O₂-Induced Cytotoxicity, Oxidative Stress and Inflammation in PC12 Cells by Shih-Wei Wang, Chi-Chang Chang, Chin-Feng Hsuan, Tzu-Hsien Chang, Ya-Ling Chen, Yun-Ya Wang, Teng-Hung Yu, Cheng-Ching Wu, Jer-Yiing Houng

“…Under the stimulation of H₂O₂, AME significantly up-regulated the expression of antioxidant enzymes, such as catalase, glutathione peroxidase and superoxide dismutase; promoted the production of the intracellular antioxidant; reduced glutathione; and reduced ROS generation in PC12 cells. When the acute inflammation was induced under the H₂O₂ stimulation, AME significantly down-regulated the pro-inflammatory cytokines and mediators (e.g., TNF-α, IL-1β, IL-6, COX-2 and iNOS). …”
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In vivo anti-inflammatory activity of M116, one extract obtained from the marine bacterium Bacillus amyloliquefaciens by Ivones Hernández-Balmaseda, Fernando López Lezcano, Cindel Cuellar Duarte, Bárbara B. Garrido-Suárez, Eudalys Ortiz Guilarte, Miguel D. Fernández Pérez, Idania Rodeiro Guerra

“…Results: A single application of M116 (50-200 mg/kg, 10 mL/kg, p.o.) decreases croton oil-induced acute inflammation in a dose-dependent manner. Single and repeated doses of extract (100-400 mg/kg, p.o.) also were able to inhibit chronic inflammation during both, transudative and proliferative phases of the inflammatory process. …”
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Sex-dependent vulnerability for Wistar rats model following intranasal instillation with Klebsiella pneumoniae ATCC 43816 causing lobar pneumonia by Patrick Hervé Diboue Betote, Esther Del Florence Ndedi Moni, Sonia Raïssa Gayap Matchuenkam, Sandrine Suzanne Bayengue Beack, Rodrigue Fifen, Raogo Ouedraogo, Gabriel A. Agbor, Rasmané Semde, Nga Nnanga, Maximilienne Ascension Nyegue

“…This infection causes acute inflammation in the lung, characterized by the recruitment of polymorphonuclear cells, generating free radicals, and decreasing the endogenous antioxidant balance system. …”
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Prevalence of Helicobacter pylori genotypes: cagA, vacA (m1), vacA (s1), babA2, dupA, iceA1, oipA and their association with gastrointestinal diseases. A cross-sectional study in Q... by Santiago Bustos-Fraga, Marco Salinas-Pinta, Yosselin Vicuña-Almeida, Ricardo Brandt de Oliveira, Lucy Baldeón-Rojas

“…Genes oipA (93.6%), vacA (s1) (70.9%), and babA2 (70.2%) were the most prevalent. cagA/vacA (s1m1) and cagA/oipA (s1m1) combinations were found in 31.2% and 22.7% of the cases, respectively. Acute inflammation has a significant correlation with the genes cagA (OR = 4.96 95% CI: 1.1–22.41), babA2 (OR = 2.78 95% CI: 1.06–7.3), and the cagA/oipA combination (OR = 4.78, 95% CI: 1.06–21.62). …”
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Inflammatory macrophages reprogram to immunosuppression by reducing mitochondrial translation by Marlies Cortés, Agnese Brischetto, M. C. Martinez-Campanario, Chiara Ninfali, Verónica Domínguez, Sara Fernández, Raquel Celis, Anna Esteve-Codina, Juan J. Lozano, Julia Sidorova, Gloria Garrabou, Anna-Maria Siegert, Carlos Enrich, Belén Pintado, Manuel Morales-Ruiz, Pedro Castro, Juan D. Cañete, Antonio Postigo

“…Abstract Acute inflammation can either resolve through immunosuppression or persist, leading to chronic inflammation. …”
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