Development and validation of outcome prediction models for aneurysmal subarachnoid haemorrhage: the SAHIT multinational cohort study by Jaja, BNR, Saposnik, G, Lingsma, HF, Macdonald, E, Thorpe, KE, Mamdani, M, Steyerberg, EW, Molyneux, A, Manoel, ALDO, Schatlo, B, Hanggi, D, Hasan, D, Wong, GKC, Etminan, N, Fukuda, H, Torner, J, Schaller, KL, Suarez, JI, Stienen, MN, Vergouwen, MDI, Rinkel, GJE, Spears, J, Cusimano, MD, Todd, M

“…The web based SAHIT prognostic calculator (http://sahitscore.com) and the related app could be adjunctive tools to support management of patients.…”

The effect of regularly dosed paracetamol versus no paracetamol on renal function in Plasmodium knowlesi malaria (PACKNOW) : study protocol for a randomised controlled trial by Cooper, Daniel J., Plewes, Katherine, Grigg, Matthew J., Rajahram, Giri S., Piera, Kim A., William, Timothy, Chatfield, Mark D., Yeo, Tsin Wen, Dondorp, Arjen M., Anstey, Nicholas M., Barber, Bridget E.

“…Methods: PACKNOW is a two-arm, open-label randomised controlled trial of adjunctive paracetamol versus no paracetamol in patients aged ≥ 5 years with knowlesi malaria, conducted over a 2-year period at four hospital sites in Sabah, Malaysia. …”
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Cell-free hemoglobin mediated oxidative stress is associated with acute kidney injury and renal replacement therapy in severe falciparum malaria: an observational study by Plewes, Katherine, Kingston, Hugh W.F., Ghose, Aniruddha, Maude, Richard J., Herdman, M. Trent, Leopold, Stije J., Ishioka, Haruhiko, Hasan, Md. Mahtab Uddin, Haider, Md. Shafiul, Alam, Shamsul, Piera, Kim A., Charunwatthana, Prakaykaew, Silamut, Kamolrat, Yeo, Tsin Wen, Faiz, Md. Abul, Lee, Sue J., Mukaka, Mavuto, Turner, Gareth D. H., Anstey, Nicholas M., Jackson Roberts II, L., White, Nicholas J., Day, Nicholas P. J., Hossain, Md. Amir, Dondorp, Arjen M.

“…Conclusions: Cell-free hemoglobin and lipid peroxidation are associated with acute kidney injury and disease severity in falciparum malaria, suggesting a pathophysiological role in renal tubular injury. Evaluation of adjunctive therapies targeting cell-free hemoglobin-mediated oxidative stress is warranted.…”
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