Current Approaches to the Preclinical Assessment of Endocrine Toxicity by D. A. Babkov

“…The main endpoints for endocrine toxicity include changes in the mass and histopathology of the major endocrine organs (adrenal glands, testes, epididymides, ovaries, and the thyroid gland), oestrous cycle effects, reproductive toxicity, and transplacental action. …”
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Ganglioneuroblastoma: A Rare Tumor in Parapharyngeal Space by Şahin Ulu, Abdullah Kınar, Abdulkadir Bucak

“…Background: Ganglioneuroblastoma is a malignant tumor, usually found in the adrenal glands, retroperitoneal ganglions or posterior mediastinum. …”
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Homeostatic Regulation of Glucocorticoid Receptor Activity by Hypoxia-Inducible Factor 1: From Physiology to Clinic by Davide Marchi, Fredericus J. M. van Eeden

“…Glucocorticoids (GCs) represent a well-known class of lipophilic steroid hormones biosynthesised, with a circadian rhythm, by the adrenal glands in humans and by the inter-renal tissue in teleost fish (e.g., zebrafish). …”
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Behavioral neuroadaptation to alcohol : from glucocorticoids to histone acetylation by Daniel Beracochea, Nicole Mons

“…A prime mechanism that contributes to the development and maintenance of alcoholism is the dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis activity and the release of glucocorticoids (cortisol in humans and primates, corticosterone in rodents) from the adrenal glands. In the brain, sustained, local elevation of glucocorticoid concentration even long after cessation of chronic alcohol consumption compromises functional integrity of a circuit including the prefrontal cortex, the hippocampus and the amygdala. …”
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Acute adrenal failure as the presenting feature of primary antiphospholipid syndrome in a child by Improda Nicola, Alessio Maria, Capalbo Donatella, Russo Giustina, D’Acunzo Ida, Palamaro Loredana, Pignata Claudio, Salerno Mariacarolina

“…An abdominal computed tomography scan showed nodular lesions in the adrenal glands. He was referred to our Department and a diagnosis of APS and acute adrenal failure was considered, based on positive aPLs (IgG and IgM), elevated ACTH levels and low cortisol levels. …”
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Systematic genetic screening in a prospective group of Danish patients with pheochromocytoma by Hansen MSS, Jacobsen N, Frederiksen AL, Lund L, Andersen MS, Glintborg D

“…Three of 31 sporadic cases (ages 60, 69, and 76 years at time of diagnosis) presented with bilateral adrenal tumors, one patient had multiple adrenal tumors in both adrenal glands, and no patients had a positive family history of pheochromocytoma. …”
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MULTISYSTEM-INFLAMMATORY SYNDROME (MIS-C) IN NEONATE ASSOCIATED WITH SARS-COVID19 by Yerdan Mukhaliyev, Faryal Imran, Akdana Darkhambayeva

“…This makes choosing the most appropriate treatment difficult.Aim: To report on case of MIS-C in neonate who developed DIC with multiple thrombotic and hemorrhagic events.Methods: In our study, we analyzed a clinical case of a neonate diagnosed with MIS-C who developed DIC with damage to the heart, kidneys, lungs, liver and adrenal glands.Results: After infection with SARS-CoV2, MIS-C developed which led to systemic inflammation that triggered DIC, as proven by laboratory markers. …”
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Functional programming of the autonomic nervous system by early life immune exposure: implications for anxiety. by Luba Sominsky, Erin A Fuller, Evgeny Bondarenko, Lin Kooi Ong, Lee Averell, Eugene Nalivaiko, Peter R Dunkley, Phillip W Dickson, Deborah M Hodgson

“…ANS function in Wistar rats, neonatally treated with LPS, was assessed via analysis of tyrosine hydroxylase (TH) in the adrenal glands on postnatal days (PNDs) 50 and 85, and via plethysmographic assessment of adult respiratory rate in response to mild stress (acoustic and light stimuli). …”
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Sleeping through anything: The effects of unpredictable disruptions on mouse sleep, healing, and affect. by Amy Robinson-Junker, Bruce O'Hara, Abigail Durkes, Brianna Gaskill

“…On Day 3, mice were euthanized and wound tissue and adrenal glands were collected. We found that the disruption predictability had no effect on mouse sleep, wound healing, or adrenal cortex:medulla ratio. …”
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MULTISYSTEM-INFLAMMATORY SYNDROME (MIS-C) IN NEONATE ASSOCIATED WITH SARS-COVID19 by Yerdan Mukhaliyev, Faryal Imran, Akdana Darkhambayeva

“…This makes choosing the most appropriate treatment difficult.Aim: To report on case of MIS-C in neonate who developed DIC with multiple thrombotic and hemorrhagic events.Methods: In our study, we analyzed a clinical case of a neonate diagnosed with MIS-C who developed DIC with damage to the heart, kidneys, lungs, liver and adrenal glands.Results: After infection with SARS-CoV2, MIS-C developed which led to systemic inflammation that triggered DIC, as proven by laboratory markers. …”
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Retinal metastases as the initial presentation of advanced lung adenocarcinoma by Catarina Oliveira-Silva, Maria Manuel Pereira, Catarina Ferreira, Eduardo Macedo, Marta Mendes, Ana Rita Marques, Ilídio Brandão

“…Common metastatic sites include the brain, bone, liver and adrenal glands. Ocular metastases, however, are extremely rare. …”
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Psoriasis, chronic eczema and atopic dermatitis in males: functioning of sympathoadrenal and vagoinsular systems by N. Yu. Reznichenko

“…The high tension of glucocorticoid function of adrenal glands and increased activity of autonomic system; the intensive violations of autonomic homeostasis; the reduction of activity of compensatory organism reactions were found in male patients with chronic dermatoses. …”
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A Case of Echinococcal Cyst of the Lung by Majid Dudha, Zakir Shaikh, Mohammed Bhaiyat, Ishaq J. Wadiwala, Zainab-Tasneem Bhaiyat

“…It commonly involves the liver, lungs, brain and adrenal glands. Pulmonary disease is significant for its propensity to affect children and young adults. …”
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Inhibition of Cyclooxygenase Type 1 and 2 Enzyme by Aqueous Extract of Elaeagnus Angustifolia in Mice by Shahedeh Farahbakhsh, Sedigheh Arbabian, Fatemeh Emami, Banafsheh Rastegar Moghadam, Hassan Ghoshooni, Ali Noroozzadeh, Hedayat Sahraei, Leila Golmanesh, Cyrus Jalili, Homeira Zrdooz

“…The aim of the present study is to reach evaluations of possible cellular and molecular mechanisms of Elaeagnus angustifolia extract in reducing pain and inflammation through examining the extract ability for inhibition of cyclooxygenase (Cox) type 1 and 2 enzymes and corticosterone release from adrenal glands in mice. Methods: Male Swiss Webster mice were evaluated through the injection of 2 μliters to the plantar part of right foot. …”
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DNA Content of Various Fluids and Tissues of the Human Body by Jędrzej Siuta, Agnieszka Dobosz, Jerzy Kawecki, Tadeusz Dobosz

“…The results have shown that the maximum amount of genetic material was obtained from hair roots, adrenal glands, gonads and lymph nodes. The lowest DNA content per gram or milliliter of tissue or body fluid was found in adipose tissue, blood, saliva, bile, sweat, tears and the vitreous body of the eye. …”
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The Therapeutic Potential of Orphan GPCRs, GPR35 and GPR55 by Patricia Hodapp Reggio, Derek M Shore

“…Second, GPR55 has been observed to be expressed in the central nervous system, adrenal glands, gastrointestinal tract, lung, liver, uterus, bladder, kidney and bone, as well as, other tissues/organ systems. …”
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ON THE BIOLOGICAL ROLE OF CHOLINE IN HUMAN AND HIGHER ANIMAL ORGANISMS (A LITERATURE REVIEW) by Roman A. Bekker, Yuriy V. Bykov, Anastasia Yu. Bykova

“…Sufficient dietary choline is needed to maintain the normal state of the skin and its appendages, articular cartilage, skeletal muscles, to support the normal functioning of the liver and the endocrine system (especially the cortex and the medulla of the adrenal glands, and the gonads), to prevent stone formation in bile, to improve memory and cognitive functioning, to reduce blood plasma atherogenicity and improve its lipid profile, to delay the development of atherosclerosis. …”
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Glycosphingolipids with Very Long-Chain Fatty Acids Accumulate in Fibroblasts from Adrenoleukodystrophy Patients by Yuko Fujiwara, Kotaro Hama, Nobuyuki Shimozawa, Kazuaki Yokoyama

“…Defective ALDP leads to the accumulation of saturated VLCFAs in plasma and tissues, which results in damage to myelin and the adrenal glands. Here, we profiled the glycosphingolipid (GSL) species in fibroblasts from X-ALD patients. …”
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Recent advances in biochemical and molecular analysis of congenital adrenal hyperplasia due to 21-hydroxylase deficiency by Jin-Ho Choi, Gu-Hwan Kim, Han-Wook Yoo

“…The term congenital adrenal hyperplasia (CAH) covers a group of autosomal recessive disorders caused by defects in one of the steroidogenic enzymes involved in the synthesis of cortisol or aldosterone from cholesterol in the adrenal glands. Approximately 95% of all CAH cases are caused by 21-hydroxylase deficiency encoded by the CYP21A2 gene. …”
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Placental Aromatase Is Deficient in Placental Ischemia and Preeclampsia. by Alejandra Perez-Sepulveda, Lara J Monteiro, Aneta Dobierzewska, Pedro P España-Perrot, Pía Venegas-Araneda, Alejandra M Guzmán-Rojas, María I González, Macarena Palominos-Rivera, Carlos E Irarrazabal, Horacio Figueroa-Diesel, Manuel Varas-Godoy, Sebastián E Illanes

“…In human placenta androgens derived from the maternal and fetal adrenal glands are converted into estrogens by the enzymatic action of placental aromatase. …”
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