Trends in antineoplastic drug use, cost and prescribing patterns among patients with lung cancer in nine major cities of China, 2016–2020: a retrospective observational study based... by Yi Liu, Lixin Zhou, Xiaohong Zhang, Feng Yang, Rongrong Fan, Jingyuan Shang, Lin Huang, Yanguo Liu, Chunyan Zhang, Li'an Zu, Yufei Feng

“…Significant increases were seen in the prescriptions for protein kinase inhibitors (PKIs) and monoclonal antibodies (mAbs), whereas significant decreases were observed in antimetabolites, plant alkaloids and platinum compounds. The yearly cost increased progressively by 145.0% from ¥113.6 million in 2016 to ¥278.3 million in 2020 (Z=2.20, p=0.027). …”
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Bioactive compounds, anti-inflammatory, anti-nociceptive and antioxidant potentials of ethanolic leaf fraction of Sida linifolia L. (Malvaceae) by Nicodemus Emeka Nwankwo, Emmanuel Chimeh Ezeako, Florence Nkechi Nworah, Amaechi Linda Ogara, Samon A. Oka, Emmanuel Chigozie Aham, Parker Elijah Joshua, Barine Innocent Nwiloh, Tobechukwu Christian Ezike, Nwachukwu Philip Ashiakpa, Hope Chimbuezie Ngozi, Chidimma Peace Ezeugwu, Onyinye Mary-Jane Obiora, Godspower Chima Nwadike, Theresa Chinyere Ezeh, Saqer S. Alotaibi, Sarah M. Albogami, Gaber El-Saber Batiha

“…Varying quantities of flavonoids, phenols, tannins, saponins, terpenoids, steroids, and alkaloids, were detected in the fraction. GC-FID phytochemical profiling of ELFSL revealed a high level of epicatechin, moderate levels of catechin, kaempferol, flavone, naringenin, rutin flavanones, tannins, sapogenins, proanthocyanidin, and steroids, and small amounts of sparteine, resveratrol, and lunamarine. …”
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Algae: Study of Edible and Biologically Active Fractions, Their Properties and Applications by Olga Babich, Stanislav Sukhikh, Viktoria Larina, Olga Kalashnikova, Egor Kashirskikh, Alexander Prosekov, Svetlana Noskova, Svetlana Ivanova, Imen Fendri, Slim Smaoui, Slim Abdelkafi, Philippe Michaud, Vyacheslav Dolganyuk

“…They are also rich in polyunsaturated fatty acids, proteins, mycosporine-like amino acids, polysaccharides, polyphenols, carotenoids, sterols, steroids, lectins, halogenated compounds, polyketides, alkaloids, and carrageenans. Different extraction parameters are used depending on the purpose and the substances to be isolated. …”
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Antimicrobial Potential of Different Isolates of <i>Chaetomium globosum</i> Combined with Liquid Chromatography Tandem Mass Spectrometry Chemical Profiling by Marwa S. Goda, Noura El-Kattan, Mohamed A. Abdel-Azeem, Kamilia A. M. Allam, Jihan M. Badr, Nourelhuda Ahmed Nassar, Ahmad J. Almalki, Majed Alharbi, Sameh S. Elhady, Enas E. Eltamany

“…The LC-MS/MS analysis of <i>Chaetomium</i> species isolated from cultivated soil at Assuit Governate, Upper Egypt (<b>3</b>), and the host plant <i>Zygophyllum album</i> grown in Wadi El-Arbaein, Saint Katherine, South Sinai (<b>5</b>), revealed the presence of alkaloids as the predominant bioactive metabolites. …”
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<i>Buchholzia coriacea</i> Leaves Attenuated Dyslipidemia and Oxidative Stress in Hyperlipidemic Rats and Its Potential Targets <i>In Silico</i> by Daniel E. Uti, Udu A. Ibiam, Wilson A. Omang, Precious A. Udeozor, Grace U. Umoru, Solomon K. Nwadum, Inalegwu Bawa, Esther U. Alum, Joseph C. Mordi, Edith O. Okoro, Uket Nta Obeten, Eucharia N. Onwe, Suleiman Zakari, Ohunene Rukayat Opotu, Patrick M. Aja

“…The gas chromatography-mass spectrometry analysis identified alkaloids, saponins, flavonoids, phenols, terpenoids, and 44 chemical compounds in the leaf extract of BCE. …”
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Inoculation of cucumber plants with Beauveria bassiana enhances resistance to Aphis gossypii (Hemiptera: Aphididae) and increases aphid susceptibility to pirimicarb by Mohammad HOMAYOONZADEH, Mojtaba ESMAEILY, Khalil TALEBI, Hossein ALLAHYARI, Stuart REITZ, J.P. MICHAUD

“…The fungus grew endophytically into foliage when sprayed on cucumbers at the 2-leaf stage and concentrations of alkaloids, flavonoids, phenols, hydrogen peroxide, and total chlorophyll were higher than in control plants 28 days after inoculation. …”
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Antimicrobial Activity and Phytochemical Characterization of <i>Baccharis concava</i> Pers., a Native Plant of the Central Chilean Coast by Maité Rodríguez-Díaz, Fabián E. Pérez, Paloma M. Manosalva, Juan I. Cerda, Consuelo F. Martínez-Contreras, Aracely Y. Mora, Nicolás A. Villagra, Sergio A. Bucarey, Andrés Barriga, Jorge Escobar, José L. Martínez, Alejandro A. Hidalgo

“…Qualitative phytochemical characterization indicated the presence of alkaloids, steroids, terpenoids, flavonoids, phenolic, and tannin compounds. …”
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Characteristic chemical profile of Juhe Fang extract with lipid-lowering properties by Jing Kong, Lulu Liu, Yuanyuan Gao, Siyu Chen, Linfu Li, Yisong Shu, Daohan Sun, Yanyan Jiang, Renbing Shi

“…A total of 95 compounds from JHEF including 15 phenolic acids (PA), 4 phenylethanoid glycosides (PG), 24 flavonoids (F), 14 triterpenoids (T), 10 diterpenoid glycosides (D), 18 alkaloids (A) and 10 others (O) were identified. Trigonelline was discovered for the first time in a herbal medicine of Juhe Fang. …”
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Wood Waste from Fruit Trees: Biomolecules and Their Applications in Agri-Food Industry by Maria Jose Aliaño-González, Julien Gabaston, Victor Ortiz-Somovilla, Emma Cantos-Villar

“…The main bioactive compounds found in wood are polyphenols, terpenes, polysaccharides, organic compounds, fatty acids, and alkaloids. Polyphenols are the most ubiquitous compounds in wood. …”
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Tyrosinase Inhibitors Derived from Chemical Constituents of <i>Dianella ensifolia</i> by Yu-Chang Chen, Sheng-Han Su, Jheng-Cian Huang, Che-Yi Chao, Ping-Jyun Sung, Yih-Fung Chen, Horng-Huey Ko, Yueh-Hsiung Kuo

“…Four new flavans, (2<i>S</i>)-4’-hydroxy-6,7-dimethoxyflavan (<b>1</b>), (2<i>S</i>)-3’,4’-dihydroxy-7-methoxy-8-methylflavan (<b>2</b>), (2<i>S</i>)-2’-hydroxy-7-methoxyflavan (<b>3</b>), and (2<i>S</i>,1′<i>S</i>)-4-hydroxy-4-(7-methoxy-8-methylchroman-2-yl)-cyclohex-2-enone (<b>4</b>), together with 67 known compounds, including 10 flavans (<b>5</b>–<b>14</b>), 5 flavanones (<b>15</b>–<b>19</b>), 3 flavone (<b>20</b>–<b>22</b>), 5 chalcones (<b>23</b>–<b>27</b>), 3 chromones (<b>28</b>–<b>30</b>), 15 aromatics (<b>31</b>–<b>45</b>), 7 phenylpropanoids (<b>46</b>–<b>52</b>), one lignan (<b>53</b>), 7 steroids (<b>54</b>–<b>60</b>), one monoterpene (<b>61</b>), one diterpene (<b>62</b>), 4 triterpenes (<b>63</b>–<b>66</b>), a carotenoid (<b>67</b>), 2 alkaloids (<b>68</b> and <b>69</b>), and 2 fatty acids (<b>70</b> and <b>71</b>) were isolated from <i>D. ensifolia</i>. …”
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Phytochemical profile and antioxidant activity of various solvent extracts of two varieties of ginger and garlic by Jolly Oder Akullo, Beatrice N. Kiage-Mokua, Dorothy Nakimbugwe, Jeremiah Ng’ang’a, John Kinyuru

“…The highest total phenolic and flavonoid content was in ethanol and methanol extracts of local ginger: 1968.49 and 2172.65 mg GAE/100 g; 254.24 and 184.62 mg QE/100 g, respectively. Tannins, alkaloids, saponins, and terpenoids were in varying concentrations in the extracts. …”
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In vitro Anti-Leishmanial Activities of Methanol Extract of Brucea antidysenterica J.F. Mill Seeds and Its Solvent Fractions by Ketema T, Tadele M, Gebrie Z, Makonnen E, Hailu A, Abay SM

“…The quantitative estimations of total phenolic compounds (TPCs), flavonoids (TFCs) and alkaloids (TACs) were determined, spectrophotometrically. …”
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Phytochemical Profiling, Biological Activities, and In Silico Molecular Docking Studies of <i>Causonis trifolia</i> (L.) Mabb. & J.Wen Shoot by Samik Hazra, Anindya Sundar Ray, Swetarka Das, Arunava Das Gupta, Chowdhury Habibur Rahaman

“…From the quantitative phytochemical estimation, it was evident that the PECTS contained good amounts of phenolics, flavonoids, tannins, and alkaloids. During the HPLC analysis, we identified a total of eight phenolic and flavonoid compounds (gallic acid, catechin hydrate, chlorogenic acid, caffeic acid, p-coumaric acid, sinapic acid, coumarin, and kaempferol) and quantified their respective contents from the PECTS. …”
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POTENTIAL TESTING OF WASTE SKIN ONION (Allium ascalonicum) AS A LARVACIDE AGAINST THE DEATH OF MOSQUITO LARVAS Culex sp by Rahmayanti Rahmayanti, Siti Hadijah, Fitriana Fitriana

“…Onion peel waste was proven positive for containing alkaloids, saponins, flavonoids and tannins. The purpose of this study was to determine the effective concentration of onion peel waste powder (Allium ascalonicum) and the effective LC50 of onion peel waste powder (Allium ascalonicum) as larvicides against the death of Culex sp mosquito larvae at an effective powder concentration of 0.025 gr/ml, 0.05 gr. …”
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An Integrative Pharmacology-Based Strategy to Uncover the Mechanism of Zuogui Jiangtang Shuxin Formula in Diabetic Cardiomyopathy by Huang Y, Zhang Y, Wu Y, Xiang Q, Yu R

“…The DCM model mice were treated with ZGJTSXF, and the predicted important signaling pathways were verified using quantitative PCR and Western blot.Results: We identified 78 compounds in serum of medicated rats, which mainly included flavonoids, small peptides, nucleosides, organic acids, phenylpropanoids, alkaloids, phenanthrenequinones, iridoids, phenols, and saponins. …”
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Morphological Characterization of <i>Nicotiana tabacum</i> Inflorescences and Chemical-Functional Analysis of Extracts Obtained from Its Powder by Using Green Solvents (NaDESs) by Mariana Leal, María Alejandra Moreno, Patricia Liliana Albornoz, María Inés Mercado, Iris Catiana Zampini, María Inés Isla

“…CU was the best solvent for flavonoids and alkaloids extraction (215.3 ± 3.2 µg QE/mL and 392.3 ± 8.0 µg ACE/mL, respectively). …”
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Natural Anophelin mosquito repellents and phytochemical analysis of ethanol and hexane leaf extracts from four plant species by Emad I. Y. Adam, Yousif O.H.M. Assad, Marwa M. E. Eltohami, Nabil H.H. Bashir, Samira H. Abdelrahman, Bakri Y. M. Nour

“…Phytochemical analysis showed that alkaloids, saponins, flavonoids, terpenes, tannins and terpenoids were present/or absent in the 4 plant-LEs. …”
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Screening of Anti-Inflammatory Activity and Metabolomics Analysis of Endophytic Fungal Extracts; Identification and Characterization of Perylenequinones and Terpenoids from the Int... by Rosella Spina, Armelle Ropars, Sihem Bouazzi, Safa Dadi, Pascal Lemiere, François Dupire, Afra Khiralla, Sakina Yagi, Jean-Pol Frippiat, Dominique Laurain-Mattar

“…A large family of metabolites (carboxylic acids and derivatives, steroid derivatives, alkaloids, hydroxyanthraquinones, valerolactones and perylenequinones) were detected. …”
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Agents contributing to secondary immunodeficiency development in patients with multiple myeloma, chronic lymphocytic leukemia and non-Hodgkin lymphoma: A systematic literature revi... by Stephen Jolles, Sergio Giralt, Tessa Kerre, Hillard M. Lazarus, S. Shahzad Mustafa, S. Shahzad Mustafa, Roberto Ria, Donald C. Vinh

“…Here, we report the results of a systematic literature review on the potential association of various cancer regimens with infection rates, neutropenia, lymphocytopenia, or hypogammaglobulinemia, indicative of SID.MethodsA systematic literature search was performed in 03/2022 using PubMed to search for clinical trials that mentioned in the title and/or abstract selected cancer (CLL, MM, or NHL) treatments covering 12 classes of drugs, including B-lineage monoclonal antibodies, CAR T therapies, proteasome inhibitors, kinase inhibitors, immunomodulators, antimetabolites, anti-tumor antibiotics, alkylating agents, Bcl-2 antagonists, histone deacetylase inhibitors, vinca alkaloids, and selective inhibitors of nuclear export. …”
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Amelioration of Scopolamine-Induced Amnesic, Anxiolytic and Antidepressant Effects of <i>Ficus benghalensis</i> in Behavioral Experimental Models by Humna Malik, Sana Javaid, Muhammad Fawad Rasool, Noreen Samad, Syed Rizwan Ahamad, Faleh Alqahtani, Imran Imran

“…<i>Results:</i> phytochemical studies showed the presence of various phytoconstituents including alkaloids, flavonoids, terpenes, phenolics and anthraquinones. …”
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