A Rapid and Highly Predictive in vitro Screening Platform for Osteogenic Natural Compounds Using Human Runx2 Transcriptional Activity in Mesenchymal Stem Cells by Li-Tzu Wang, Yu-Wei Lee, Chyi-Huey Bai, Chyi-Huey Bai, Hui-Chun Chiang, Hsiu-Huan Wang, B. Linju Yen, B. Linju Yen, Men-Luh Yen

“…We screened eight plant-derived compounds from different families including flavonoids, polyphenolic compounds, alkaloids, and isothiocyanates for osteogenic capacity using the human RUNX2-promoter luciferase reporter (hRUNX2-luc) transduced into the mouse MSC line, C3H10T1/2, with daidzein—a well-studied osteogenic phytoestrogen—as a positive control. …”
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A review of the research progress on Pinellia ternata (Thunb.) Breit.: Botany, traditional uses, phytochemistry, pharmacology, toxicity and quality control by Ting Zou, Jing Wang, Xu Wu, Kai Yang, Qiao Zhang, Changli Wang, Xiao Wang, Chongbo Zhao

“…Approximately 212 chemical constituents have been isolated from Pinellia ternata, including alkaloids, volatile oils, amino acids, organic acids, flavonoids, cerebrosides, phenylpropanoids and other compounds. …”
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Transcriptome and Metabolome Analyses Reveals the Pathway and Metabolites of Grain Quality Under Phytochrome B in Rice (Oryza sativa L.) by Fei Li, Ye Liu, Xiaohua Zhang, Lingzhi Liu, Yun Yan, Xin Ji, Fanshu Kong, Yafan Zhao, Junzhou Li, Ting Peng, Hongzheng Sun, Yanxiu Du, Quanzhi Zhao

“…An analysis of grain metabolites showed an increase in the free fatty acids and lysophosphatidylcholine, whereas the amounts of sugars, alcohols, amino acids and derivatives, organic acids, phenolic acids, alkaloids, nucleotides and derivatives, and flavonoids decreased, which were significantly associated with grain size and chalk formation. …”
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Combined Metabolomic and Quantitative RT-PCR Analyses Revealed the Synthetic Differences of 2-Acetyl-1-pyrroline in Aromatic and Non-Aromatic Vegetable Soybeans by Man Zhao, Linlin Qian, Zhuoyu Chi, Xiaoli Jia, Fengjie Qi, Fengjie Yuan, Zhiqiang Liu, Yuguo Zheng

“…The results showed that the differentially accumulated metabolites (DAMs) of the two varieties can be classified into nine main categories including flavonoids, lipids, amino acids and derivatives, saccharides and alcohols, organic acids, nucleotides and derivatives, phenolic acids, alkaloids and vitamin, which mainly contributed to their phenotypic differences. …”
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Selection of Suitable Reference Genes for Gene Expression Normalization Studies in <i>Dendrobium huoshanense</i> by Shanyong Yi, Haibo Lu, Chuanjun Tian, Tao Xu, Cheng Song, Wei Wang, Peipei Wei, Fangli Gu, Dong Liu, Yongping Cai, Bangxing Han

“…Recent studies have paid close attention to the genetic expression of the biosynthetic pathway of the main active components (polysaccharides, alkaloids, and flavonoids), and real-time polymerase chain reaction (qPCR) is one of the most widely used methods for doing so. …”
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Blood Parameters, Kidney Histology and Growth Performances in <i>Gallus gallus</i> Domesticus (Brahma) Hens Fed a Diet Supplemented with <i>Dacryodes edulis</i> (Safou) Powder Leav... by Herve Tchoffo, Nathalie Ngwemetah, Donatien Albert Atsamo, Chongsi Margaret Mary Momo, Christelle Yolande Djoukouo Signe, Blandine Kambou, Arius Baulland Nguedia Dongmo, Nadege Djuissi Motchewo, Ferdinand Ngoula

“…The leaf extracts of <i>Dacryodes edulis</i> possess high concentrations of alkaloids, saponins, flavonoids, and tannins with various biological activities, including antimicrobial, antifungal, and antioxidant activities. …”
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Integrated transcriptomic and metabolomic analyses reveal key metabolic pathways in response to potassium deficiency in coconut (Cocos nucifera L.) seedlings by Lilan Lu, Siting Chen, Weibo Yang, Yi Wu, Yingying Liu, Xinxing Yin, Yaodong Yang, Yanfang Yang

“…Metabolomic analysis showed that metabolites related to fatty acids, lipidol, amines, organic acids, amino acids, and flavonoids were generally down-regulated in coconut seedlings under K+ deficiency, whereas metabolites related to phenolic acids, nucleic acids, sugars, and alkaloids were mostly up-regulated. Therefore, coconut seedlings respond to K+ deficiency stress by regulating signal transduction pathways, primary and secondary metabolism, and plant-pathogen interaction. …”
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Annona Muricata L. extract restores renal function, oxidative stress, immunohistochemical structure, and gene expression of TNF-α, IL-β1, and CYP2E1 in the kidney of DMBA-intoxicat... by Mohamed M. Zeweil, Asmaa F. Khafaga, Sahar F. Mahmoud, Lamiaa Wasef, Hamida Saleh, Attaa. M. Abd Elrehim, Naglaa F. Bassuoni, Maha Abdullah Alwaili, Nizar H. Saeedi, Hanan A. Ghoneim

“…The reno-protective effects of GRV may involve its anti-inflammatory and/or antioxidant properties, which are based on the presence of phytochemical compounds such as acetogenins, alkaloids, and flavonoids.…”
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A Comparative Analysis of <em>Bombyx mori</em> (Lepidoptera: Bombycidae) <em>β</em>-fructofuranosidase Homologs Reveals Different Post-Translational Regulations in <em>Glyphodes py... by Yue Zhao, Liangli Yang, Yu Chen, Xinwei Zhang, Jing Li, Dan Liang, Song Jiang, Junshan Gao, Yan Meng

“…The <i>BmSuc1</i> gene is the first <i>β</i>-fructofuranosidase (<i>β</i>-FFase) encoding gene identified in animals, and <i>β</i>-FFase acts as an essential sucrase for glycometabolism modulation in the silkworm larvae, involved in resistance to mulberry alkaloids. <i>Glyphodes pyloalis</i> Walker (Lepidoptera: Pyralidae) is an important mulberry pest leading to heavy economic loss of sericulture. …”
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Revealing ecotype influences on Cistanche sinensis: from the perspective of endophytes to metabolites characteristics by Min Zhang, Min Zhang, Min Zhang, Min Zhang, Yujing Miao, Xinke Zhang, Xiao Sun, Minhui Li, Minhui Li, Minhui Li, Linfang Huang, Linfang Huang

“…Further analysis of 34 core differential metabolites showed that 15 compounds with up-regulated belonged to phenolic acids, flavonoids, and organic acids, while 19 compounds with down-regulated belonged to phenolic acids, flavonoids, alkaloids, amino acids, lipids, and nucleotides. There was no noteworthy discrepancy in the endophytic bacteria’s α and β diversity between sandy and loam ecotypes. …”
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Atropine and Scopolamine in Maize Products from the Retail Stores in the Republic of Serbia by Gorica Vuković, Tijana Stojanović, Bojan Konstantinović, Vojislava Bursić, Nikola Puvača, Milena Popov, Nataša Samardžić, Aleksandra Petrović, Dušan Marinković, Svetlana Roljević Nikolić, Rada Đurović Pejčev, Bojana Špirović Trifunović

“…Therefore, a total of 103 samples of maize products were analyzed for the presence of toxins, i.e., tropane alkaloids (TAs). The samples were collected from the retail stores in the Republic of Serbia in 2021 and analyzed for the presence of atropine and scopolamine (33 corn grits, 39 polenta, and 31 semolina samples). …”
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Comprehensive analysis of the complete mitochondrial genomes of three Coptis species (C. chinensis, C. deltoidea and C. omeiensis): the important medicinal plants in China by Furong Zhong, Furong Zhong, Wenjia Ke, Wenjia Ke, Yirou Li, Yirou Li, Xiaoyan Chen, Xiaoyan Chen, Tao Zhou, Tao Zhou, Binjie Xu, Luming Qi, Luming Qi, Zhuyun Yan, Zhuyun Yan, Yuntong Ma, Yuntong Ma

“…Coptis plants (Ranunculaceae) contain high levels of isoquinoline alkaloids and have a long history of medicinal use. …”
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Effect of Elevated CO₂ on Biomolecules’ Accumulation in Caraway (<i>Carum carvi</i> L.) Plants at Different Developmental Stages by Hamada AbdElgawad, Mohammad K. Okla, Saud S. Al-amri, Abdulrahman AL-Hashimi, Wahida H. AL-Qahtani, Salem Mesfir Al-Qahtani, Zahid Khorshid Abbas, Nadi Awad Al-Harbi, Ayman Abd Algafar, Mohammed S. Almuhayawi, Samy Selim, Mohamed Abdel-Mawgoud

“…Caraway plants have been known as a rich source of phytochemicals, such as flavonoids, monoterpenoid glucosides and alkaloids. In this regard, the application of elevated CO₂ (eCO₂) as a bio-enhancer for increasing plant growth and phytochemical content has been the focus of many studies; however, the interaction between eCO₂ and plants at different developmental stages has not been extensively explored. …”
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NUTRITIONAL COMPOSITION OF DIOSCOREA HISPIDA FROM DIFFERENT LOCATIONS AROUND LEUSER ECOSYSTEM AREA by Sitti Saleha, Nurdin Saidi, Saiful ., Murniana ., Saida Rasnovi, Teuku M. Iqbalsyah

“…Phytochemical tests showed that all of the samples contained alkaloids and terpenoids. One of the samples (LP) also contained phenol and steroid. …”
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Pharmacognostic characterization, wound healing and toxicity assessment of the stem bark of Xylia evansii Hutch (Leguminosae) by Lord Gyimah, Evelyn Asante-Kwatia, Silas Adjei, Frederick Akuffo Owusu, Fanny Darko, Ernest Tabiri, Abraham Yeboah Mensah

“…Tannins, flavonoids, coumarins, saponins, triterpenes and alkaloids were identified in the bark. This is the first report on the wound healing potential and safety profile of X. evansii, giving scientific credence to its use in traditional medicine.…”
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The Feasibility of Utilizing Cultured <i>Cordyceps militaris</i> Residues in Cosmetics: Biological Activity Assessment of Their Crude Extracts by Punyawatt Pintathong, Putarak Chomnunti, Sarita Sangthong, Areeya Jirarat, Phanuphong Chaiwut

“…Furthermore, the other compounds present included nucleosides, nucleobases, amino acids, sugars, phospholipids, alkaloids, organic acids, vitamins, and peptides. Therefore, it is emphasized that SBRs from <i>C. militaris</i> can be a prospective source for preparing crude extracts employed in cosmetics. …”
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The Impact of Growth Years on the Medicinal Material Characteristics and Metabolites of <i>Stellaria dichotoma</i> L. var. <i>lanceolata</i> Bge. Reveals the Optimal Harvest Age by Zhenkai Li, Lu Feng, Hong Wang, Lin Zhang, Haishan Li, Yanqing Li, Pilian Niu, Gege Tian, Yan Yang, Xiangui Mei, Li Peng

“…Moreover, different highly expressed metabolites in SDL at different growth years were observed: 1–2 years old was beneficial to the accumulation of more lipids, while 3–5 years old was conducive to accumulating more alkaloids, benzenoids, etc. Furthermore, 12 metabolites accumulating with growth years and 20 metabolites decreasing with growth years were screened, and 17 significantly different metabolites were noted in 3-year-old SDL. …”
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Wound healing, antidiabetic and antioxidant activity of Neolamarckia cadamba, quercetin rich, extract by Jagat Pal Yadav, Amita Verma, Prateek Pathak, Vikas Kumar, Dinesh Kumar Patel

“…Result: The ethanolic extract of NMCA was subjected to phytochemical analysis, which revealed the presence of diverse phytoconstituents, including alkaloids, flavonoid phenols, saponins, steroids, glycosides, and tannins. …”
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Phytochemical Constituents and Biological Activities of the Unexplored Plant <i>Rhinanthus angustifolius</i> subsp. <i>grandiflorus</i> by Leilei Zhang, Gokhan Zengin, Gabriele Rocchetti, Ismail Senkardes, Jugreet B. Sharmeen, Mohamad Fawzi Mahomoodally, Tapan Behl, Youssef Rouphael, Luigi Lucini

“…Additionally, untargeted profiling based on high-resolution mass spectrometry targeted different phytochemical classes, namely, polyphenols, terpenoids, and alkaloids. The highest total phenolic and flavonoid contents were detected using methanol as the extraction solvent. …”
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<i>Malva parviflora</i> Leaves Mucilage: An Eco-Friendly and Sustainable Biopolymer with Antioxidant Properties by Ans Munir, Fadia S. Youssef, Saiqa Ishtiaq, Sairah H. Kamran, Alaa Sirwi, Safwat A. Ahmed, Mohamed L. Ashour, Sameh S. Elhady

“…Results showed that the yield of mucilage was 7.50%, and it was free from starch, alkaloids, glycosides, saponins, steroids, lipids and heavy metals. …”
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