Asymmetric allylic alkylation of Morita–Baylis–Hillman carbonates with α-fluoro-β-keto esters av Yan, Lin, Han, Zhiqiang, Zhu, Bo, Yang, Caiyun, Tan, Choon-Hong, Jiang, Zhiyong

“…In the presence of a commercially available Cinchona alkaloid as catalyst, the asymmetric allylic alkylation of Morita–Baylis–Hillman carbonates, with α-fluoro-β-keto esters as nucleophiles, have been successfully developed. …”
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Chemical constituents of Garcinia parvifolia (Guttiferae) av Ee, Gwendoline Cheng Lian, Ng, Sook Han, Goh, Joo Kheng, Md.Sukari, Mohd. Aspollah, Rahmani, Mawardi

“…-sitosterol (2), three xanthones, 6-deoxyjacareubin (3), daphnifolin (4) and rubraxanthone (5), one benzophenone, isoxanthochymol (6) and one alkaloid, caffeine (7). These compounds were isolated using common chromatographic techniques and were identified by using spectroscopic experiments such as NMR, MS, IR and UV. …”
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Skrining senyawa bioaktif dari beberapa ekstrak tumbuhan asal kawasan hutan Kalimantan Tengah dan isolasi senyawa bioaktif Fibraurea chloroleuca Miers = Bioactive compound screenin... av Perpustakaan UGM, i-lib

“…Based onTLC pictured visualized by Dragendorff, bl is confirmed as an alkaloid. Mass spectrum (EIMS) data of bl showed the highest mass peak at m/z 351 (75%). …”

Extraction And Isolation Of Chemical Compound From Tabernaemontana Divaricata (L.) R.Br. Ex Roem. & Schult. Leaves With Potential Anti-Neuraminidase Activity av Zalaludin, Ayunni Salihah

“…This study is focused on the extraction, fractionation and isolation of alkaloid chemical constituent with potential anti-neuraminidase activity from Tabernaemontana divaricata, identified by virtual screening from NADI database followed by in vitro and in silico evaluations of the isolated compound along with standard drug (DANA).…”
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Pharmacokinetics And Investigation Of The Anxiolytic-Like Effect Of Mitragynine In Rats av Imad Hazim Al Ganaby, Ammar

“…Mitragyna speciose Korth (Rubiaceae) merupakan sejenis pokok yang berasal dari bahagian utara Semenanjung Malaysia dan selatan Thailand. Alkaloid utama dalam tumbuhan ini, iaitu mitraginina (MG), telah dilaporkan bertanggungjawab terhadap kebanyakan sifat farmakologinya. …”
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Enantioselective total synthesis of (-)-deoxoapodine av Kang, Taek, White, Kolby L., Mann, Tyler J., Hoveyda, Amir H., Movassaghi, Mohammad

“…Our synthesis of this hexacyclic aspidosperma alkaloid includes an efficient molybdenum-catalyzed enantioselective ring-closing metathesis reaction for the desymmetrization of an advanced intermediate that introduces the C5-quaternary stereocenter. …”
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Catalytic asymmetric conjugate addition of mercaptans to β-substituted-β-trifluoromethyl oxazolidinone enoates: access to chiral trifluoromethylated tertiary thioethers and thiols... av Chen, Wenchao, Jing, Zhengzhong, Chin, Kek Foo, Qiao, Baokun, Zhao, Yan, Yan, Lin, Tan, Choon-Hong, Jiang, Zhiyong

“…The opposite enantiomers of adducts, containing a trifluoromethylated hetero-quaternary stereogenic centers, could be obtained by utilizing two pseudo-enantiomeric Cinchona alkaloid-derived tertiary amine/squaramides as catalysts. …”
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Catalytic asymmetric conjugate addition of mercaptans to β-substituted-β-trifluoromethyl oxazolidinone enoates : access to chiral trifluoromethylated tertiary thioethers and thiols... av Chen, Wenchao, Jing, Zhengzhong, Chin, Kek Foo, Qiao, Baokun, Zhao, Yan, Yan, Lin, Tan, Choon-Hong, Jiang, Zhiyong

“…The opposite enantiomers of adducts, containing a trifluoromethylated hetero-quaternary stereogenic centers, could be obtained by utilizing two pseudo-enantiomeric Cinchona alkaloid-derived tertiary amine/squaramides as catalysts. …”
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Direct asymmetric allylic alkenylation of N-itaconimides with Morita–Baylis–Hillman carbonates av Yang, Wenguo, Tan, Davin, Li, Lixin, Han, Zhiqiang, Yan, Lin, Huang, Kuo-Wei, Tan, Choon-Hong, Jiang, Zhiyong

“…The asymmetric allylic alkenylation of Morita–Baylis–Hillman (MBH) carbonates with N-itaconimides as nucleophiles has been developed using a commercially available Cinchona alkaloid catalyst. A variety of multifunctional chiral α-methylene-β-maleimide esters were attained in moderate to excellent yields (up to 99%) and good to excellent enantioselectivities (up to 91% ee). …”
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Conjugate addition of lithium N-phenyl-N-(α-methylbenzyl)amide: application to the asymmetric synthesis of (R)-(-)-angustureine. av Bentley, SA, Davies, S, Lee, J, Roberts, P, Thomson, J

“…The synthetic utility of this methodology has been demonstrated via the short and concise asymmetric synthesis of the tetrahydroquinoline alkaloid (R)-(-)-angustureine in six steps and 32% overall yield from commercially available oct-2-enoic acid.…”

N-acetylcolchinol methyl ether (a natural product); suhailamine (a phantom natural product) av Davies, S, Fletcher, A, Roberts, P, Thomson, J, Yeung, A

“…<p>The reported characterization data for the allocolchicinoid alkaloid suhailamine, isolated from <em>Colchicum decaisnei</em> and known to have an erroneous structure, have been reanalyzed. …”

Organocatalytic diastereo- and enantioselective Michael addition reactions of 5-aryl-1,3-dioxolan-4-ones. av Hynes, P, Stranges, D, Stupple, P, Guarna, A, Dixon, D

“…5-Aryl-1,3-dioxolan-4-one heterocycles derived from mandelic acid derivatives and hexafluoroacetone have been identified as new and effective pro-nucleophiles in highly diastereo- and enantioselective Michael addition reactions to nitro olefins catalyzed by bifunctional epi-9-amino-9-deoxy cinchona alkaloid derivatives. Diastereoselectivities up to 98% and enantioselectivities up to 89% for a range of nitro olefins and 5-aryl-1,3-dioxolan-4-ones under mild reaction conditions are reported.…”

Synthesis of N-Alkylated and N-Acylated derivatives of girinimbine av Nor, Siti Mariam Mohd, Osman, Fatin Nurul Atiqah, Ahmad, Kartini, Nafiah, Mohd Azlan

“…Girinimbine, a carbazole alkaloid has drawn an attention due to its wide range of pharmacological effects such as antiplatelet, antibacterial and anticancer activities. …”
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Total synthesis of (-)-deglycocadambine av Wang, Fang-Xin, Chen, Ying-Tao, Liu, Hui, Wang, Heng-Shan, Liang, Hong, Chen, Zhen-Feng, Chi, Robin Yonggui

“…The first total synthesis of the monoterpene indole alkaloid (-)-deglycocadambine is achieved in 12 steps with (+)-genipin as the chiral starting material. …”
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POTENT COMPETITIVE-INHIBITION OF ALPHA-GALACTOSIDASE AND ALPHA-GLUCOSIDASE ACTIVITY BY 1,4-DIDEOXY-1,4-IMINOPENTITOLS - SYNTHESES OF 1,4-DIDEOXY-1,4-IMINO-D-LYXITOL AND OF BOTH ENA... av Fleet, G, Nicholas, S, Smith, P, Evans, S, Fellows, L, Nash, R

“…The syntheses of 1,4-dideoxy-1,4-imino-D-lyxitol (3), 1,4-dideoxy-1,4-imino-d-arabinitol (4) and 1,4-dideoxy-1,4-imino-l-arabinitol (5) are reported; (3) is a potent competitive inhibitor of α-galactosidase (green coffee beans) and (4) a competitive inhibitor of α-glucosidase (Brewer's yeast) suggesting that iminopentitols have considerable potential as glycosidase inhibitors. (4) was found to be identical to an alkaloid recently isolated from Angylocalyx boutiqueanus. © 1985.…”

THE SYNTHESIS FROM D-XYLOSE OF THE POTENT AND SPECIFIC ENANTIOMERIC GLUCOSIDASE INHIBITORS, 1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL AND 1,4-DIDEOXY-1,4-IMINO-L-ARABINITOL av Fleet, G, Smith, P

“…The synthesis of 1,4-dideoxy-1,4-imino-D-arabinitol involves connecting C2 and C5 of xylose together with nitrogen, whereas the synthesis of 1,4-dideoxy-1.4-imino-L-arabinitol requires C1 and C4 of xylose to be joined together by nitrogen. 1,4-Dideoxy-1,4-imino-D-arabinitol is a naturally occurring pyrrolidine alkaloid found in Arachniodes standishii and Angylocalyx boutiqueanus. © 1986.…”

Effect of leaf position on phytochemical content, antioxidant and antimicrobial activities of Senduduk (Melastoma Malabathricum) av Cheong, Kah Kei

“…The objective of the study was to study the effect of leaf position on phytochemical content (flavonoid, phenolic, alkaloid, tannin, saponin, glycoside and terpene), antioxidant and antimicrobial activities of M. malabathricum. …”
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Potensi Tepung Daun Binahong (Anredera cordifolia (Ten) Steenis) sebagai Fitobiotik Pada Pakan Ayam Broiler av Widodo, Nur, Wihandoyo, Wihandoyo, Dono, Nanung Danar, Zuprizal, Zuprizal

“…U|ji kuantitatif kandungan metabolit sekunder diawali dengan ekstrak menggunakan metode maserasi kemudian dilakukan pengukuran kandungan metabolit sekunder (total fenol, total flavonoid, saponin, dan alkaloid) dengan menggunakan spektrofotometer. Hasil penelitian menunjukkan bahwa daun binahong memiliki kandungan bahan kering (BK) 94,54%, energi termetabolis (EM) 2068,71 kcal/kg, protein kasar (PK) 14,80%, lemak kasar (LK) 5,20%, serat kasar (SK) 8,08%, kalsium (Ca) 1,28%, dan fosfor (P) 0,46% dan kandungan metabolit sekunder tepung daun binahong yaitu: total fenol 85,30 mg/kg, total flavonoid 47,40 mg/kg, saponin 66,00 mg/kg, dan alkaloid 2,60 mg/kg. …”
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EKSTRAK ETANOLIK DAUN AWAR-AWAR (Ficus septicQ Burm. f.) MEMACU APOPTOSIS SEL KANKER PAYUDARA MCF-7 MELALUI PENEKANAN EKSPRESI Bcl-2 av Perpustakaan UGM, i-lib

“…Alkaloid fenantroindolisidin memiliki aktivitas sitotoksik terhadap beberapa sel kanker. …”

EFEK SITOTOKSIK, PROLIFERASI DAN APOPTOSIS FRAKSI AKTIF AKAR TUMBUHAN MEKAI (Albertisia papuana Becc.) TERHADAP SEL KANKER PAYUDARA (T47D) av , WIDYASARI, , Prof. Dr. Istriyati, MS.

“…The active compound in those fraction was alkaloid. It could be concluded that mekai root extract could inhibit proliferation and increased apoptosis of breast cancer cell (T47D), the active compound in mekai root was alkaloid.…”