The significant influence of residual feed intake on flavor precursors and biomolecules in slow-growing Korat chicken meat by Chotima Poompramun, Wittawat Molee, Kanjana Thumanu, Amonrat Molee

“…The correlation loading results showed that the LRFI group was correlated with high ratios of lipids, lipid esters, collagen content (amide III) and beta sheet protein (rg loading >0.5) while the HRFI group was positively correlated with protein (amide I, amide II), alpha helix protein, IMP content, carbohydrate, ultimate pH and WHC (rg loading >0.5). …”
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Golgi localisation of GMAP210 requires two distinct cis-membrane binding mechanisms by Goud Bruno, Rivero Sabrina, Cardenas Jesus, Bornens Michel, Rios Rosa M

“…GMAP210 is a long coiled-coil cis-Golgi associated protein that plays a role in maintaining Golgi ribbon integrity and position and contributes to the formation of the primary cilium. An amphipathic alpha-helix able to bind liposomes <it>in vitro </it>has been recently identified at the first 38 amino acids of the protein (amphipathic lipid-packing sensor motif), and an ARF1-binding domain (Grip-related Arf-binding domain) was found at the C-terminus. …”
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Schistosoma mansoni immunomodulatory molecule Sm16/SPO-1/SmSLP is a member of the trematode-specific helminth defence molecules (HDMs). by Jenna Shiels, Krystyna Cwiklinski, Raquel Alvarado, Karine Thivierge, Sophie Cotton, Bibiana Gonzales Santana, Joyce To, Sheila Donnelly, Clifford C Taggart, Sinead Weldon, John P Dalton

“…Structural analyses of Sm16 shows that it consists predominantly of an amphipathic alpha-helix, much like other HDMs. In S. mansoni, Sm16 is highly expressed in the cercariae and eggs but not in adult worms, suggesting that the molecule is of importance not only during skin invasion but also in the pro-inflammatory response to eggs in the liver tissues. …”
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Systematic identification and characterization of repeat sequences in African swine fever virus genomes by Zhaozhong Zhu, Shengqiang Ge, Zena Cai, Yifan Wu, Congyu Lu, Zheng Zhang, Ping Fu, Longfei Mao, Xiaodong Wu, Yousong Peng

“…Noncoding repeat sequences tended to form enhancers, whereas coding repeat sequences had a lower ratio of alpha-helix and beta-sheet and a higher ratio of loop structure and surface amino acids than nonrepeat sequences. …”
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The Flexible, Extended Coil of the PDZ-Binding Motif of the Three Deadly Human Coronavirus E Proteins Plays a Role in Pathogenicity by Dewald Schoeman, Ruben Cloete, Burtram C. Fielding

“…The PDZ-binding motif (PBM) of the SARS-CoV-1 and -2 and MERS-CoV models adopted a more flexible, extended coil, while the HCoV-229E and HCoV-NL63 models adopted a less flexible alpha helix. All the E peptides docked to PALS1 occupied the same binding site and the more virulent hCoV E peptides generally interacted more stably with PALS1 than the less virulent ones. …”
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In-silico predictions of deleterious SNPs in human ephrin type-A receptor 3 (EPHA3) gene by Dipankor Chatterjee, Umar Faruq Chowdhury, Mohammad Umer Sharif Shohan, Md Mohasin, Yearul Kabir

“…Many of these predicted SNPs resided in the alpha-helix, extended sheet, and β turn of secondary structure, and they conferred a significant impact on the structure due to changes in charge density, hydrophobicity, hydrogen bond, and other favorable bonds. …”
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An mRNA-based broad-spectrum vaccine candidate confers cross-protection against heterosubtypic influenza A viruses by Feifei Xiong, Chi Zhang, Baoyuan Shang, Mei Zheng, Qi Wang, Yahong Ding, Jian Luo, Xiuling Li

“…In this study, we have conceptualized a novel mRNA-based multi-antigen influenza vaccine consisting of three conserved antigens of influenza A virus, including the ectodomain of the M2 ion channel (M2e), the long alpha helix of haemagglutinin stalk region (LAH), and nucleoprotein (NP). …”
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Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays. by Jason M Wilham, Christina D Orrú, Richard A Bessen, Ryuichiro Atarashi, Kazunori Sano, Brent Race, Kimberly D Meade-White, Lara M Taubner, Andrew Timmes, Byron Caughey

“…The underlying reaction blends aspects of the previously described quaking-induced conversion (QuIC) and amyloid seeding assay (ASA) methods and involves prion-seeded conversion of the alpha helix-rich form of bacterially expressed recombinant PrP(C) to a beta sheet-rich amyloid fibrillar form. …”
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A Low Molecular Weight Protein from the Sea Anemone Anemonia viridis with an Anti-Angiogenic Activity by Erwann P. Loret, José Luis, Christopher Nuccio, Claude Villard, Pascal Mansuelle, Régine Lebrun, Pierre Henri Villard

“…The presence of a two-turn alpha helix observed with circular dichroism and a trypsin activity inhibition suggested that the active principle could be a Kunitz-type inhibitor, which may interact with an integrin due to an Arginine Glycin Aspartate (RGD) motif. …”
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Interaction of class A amphipathic helical peptides with phospholipid unilamellar vesicles by J A Gazzara, M C Phillips, S Lund-Katz, M N Palgunachari, J P Segrest, G M Anantharamaiah, J W Snow

“…Five model peptides, 18A, Ac-18A-NH2, Ac-18R-NH2, 37pA, and 37aA, have been designed to investigate variations of the amphipathic alpha-helix structural motif on their lipid-binding properties. …”
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Machine learning model for fast prediction of the natural frequencies of protein molecules by Qin, Zhao, Yu, Qingyi, Buehler, Markus J

“…In addition to the computational advance, we demonstrate that this model can be used to directly obtain the natural frequencies by merely using five structural features of protein molecules as predictor variables, including the largest and smallest diameter, and the ratio of amino acid residues with alpha-helix, beta strand and 3-10 helix domains. These structural features can be either experimentally or computationally obtained, and do not require a full-atomistic model of a protein of interest. …”
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Liquified protein vibrations, classification and cross-paradigm de novo image generation using deep neural networks by Buehler, Markus J

“…Not only can the method distinguish different types of proteins (e.g. alpha-helix vs. hybrids of alpha-helices and beta-sheets), but it is also capable of determining different folding states of the same protein, or the binding events of proteins to ligands. …”
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How Protein Materials Balance Strength, Robustness And Adaptability by Buehler, Markus J., Yung, Yu Ching

“…To illustrate this, we review bottom-up materiomics studies focused on the mechanical behavior of protein materials at multiple scales, from nano to macro. We focus on alpha-helix based intermediate filament proteins as a model system to explain why the utilization of hierarchical structural features is vital to their ability to combine strength, robustness, and adaptability. …”
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Effects of lid 1 mutagenesis on lid displacement, catalytic performances and thermostability of cold-active Pseudomonas AMS8 lipase in toluene by Yaacob, Norhayati, Ahmad Kamarudin, Nor Hafizah, Leow, Adam Thean Chor, Salleh, Abu Bakar, Raja Abdul Rahman, Raja Noor Zaliha, Mohamad Ali, Mohd Shukuri

“…As a conclusion, Thr-52 and Gly-55 are important residues for lid 1 stability as their existence helps to retain the geometrical structure of alpha-helix and connecting hinge.…”
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In silico screening of non-synonymous SNPs in human TUFT1 gene by Athira Ajith, Usha Subbiah

“…Meanwhile, all the eight deleterious nsSNPs altered the size, charge, hydrophobicity, and spatial organization of the amino acids and predominantly had alpha helix domains. These deleterious variants were located in highly conserved regions except R203W. …”
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Genome-Wide Identification, Characterization and Expression Analysis of <i>Lipoxygenase</i> Gene Family in <i>Artemisia annua</i> L. by Ying Meng, Yu Liang, Baosheng Liao, Wenrui He, Qianwen Liu, Xiaofeng Shen, Jiang Xu, Shilin Chen

“…The secondary structure was mainly composed of alpha helix and random coil, and the tertiary structure was similar for most <i>AaLOX</i>. …”
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t‐Darpp is an elongated monomer that binds calcium and is phosphorylated by cyclin‐dependent kinases 1 and 5 by Jamil Momand, Patrycja Magdziarz, You Feng, Dianlu Jiang, Elizabeth Parga, Arianna Celis, Erin Denny, Xiaoying Wang, Martin L. Phillips, Estuardo Monterroso, Susan E. Kane, Feimeng Zhou

“…To shed light on t‐Darpp function, we studied its secondary structure, oligomerization status, metal‐binding properties, and phosphorylation by cyclin‐dependent kinases 1 and 5. t‐Darpp exhibits 12% alpha helix, 29% beta strand, 24% beta turn, and 35% random coil structures. …”
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Phylogenetic analysis of Harmonin homology domains by Baptiste Colcombet-Cazenave, Karen Druart, Crystel Bonnet, Christine Petit, Olivier Spérandio, Julien Guglielmini, Nicolas Wolff

“…Abstract Background Harmonin Homogy Domains (HHD) are recently identified orphan domains of about 70 residues folded in a compact five alpha-helix bundle that proved to be versatile in terms of function, allowing for direct binding to a partner as well as regulating the affinity and specificity of adjacent domains for their own targets. …”
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Analysis of Protein Structure and Functional Properties of Hemp Seeds of Different Varieties by Weiyu SONG, Hao YIN, Yu ZHONG, Danfeng WANG, Yun DENG

“…Compared with other plant proteins, HPI had poor emulsifying and foaming capacity. Alpha-helix and surface hydrophobicity were significantly positive in correlation with emulsifying ability (r=0.70, 0.65, P<0.05). …”
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Development and Analytical Evaluation of a Point-of-Care Electrochemical Biosensor for Rapid and Accurate SARS-CoV-2 Detection by Mesfin Meshesha, Anik Sardar, Ruchi Supekar, Lopamudra Bhattacharjee, Soumyo Chatterjee, Nyancy Halder, Kallol Mohanta, Tarun Kanti Bhattacharyya, Biplab Pal

“…The biosensor employs a stapled hACE-2 N-terminal alpha helix peptide to functionalize an in situ grown polypyrrole conductive polymer on a nitrocellulose membrane backbone through a chemical process. …”
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