Antibacterial mechanism of peptide Cec4 against Acinetobacter baumannii by Peng J, Long H, Liu W, Wu Z, Wang T, Zeng Z, Guo G, Wu J

“…The biofilm formation and the sensitivity detection of biofilms to antimicrobial peptides were detected by crystal violet staining.Results: In this study, the main secondary structure of the antibacterial peptide Cec4 is α-helix (99.7%) in the hydrophobic environment. …”
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Octominin: A Novel Synthetic Anticandidal Peptide Derived from Defense Protein of <i>Octopus minor</i> by Chamilani Nikapitiya, S.H.S. Dananjaya, H.P.S.U. Chandrarathna, Mahanama De Zoysa, Ilson Whang

“…Octominin was predicted to have an alpha-helix secondary structure. The synthesized Octominin was 2625.2 Da with 92.5% purity. …”
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Case Report: A Novel In-Frame Deletion of GLIS2 Leading to Nephronophthisis and Early Onset Kidney Failure by Intisar Al Alawi, Intisar Al Alawi, Laura Powell, Sarah J. Rice, Mohammed S. Al Riyami, Marwa Al-Riyami, Issa Al Salmi, Issa Al Salmi, John A. Sayer, John A. Sayer, John A. Sayer

“…The five amino acid deletion disrupts the alpha-helix of GLIS2 zinc-finger motif with predicted misfolding of the protein leading to its predicted pathogenicity. …”
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Analysis of functional differences between hepatitis C virus NS5A of genotypes 1-7 in infectious cell culture systems. by Troels K H Scheel, Jannick Prentoe, Thomas H R Carlsen, Lotte S Mikkelsen, Judith M Gottwein, Jens Bukh

“…We studied the function of NS5A using infectious NS5A genotype 1-7 cell culture systems, and through reverse genetics demonstrated a universal importance of the amphipathic alpha-helix, domain I and II and the low-complexity sequence (LCS) I for HCV replication; the replicon-enhancing LCSI mutation S225P attenuated all genotypes. …”
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Encrypted antimicrobial and antitumoral peptides recovered from a protein-rich soybean (Glycine max) by-product by Cyntia Silva Freitas, Mauricio Afonso Vericimo, Manuela Leal da Silva, Giovani Carlo Veríssimo da Costa, Patricia Ribeiro Pereira, Vania Margaret Flosi Paschoalin, Eduardo Mere Del Aguila

“…Three-dimensional structure of β-conglycinin domains containing the best AMP candidates, determined by molecular modeling, indicated an alpha-helix conformation. The production in large scale and use of multifunctional peptides encrypted in soybean meal proteins is an innovative application of the concept of circular bioeconomy.…”
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Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan by Jasper Fuk-Woo Chan, Kin-Hang Kok, Zheng Zhu, Hin Chu, Kelvin Kai-Wang To, Shuofeng Yuan, Kwok-Yung Yuen

“…Furthermore, its new orf8 likely encodes a secreted protein with an alpha-helix, following with a beta-sheet(s) containing six strands. …”
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The role of glycogen synthase kinase 3 (GSK3) in cancer with emphasis on ovarian cancer development and progression: A comprehensive review by Mislav Glibo, Alan Serman, Valentina Karin-Kujundzic, Ivanka Bekavac Vlatkovic, Berivoj Miskovic, Semir Vranic, Ljiljana Serman

“…GSK3 exists in two different isoforms, GSK3α and GSK3β, both containing seven antiparallel beta-plates, a short linking part and an alpha helix, but coded by different genes and variously expressed in human tissues. …”
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Genetic Code Optimization for Cotranslational Protein Folding: Codon Directional Asymmetry Correlates with Antiparallel Betasheets, tRNA Synthetase Classes by Hervé Seligmann, Ganesh Warthi

“…Keywords: Secondary structure, Codon-amino acid assignment, Mitochondrial genetic code, Synonymous codon, Alpha helix, Beta turn…”
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PRRT2 gene and protein in human: characteristics, evolution and function by Yinchao Li, Shuda Chen, Chengzhe Wang, Peiling Wang, Xi Li, Liemin Zhou

“…Results (1) Evolutionary analysis of PRRT2 protein showed that the human PRRT2 had closest genetic distance from Pongo abelii. (2) The human PRRT2 protein was an unstable hydrophilic protein located on the plasma membrane. (3) The forms of random coil (67.65%) and alpha helix (23.24%) constituted the main secondary structure elements of PRRT2 protein. …”
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In Silico Selection and Evaluation of Pugnins with Antibacterial and Anticancer Activity Using Skin Transcriptome of Treefrog (<i>Boana pugnax</i>) by Yamil Liscano, Laura Medina, Jose Oñate-Garzón, Fanny Gúzman, Monica Pickholz, Jean Paul Delgado

“…Subsequently, their alpha-helix structure was determined by circular dichroism, after which antibacterial tests were then performed to evaluate their antimicrobial activity. …”
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A Transmembrane Histidine Kinase Functions as a pH Sensor by Ana Bortolotti, Daniela Belén Vazquez, Juan Cruz Almada, Maria Eugenia Inda, Salvador Iván Drusin, Juan Manuel Villalba, Diego M. Moreno, Jean Marie Ruysschaert, Larisa Estefania Cybulski

“…This helix contains several glutamate, lysine, and arginine residues At neutral pH, the linker forms an alpha helix that is stabilized by hydrogen bonds in the i, i + 4 register and thus favors the kinase state. …”
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New Mastoparan Peptides in the Venom of the Solitary Eumenine Wasp Eumenes micado by Katsuhiro Konno, Kohei Kazuma, Marisa Rangel, Joacir Stolarz-de-Oliveira, Renato Fontana, Marii Kawano, Hiroyuki Fuchino, Izumi Hide, Tadashi Yasuhara, Yoshihiro Nakata

“…Indeed, the CD spectra of these new peptides showed predominantly &alpha;-helix conformation in TFE and SDS. In biological evaluation, both peptides exhibited potent antibacterial activity, moderate degranulation activity from rat peritoneal mast cells, and significant leishmanicidal activity, while they showed virtually no hemolytic activity on human or mouse erythrocytes. …”
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The MX-Helix of Muscle nAChR Subunits Regulates Receptor Assembly and Surface Trafficking by Jolene Chang Rudell, Lucia Soares Borges, Vladimir Yarov-Yarovoy, Michael Ferns, Michael Ferns

“…Here, we show that the Golgi retention motifs are localized in the MX-helix, a juxta-membrane alpha-helix present in the proximal cytoplasmic loop of receptor subunits, which was defined in recent crystal structures of cys-loop receptor family members. …”
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Identity, Structure and Compositional Analysis of Aluminum Phosphate Adsorbed Pediatric Quadrivalent and Pentavalent Vaccines by Kristen Kalbfleisch, Sasmit Deshmukh, Carmen Mei, Moriam Ore, Wayne Williams, Ibrahim Durowoju, Jessica Duprez, Sylvie Morin, Bruce Carpick, Marina Kirkitadze

“…Secondary structure alpha-helix and beta-sheet content of DT and TT has increased after adsorption to AlPO4 adjuvant as shown by FTIR, whereas no significant changes were noted for other protein antigens. …”
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Characterization of the zinc finger μ-protein HVO_0758 from Haloferax volcanii: biological roles, zinc binding, and NMR solution structure by Deniz Üresin, Dennis J. Pyper, Andreas Borst, Lydia Hadjeras, Rick Gelhausen, Rolf Backofen, Rolf Backofen, Cynthia Sharma, Harald Schwalbe, Jörg Soppa

“…The NMR solution structure was solved, revealing that HVO_0758 is comprised of an N-terminal alpha helix containing several positively charged residues and a globular core with the zinc finger domain. …”
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Four plant defensins from an indigenous South African Brassicaceae species display divergent activities against two test pathogens despite high sequence similarity in the encoding... by de Beer Abré, Vivier Melané A

“…Homology modelling showed that the few amino acids that differed between the four peptides had an effect on the surface properties of the defensins, specifically in the alpha-helix and the loop connecting the second and third beta-strands. …”
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Intrinsic disorder in the open reading frame 2 of hepatitis E virus: a protein with multiple functions beyond viral capsid by Zoya Shafat, Anwar Ahmed, Mohammad K. Parvez, Shama Parveen

“…Results The modeled three dimensional (3D) structures of ORF2 showed the predominance of random coils or unstructured regions in addition to major secondary structure components (alpha helix and beta strand). After initial scrutinization, the predictors VLXT and VSL2 predicted ORF2 as a highly disordered protein while the predictors VL3 and DISOPRED3 predicted ORF2 as a moderately disordered protein, thus categorizing HEV-ORF2 into IDP (intrinsically disordered protein) or IDPR (intrinsically disordered protein region) respectively. …”
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SARS-CoV-2 inhibitory activity of a short peptide derived from internal fusion peptide of S2 subunit of spike glycoprotein by Maria Alfreda Stincarelli, Michael Quagliata, Andrea Di Santo, Lorenzo Pacini, Feliciana Real Fernandez, Rosaria Arvia, Silvia Rinaldi, Anna Maria Papini, Paolo Rovero, Simone Giannecchini

“…Circular dichroism spectra of the active peptide exhibited an alpha-helix propensity, confirmed by secondary structure prediction analysis. …”
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Construction and Immunogenicity of a Novel Multivalent Vaccine Prototype Based on Conserved Influenza Virus Antigens by Anna Kirsteina, Inara Akopjana, Janis Bogans, Ilva Lieknina, Juris Jansons, Dace Skrastina, Tatjana Kazaka, Kaspars Tars, Irina Isakova-Sivak, Daria Mezhenskaya, Tatiana Kotomina, Victoria Matyushenko, Larisa Rudenko, Andris Kazaks

“…A number of conserved protein targets to elicit such cross-protective immunity have been under investigation, with long alpha-helix (LAH) from hemagglutinin stalk and ectodomain of matrix protein 2 ion channel (M2e) being the most studied ones. …”
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Interaction of Synthetic Cannabinoid Receptor Agonists with Cannabinoid Receptor I: Insights into Activation Molecular Mechanism by Sergei Gavryushov, Anton Bashilov, Konstantin V. Cherashev-Tumanov, Nikolay N. Kuzmich, Tatyana I. Burykina, Boris N. Izotov

“…The key feature of the suggested activation mechanism is the determination of the stiff core of the CB₁ transmembrane domain and the statement that the entire conformational transformation of the receptor to the active state is caused by a shift of alpha helix TM7 relative to this core. The shift itself is caused by protein–ligand interactions. …”
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