Analogs of the Scorpion Venom Peptide Stigmurin: Structural Assessment, Toxicity, and Increased Antimicrobial Activity by Adriana M. S. Parente, Alessandra Daniele-Silva, Allanny A. Furtado, Menilla A. Melo, Ariane F. Lacerda, Moacir Queiroz, Cláudia Moreno, Elizabeth Santos, Hugo A. O. Rocha, Euzébio G. Barbosa, Eneas Carvalho, Arnobio A. Silva-Júnior, Marcelo S. Silva, Matheus de F. Fernandes-Pedrosa

“…In silico analysis revealed the α-helix structure for both analog peptides, which was confirmed by circular dichroism. …”
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Study of the Antihypertensive Peptides Derived from Alpha-Lactalbumin Hydrolysate after Simulation of Digestion by Antonella Alba, Jessica Báez, Adriana Maite Fernández-Fernández, Agustina Nardo, María Cristina Añón, Alejandra Medrano, Margot Paulino

“…A secondary structure (alpha-helix) was observed in the P1 peptide, but in general, all peptides showed an extended folding. …”
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Tachykinin-3 Genes and Peptides Characterized in a Basal Teleost, the European Eel: Evolutionary Perspective and Pituitary Role by Aurora Campo, Anne-Gaëlle Lafont, Benjamin Lefranc, Jérôme Leprince, Hervé Tostivint, Nédia Kamech, Sylvie Dufour, Karine Rousseau

“…The four eel peptides present the characteristic C-terminal tachykinin sequence, as well as a similar alpha helix 3D structure. Tac3 genes were identified in silico in 52 species of vertebrates, and a phylogeny analysis was performed on the predicted TAC3 pre-pro-peptide sequences. …”
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Pathogen Evasion of Chemokine Response Through Suppression of CXCL10 by Alejandro L. Antonia, Kyle D. Gibbs, Esme D. Trahair, Kelly J. Pittman, Amelia T. Martin, Benjamin H. Schott, Jeffrey S. Smith, Sudarshan Rajagopal, Sudarshan Rajagopal, J. Will Thompson, Richard Lee Reinhardt, Richard Lee Reinhardt, Dennis C. Ko, Dennis C. Ko

“…Specifically, GP63 cleaves CXCL10 after amino acid A81 at the base of a C-terminal alpha-helix. Cytokine cleavage by GP63 demonstrated specificity, as GP63 cleaved CXCL10 and its homologs, which all bind the CXCR3 receptor, but not distantly related chemokines, such as CXCL8 and CCL22. …”
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Genetic determinants of SARS‐CoV‐2 and the clinical outcome of COVID‐19 in Southern Bangladesh by Md. Mahbub Hasan, Chayan Kumar Saha, H. M. Hamidullah Mehedi, Kallyan Chakma, Asma Salauddin, Md. Shakhawat Hossain, Farjana Sharmen, S. M. Rafiqul Islam, Afroza Akter Tanni, Farhana Yasmin, Al‐Shahriar Akash, Mohammad Enayet Hossain, Mojnu Miah, Sanjoy Kanti Biswas, Nahid Sultana, Adnan Mannan

“…Moreover, we observed many unique mutations in S protein in mild cases compared to severe, and homology modeling revealed that those might cause more folding in the protein's alpha helix and beta sheets. Conclusion Our study identifies some risk factors such as age comorbidities (diabetes, hypertension, and renal disease) that are associated with severe COVID‐19, providing valuable insight regarding prioritizing vaccination for high‐risk individuals and allocating health care and resources. …”
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Long-Term Liver Expression of an Apolipoprotein A-I Mimetic Peptide Attenuates Interferon-Alpha-Induced Inflammation and Promotes Antiviral Activity by Myriam Fernandez-Sendin, Myriam Fernandez-Sendin, Claudia Augusta Di Trani, Claudia Augusta Di Trani, Angela Bella, Angela Bella, Marcos Vasquez, Marcos Vasquez, Nuria Ardaiz, Nuria Ardaiz, Celia Gomar, Celia Gomar, Leire Arrizabalaga, Leire Arrizabalaga, Sergio Ciordia, Sergio Ciordia, Fernando J. Corrales, Fernando J. Corrales, Fernando Aranda, Fernando Aranda, Pedro Berraondo, Pedro Berraondo, Pedro Berraondo

“…Apolipoprotein A-I mimetic peptides are amphipathic alpha-helix peptides that display similar functions to apolipoprotein A-I. …”
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PEO-containing copolymers as polyurethane soft segments in the development of high performance materials by James-Korley, LaShanda Teresa

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A multi-epitope vaccine GILE against Echinococcus Multilocularis infection in mice by Pei Zhou, Pei Zhou, Zhen Zhou, Meiduo Huayu, Lei Wang, Lin Feng, Lin Feng, Yang Xiao, Yang Xiao, Yao Dai, Yao Dai, Mingyuan Xin, Feng Tang, Runle Li, Runle Li

“…The SOPMA results showed that there were Alpha helix (14.88%), Extended strand (26.25%), Beta turn (3.73%) and Random coil (45.82%) in the secondary structure of GILE. …”
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A comprehensive genomic study, mutation screening, phylogenetic and statistical analysis of SARS-CoV-2 and its variant omicron among different countries by Syed Umair Ahmad, Bushra Hafeez Kiani, Muhammad Abrar, Zainab Jan, Imran Zafar, Yasir Ali, Amer M. Alanazi, Abdul Malik, Mohd Ashraf Rather, Asrar Ahmad, Azmat Ali Khan

“…The Omicron variant has 30 mutations in the Spike protein and has a higher alpha-helix shape (23.46%) than the Delta version (22.03%). …”
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Obtaining New Candidate Peptides for Biological Anticancer Drugs from Enzymatic Hydrolysis of Human and Bovine Hemoglobin by Ahlam Outman, Mohamed Bouhrim, Codjo Hountondji, Omar M. Noman, Ali S. Alqahtani, Bernard Gressier, Naïma Nedjar, Bruno Eto

“…DH levels of 3 to 10% produce a considerably stronger inhibition of radicle growth than DH 0 (the native form of hemoglobin), with an intensity three to four times greater. (2) Certain peptide fractions of bovine hemoglobin have a higher activity than those of human hemoglobin. (3) The structural characteristics of peptides (random coil or alpha helix) play a crucial role in the biological effects observed. (4) The α137–141 peptide, the target of the study, was the most active of the fractions obtained from bovine hemoglobin (IC₅₀ = 29 ± 1 µg/mL) and human hemoglobin (IC₅₀ = 48 ± 2 µg/mL), proving to be 10 to 15 times more potent than the other hemoglobin fractions, attributed to its strong antimicrobial potential. …”
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Molecular mimicry between Zika virus and central nervous system inflammatory demyelinating disorders: the role of NS5 Zika virus epitope and PLP autoantigens by Laise Carolina França, Fabrícia Lima Fontes-Dantas, Diogo Gomes Garcia, Amanda Dutra de Araújo, João Paulo da Costa Gonçalves, Cláudia Cecília da Silva Rêgo, Elielson Veloso da Silva, Osvaldo José Moreira do Nascimento, Fernanda Cristina Rueda Lopes, Alice Laschuk Herlinger, Renato Santana de Aguiar, Orlando da Costa Ferreira Junior, Fernando Faria Andrade Figueira, Jorge Paes Barreto Marcondes de Souza, Joelma Freire De Mesquita, Soniza Vieira Alves-Leon

“…Analysis of the 3D structures revealed a similar conformation with alpha helix presentation. Conclusions Molecular mimicry between NS5 Zika virus antigen and PLP MS autoantigens emerge as a possible mechanism for IDD spectrum in genetically susceptible individuals.…”
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Biophysical investigations into membrane-active peptides and proteins by Yin, D

“…In the presence of anionic model membranes (mimicking Gram-negative inner membranes and Gram-positive membranes), tilamin and chom adopt amphipathic alpha helix conformations as determined by circular dichroism, while remaining unstructured in solution and in the presence of zwitterionic model membranes mimicking mammalian model membranes. …”

Developing protein force fields for implicit solvent simulation by Zhang, Haiping

“…The modified force field is able to fold peptides ab initio with reasonable alpha helix/beta sheet propensity, maintaining the protein’s secondary and tertiary structure. …”
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Analysis on the genome of a teschovirus type 1 isolates with swine diarrhea by Baotai Zhang, Rongli Guo, Li Xiao, Chunyan Zhong, Xuesong Yuan, Jin Huang, Xuejiao Zhu, Jinzhu Zhou, Baochao Fan, Tao Xue, Chuanmin Liu, Xing Zhu, Jizong Li, Bin Li

“…By analyzing the tertiary structure, we found that the amino acid at position 129 of VP1 mutated and reduction a larger alpha helix. This may lead to the main cause of piglet diarrhea. …”
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The Rare <i>IL22RA2</i> Signal Peptide Coding Variant rs28385692 Decreases Secretion of IL-22BP Isoform-1, -2 and -3 and Is Associated with Risk for Multiple Sclerosis by Paloma Gómez-Fernández, Aitzkoa Lopez de Lapuente Portilla, Ianire Astobiza, Jorge Mena, Andoni Urtasun, Vivian Altmann, Fuencisla Matesanz, David Otaegui, Elena Urcelay, Alfredo Antigüedad, Sunny Malhotra, Xavier Montalban, Tamara Castillo-Triviño, Laura Espino-Paisán, Orhan Aktas, Mathias Buttmann, Andrew Chan, Bertrand Fontaine, Pierre-Antoine Gourraud, Michael Hecker, Sabine Hoffjan, Christian Kubisch, Tania Kümpfel, Felix Luessi, Uwe K. Zettl, Frauke Zipp, Iraide Alloza, Manuel Comabella, Christina M. Lill, Koen Vandenbroeck

“…In silico analysis predicted both disruption of the alpha helix of the H-region of the SP and decreased hydrophobicity of this region, ultimately affecting the SP cleavage site. …”
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Immunogenicity and Protective Potential of Mucosal Vaccine Formulations Based on Conserved Epitopes of Influenza A Viruses Fused to an Innovative Ring Nanoplatform in Mice and Chic... by Cynthia Calzas, Molida Mao, Mathilde Turpaud, Quentin Viboud, Joelle Mettier, Thomas Figueroa, Pierre Bessière, Antoine Mangin, Antoine Mangin, Laura Sedano, Pierre-Louis Hervé, Pierre-Louis Hervé, Romain Volmer, Mariette F. Ducatez, Steve Bourgault, Denis Archambault, Ronan Le Goffic, Christophe Chevalier

“…In this study, we evaluated the potential of intranasal formulations incorporating conserved IAV epitopes, namely the long alpha helix (LAH) of the stalk domain of hemagglutinin and three tandem repeats of the ectodomain of the matrix protein 2 (3M2e), as universal mucosal anti-IAV vaccines in mice and chickens. …”
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Phyletic distribution of fatty acid-binding protein genes. by Yadong Zheng, David Blair, Janette E Bradley

“…Although they have 20 to 70% amino acid sequence identity, these proteins share a conserved tertiary structure comprised of ten beta sheets and two alpha helixes. Availability of the complete genomes of 34 invertebrates, together with transcriptomes and ESTs, allowed us to systematically investigate the gene structure and alternative splicing of FABP genes over a wide range of phyla. …”
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Isolation and Characterization of an Antibacterial Peptide Fraction from the Pepsin Hydrolysate of Half-Fin Anchovy (Setipinna taty) by Dong-Feng Wang, Ru Song, Rong-Bian Wei, Hong-Yu Luo

“…Prediction of peptide secondary structure indicated that these anionic peptides should have extended strand and random coil structures, whereas cationic peptides PTAGVANALQHA and VNVDERWRKL could form alpha helixes. In addition, results of scanning electron microscopy (SEM) revealed that treatment by HAHp2-3-I could cause the morphological changes of E. coli and destruction of the cell integrity via irreversible membrane damage. …”
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Computational Prediction of acyl-coA Binding Proteins Structure in Brassica napus. by Nadia Haingotiana Raboanatahiry, Guangyuan Lu, Maoteng Li

“…However, conserved residues of common ACBPs in all species of animal, plant, bacteria and fungi were only inclusive in small ACBPs. Alpha-helixes were displayed and conserved in all the acyl-coA binding domains, representing almost the half of the protein structure. …”
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Functional Role of Spliced Cytoplasmic Tails in P2X2-Receptor-Mediated Cellular Signaling by Koshimizu Taka-aki, Tsujimoto Gozoh

“….: P2X receptors belong to a unique family of ligand-gated channels in terms of their molecular architecture, in which the channel subunit has two transmembrane alpha-helixes with a large extracellular loop keeping amino- and carboxy-termini in the cytoplasm. …”
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