An alpha-helix variant p.Arg156Pro in LMNA as a cause of hereditary dilated cardiomyopathy: genetics and bioinfomatics exploration by Lei Chang, Rong Huang, Jianzhou Chen, Guannan Li, Guangfei Shi, Biao Xu, Lian Wang

Subjects: Get full text

An amphipathic alpha-helix controls multiple roles of brome mosaic virus protein 1a in RNA replication complex assembly and function. by Ling Liu, William M Westler, Johan A den Boon, Xiaofeng Wang, Arturo Diaz, H Adam Steinberg, Paul Ahlquist

“…Here we identify in BMV 1a an amphipathic alpha-helix, helix A, and use NMR analysis to define its structure and propensity to insert in hydrophobic membrane-mimicking micelles. …”
Get full text

An amphipathic alpha-helix in the prodomain of cocaine and amphetamine regulated transcript peptide precursor serves as its sorting signal to the regulated secretory pathway. by Elías H Blanco, Carlos F Lagos, María Estela Andrés, Katia Gysling

“…In silico modeling predicted an alpha-helix structure located between residues 24-37 of proCART. …”
Get full text

Molecular Dynamics Simulation of the alpha-Helix to beta-Sheet Transition in Coiled Protein Filaments: Evidence for a Critical Filament Length Scale by Qin, Zhao, Buehler, Markus J

“…The alpha-helix to beta-sheet transition (α-β transition) is a universal deformation mechanism in alpha-helix rich protein materials such as wool, hair, hoof, and cellular proteins. …”
Get full text
Get full text

Melittin Tryptophan Substitution with a Fluorescent Amino Acid Reveals the Structural Basis of Selective Antitumor Effect and Subcellular Localization in Tumor Cells by Yonghui Lv, Xu Chen, Zhidong Chen, Zhanjun Shang, Yongxiao Li, Wanting Xu, Yuan Mo, Xinpei Wang, Daiyun Xu, Shengbin Li, Zhe Wang, Meiying Wu, Junqing Wang

Subjects: Get full text

Structural bioinformatics studies of six human ABC transporters and their AlphaFold2-predicted water-soluble QTY variants by Emily Pan, Fei Tao, Eva Smorodina, Shuguang Zhang

Subjects: “…convert hydrophobic alpha helix to hydrophilic alpha helix…”
Get full text

Naturally occurring variant of mouse apolipoprotein A-I alters the lipid and HDL association properties of the protein by Timothy J. Sontag, Ronald Carnemolla, Tomas Vaisar, Catherine A. Reardon, Godfrey S. Getz

Subjects: Get full text

Applying Unique Molecular Identifiers in Next Generation Sequencing Reveals a Constrained Viral Quasispecies Evolution under Cross-Reactive Antibody Pressure Targeting Long Alpha Helix of Hemagglutinin by Nastasja C. Hauck, Josiane Kirpach, Christina Kiefer, Sophie Farinelle, Sophie Maucourant, Stephen A. Morris, William Rosenberg, Feng Q. He, Claude P. Muller, I-Na Lu

“…Here we applied unique molecular identifiers in next generation sequencing to analyze the evolution of influenza quasispecies under in vivo antibody pressure targeting the hemagglutinin (HA) long alpha helix (LAH). Our vaccine targeting LAH of hemagglutinin elicited significant seroconversion and protection against homologous and heterologous influenza virus strains in mice. …”
Get full text

A novel single alpha-helix DNA-binding domain in CAF-1 promotes gene silencing and DNA damage survival through tetrasome-length DNA selectivity and spacer function by Ruben Rosas, Rhiannon R Aguilar, Nina Arslanovic, Anna Seck, Duncan J Smith, Jessica K Tyler, Mair EA Churchill

“…Structural and biophysical characterization of the lysine/glutamic acid/arginine-rich (KER) region of CAF-1 revealed a 128-Å single alpha-helix (SAH) motif with unprecedented DNA-binding properties. …”
Get full text

Modeling of helix formation in peptides containing aspartic and glutamic residues by Maksim Sergeevich Kondratyev, Artem V. Kabanov, Vladislav Mikhailovich Komarov

Subjects: “…alpha-helix…”
Get full text

Sarconesin II, a New Antimicrobial Peptide Isolated from <i>Sarconesiopsis magellanica</i> Excretions and Secretions by Andrea Díaz-Roa, Abraham Espinoza-Culupú, Orlando Torres-García, Monamaris M. Borges, Ivan N. Avino, Flávio L. Alves, Antonio Miranda, Manuel A. Patarroyo, Pedro I. da Silva, Felio J. Bello

Subjects: Get full text

Insights on the Hair Keratin Structure Under Different Drying Conditions by José Pedro Carvalho, Carla Silva, Madalena Martins, Artur Cavaco-Paulo

Subjects: Get full text

Characterizing alpha helical properties of Ebola viral proteins as potential targets for inhibition of alpha-helix mediated protein-protein interactions [v3; ref status: indexed, http://f1000r.es/50u] by Sandeep Chakraborty, Basuthkar J. Rao, Bjarni Asgeirsson, Abhaya Dandekar

Get full text

Improving Membrane Activity and Cargo Delivery Efficacy of a Cell-Penetrating Peptide by Loading with Carboranes by Tamara Lützenburg, Nele Burdina, Matthias S. Scholz, Ines Neundorf

Subjects: “…alpha-helix stabilization…”
Get full text

Hydrophobic Alpha-Helical Short Peptides in Overlapping Reading Frames of the Coronavirus Genome by Takashi Okura, Kazuya Shirato, Masatoshi Kakizaki, Satoko Sugimoto, Shutoku Matsuyama, Tomohisa Tanaka, Yohei Kume, Mina Chishiki, Takashi Ono, Kohji Moriishi, Masashi Sonoyama, Mitsuaki Hosoya, Koichi Hashimoto, Katsumi Maenaka, Makoto Takeda

Subjects: Get full text

Analogs of a Natural Peptaibol Exert Anticancer Activity in Both Cisplatin- and Doxorubicin-Resistant Cells and in Multicellular Tumor Spheroids by Naike Casagrande, Cinzia Borghese, Laura Gabbatore, Laura Morbiato, Marta De Zotti, Donatella Aldinucci

Subjects: Get full text

Interactive association between processing induced molecular structure changes and nutrient delivery on a molecular basis, revealed by cutting-edge vibrational biomolecular spectro... by Aya Ismael, Victor Hugo Guevara-Oquendo, Basim Refat, Peiqiang Yu

Subjects: “…Alpha-helix and beta-sheet…”
Get full text

Missense Mutations Modify the Conformational Ensemble of the α-Synuclein Monomer Which Exhibits a Two-Phase Characteristic by Adrien Guzzo, Patrice Delarue, Ana Rojas, Adrien Nicolaï, Gia G. Maisuradze, Patrick Senet, Patrick Senet

Subjects: “…CUrvature and Torsion based of Alpha-helix and Beta-sheet Identification…”
Get full text

The Role of Chirality and Helicity between d- and l-Valine Optical Lattices by Jingjing Li, Wenqing Wang, Yan Gong

Subjects: “…hydrogen (e-p) in the alpha-helix…”
Get full text

An insight in the mechanism of beta sheet formation via CSAW. by Goh, Boon Chong.

“…Though simple, these models have successfully formed hydrophobic core and alpha helix. However, none of them has consistently folded a beta sheet, the complementary secondary structure of alpha helix. …”
Get full text