Molecular verification and bioinformatics analysis of a metalloprotease gene from acinetobacter baumannII by Jalal Mohammed, Diana

“…The generated model consists of five beta sheets and four alpha helixes, alpha helix number three (a 3), alpha helix number four (a 4) and beta sheet number five (ß 5) are located in the Zinc-dependent metalloprotease domain. …”
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Designed antimicrobial peptides : structure-activity correlations and mode of action by Harini Mohanram

“…These series of designed peptides were found to be salt tolerant and adopt alpha helix upon interaction with LPS outer membrane.…”
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Parallel solid-phase synthesis of diaryltriazoles by Matthias Wrobel, Jeffrey Aubé, Burkhard König

“…Substituted diaryltriazoles resemble a molecular structure similar to established terphenyl-alpha-helix peptide mimics and have therefore the potential to act as selective inhibitors for protein–protein interactions.…”
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A tick protein with a modified Kunitz fold inhibits human tryptase. by Paesen, G, Siebold, C, Harlos, K, Peacey, M, Nuttall, P, Stuart, D

“…The loop of TdPI connecting the beta-sheet with the C-terminal alpha-helix is shortened, the disulphide-bridge pattern altered and N and C termini separated to produce a highly pointed molecule capable of penetrating the cramped active sites of tryptase. …”

Tick histamine-binding proteins: lipocalins with a second binding cavity. by Paesen, G, Adams, P, Nuttall, P, Stuart, D

“…Typical lipocalin characteristics, such as the 3(10) helix and a structural cluster of highly conserved residues, have been lost, while an alpha-helix now shields the cavity from the exterior. …”

The crystal structure and biological function of leukemia inhibitory factor: implications for receptor binding. by Robinson, R, Grey, L, Staunton, D, Vankelecom, H, Vernallis, AB, Moreau, J, Stuart, D, Heath, J, Jones, E

“…The main chain fold conforms to the four alpha-helix bundle topology previously observed for several members of the hematopoietic cytokine family. …”

NN-PRED: A novel consensus secondary structure prediction program using neural networks by Oscar Fernando Bedoya Leiva, Eduard Alberto Satizábal Tascón

“…The NN-Pred program provides a three-state (alpha-helix, beta-sheet, and other) prediction of secondary structure. …”
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Structural requirements for Yersinia YopJ inhibition of MAP kinase pathways. by Yi-Heng Hao, Yong Wang, Dara Burdette, Sohini Mukherjee, Gladys Keitany, Elizabeth Goldsmith, Kim Orth

“…Mutations on the hydrophobic face of the conserved G alpha-helix in the kinase domain prevent both binding and acetylation by YopJ. …”
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Evidence of evolutionary constraints that influences the sequence composition and diversity of mitochondrial matrix targeting signals. by Stephen R Doyle, Naga R P Kasinadhuni, Chee Kai Chan, Warwick N Grant

“…These sequences are diverse, sharing little amino acid homology and vary significantly in length, and although the formation of a positively-charged amphiphilic alpha helix within the MTS is considered to be necessary and sufficient to mediate import, such a feature does not explain their diversity, nor how such diversity influences target sequence function, nor how such dissimilar signals interact with a single, evolutionarily conserved import mechanism. …”
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Observações adicionais sobre os pigmentos visuais e filtros amarelos nos olhos de peixes amazônicos by W. R. A. Muntz

“…O presente artigo representa uma extensão daquele trabalho, efetuado durante a Fase 5 do cruzeiro Alpha-Helix ao sistema do rio Amazonas em 1977. Os peixes para estudo foram coletados, durante janeiro e fevereiro, de nove locais próximos a Manaus, com ambientes luminosos muito diferentes, e as absorvâncias espectrais de suas retinas, lentes e córneas medidas. …”
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Site of attachment of retinal in bacteriorhodopsin. by Bayley, H, Huang, K, Radhakrishnan, R, Ross, A, Takagaki, Y, Khorana, H

“…Our finding places of Schiff's base linkage close to the midpoint of the putative membrane-spanning alpha-helix that is directly connected to the COOH terminus of bacteriorhodopsin.…”

A peptidomimetic approach to targeting pre-amyloidogenic states in type II diabetes. by Hebda, J, Saraogi, I, Magzoub, M, Hamilton, A, Miranker, A

“…Here, a small molecule alpha helix mimetic, IS5, is shown to inhibit bilayer catalysis of fibrillogenesis and to rescue IAPP-induced toxicity in cell culture. …”

Multiple isoforms of a protein kinase C inhibitor (KCIP-1/14-3-3) from sheep brain. Amino acid sequence of phosphorylated forms. by Toker, A, Sellers, L, Amess, B, Patel, Y, Harris, A, Aitken, A

“…The N-termini of KCIP-1 isoforms were shown to be acetylated, and secondary structure predictions revealed a high degree of alpha-helix with an amphipathic nature. KCIP-1 showed no inhibitory activity towards protein kinase M (the catalytic fragment of PKC) and had no effect on the activities of three other protein kinases, cAMP-dependent protein kinase, Ca2+/calmodulin-dependent protein kinase II and casein kinase 2. …”

Morphoscanner2.0: A new python module for analysis of molecular dynamics simulations by Federico Fontana, Calogero Carlino, Ashish Malik, Fabrizio Gelain

“…Morphoscanner2.0 also includes a routine for tracking the alpha-helix domain formation.…”
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Characterization of the oligomerization and aggregation of human Serum Amyloid A. by Sanket Patke, Saipraveen Srinivasan, Ronak Maheshwari, Sunit K Srivastava, J Javier Aguilera, Wilfredo Colón, Ravi S Kane

“…We found that hSAA1.1 formed alpha helix-rich, marginally stable oligomers in vitro on refolding and cross-beta-rich aggregates following incubation at 37°C. …”
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How force might activate talin's vinculin binding sites: SMD reveals a structural mechanism. by Vesa P Hytönen, Viola Vogel

“…The proposed force-activated alpha-helix swapping mechanism by which vinculin binding sites in talin rods are exposed works distinctly different from that of other force-activated bonds, including catch bonds.…”
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Morphoscanner2.0: A new python module for analysis of molecular dynamics simulations. by Federico Fontana, Calogero Carlino, Ashish Malik, Fabrizio Gelain

“…Morphoscanner2.0 also includes a routine for tracking the alpha-helix domain formation.…”
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Cascading classifier application for topology prediction of TMB proteins by Kazemian, Hassan, Grimaldi, Cédric Maxime

“…In the field of bioinformatics, many years have been spent on the trans-membrane protein structure prediction focusing on the alpha-helix membrane proteins. Technological developments have been increasingly utilized in order to understand in more details membrane protein function and structure. …”
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Switching catalytic activity in the XerCD site-specific recombination machine. by Ferreira, H, Sherratt, D, Arciszewska, L

“…The primary determinants for the mutant phenotype reside in the region of alpha-helix B of XerD. We propose that altered interactions within the recombining heterotetramer lead to changes in the relative concentrations of the two alternative Holliday junction substrates that are recombined by XerC or XerD, respectively.…”

Gas phase characterization of the noncovalent quaternary structure of cholera toxin and the cholera toxin B subunit pentamer. by Williams, J, Smith, D, Green, B, Marsden, B, Jennings, K, Roberts, L, Scrivens, J

“…Structural comparison of the CTx B monomer interface reveals an additional alpha-helix that is absent in the SLTx B monomer. In silico energy calculations support interactions between this helix and the adjacent monomer. …”