Expedição Alpha Helix. 1976/77 by J. A. S. Nunes de Mello

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Energetics of [alpha]-helix formation in peptides and proteins by Schubert, Christian Reinhold

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Learning biophysically-motivated parameters for alpha helix prediction by van Dijk Marten, Lee Andrew, Thies William, O'Donnell Charles W, Gassend Blaise, Devadas Srinivas

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alpha-Helix mimetics as inhibitors of protein-protein interactions. by Saraogi, I, Hamilton, A

“…Our strategy for the design of such agents involves the mimicry of side-chain residues on one face of the alpha-helix; these residues frequently play a key role in mediating protein-protein interactions. …”

Principal component analysis of alpha-helix deformations in transmembrane proteins. by Alexander Bevacqua, Sachit Bakshi, Yu Xia

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Controlling curvature in a family of oligoamide alpha-helix mimetics. by Saraogi, I, Incarvito, C, Hamilton, A

Novel, simplified alpha-helix mimetics targeted to Bcl-xL by Rodriguez, J, Lee, G, Dhar, D, Hamilton, A

MEDI 277-Novel alpha-helix mimetics with increased water solubility by Cummings, C, Hamilton, A

Synthetic alpha-helix mimetics as agonists and antagonists of islet amyloid polypeptide aggregation. by Saraogi, I, Hebda, J, Becerril, J, Estroff, L, Miranker, A, Hamilton, A

Site-directed mutagenesis of n-terminal Alpha Helix of J15 lipase by Lee, Mei Ying

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An efficient alpha helix model and simulation framework for stationary electrostatic interaction force estimation by Guy G. Butcher, William S. Harwin, Chris I. Jones

“…Abstract The alpha-helix coiled-coils within talin’s rod domain have mechanical and signalling functions through their unfolding and refolding dynamics. …”
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Disrupting protein-protein interactions with non-peptidic, small molecule alpha-helix mimetics. by Cummings, C, Hamilton, A

“…Herein recent applications of the indane, terphenyl, terphenyl-inspired templates, polycyclic ether and benzodiazepinedione scaffolds, as non-peptidic, small molecule alpha-helix mimetics, to disrupt PPIs are detailed.…”

MEDI 77-Small alpha-helix mimetics for the inhibition of the estrogen receptor-coactivator interaction by Becerril, J, Hamilton, A

Folding of apocytochrome c in lipid micelles: formation of alpha-helix precedes membrane insertion. by Bryson, E, Rankin, SE, Carey, M, Watts, A, Pinheiro, T

“…Apocytochrome c, which in aqueous solution is largely unstructured, acquires a highly alpha-helical structure upon interaction with lipid. The alpha-helix content induced in apocytochrome c depends on the lipid system, and this folding process is driven by both electrostatic and hydrophobic lipid-protein interactions. …”

An Amphipathic Alpha-Helix Domain from Poliovirus 2C Protein Tubulate Lipid Vesicles by Jobin Varkey, Jiantao Zhang, Junghyun Kim, Gincy George, Guijuan He, George Belov, Ralf Langen, Xiaofeng Wang

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Tipping the Scale from Disorder to Alpha-helix: Folding of Amphiphilic Peptides in the Presence of Macroscopic and Molecular Interfaces. by Cahit Dalgicdir, Christoph Globisch, Christine Peter, Mehmet Sayar

“…In this study we use molecular dynamics simulations to analyze the conformational behavior of two synthetic peptides, LKKLLKLLKKLLKL (LK) and EAALAEALAEALAE (EALA), with built-in secondary amphiphilicity upon forming an alpha-helix. We use these model peptides to systematically study their aggregation and the influence of macroscopic and molecular interfaces on their conformational preferences. …”
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A Highly Conserved Residue in HIV-1 Nef Alpha Helix 2 Modulates Protein Expression by Aaron L. Johnson, Brennan S. Dirk, Mathieu Coutu, S. M. Mansour Haeryfar, Eric J. Arts, Andrés Finzi, Jimmy D. Dikeakos

“…An alanine-to-valine substitution at position 84, located in alpha helix 2 of Nef, was sufficient to alter the rate of turnover of an otherwise highly expressed Nef protein. …”
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Molecular Probing of the HPV-16 E6 Protein Alpha Helix Binding Groove with Small Molecule Inhibitors. by Anne Rietz, Dino P Petrov, Matthew Bartolowits, Marsha DeSmet, V Jo Davisson, Elliot J Androphy

“…A majority of the E6 protein interactions within the human proteome use an alpha-helix groove interface for binding. The UBE3A/E6AP HECT domain ubiquitin ligase binds E6 at this helix-groove interface. …”
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Structure and function of benzoylurea-derived alpha-helix mimetics targeting the Bcl-x(L)/Bak binding interface. by Rodriguez, J, Ross, N, Katt, W, Dhar, D, Lee, G, Hamilton, A

“…Bak, a pro-apoptotic Bcl-2 protein, projects four hydrophobic side chains (V74, L78, I81, and I85), corresponding to the i, i+4, i+7, and i+11 positions of an alpha-helix, into a hydrophobic cleft on Bcl-x(L). Herein, we present a novel family of rationally designed alpha-helix mimetics with improved solubility and synthetic feasibility based on a benzoylurea scaffold. …”

Synthesis and biological evaluation of a 5-6-5 imidazole-phenyl-thiazole based alpha-helix mimetic. by Cummings, C, Ross, N, Katt, W, Hamilton, A

“…One of the primary drawbacks of many small molecule alpha-helix mimetics is their hydrophobic core structures. …”