Neural processing in the primary auditory cortex following cholinergic lesions of the basal forebrain in ferrets by Nodal, FR, Leach, ND, Keating, P, Dahmen, JC, Zhao, D, King, AJ, Bajo, VM

“…These results show that while ACh is required for behavioral adaptation to altered spatial cues, it is not required for maintenance of the spectral and spatial response properties of A1 neurons.…”

PARP1 resolves DNA replication defects in PCNA-associated DNA repair disorder by Wang, L

“…The aim of this thesis was to determine cellular pathways that are affected by the S228I alteration and to uncover mechanisms by which PCNAS^228I cells tolerate the perturbed PCNA interactions in specific pathways. …”

Changes in gene expression in human skeletal stem cells transduced with constitutively active Gsα correlates with hallmark histopathological changes seen in fibrous dysplastic bone... by Raimondo, Domenico, Remoli, Cristina, Astrologo, Letizia, Burla, Romina, La Torre, Mattia, Vernì, Fiammetta, Tagliafico, Enrico, Corsi, Alessandro, Del Giudice, Simona, Persichetti, Agnese, Giannicola, Giuseppe, Robey, Pamela G., Riminucci, Mara, Saggio, Isabella

“…Our data suggest that this FD mutation profoundly alters the properties of skeletal stem/progenitor cells by pushing them towards formation of disorganized bone with a concomitant alteration of adipogenic differentiation. …”
Get full text

Evolution of an extracellular pathogen recognition mechanism in Solanaceae by Kourelis, J

“…</p> <p>By elucidating the evolution of a pathogen recognition mechanism in Solanaceae and establishing the engineering of this mechanism, this thesis provides a framework for the generation of an altered recognition spectrum not found in nature.</p>…”

Continuous adaptation in a high-velocity environment : the dot-com experience. by Singh, Harminder.

“…Examine the phenomenon of the decline in valuation of dot-com organizations and propose that dot-com organizations that have continuously altered their business model in response to a dynamic environment have been rewarded by superior valuations in the market place.…”
Get full text

Business process reengineering within enterprise resource planning context : the case of united technologies. by Tan, Cheng Teng., Soh, Doreen Shil Fang.

“…It analyzes observed business process performance improvements in terms of changes in business process architecture characteristics using Steven Alter’s Work-centered Analysis (WCA) framework.…”
Get full text

Pakistan and Benazir : the way forward by Mohamed Nawab Mohamed Osman

“…The landscape of Pakistani politics may be altered completely. The turbulence and instability could be overcome if the two main opposition parties come together to form a unity government.…”
Get full text
Get full text

Specialized replication mechanisms maintain genome stability at human centromeres by Scelfo, A, Angrisani, A, Grillo, M, Barnes, BM, Muyas, F, Sauer, CM, Leung, CWB, Dumont, M, Grison, M, Mazaud, D, Garnier, M, Guintini, L, Nelson, L, Esashi, F, Cortés-Ciriano, I, Taylor, SS, Déjardin, J, Wilhelm, T, Fachinetti, D

“…Prolonged stress causes centromeric alterations like ruptures and translocations, as observed in ovarian cancer models experiencing replication stress. …”

Cryo-EM reveals transition states of the Acinetobacter baumannii F1-ATPase rotary subunits γ and ε, unveiling novel compound targets by Le, Khoa Cong Minh, Wong, Chui Fann, Müller, Volker, Grüber, Gerhard

“…We determined cryo-electron microscopy structures of the ATPase active A. baumannii F1-αßγεΔ134-139 mutant in four distinct conformational states, revealing four transition states and structural transformation of the ε's C-terminal domain, forming the switch of an ATP hydrolysis off- and an ATP synthesis on-state based. These alterations go in concert with altered motions and interactions in the catalytic- and rotary subunits of this engine. …”
Get full text

Investigating S-acylation in the metabolic dysfunction of the T2D heart by Dennis, KMJH

“…</p> <br> <p>The last part of this thesis explored alterations in CD36 in human heart failure (HF) biopsies and myocardial ischemia in rodents. …”

Focused array analysis of diabetic skin wound. by Ling, Wei Yin.

“…Literature mining based on the altered expression profiles generated a molecular network allowing us to derive appropriate therapeutic interventions. …”
Get full text

Investigation of cellular changes on blood cells relevant for the destabilization of blood flow by Stephanie.

“…In conclusion, depletion interaction is a significant determinant in red blood cell – endothelial cell adhesion, electrostatic repulsion is the key nonspecific force governing cell – cell interaction, and deformability reduction alters cell rheological properties which in turn reduce red blood cell – endothelial cell adhesion.…”
Get full text

Reduced mRNA and protein expression levels of Tet Methylcytosine Dioxygenase 3 in endothelial progenitor cells of patients of type 2 diabetes with peripheral artery disease by Zhao, Shi, Jia, Ting, Tang, Yang, Zhang, Xiaotong, Mao, Hong, Tian, Xiaojia, Li, Rui, Ma, Lu, Chen, Guoxun

“…Epigenetic changes such as DNA methylation alter the functions of cells. Tet methylcytosine dioxygenases (TETs) are enzymes responsible for the demethylation of cytosine on genomic DNA in cells. …”
Get full text
Get full text

A regulatory role for repeated decoy transcription factor binding sites in target gene expression by Lee, Tek‐Hyung, Maheshri, Narendra

“…Finally, we show that the altered sigmoidal‐like response can convert the graded response of a transcriptional positive‐feedback loop to a bimodal response. …”
Get full text

Comparative effects of domain-specific human monoclonal antibodies against LGI1 on neuronal excitability by Sell, J, Rahmati, V, Kempfer, M, Irani, SR, Ritzau-Jost, A, Hallermann, S, Geis, C

“…Moreover, considering the effective triggering of action potentials at the distal AIS, the altered spatial distribution of Kv1.1 channel density may contribute to these effects through impairing neuronal control of action potential initiation and synaptic integration.…”

Biofilms: Microbial Cities Wherein Flow Shapes Competition by Chew, Su Chuen, Yang, Liang

“…However, two recent publications demonstrate how hydrodynamic flow and substrate topography can also alter the competitive outcomes of different bacterial phenotypes, increasing biofilm phenotypic variation.…”
Get full text
Get full text

Disrupted working memory event-related network dynamics in multiple sclerosis by Rossi, C, Vidaurre, D, Costers, L, D’hooghe, MB, Akbarian, F, D’haeseleer, M, Woolrich, M, Nagels, G, Van Schependom, J

“…Altogether, the TDE-HMM technique extracts task-relevant functional networks showing disease-specific and treatment-related alterations, revealing potential new markers to assess and track WM impairment in MS.…”

Morphological multiparameter filtration and persistent homology in mitochondrial image analysis by Chung, Yu-Min, Hu, Chuan-Shen, Sun, Emily, Tseng, Henry C.

“…As proof of concept, we utilize this approach to study how mitochondrial networks are altered by genetic changes in the Optineurin gene. …”
Get full text

'Proper' Sikh woman and the female Sikh migrant to Singapore in the mid 20th century by Rajveen Kaur Aujla

“…She was able to renegotiate gender norms and assert her agency in both the private and public spaces.By doing so, she was able to alter patriarchal hierarchy of the society and ideas of how a 'proper' Sikh woman should behave.…”
Get full text

CNT work function modification for transparent electrode application in organic photovoltaics by Low, Keith Ying Jie.

“…This project will focus on using various n- and p-dopants at various concentrations and doping timings to alter the work function and sheet resistance of the Cnt which are the key factors in OPV fabrication. …”
Get full text