Serum metabolomics profiling of commercially mixed functional foods—effects in Beta-amyloid induced rats measured using 1H NMR spectroscopy by Mohd Rosli, Nur Hasnieza, Yahya, Hanis Mastura, Ibrahim, Farah Wahida, Shahar, Suzana, Ismail, Intan Safinar, Ahmad Azam, Amalina, Rajab, Nor Fadilah

“…In this novel and original study, an 1H NMR spectroscopy tool was used to identify the metabolic neuroprotective mechanism of commercially mixed functional foods (MFF) consisting of pomegranate, dates and honey, in rats injected with amyloid-beta 1-42 (Aβ-42). Forty-five male albino Wistar rats were randomly divided into five groups: NC (0.9% normal saline treatment + phosphate buffer solution (PBS) solution injection), Abeta (0.9% normal saline treatment + 0.2 µg/µL Aβ-42 injection), MFF (4 mL/kg MFF treatment + PBS solution injection), Abeta-MFF (4 mL/kg MFF treatment + 0.2 µg/µL Aβ-42 injection) and Abeta-NAC (150 mg/kg N-acetylcysteine + 0.2 µg/µL Aβ-42 injection). …”

Asymptomatic neurotoxicity of amyloid β-peptides (Aβ1-42 and Aβ25-35) on mouse embryonic stem cell-derived neural cells by Mansor, Nur Izzati, Ntimi, Carolindah Makena, Abdul Aziz, Noraishah Mydin, Ling, King Hwa, Adam, Aishah, Rosli, Rozita, Hassan, Zurina, Nordin, Norshariza

“…One of the strategies in the establishment of in vitro oxidative stress models for neurodegenerative diseases, such as Alzheimer's disease (AD), is to induce neurotoxicity by amyloid beta (Aβ) peptides in suitable neural cells. …”
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Topographical patterns of whole-brain structural alterations in association with genetic risk, cerebrospinal fluid, positron emission tomography biomarkers of Alzheimerâs disease,... by Dayor Piersson, Albert, Mohamad, Mazlyfarina, Rajab, Nor Fadilah, Suppiah, Subapriya

“…This study aimed at investigating the topographical pattern of whole-brain structural alterations in association with apolipoprotein E e4 (APOE e4), cerebrospinal fluid (CSF) [amyloid-beta 42 (Aβ42), and neurofibrillary tau protein], positron emission tomography (PET) biomarkers [Aβ, tau, and 2-[18F]fluoro-2-deoxy-d-glucose (FDG)], and neuropsychological measures. …”

Asymptomatic neurotoxicity of amyloid Î-peptides AÎ1-42 and AÎ25-35 on mouse embryonic stem cell-derived neural cells by Mansor, Nur Izzati, Ntimi, Carolindah Makena, Abdul Aziz, Noraishah Mydin, King, Hwa Ling, Adam, Aishah, Rosli, Rozita, Hassan, Zurina, Nordin, Norshariza

“…One of the strategies in the establishment of in vitro oxidative stress models for neurodegenerative diseases, such as Alzheimer's disease (AD), is to induce neurotoxicity by amyloid beta (Aβ) peptides in suitable neural cells. …”

Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology by Carmen Romero-Molina, Carmen Romero-Molina, Carmen Romero-Molina, Victoria Navarro, Victoria Navarro, Victoria Navarro, Raquel Sanchez-Varo, Raquel Sanchez-Varo, Sebastian Jimenez, Sebastian Jimenez, Sebastian Jimenez, Juan J. Fernandez-Valenzuela, Juan J. Fernandez-Valenzuela, Maria V. Sanchez-Mico, Maria V. Sanchez-Mico, Maria V. Sanchez-Mico, Clara Muñoz-Castro, Clara Muñoz-Castro, Clara Muñoz-Castro, Antonia Gutierrez, Antonia Gutierrez, Javier Vitorica, Javier Vitorica, Javier Vitorica, Marisa Vizuete, Marisa Vizuete, Marisa Vizuete

“…Microglial response in AD has been principally studied in relation to amyloid-beta pathology but, comparatively, little is known about inflammatory processes associated to tau pathology. …”
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Quercetin protects human brain microvascular endothelial cells from fibrillar β-amyloid1–40-induced toxicity by Yongjie Li, Sibai Zhou, Jinze Li, Yuhua Sun, Hamlati Hasimu, Rui Liu, Tiantai Zhang

“…Amyloid beta-peptides (Aβ) are known to undergo active transport across the blood-brain barrier, and cerebral amyloid angiopathy has been shown to be a prominent feature in the majority of Alzheimer׳s disease. …”
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Longitudinal microbiome investigation throughout prion disease course reveals pre- and symptomatic compositional perturbations linked to short-chain fatty acid metabolism and cogni... by Marco Losa, Marco Losa, Yasser Morsy, Marc Emmenegger, Marc Emmenegger, Salomon M. Manz, Petra Schwarz, Adriano Aguzzi, Michael Scharl

“…They conspicuously impact disease development and progression, including amyloid-beta (Aβ) and alpha (α)-synuclein pathology in neurodegenerative diseases, conveying the importance of the brain–gut–microbiome axis in such conditions. …”
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Association of tear fluid amyloid and tau levels with disease severity and neurodegeneration by Marlies Gijs, Inez H. G. B. Ramakers, Pieter Jelle Visser, Frans R. J. Verhey, Marjo P. H. van de Waarenburg, Casper G. Schalkwijk, Rudy M. M. A. Nuijts, Carroll A. B. Webers

“…Tear fluid was collected from a total of 65 subjects, including 23 patients with subjective cognitive decline (SCD), 22 patients with mild cognitive impairment (MCI), 11 dementia patients and 9 healthy controls (HC). Levels of amyloid-beta peptides (AB38, AB40, AB42), total-tau (t-tau) and phosphorylated-tau (p-tau) were determined using multiplex immunoassays. …”
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The Oral-Gut-Brain AXIS: The Influence of Microbes in Alzheimer’s Disease by Narengaowa, Wei Kong, Fei Lan, Umer Farooq Awan, Hong Qing, Junjun Ni

“…Neurofibrillary tangles and the deposition of amyloid-beta (Aβ) protein are typical pathological features and fundamental causes of cognitive impairment in AD patients. …”
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Single domain antibody-scFv conjugate targeting amyloid β and TfR penetrates the blood–brain barrier and interacts with amyloid β by Rebecca Faresjö, Elisabet O. Sjöström, Tiffany Dallas, Magnus M. Berglund, Jonas Eriksson, Dag Sehlin, Stina Syvänen

“…We developed and evaluated fusion proteins (FPs) combining VHHs with human IgG Fc domains or single-chain variable fragments (scFvs) of the anti-amyloid-beta (Aβ) antibody 3D6. In vitro assessments showed varying affinities of the FPs for TfR. …”
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Cardiac functional and structural impairments, endothelial apoptosis and blood-brain barrier dysfunction in models of cerebrovascular amyloidosis in the presence or absence of hype... by Ashley Carey, Andrea Elia, Rebecca Parodi-Rullan, Silvia Fossati

“…Recent evidence suggests that cardiovascular (CV)/cerebrovascular risk factors, such as hyperhomocysteinemia (Hhcy) contribute to increasing AD pathology and risk, but it remains unknown whether Amyloid beta (Aβ) and homocysteine function through common molecular mechanisms to induce EC dysfunction. …”
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Acute exercise and brain BACE1 protein content: a time course study by Alex J. Yang, Grant C. Hayward, Rebecca E. K. MacPherson

“…The rate limiting enzyme in the production of amyloid‐beta peptides, BACE1, was reduced in the prefrontal cortex 2 h post‐exercise, however if these effects remain over time is unknown. …”
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Specific serum and CSF microRNA profiles distinguish sporadic behavioural variant of frontotemporal dementia compared with Alzheimer patients and cognitively healthy controls. by Johannes Denk, Felix Oberhauser, Johannes Kornhuber, Jens Wiltfang, Klaus Fassbender, Matthias L Schroeter, Alexander E Volk, Janine Diehl-Schmid, Johannes Prudlo, Adrian Danek, Bernhard Landwehrmeyer, Martin Lauer, Markus Otto, Holger Jahn, FTLDc study group

“…Correlation analysis revealed that miRNAs from the 3-factor model also correlated with levels of protein biomarker amyloid-beta1-42 and phosphorylated neurofilament heavy chain, indicating their potential role in the monitoring of progressive neuronal degeneration. …”
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Optimization of Culture Conditions for High Cell Productivity and Astaxanthin Accumulation in Vietnam’s Green Microalgae <i>Haematococcus pluvialis</i> HB and a Neuroprotective Act... by Nguyen Cam Ha, Luu Thi Tam, Hoang Thi Minh Hien, Ngo Thi Hoai Thu, Dang Diem Hong, Le Thi Thom

“…It also showed neuroprotective effects against H₂O₂ and amyloid beta-induced neurotoxicity in C6 cells. Conclusions: This study highlights <i>H. pluvialis</i> HB as a promising source for large-scale astaxanthin production with potential applications in neuroprotective health products.…”
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Differential blood-based biomarkers of subcortical and deep brain small vessel disease by Pablo Hervella, Maria Luz Alonso-Alonso, Ana Sampedro-Viana, Manuel Rodríguez-Yáñez, Iria López-Dequidt, José M. Pumar, Alberto Ouro, Daniel Romaus-Sanjurjo, Francisco Campos, Tomás Sobrino, José Castillo, Yago Leira, Ramón Iglesias-Rey

“…Methods: We examined the relationship between Alzheimer’s disease biomarkers [amyloid beta (Aβ 1–40 , Aβ 1–42 )], serum inflammatory marker (interleukin-6, IL-6), and endothelial dysfunction markers [soluble tumor necrosis factor-like weak inducer of apoptosis, and pentraxin-3 (sTWEAK, PTX3)] with respect to LS occurring in deep brain structures and subcortical white matter. …”
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Formaldehyde initiates memory and motor impairments under weightlessness condition by Tianhao Mei, Ying Chen, Yajuan Gao, Hang Zhao, Xingzhou Lyu, Jing Lin, Tianye Niu, Hongbin Han, Zhiqian Tong

“…However, excessive FA has the potential to form cross-links between these two proteins and amyloid-beta (Aβ), thereby obstructing ECS and inducing neuron death. …”
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Discovery of Novel Drug Candidates for Alzheimer’s Disease by Molecular Network Modeling by Jiaxin Zhou, Qingyong Li, Wensi Wu, Xiaojun Zhang, Zhiyi Zuo, Yanan Lu, Huiying Zhao, Zhi Wang

“…Pretreatment with GHK showed a neuroprotective effect against amyloid-beta-induced injury in differentiated human neuron-like SH-SY5Y cells. …”
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Yeast-Based Aβ1-15 Vaccine Elicits Strong Immunogenicity and Attenuates Neuropathology and Cognitive Deficits in Alzheimer’s Disease Transgenic Mice by Dong-qun Liu, Shuai Lu, Lun Zhang, Ya-ru Huang, Mei Ji, Xiao-ying Sun, Xiao-ge Liu, Rui-tian Liu

“…Immunotherapy focusing on reducing the amyloid-beta (Aβ) burden is a promising treatment strategy for Alzheimer’s disease (AD). …”
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Coupling of the spatial distributions between sMRI and PET reveals the progression of Alzheimer’s disease by Kun Zhao, Jiaji Lin, Martin Dyrba, Dong Wang, Tongtong Che, Haoyang Wu, Jingyu Wang, Yong Liu, Shuyu Li

“… AbstractAmyloid-beta (Aβ) deposition and altered brain structure are the most relevant neuroimaging biomarkers for Alzheimer’s disease (AD). …”
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The canine activated platelet secretome (CAPS): A translational model of thrombin‐evoked platelet activation response by Signe E. Cremer, James L. Catalfamo, Robert Goggs, Stefan E. Seemann, Annemarie T. Kristensen, Paulina B. Szklanna, Patricia B. Maguire, Marjory B. Brooks

“…Among the differences from human platelets were a canine lack of platelet factor 4 and vascular endothelial growth factor C, and a 10‐ to 20‐fold lower concentration of proteins such as haptoglobin, alpha‐2 macroglobulin, von Willebrand factor, and amyloid‐beta A4. Twenty‐eight CAPS proteins, including cytokines, adhesion molecules, granule proteins, and calcium regulatory proteins have not previously been attributed to human platelets. …”
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