Familial versus sporadic amyotrophic lateral sclerosis -A false dichotomy? by Talbot, K

Integration of structural and functional magnetic resonance imaging in amyotrophic lateral sclerosis. by Douaud, G, Filippini, N, Knight, S, Talbot, K, Turner, M

“…Amyotrophic lateral sclerosis as a system failure is a concept supported by the finding of consistent extramotor as well as motor cerebral pathology. …”

Integration of structural and functional magnetic resonance imaging in amyotrophic lateral sclerosis by Douaud, G, Filippini, N, Knight, S, Talbot, K, Turner, MR

“…Amyotrophic lateral sclerosis as a system failure is a concept supported by the finding of consistent extramotor as well as motor cerebral pathology. …”

CSF chitinases before and after symptom onset in amyotrophic lateral sclerosis by Gray, E, Thompson, A, Wuu, J, Pelt, J, Talbot, K, Benatar, M, Turner, M

“…<p><strong>Objective</strong> To evaluate the CSF levels of chitinase proteins during the presymptomatic and early symptomatic phases of amyotrophic lateral sclerosis (ALS).</p> <p><strong>Methods</strong> CSF samples were obtained from 16 controls, 55 individuals at‐risk for ALS (including 18 carrying a mutation in C9ORF72 , 33 in SOD1 ), 12 ALS patients, and 7 phenoconverters (individuals diagnosed with ALS during follow‐up). …”

Large-scale pathways-based association study in amyotrophic lateral sclerosis by Kasperavičiute, D, Weale, M, Shianna, K, Banks, G, Simpson, C, Hansen, V, Turner, M, Shaw, C, Al-Chalabi, A, Pall, H, Goodall, E, Morrison, K, Orrell, R, Beck, M, Jablonka, S, Sendtner, M, Brockington, A, Ince, P, Hartley, J, Nixon, H, Shaw, P, Schiavo, G, Wood, N, Goldstein, D, Fisher, E

“…Sporadic amyotrophic lateral sclerosis (ALS), a devastating neurodegenerative disease, most likely results from complex genetic and environmental interactions. …”

Analysis of FGGY as a risk factor for sporadic amyotrophic lateral sclerosis. by Es, V, Van Vught, P, Veldink, J, Andersen, P, Birve, A, Lemmens, R, Cronin, S, Van Der Kooi, A, De Visser, M, Schelhaas, H, Hardiman, O, Ragoussis, I, Lambrechts, D, Robberecht, W, Wokke, J, Ophoff, R, Van Den Berg, L

Large-scale pathways-based association study in amyotrophic lateral sclerosis. by Kasperaviciute, D, Weale, M, Shianna, K, Banks, G, Simpson, C, Hansen, V, Turner, M, Shaw, C, Al-Chalabi, A, Pall, H, Goodall, E, Morrison, K, Orrell, R, Beck, M, Jablonka, S, Sendtner, M, Brockington, A, Ince, P, Hartley, J, Nixon, H, Shaw, P, Schiavo, G, Wood, N, Goldstein, D, Fisher, E

“…Sporadic amyotrophic lateral sclerosis (ALS), a devastating neurodegenerative disease, most likely results from complex genetic and environmental interactions. …”

Magnetic resonance spectroscopic imaging--of prognostic value in amyotrophic lateral sclerosis? by Matthews, P, Talbot, K

The use of biotelemetry to explore disease progression markers in amyotrophic lateral sclerosis by Kelly, M, Lavrov, A, Garcia-Gancedo, L, Parr, J, Hart, R, Chiwera, T, Shaw, CE, Al-Chalabi, A, Marsden, R, Turner, M, Talbot, K

“…<p><strong>Objective:</strong> To explore novel, real-world biotelemetry disease progression markers in patients with amyotrophic lateral sclerosis (ALS) and to compare with clinical gold-standard measures. …”

Regional callosal integrity and bilaterality of limb weakness in amyotrophic lateral sclerosis by Tu, S, Wang, C, Menke, R, Talbot, K, Barnett, M, Kiernan, MC, Turner, M

“…<p><strong>Background and Objectives:</strong> The corpus callosum is a site of pathological involvement in the neurodegenerative disorder amyotrophic lateral sclerosis (ALS). The corpus callosum shows widespread cortical connectivity topographically distributed along its length. …”

Exploring neuroinflammatory processes in a mouse model of amyotrophic lateral sclerosis by Evans, M, Mr Matthew C Evans

“…<p>Amyotrophic lateral sclerosis (ALS) is a devastating degenerative disease, affecting both upper and lower motor neurons in the CNS. …”

Amyotrophic lateral sclerosis and cancer: a register-based study in Sweden. by Fang, F, Al-Chalabi, A, Ronnevi, L, Turner, M, Wirdefeldt, K, Kamel, F, Ye, W

Combining digital histology with magnetic resonance imaging in amyotrophic lateral sclerosis by Huszar, IN

“…Various magnetic resonance imaging (MRI) methods have shown great potential to indicate the event of upper motor neuron involvement in the progression of amyotrophic lateral sclerosis (ALS) at the population level, but almost none of these have been systematically validated against traditional histological markers at the individual level. …”

Concordance between site of onset and limb dominance in amyotrophic lateral sclerosis. by Turner, M, Wicks, P, Brownstein, C, Massagli, M, Toronjo, M, Talbot, K, Al-Chalabi, A

“…BACKGROUND: Focality of onset of amyotrophic lateral sclerosis (ALS) is not understood. Attempts to implicate physical exercise in the aetiology of ALS have provided inconsistent results. …”

Analysis of FGGY as a risk factor for sporadic amyotrophic lateral sclerosis. by Es, V, Van Vught, P, Veldink, J, Andersen, P, Birve, A, Lemmens, R, Cronin, S, Van Der Kooi, A, Visser, MD, Schelhaas, H, Hardiman, O, Ragoussis, I, Lambrechts, D, Robberecht, W, Wokke, J, Ophoff, R, Van Den Berg, L

Health utility decreases with increasing clinical stage in amyotrophic lateral sclerosis. by Jones, A, Jivraj, N, Balendra, R, Murphy, C, Kelly, J, Thornhill, M, Young, C, Shaw, P, Leigh, P, Turner, M, Steen, I, McCrone, P, Al-Chalabi, A

“…Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease typically causing death within three years. …”

Relation between cognitive dysfunction and pseudobulbar palsy in amyotrophic lateral sclerosis. by Abrahams, S, Goldstein, L, Al-Chalabi, A, Pickering, A, Morris, R, Passingham, R, Brooks, D, Leigh, P

“…OBJECTIVES: To examine the relation between cognitive dysfunction and pseudobulbar features in patients with amyotrophic lateral sclerosis (ALS). METHODS: The performance of two patient groups, ALS with pseudobulbar palsy (n = 24) and ALS without pseudobulbar palsy (n = 28), was compared with 28 healthy age matched controls on an extensive neuropsychological battery. …”

Non-neuronal cells in amyotrophic lateral sclerosis — from pathogenesis to biomarkers by Vahsen, BF, Gray, E, Thompson, AG, Ansorge, O, Anthony, DC, Cowley, SA, Talbot, K, Turner, MR

“…The prevailing motor neuron-centric view of amyotrophic lateral sclerosis (ALS) pathogenesis could be an important factor in the failure to identify disease-modifying therapy for this neurodegenerative disorder. …”

Corpus callosum involvement is a consistent feature of amyotrophic lateral sclerosis. by Filippini, N, Douaud, G, Mackay, C, Knight, S, Talbot, K, Turner, M

“…OBJECTIVE: While the hallmark of amyotrophic lateral sclerosis (ALS) is corticospinal tract in combination with lower motor neuron degeneration, the clinical involvement of both compartments is characteristically variable and the site of onset debated. …”

Occasional essay: Upper motor neuron syndrome in amyotrophic lateral sclerosis by Swash, M, Burke, D, Turner, MR, Grosskreutz, J, Leigh, PN, deCarvalho, M, Kiernan, MC

“…The diagnosis of amyotrophic lateral sclerosis (ALS) requires recognition of both lower motor neuron (LMN) and upper motor neuron (UMN) dysfunction.1 However, classical UMN signs are frequently difficult to identify in ALS.2 LMN involvement is sensitively detected by electromyography (EMG),3 but, as yet, there are no generally accepted markers for monitoring UMN abnormalities,4 the neurobiology of ALS itself and disease spread through the brain and the spinal cord.5 Full clinical assessment is therefore necessary to exclude other diagnoses and to monitor disease progression. …”