CSF chitinase proteins in amyotrophic lateral sclerosis by Thompson, A, Gray, E, Bampton, A, Raciborska, D, Talbot, K, Turner, M

“…<p>Objective: To evaluate the classifier performance, clinical and biochemical correlations of cerebrospinal fluid (CSF) levels of the chitinase proteins Chitotriosidase-1 (CHIT1), Chitinase-3-like protein 1 (CHI3L1) and Chitinase-3-like protein 2 (CHI3L2) in amyotrophic lateral sclerosis (ALS).</p> <p>Methods: CSF levels of CHIT1, CHI3L1, CHI3L2, phosphorylated neurofilament heavy chain (pNFH) and C-reactive protein were measured by ELISA in a longitudinal cohort of patients with ALS (n=82), primary lateral sclerosis (PLS, n=10), ALS-mimic conditions (n=12), healthy controls (n=25) and asymptomatic carriers of ALS-causing genetic mutations (AGC; n=5).…”

Defective cholesterol metabolism in amyotrophic lateral sclerosis. by Abdel-Khalik, J, Yutuc, E, Crick, P, Gustafsson, J, Warner, M, Roman, G, Talbot, K, Gray, E, Griffiths, W, Turner, M, Wang, Y

“…As neurons die cholesterol is released in the central nervous system (CNS), hence this sterol and its metabolites may represent a biomarker of neurodegeneration, including in amyotrophic lateral sclerosis (ALS) in which altered cholesterol levels have been linked to prognosis. …”

Imaging cerebral activity in amyotrophic lateral sclerosis by Proudfoot, M, Bede, P, Turner, M

“…Advances in neuroimaging, complementing histopathological insights, have established a multi-system involvement of cerebral networks beyond the traditional neuromuscular pathological view of amyotrophic lateral sclerosis (ALS). The development of effective disease-modifying therapy remains a priority and this will be facilitated by improved biomarkers of motor system integrity against which to assess the efficacy of candidate drugs. …”

Psychiatric disorders prior to amyotrophic lateral sclerosis by Turner, M, Goldacre, R, Talbot, K, Goldacre, M

Mechanisms, models and biomarkers in amyotrophic lateral sclerosis. by Turner, M, Bowser, R, Bruijn, L, Dupuis, L, Ludolph, A, McGrath, M, Manfredi, G, Maragakis, N, Miller, R, Pullman, S, Rutkove, S, Shaw, P, Shefner, J, Fischbeck, K

“…The last 30 years have seen a major advance in the understanding of the clinical and pathological heterogeneity of amyotrophic lateral sclerosis (ALS), and its overlap with frontotemporal dementia. …”

Motor system biomarkers in amyotrophic lateral sclerosis by Edmond, EC, Menke, R, Proudfoot, M, Talbot, K, Stagg, CJ, Turner, MR

Advances in the application of MRI to amyotrophic lateral sclerosis. by Turner, M, Modo, M

“…IMPORTANCE OF THE FIELD: With the emergence of therapeutic candidates for the incurable and rapidly progressive neurodegenerative condition of amyotrophic lateral sclerosis (ALS), it will be essential to develop easily obtainable biomarkers for diagnosis, as well as monitoring, in a disease where clinical examination remains the predominant diagnostic tool. …”

Murine experimental models of amyotrophic lateral sclerosis: an update by L. Moreno-Jiménez, M.S. Benito-Martín, I. Sanclemente-Alamán, J.A. Matías-Guiu, F. Sancho-Bielsa, A. Canales-Aguirre, J.C. Mateos-Díaz, J. Matías-Guiu, J. Aguilar, U. Gómez-Pinedo

“…Introduction: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease whose aetiology is unknown. …”
Get full text

Motor neuron replacement therapy for amyotrophic lateral sclerosis by Bochao Liu, Mo Li, Lingyan Zhang, Zhiguo Chen, Paul Lu

Subjects: “…amyotrophic lateral sclerosis; motor neuron replacement; neural progenitor cells; neural stem cells; stem cells…”
Get full text

The complexity of multidisciplinary respiratory care in amyotrophic lateral sclerosis by David J. Berlowitz, Susan Mathers, Karen Hutchinson, Anne Hogden, Kate A. Carey, Marnie Graco, Brooke-Mai Whelan, Salma Charania, Frederik Steyn, Peter Allcroft, Ashley Crook, Nicole L. Sheers

“…Motor neurone disease/amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder with no known cure, where death is usually secondary to progressive respiratory failure. …”
Get full text

Defective Oligodendroglial Lineage and Demyelination in Amyotrophic Lateral Sclerosis by Elisabeth Traiffort, Séverine Morisset-Lopez, Mireille Moussaed, Amina Zahaf

“…Motor neurons and their axons reaching the skeletal muscle have long been considered as the best characterized targets of the degenerative process observed in amyotrophic lateral sclerosis (ALS). However, the involvement of glial cells was also more recently reported. …”
Get full text

Oropharyngeal Dysphagia as the Main Expression of Amyotrophic Lateral Sclerosis by Margarita Rugaitienė, Gytė Damulevičienė, Vita Lesauskaitė, Ingrida Ulozienė

Subjects: Get full text

The Role of Nucleocytoplasmic Transport Defects in Amyotrophic Lateral Sclerosis by Joni Vanneste, Ludo Van Den Bosch

“…There is ample evidence that nucleocytoplasmic-transport deficits could play an important role in the pathology of amyotrophic lateral sclerosis (ALS). However, the currently available data are often circumstantial and do not fully clarify the exact causal and temporal role of nucleocytoplasmic transport deficits in ALS patients. …”
Get full text

Comorbidity Pattern Analysis for Predicting Amyotrophic Lateral Sclerosis by Chia-Hui Huang, Bak-Sau Yip, David Taniar, Chi-Shin Hwang, Tun-Wen Pai

Subjects: Get full text

Anti-ganglioside antibodies in amyotrophic lateral sclerosis revisited. by Katja Kollewe, Ulrich Wurster, Thomas Sinzenich, Sonja Körner, Reinhard Dengler, Bahram Mohammadi, Susanne Petri

“…BACKGROUND:Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disorder with typical onset in the 5th- 6th decade of life. …”
Get full text

Muscle ultrasound imaging in the diagnosis of amyotrophic lateral sclerosis by Yu. N. Rushkevich, G. V. Zabrodets, S. A. Likhachev

“…Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease. …”
Get full text

Cortical markers of cognitive syndromes in amyotrophic lateral sclerosis by Monica Consonni, Valeria E. Contarino, Eleonora Catricalà, Eleonora Dalla Bella, Viviana Pensato, Cinzia Gellera, Giuseppe Lauria, Stefano F. Cappa

“…Amyotrophic lateral sclerosis (ALS) can be associated with a spectrum of cognitive and behavioural symptoms, but the related patterns of focal cortical atrophy in non-demented ALS patients remain largely unknown. …”
Get full text

RNA Deregulation in Amyotrophic Lateral Sclerosis: The Noncoding Perspective by Pietro Laneve, Paolo Tollis, Elisa Caffarelli

“…This review aims to explore the link between ncRNA dysregulation and amyotrophic lateral sclerosis (ALS), the most frequent motoneuron (MN) disorder in adults. …”
Get full text

Alterations in Leptin Signaling in Amyotrophic Lateral Sclerosis (ALS) by Agueda Ferrer-Donato, Ana Contreras, Laura M. Frago, Julie A. Chowen, Carmen M. Fernandez-Martos

Subjects: Get full text

Repetitive nerve stimulation on survival in amyotrophic lateral sclerosis by Yahui Zhu, Yahui Zhu, Jiongming Bai, Jiongming Bai, Mao Li, Hongfen Wang, Jiao Wang, Jiao Wang, Xusheng Huang, Xusheng Huang

Subjects: Get full text