Progress and new frontiers in biomarkers for amyotrophic lateral sclerosis by Turner, M

“…<p>The adult-onset neurodegenerative disorder amyotrophic lateral sclerosis (ALS) is life-shortening for majority of those affected. …”

Evolution of white matter damage in amyotrophic lateral sclerosis by Gabel, M, Broad, R, Young, A, Abrahams, S, Bastin, M, Menke, R, Al-Chalabi, A, Goldstein, LH, Tsermentseli, S, Alexander, D, Turner, M, Leigh, PN, Cercignani, M

“…<p><strong>Objective</strong> To characterize disease evolution in amyotrophic lateral sclerosis using an event‐based model designed to extract temporal information from cross‐sectional data. …”

Towards a neuroimaging biomarker for amyotrophic lateral sclerosis. by Turner, M, Grosskreutz, J, Kassubek, J, Abrahams, S, Agosta, F, Benatar, M, Filippi, M, Goldstein, L, van den Heuvel, M, Kalra, S, Lulé, D, Mohammadi, B

Cerebrospinal fluid macrophage biomarkers in amyotrophic lateral sclerosis by Thompson, A, Gray, E, Thézénas, M, Charles, P, Evetts, S, Hu, M, Talbot, K, Fischer, R, Kessler, B, Turner, M

“… <p><b>Objective:</b> The neurodegenerative disease amyotrophic lateral sclerosis (ALS) is a heterogeneous clinical syndrome involving multiple molecular pathways. …”

Alzheimer's disease, amyotrophic lateral sclerosis, and transgenic mice. by Bajaj, N, Irving, N, Leigh, P, Miller, C

Assessment of the upper motor neuron in amyotrophic lateral sclerosis by Huynh, W, Simon, N, Grosskreutz, J, Turner, M, Vucic, S, Kiernan, M

“…Clinical signs of upper motor neuron (UMN) involvement are an important component in supporting the diagnosis of amyotrophic lateral sclerosis (ALS), but are often not easily appreciated in a limb that is concurrently affected by muscle wasting and lower motor neuron degeneration, particularly in the early symptomatic stages of ALS. …”

Cerebrospinal fluid biomarker development in amyotrophic lateral sclerosis by Thompson, AG

“…<p>Amyotrophic lateral sclerosis (ALS), the commonest form of motor neuron disease (MND), is a fatal, typically rapidly-progressive neurodegenerative syndrome without highlyeffective disease-modifying treatment. …”

Amyotrophic lateral sclerosis: the complex path to precision medicine by Talbot, K, Feneberg, E, Scaber, J, Thompson, A, Turner, M

“…Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of the corticomotorneuronal network responsible for voluntary movement. …”

Understanding the role of microglia in the pathogenesis of amyotrophic lateral sclerosis by Vahsen, BF

“…Amyotrophic lateral sclerosis (ALS), the third commonest neurodegenerative disorder, is primarily characterised by progressive motor neuron loss with additional involvement of non-neuronal cells. …”

Biomarkers of motor network excitability in amyotrophic lateral sclerosis by Edmond, E

Subjects:

Nerve fibre degeneration in the brain in amyotrophic lateral sclerosis. by Turner, M

No association between gluten sensitivity and amyotrophic lateral sclerosis by Visser, A, Pazoki, R, Pulit, S, van Rheenen, W, Raaphorst, J, van der Kooi, A, Ricaño-Ponce, I, Wijmenga, C, Otten, H, Veldink, J, van den Berg, L

A proposed staging system for amyotrophic lateral sclerosis. by Roche, J, Rojas-Garcia, R, Scott, K, Scotton, W, Ellis, C, Burman, R, Wijesekera, L, Turner, M, Leigh, P, Shaw, C, Al-Chalabi, A

“…Amyotrophic lateral sclerosis is a neurodegenerative disorder characterized by progressive loss of upper and lower motor neurons, with a median survival of 2-3 years. …”

Ensuring continued progress in biomarkers for amyotrophic lateral sclerosis. by Turner, M, Benatar, M

“…Multiple candidate biomarkers for amyotrophic lateral sclerosis (ALS) have emerged across a range of platforms. …”

Prognostic modelling of therapeutic interventions in amyotrophic lateral sclerosis. by Turner, M, Bakker, M, Sham, P, Shaw, C, Leigh, P, Al-Chalabi, A

“…BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a disease with a widely varying prognosis. …”

Kinnier Wilson's puzzling features of amyotrophic lateral sclerosis by Turner, MR, Eisen, A, Kiernan, MC, Ravits, J, Swash, M

“…Kinnier Wilson’s posthumously published 1940 textbook ‘Neurology’ included a detailed clinicopathological account of the neurodegenerative disorder amyotrophic lateral sclerosis (ALS). In providing a comprehensive discussion of the breadth of the clinical heterogeneity, he highlighted five “puzzling features” that appear prescient of the modern recognition of ALS as a complex multisystem syndrome. …”

Microglial crosstalk with astrocytes and immune cells in amyotrophic lateral sclerosis by Matteo Calafatti, Germana Cocozza, Cristina Limatola, Cristina Limatola, Stefano Garofalo

“…In recent years, biomedical research efforts aimed to unravel the mechanisms involved in motor neuron death that occurs in amyotrophic lateral sclerosis (ALS). While the main causes of disease progression were first sought in the motor neurons, more recent studies highlight the gliocentric theory demonstrating the pivotal role of microglia and astrocyte, but also of infiltrating immune cells, in the pathological processes that take place in the central nervous system microenvironment. …”
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The severity of respiratory disorders in different forms of amyotrophic lateral sclerosis by Yu. N. Rushkevich, N. M. Chechik, S. A. Likhachev, O. V. Merkul, T. V. Korbut

Subjects: “…amyotrophic lateral sclerosis…”
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Prospective study to evaluate quality of life in amyotrophic lateral sclerosis by Candela Caballero-Eraso, Carlos Carrera-Cueva, Esther de Benito Zorrero, Cecilia Lopez-Ramirez, Samira Marin-Romero, Maria Isabel Asensio-Cruz, Emilia Barrot-Cortes, Luis Jara-Palomares

“…Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative rare disease characterized by symptoms and signs in the upper and lower motor neurons, leading to progressive neuro-degeneration and muscle atrophy. …”
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Accurate personalized survival prediction for amyotrophic lateral sclerosis patients by Li-Hao Kuan, Pedram Parnianpour, Rafsanjany Kushol, Neeraj Kumar, Tanushka Anand, Sanjay Kalra, Russell Greiner

“…Abstract Amyotrophic Lateral Sclerosis (ALS) is a rapidly progressive neurodegenerative disease. …”
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