Androgens are differentially associated with ovarian cancer subtypes in the Ovarian Cancer Cohort Consortium by Ose, J, Poole, E, Schock, H, Lehtinen, M, Arslan, A, Zeleniuch-Jacquotte, A, Visvanathan, K, Helzlsouer, K, Buring, J, Lee, I, Tjønneland, A, Dossus, L, Trichopoulou, A, Masala, G, Onland-Moret, N, Weiderpass, E, Duell, E, Idahl, A, Travis, R, Rinaldi, S, Merritt, M, Trabert, B, Wentzensen, N, Tworoger, S, Kaaks, R, Fortner, R

“…An inverse association was observed between androstenedione and high grade serous tumors (ORlog2=0.76 [0.60-0.96]). …”

Low Serum Total Testosterone Is Associated with Non-Alcoholic Fatty Liver Disease in Men but Not in Women with Type 2 Diabetes Mellitus by Xinxin Zhang, Jinfeng Xiao, Qi Liu, Yuanyuan Ye, Weihong Guo, Jingqiu Cui, Qing He, Wenli Feng, Ming Liu

“…Moreover, women showed no significant associations of total testosterone, androstenedione, DHEA, and DHEAS, with the odds of NAFLD (all P>0.05). …”
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Modified release and conventional glucocorticoids and diurnal androgen excretion in congenital adrenal hyperplasia by Jones, C, Mallappa, A, Reisch, N, Nikolaou, N, Krone, N, Hughes, B, O'Neil, D, Whitaker, M, Tomlinson, J, Storbeck, K, Merke, D, Ross, R, Arlt, W

“…<p>CONTEXT: The classic androgen synthesis pathway proceeds via DHEA, androstenedione and testosterone to 5α-dihydrotestosterone (DHT). …”

Effects of 5α-dihydrotestosterone and 17β-estradiol on the mouse ovarian follicle development and oocyte maturation. by Wataru Tarumi, Masanori T Itoh, Nao Suzuki

“…We have previously reported that androstenedione induces abnormalities of follicle development and oocyte maturation in the mouse ovary. …”
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Steroid hormone interconversions in human adipose tissue in vivo. by Boulton, K, Hudson, D, Coppack, S, Frayn, K

“…Simultaneous arterial (or arterialized) and adipose tissue-venous plasma samples were collected from eight men and seven women, for measurement of estradiol, estrone, testosterone, and androstenedione concentrations by radioimmunoassay. Despite the heterogeneity of the groups (premenopausal and postmenopausal women, one subject with insulin-dependent diabetes mellitus), some very consistent findings emerged. …”

Clinical and diagnostic manifestations in women of reproductive age having both hyperthyroidism and hyperandrogenism by N. E. Akhundova

“…The levels of follicle-stimulating (FSH), luteinizing (LH), thyroid-stimulating (TSH) hormones, prolactin, estradiol (E2), estrone, and total testosterone (Ttotal) were measured as well as the levels of dehydroepiandrosterone- sulfate (DHEA-S), 17-hydroxyprogesterone (17-OHP), free triiodothyronine (T3free), free thyroxin (T4free), sex hormone binding globulin (SHBG), androstenedione, and antimullerian hormone.Results. Patients with hyperthyroidism and HA had significantly (р &lt; 0.05) higher (than normal) levels of FSH, LH, LH/FSH, estrone, 17-OHP, Ttotal, androstenedione, DHEA-S, T3free , and T4free, as well as lower levels (р &lt; 0,05) of TSH (0,390 ± 0,003 mU/ml), E2 (49.86 ± 4.00 pg/ml), and SHBG (49.65 ± 1.20 nmol/L). …”
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Postmenopausal serum androgens, oestrogens and breast cancer risk: the European prospective investigation into cancer and nutrition. by Kaaks, R, Rinaldi, S, Key, T, Berrino, F, Peeters, P, Biessy, C, Dossus, L, Lukanova, A, Bingham, S, Khaw, K, Allen, N, Bueno-de-Mesquita, H, Gils, v, Grobbee, D, Boeing, H, Lahmann, P, Nagel, G, Chang-Claude, J, Clavel-Chapelon, F, Fournier, A, Thiébaut, A, González, C, Quirós, JR, Tormo, M, Ardanaz, E

“…Levels of DHEA sulphate (DHEAS), (Delta4-androstenedione), testosterone, oestrone, oestradiol and sex-hormone binding globulin (SHBG) were measured in prediagnostic serum samples of 677 postmenopausal women who subsequently developed breast cancer and 1309 matched control subjects. …”

Effects of steroid hormones on lipid metabolism in sexual dimorphism: A Mendelian randomization study by Junzhi Liang, Bowen Zhang, Yannan Hu, Zhijing Na, Zhijing Na, Da Li, Da Li, Da Li

“…In females, DHEAS was negatively correlated with TC (P = 0.026) and androstenedione was negatively correlated with triglycerides and apolipoprotein A (P = 0.022; P = 0.009, respectively). …”
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46,XY Sex Development Defect due to a Novel Homozygous (Splice Site) c.673_1G>C Variation in the HSD17B3 Gene: Case Report by Nurdan Çiftci, Leman Kayaş, Emine Çamtosun, Ayşehan Akıncı

“…Hormonal evaluation showed low levels of basal and stimulated serum T, a high level of androstenedione (A), and a low T/A ratio. Chromosomal analysis showed 46,XY karyotype. …”
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Luteinizing hormone-induced Akt phosphorylation and androgen production are modulated by MAP Kinase in bovine theca cells by Fukuda Shin, Orisaka Makoto, Tajima Kimihisa, Hattori Katsushige, Kotsuji Fumikazu

“…LH significantly increased androstenedione production in bovine theca cells, whereas addition of the wortmannin and LY294002 significantly decreased LH-induced androstenedione production. …”
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Androgen generation in adipose tissue in women with simple obesity--a site-specific role for 17beta-hydroxysteroid dehydrogenase type 5. by Quinkler, M, Sinha, B, Tomlinson, J, Bujalska, I, Stewart, P, Arlt, W

“…Functional activity of 17beta-HSD5 also significantly increased with differentiation, revealing a net gain in androgen activation (androstenedione to testosterone) in subcutaneous cultures, contrasting with a net gain in androgen inactivation (testosterone to androstenedione) in omental cultures. …”

Steroid profiling using liquid chromatography mass spectrometry during adrenal vein sampling in patients with primary bilateral macronodular adrenocortical hyperplasia by Ru Zhang, German Rubinstein, Sharmilee Vetrivel, Sonja Kunz, Frederick Vogel, Lucas Bouys, Jérôme Bertherat, Matthias Kroiss, Matthias Kroiss, Sinan Deniz, Andrea Osswald, Thomas Knösel, Martin Bidlingmaier, Silviu Sbiera, Martin Reincke, Anna Riester

“…ARMC5 mutation carriers (n=6) showed lower androstenedione/17-hydroxyprogesterone and higher testosterone/androstenedione (p&lt;0.05) ratios in peripheral blood, in line with lower peripheral androstenedione concentrations (p&lt;0.05).ConclusionSteroid profiling by LC-MS/MS led us to select DHEA as a candidate reference hormone for cortisol secretion. …”
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Predictive value of ovarian stroma measurement for cardiovascular risk in polycyctic ovary syndrome: a case control study by Loverro Giuseppe, De Pergola Giovanni, Di Naro Edoardo, Tartagni Massimo, Lavopa Cristina, Caringella Anna

“…Concerning hormones, insulin, LH, FSH, estradiol, androstenedione, testosterone, DHEAS, 17-hydroxy-progesterone, and SHBG were measured during the early follicular phase (days 2-5). …”
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Steroid hormone levels and bone mineral density in women over 65 years of age by Elsa Nunes, Eugenia Gallardo, Sara Morgado-Nunes, José Fonseca-Moutinho

“…No statistically significant associations were found between E2, DHEA, androstenedione and the T scores of the hip and the lumbar spine. …”
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Clinical Outcome and Hormone Profiles Before and After Laparoscopic Electroincision of the Ovaries in Women With Polycystic Ovary Syndrome by Zulfo Godinjak, Ranka Javorić

“…Serum levels of T, androstenedione, 17 OH progesterone, and beta endorphins were significantly reduced 24 hours after laparoscopic electroincision of the ovaries. …”
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Persistent organochlorine pollutants with endocrine activity and blood steroid hormone levels in middle-aged men. by Elise Emeville, Frank Giton, Arnaud Giusti, Alejandro Oliva, Jean Fiet, Jean-Pierre Thomé, Pascal Blanchet, Luc Multigner

“…PCB 153 was positively associated to androstenedione and estrone levels. No association was found for chlordecone. …”
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Impact of Gold Nanoparticles on Testosterone Metabolism in Human Liver Microsomes by Kyoungju Choi, Hyun Joo

“…Meanwhile, naked AuNP increased androstenedione production. Interindividual variation in TST metabolism occurred within single donor HLM. …”
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Dihydrotestosterone- A Potential Biomarker of Hyperandrogenaemia in Polycystic Ovary Syndrome: A Case-control Study from North India by Hemant Kumar, Ashutosh Halder, Mona Sharma, Manish Jain, Amanpreet Kaur Kalsi

“…Serum total testosterone (T), FAI, Dehydroepiandrosterone Sulphate (DHEAS), androstenedione and Dihydrotestosterone (DHT) were measured besides assessment of hirsutism using the Ferriman-Gallwey (FG) scale. …”
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Brain and circulating steroids in an electric fish: Relevance for non-breeding aggression. by Lucia Zubizarreta, Cecilia Jalabert, Ana C Silva, Kiran K Soma, Laura Quintana

“…We show that: 1) systemic steroid levels in the non-breeding season are similar in both sexes, although only males have detectable circulating 11-ketotestosterone, 2) brain steroid levels are sexually dimorphic, as females display higher levels of androstenedione, testosterone and estrone, and only males had detectable 11-ketotestosterone, 3) systemic androgens such as androstenedione and testosterone in the non-breeding season are potential precursors for neuroestrogen synthesis, and 4) estrogens, which play a key role in non-breeding aggression, are detectable in the brain (but not the plasma) in both sexes. …”
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Impact of metformin on the clinical and metabolic parameters of women with polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials by Mohammed Altigani Abdalla, Najeeb Shah, Harshal Deshmukh, Amirhossein Sahebkar, Linda Östlundh, Rami H. Al-Rifai, Stephen L. Atkin, Thozhukat Sathyapalan

“…Conclusion: In women with PCOS, metformin use has shown a positive impact in reducing body weight, BMI, total testosterone, androstenedione, 17-OHP, LDL-C, fasting blood glucose and increasing the likelihood of pregnancy in women with PCOS.…”
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