Interactions between genome-wide significant genetic variants and circulating concentrations of insulin-like growth factor 1, sex hormones, and binding proteins in relation to pros... by Tsilidis, K, Travis, R, Appleby, P, Allen, N, Lindstrom, S, Schumacher, F, Cox, D, Hsing, A, Ma, J, Severi, G, Albanes, D, Virtamo, J, Boeing, H, Bueno-de-Mesquita, H, Johansson, M, Quirós, JR, Riboli, E, Siddiq, A, Tjønneland, A, Trichopoulos, D, Tumino, R, Gaziano, J, Giovannucci, E, Hunter, D, Kraft, P

“…Using conditional logistic regression, the authors compared per-allele odds ratios for prostate cancer for 39 GWAS-identified SNPs across thirds (tertile groups) of circulating concentrations of insulin-like growth factor 1 (IGF-1), insulin-like growth factor binding protein 3 (IGFBP-3), testosterone, androstenedione, androstanediol glucuronide, estradiol, and sex hormone-binding globulin (SHBG) for 3,043 cases and 3,478 controls in the Breast and Prostate Cancer Cohort Consortium. …”

Endogenous androgens and risk of epithelial invasive ovarian cancer by tumor characteristics in the European Prospective Investigation into Cancer and Nutrition. by Ose, J, Fortner, RT, Rinaldi, S, Schock, H, Overvad, K, Tjonneland, A, Hansen, L, Dossus, L, Fournier, A, Baglietto, L, Romieu, I, Kuhn, E, Boeing, H, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Palli, D, Masala, G, Sieri, S, Tumino, R, Sacerdote, C, Mattiello, A, Ramon Quiros, J, Obón-Santacana, M, Larrañaga, N

“…We observed no association between androgens, SHBG and EOC overall. A doubling of androstenedione reduced risk of serous carcinomas by 21% (odds ratio (OR)log2 = 0.79, 95% confidence interval [CI] = [0.64-0.97]). …”

Photoperiodic Changes in Both Hypothalamus Neurotransmitters and Circulating Gonadal Steroids Metabolomic Profiles in Relation to Seasonal Reproduction in Male Quail by Yanglong Xu, Yanglong Xu, Danli Jiang, Danli Jiang, Jiaxin Liu, Jiaxin Liu, Yuting Fu, Yuting Fu, Yan Song, Yan Song, Di Fan, Di Fan, Xuefei Huang, Xuefei Huang, Sui Liufu, Sui Liufu, Jianqiu Pan, Jianqiu Pan, Hongjia Ouyang, Hongjia Ouyang, Yunbo Tian, Yunbo Tian, Xu Shen, Xu Shen, Yunmao Huang, Yunmao Huang

“…Furthermore, Serum androstenedione showed a significant increase with long light expose (P < 0.01). …”
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The Relevant Hormonal Levels and Diagnostic Features of Polycystic Ovary Syndrome in Adolescents by Elena Khashchenko, Elena Uvarova, Mikhail Vysokikh, Tatyana Ivanets, Lyubov Krechetova, Nadezhda Tarasova, Iuliia Sukhanova, Fatima Mamedova, Pavel Borovikov, Ivan Balashov, Gennady Sukhikh

“…The diagnostic accuracy of AMH, FAI, LH/FSH, T, and androstenedione levels in predicting PCOS in adolescents was established using a logistic regression model and calculating area under the receiver operator characteristic (ROC) curve (AUC). …”
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Sex Steroid Hormone Analysis in Human Tear Fluid Using a Liquid Chromatography—Mass Spectrometry Method by Alexandra Robciuc, Hanna Savolainen-Peltonen, Mikko Haanpää, Jukka A. O. Moilanen, Tomi S. Mikkola

“…Estrone, estradiol testosterone, progesterone, androstenedione, and dehydroepiandrosterone, were quantified with an HPLC coupled with a Triple Quad 5500 MS. …”
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How inversion variants can shape neural circuitry: Insights from the three-morph mating tactics of ruffs by Jasmine L. Loveland, Lina M. Giraldo-Deck, Aubrey M. Kelly

“…A gene responsible for converting testosterone to androstenedione (HSD17B2) is located inside the inverted region and is a promising candidate. …”
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Impact of Chromium Picolinate on Leydig Cell Steroidogenesis and Antioxidant Balance Using an In Vitro Insulin Resistance Model by Rúben Moreira, Ana D. Martins, Rita Ferreira, Marco G. Alves, Maria de Lourdes Pereira, Pedro F. Oliveira

“…Steroidogenesis was assessed by quantifying androstenedione through ELISA. Our results uncover the toxic effects of CrPic₃ on LCs even at low doses under IR conditions. …”
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Associations of LH and FSH with reproductive hormones depending on each stage of the menopausal transition by Takako Kawakita, Toshiyuki Yasui, Kanako Yoshida, Sumika Matsui, Takeshi Iwasa

“…Levels of LH, FSH, dehydroepiandrosterone sulfate (DHEAS), estradiol, estrone, testosterone (T), free T, androstenedione and androstenediol were measured. Results In Group A, LH showed significant positive correlations with androstenedione and estrone. …”
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A 4-hour Profile of 17-hydroxyprogesterone in Salt-wasting Congenital Adrenal Hyperplasia: Is the Serial Monitoring Strategy Worth the Effort? by Özge Besci, İbrahim Mert Erbaş, Tuncay Küme, Kübra Yüksek Acinikli, Ayhan Abacı, Ece Böber, Korcan Demir

“…Androstenedione and SHBG levels were negatively correlated in the pubertal children (rs=-0.7, p=0.04). …”
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Assessing the Toxicity of <i>Lagocephalus sceleratus</i> Pufferfish from the Southeastern Aegean Sea and the Relationship of Tetrodotoxin with Gonadal Hormones by Thekla I. Anastasiou, Eirini Kagiampaki, Gerasimos Kondylatos, Anastasios Tselepides, Panagiota Peristeraki, Manolis Mandalakis

“…Androstenedione dominated in female specimens, while GnRH was more abundant in males. …”
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Adrenal-permissive HSD3B1 genetic inheritance and risk of estrogen-driven postmenopausal breast cancer by Megan L. Kruse, Mona Patel, Jeffrey McManus, Yoon-Mi Chung, Xiuxiu Li, Wei Wei, Peter S. Bazeley, Fumihiko Nakamura, Aimalie Hardaway, Erinn Downs, Sarat Chandarlapaty, Mathew Thomas, Halle C.F. Moore, George T. Budd, W.H. Wilson Tang, Stanley L. Hazen, Aaron Bernstein, Serena Nik-Zainal, Jame Abraham, Nima Sharifi

“…The 1245A→C missense-encoding polymorphism in HSD3B1, which is common in White populations, is functionally adrenal permissive and increases synthesis of the aromatase substrate androstenedione. We hypothesized that homozygous inheritance of the adrenal-permissive HSD3B1(1245C) is associated with postmenopausal estrogen receptor–positive (ER-positive) breast cancer.METHODS A prospective study of postmenopausal ER-driven breast cancer was done for determination of HSD3B1 and circulating steroids. …”
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Acute cholinergic blockade with low dose pirenzepine reduces the insulin and glucose responses to a mixed meal in obese women with the polycystic ovary syndrome by Ismail, I.S., Premawardhana, L.D.K.E., Riad-Fahmy, D., Miell, J.P., Peters, J.R., Scanlon, M.F.

“…The late post-prandial GH surge was significantly suppressed by all three doses. However, plasma androstenedione, testosterone, IGF-I and IGFBP-1 concentrations were not significantly different when placebo was compared with pirenzepine 200 mg. …”
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Relationship between body composition, insulin resistance, and hormonal profiles in women with polycystic ovary syndrome by Haolin Zhang, Wei Wang, Jiaming Zhao, Peijie Jiao, Lin Zeng, Hua Zhang, Yue Zhao, Li Shi, Hangqi Hu, Liyan Luo, Ii Fukuzawa, Dong Li, Rong Li, Rong Li, Jie Qiao, Jie Qiao, Jie Qiao

“…LH, LH/FSH, total testosterone, and androstenedione were significantly higher in patients with PCOS than in healthy controls, regardless of WHR and BFP stratification. …”
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6-Methylideneandrost-4-ene-3,17-dione by L. C. R. Andrade, M. J. M. de Almeida, F. M. Fernandes Roleira, C. L. Varela, E. J. Tavares da Silva

“…In the title compound, C20H26O2, which is the 6-methylene derivative of androstenedione and a synthetic percursor of exemestane, the steroid A ring approximates to a sofa (or envelope) conformation, with the methylene group adjacent to the link to the B ring lying out of the plane of the other atoms. …”
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Testosterone Deficiency and Nutritional Parameters as Predictors of All-Cause Mortality among Male Dialysis Patients by Ksymena Leśniak, Aleksandra Rymarz, Maria Sobol, Jolanta Dymus, Agnieszka Woźniak-Kosek, Stanisław Niemczyk

“…Total testosterone (TT), dehydroepiandrosterone sulphate (DHEA-S), androstenedione, luteinizing hormone (LH), prolactin (PRL), and biochemical parameters were measured; Free testosterone (FT) was calculated. …”
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Long-term efficacy of metformin in overweight-obese PCOS: longitudinal follow-up of retrospective cohort by Mojca Jensterle, Nika Aleksandra Kravos, Simona Ferjan, Katja Goricar, Vita Dolzan, Andrej Janez

“…The total testosterone and androstenedione decreased to 15.4 ± 47.9% and 11.3 ± 46.4% within first year, with further decrease in tot al testosterone and androstenedione to 37.8 ± 61.8 and 24.8 ± 40.5% at the fifth yea r of the follow-up. …”
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High androgen concentrations in follicular fluid of polycystic ovary syndrome women by Alice Bongrani, Ingrid Plotton, Namya Mellouk, Christelle Ramé, Fabrice Guerif, Pascal Froment, Joëlle Dupont

“…Results In PCOS patients, the intrafollicular concentrations of the androgens synthesised by ovarian theca cells, i.e., 17OH-pregnenolone, dehydroepiandrosterone, Δ4-androstenedione and testosterone, were significantly higher than those of the androgens of adrenal origin, and positively correlated with the main PCOS clinical and biological features, as well as with the adipokines mostly expressed in the follicular fluid of PCOS patients, i.e. resistin, omentin, chemerin and apelin. …”
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The association between newborn cord blood steroids and ambient prenatal exposure to air pollution: findings from the ENVIRONAGE birth cohort by Michelle Plusquin, Congrong Wang, Charlotte Cosemans, Harry A. Roels, Maartje Vangeneugden, Bruno Lapauw, Tom Fiers, Guy T’Sjoen, Tim S. Nawrot

“…This study included 397 newborns born between the years 2010 and 2015 from the ENVIRONAGE cohort in Belgium of whom six cord blood steroid levels were measured: 17α-hydroxypregnenolone, 17α-hydroxyprogesterone, dehydroepiandrosterone, pregnenolone, androstenedione, and testosterone. Maternal ambient exposure to PM2.5 (particles with aerodynamic diameter ≤ 2.5 μm), NO2, and black carbon (BC) were estimated daily during the entire pregnancy using a high-resolution spatiotemporal model. …”
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Creating an Artificial 3-Dimensional Ovarian Follicle Culture System Using a Microfluidic System by Mae W. Healy, Shelley N. Dolitsky, Maria Villancio-Wolter, Meera Raghavan, Alexandra R. Tillman, Nicole Y. Morgan, Alan H. DeCherney, Solji Park, Erin F. Wolff

“…Somatic cell viability tests and hormonal assessments (estradiol, progesterone, and androstenedione) were performed on days 1, 6, 13, 20, and 27. …”
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Serum cortisol and 17-hydroxyprogesterone interrelation in classic 21-hydroxylase deficiency: is current replacement therapy satisfactory? by Charmandari, E, Matthews, D, Johnston, A, Brook, C, Hindmarsh, P

“…Blood investigations performed as part of monitoring of congenital adrenal hyperplasia patients should include androstenedione and 17-hydroxyprogesterone concentrations determined in the morning before the administration of hydrocortisone. …”