Ovarian morphology is a marker of heritable biochemical traits in sisters with polycystic ovaries. by Franks, S, Webber, L, Goh, M, Valentine, A, White, D, Conway, G, Wiltshire, S, McCarthy, M

“…RESULTS: Although affected sisters had fewer symptoms than probands (30% had no symptoms of PCOS), serum testosterone, androstenedione, LH, and fasting insulin and insulin sensitivity were similar in the two groups with polycystic ovaries but significantly different from those in unaffected sisters or controls. …”

Impaired Prolactin-Lowering Effects of Metformin in Women with Polycystic Ovary Syndrome by Robert Krysiak, Karolina Kowalcze, Witold Szkróbka, Bogusław Okopień

“…At baseline, both groups differed in LH, LH/FSH ratio, testosterone, FAI, DHEA-S, androstenedione and estradiol. Although metformin improved insulin sensitivity and increased SHBG in both study groups, these effects were more pronounced in control subjects than in women with PCOS. …”
Get full text

Adrenocortical steroid response to ACTH in different phenotypes of non-obese polycystic ovary syndrome by Cinar Nese, Harmanci Ayla, Aksoy Duygu, Aydin Kadriye, Yildiz Bulent

“…Total testosterone (T), SHBG and DHEAS levels at basal and serum 17-hydroxprogesterone (17-OHP), androstenedione (A4), DHEA and cortisol levels after ACTH stimulation were measured.…”
Get full text

The Potential for Ketogenic Diets to Control Glucotoxicity, Hyperinsulinemia, and Insulin Resistance to Improve Fertility in Women with Polycystic Ovary Syndrome by Leticia Ramírez-Martínez, Cecilia Palafox-Gómez, Leonardo M. Porchia, Esther López-Bayghen

“…However, nutritional interventions, specifically ketogenic diets, were shown to lower serum cholesterol, triglycerides, androstenedione, testosterone and attenuate IR. At the same time, high-density lipoprotein increased, promoting menstrual regularity and, eventually, providing a better environment for in vitro fertilization. …”
Get full text

The Impact of Maternal Hypothyroidism during Pregnancy on Minipuberty in Boys by Karolina Kowalcze, Robert Krysiak, Anna Obuchowicz

“…Salivary levels of testosterone, androstenedione, dehydroepiandrosterone sulfate, estradiol, progesterone, and 17-hydroxyprogesterone, as well as urine concentrations of FSH and LH, were assessed once a month in the first 6 months of life, and once every two months between months 6 and 12. …”
Get full text

UPLC–TOF–MS Method for Simultaneous Quantification of Steroid Hormones in Tissue Homogenates of Zebrafish with Solid-Phase Extraction by Yaxi Li, Zhi Yan, Xiaodong Li, Xiuli Yin, Ke Li

“…A UPLC–TOF–MS method was developed to provide a reproducible, sensitive, and efficient assay to determine the concentration of steroid hormones, including cortisol, testosterone, androstenedione, 11-deoxycortisol, 11-deoxycorticosterone, and 17-hydroxyprogesterone in whole-body homogenates of each zebrafish. …”
Get full text

Evaluation of Pro/Antioxidant Imbalance in Blood of Women with Polycystic Ovary Syndrome Based on Determination of Oxidized Low-Density Lipoproteins and Ferric Reducing Ability of... by Justyna Niepsuj, Grzegorz Franik, Paweł Madej, Agnieszka Piwowar, Anna Bizoń

“…Furthermore, the value of FRAP was inversely correlated with luteinizing hormone (LH), follicle-stimulating hormone (FSH) and androstenedione, whereas it was positively correlated with the LH/FSH ratio. …”
Get full text

Emerging concepts on Leydig cell development in fetal and adult testis by Indrashis Bhattacharya, Souvik Dey

“…These cells produce androstenedione (precursor of T, due to lack of HSD17β3 enzyme) and play critical a role in initial virilization and patterning of the male external genitalia. …”
Get full text

Assessment of THADA gene polymorphisms in a sample of Colombian women with polycystic ovary syndrome: A pilot study by Maria Camila Alarcón-Granados, Harold Moreno-Ortíz, Clara Inés Esteban-Pérez, Atilio Ferrebuz-Cardozo, Gloria Eugenia Camargo-Villalba, Maribel Forero-Castro

“…The CC + AA of rs12468394 genotype also was associated with an increase of androstenedione levels. THADA gene SNPs were not associated with PCOS risk. …”
Get full text

Role of Statin Drugs for Polycystic Ovary Syndrome by Lisa Cassidy Vu, Edwina Joe, Julienne K Kirk

“…The majority (10 of 12) of the trials show that statins reduce testosterone levels or other androgen hormones (DHEA-S and androstenedione), half of the trials evaluating LH/FSH ratio show an improvement, and all had positive effects on lipid profiles. …”
Get full text

Aberrant HPO Axis Alterations and Autoimmune Abnormalities in PCOS Patients with DOR: A Retrospective Analysis by Xueying Geng, Zhihong He, Zhouzhou Bao, Wen Di, Zhuowei Gu

“…The FSH levels were positively correlated with LH, testosterone (T), and androstenedione (AD) levels, but had no association with glucolipid metabolism after adjusting for body mass index (BMI). …”
Get full text

Study of Molecular Docking and Prediction of Toxicity of Morin Analogues as Anti-Cancer Agents and Aromatase Inhibitors by Tooba Abdizadeh

“…Aromatase is a key enzyme involved in the development of estrogen receptor-positive breast cancer, which catalyzes the final stage of estrogen biosynthesis from the conversion of androstenedione and testosterone, and can be a promising target in the treatment of hormone-dependent breast cancer. …”
Get full text

Artificial induction of gonadal maturation and ovulation in the Japanese eel (Anguilla japonica T. et S.) by HAO-RAN LIN, XIE-GANG, LI-HONG ZHANG, XIAO-DONG WANG, LIAN-XI CHEN

“…After serial injections of CPE, serum gonadotropin (GtH) levels increased significantly, indicating that the exogeneous GtH stimulated gonadal development and maturation in the Japanese eel. 8 implantations of 17 α-methyltestosterone (MT) or androstenedione (ADSD) (50 µg / g body weight / 15 days) stimulated ovarian maturation in female eel, GSI increasing significantly to 38-49 %. 4 implantations of MT or ADSD (50 µg / g body weight / 15 days) induced spermatogenesis and spermiation inthemale eel, GSI increasing to 2.1-3.5 %. …”
Get full text

The Comparative Effects of Myo-Inositol and Metformin Therapy on the Clinical and Biochemical Parameters of Women of Normal Weight Suffering from Polycystic Ovary Syndrome by Aleksandra Gudović, Zoran Bukumirić, Milos Milincic, Miljan Pupovac, Mladen Andjić, Katarina Ivanovic, Svetlana Spremović-Rađenović

“…A statistically significant decrease in androgenic hormones (testosterone, SHBG, free androgen index—FAI, androstenedione) was recorded in both groups and did not differ between the groups. …”
Get full text

A systematic review of hormone levels, biomarkers of cellular injury and oxidative stress in multi-stressor military field training exercises by Filipe Brasil e Silva, Mario Vaisman, Thalita Ponce, Thiago Ramos de Barros, Camila Brasil e Silva, Verônica Pinto Salerno, Míriam Raquel Meira Mainenti

“…Significant reductions were reported in thyroid hormones, T3, T4, and anabolic hormones such as testosterone, insulin and androstenedione. An exception for GH was found, which increased throughout FTX. …”
Get full text

Genetic variation reveals the influence of steroid hormones on the risk of retinal neurodegenerative diseases by Kangcheng Liu, Huimin Fan, Hanying Hu, Yanhua Cheng, Jingying Liu, Zhipeng You

“…In this study, genetic variations of aldosterone (Aldo), androstenedione (A4), progesterone (P4), hydroxyprogesterone (17-OHP), and testosterone/17β-estradiol (T/E2) were obtained from genome-wide association studies as instrumental variables. …”
Get full text

Placental Aromatase Is Deficient in Placental Ischemia and Preeclampsia. by Alejandra Perez-Sepulveda, Lara J Monteiro, Aneta Dobierzewska, Pedro P España-Perrot, Pía Venegas-Araneda, Alejandra M Guzmán-Rojas, María I González, Macarena Palominos-Rivera, Carlos E Irarrazabal, Horacio Figueroa-Diesel, Manuel Varas-Godoy, Sebastián E Illanes

“…Similarly, the circulating concentrations of 17-β-estradiol/testosterone and estrone/androstenedione were reduced in preeclamptic patients vs. controls. …”
Get full text

An epigenome-wide analysis of sex hormone levels and DNA methylation in male blood samples by Justin Harbs, Sabina Rinaldi, Pekka Keski-Rahkonen, Xijia Liu, Richard Palmqvist, Bethany Van Guelpen, Sophia Harlid

“…Sex hormone (oestradiol, oestrone, testosterone, androstenedione, dehydroepiandrosterone, and progesterone) and SHBG concentrations were measured in plasma using a high-performance liquid chromatography tandem mass spectrometry (LC/MS-MS) method and an enzyme-linked immunoassay, respectively. …”
Get full text

Aromatisation of steroids in the bivalve Mytilus trossulus by Anna Hallmann, Lucyna Konieczna, Justyna Swiezak, Ryszard Milczarek, Katarzyna Smolarz

“…Further in vivo studies using 13C-labeled steroids at 8 °C temperature window confirmed that bivalves are able to uptake testosterone and androstenedione from the ambient environment and metabolise them to estrone and 17β-estradiol thus confirming endogenous estrogen’ synthesis.…”
Get full text

Physical activity, sex steroid, and growth factor concentrations in pre- and post-menopausal women: A cross-sectional study within the EPIC cohort by Rinaldi, S, Kaaks, R, Friedenreich, C, Key, T, Travis, R, Biessy, C, Slimani, N, Overvad, K, Østergaard, J, Tjønneland, A, Olsen, A, Mesrine, S, Fournier, A, Dossus, L, Lukanova, A, Johnson, T, Boeing, H, Vigl, M, Trichopoulou, A, Benetou, V, Trichopoulos, D, Masala, G, Krogh, V, Tumino, R, Ricceri, F

“…Results: In pre-menopausal women, active women had 19 % significantly lower concentrations of androstenedione, 14 % lower testosterone, and 20 % lower free testosterone than inactive women, while no differences were observed for estrogens, progesterone, SHBG, and growth factors. …”