Original insights on thrombospondin-1-related antireceptor strategies in cancer. by Albin eJEANNE, Albin eJEANNE, Albin eJEANNE, Christophe eSCHNEIDER, Christophe eSCHNEIDER, Laurent eMARTINY, Laurent eMARTINY, Stéphane eDedieu, Stéphane eDedieu

“…While mainly considered as an endogenous angiogenesis inhibitor, TSP-1 exhibits multifaceted functionalities in a tumor context depending both on TSP-1 concentration as well as differential receptor expression by cancer cells and on tumor-associated stromal cells. …”
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Upregulation of RASSF1A in Colon Cancer by Suppression of Angiogenesis Signaling and Akt Activation by Thomas G. Blanchard, Rena Lapidus, Vivekjyoti Banerjee, Andrea C. Bafford, Steven J. Czinn, Hafiz Ahmed, Aditi Banerjee

“…This was corroborated by protein analysis demonstrating significant reductions in angiogenesis signaling pathway molecules VEGF165, FOXM1, and pAkt, but significant elevation of the endogenous angiogenesis inhibitor Tsp-2. Treatment of cells with exogenous VEGF prevented the suppression of angiogenesis signaling by AGP, resulting in sustained expression of pAkt, an upstream down-regulator of RASSF1A. …”
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Intravitreal Ranibizumab for Treatment of Posttraumatic Choroidal Neovascularization: a Case Report by A. N. Kulikov, A. Yu. Kuznetsova, N. A. Nekrash, D. S. Maltsev

“…An analysis of the case of applying a course of fibrinolytic therapy and one intravitreal injection of an angiogenesis inhibitor in a patient with traumatic rupture of the choroid complicated by choroidal neovascularization (CNV) is presented. …”
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Sorafenib and 2,3,5-triiodobenzoic acid-loaded imageable microspheres for transarterial embolization of a liver tumor by Jin Woo Choi, Ju-Hwan Park, Hye Rim Cho, Jin Wook Chung, Dae-Duk Kim, Hyo-Cheol Kim, Hyun-Jong Cho

“…Abstract Sorafenib (SOF; an angiogenesis inhibitor) and 2,3,5-triiodobenzoic acid (TIBA; a contrast agent for computed tomography imaging)-loaded poly(lactic-co-glycolic acid) (PLGA) microspheres (MSs) were fabricated. …”
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The Secreted Protein C1QL1 and Its Receptor BAI3 Control the Synaptic Connectivity of Excitatory Inputs Converging on Cerebellar Purkinje Cells by Séverine M. Sigoillot, Keerthana Iyer, Francesca Binda, Inés González-Calvo, Maëva Talleur, Guilan Vodjdani, Philippe Isope, Fekrije Selimi

“…Here, we show that the signaling pathway formed by the secreted complement C1Q-related protein C1QL1 and its receptor, the adhesion-GPCR brain angiogenesis inhibitor 3 (BAI3), controls the stereotyped pattern of connectivity established by excitatory afferents on cerebellar Purkinje cells. …”
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Citicoline affects serum angiostatin and neurospecific protein levels in patients with atrial fibrillation and ischemic stroke by A. A. Tykhomyrov, Yu. S. Kushnir, V. S. Nedzvetsky, T. V. Grinenko, O. V. Kuryata

“…The present study was undertaken to examine whether post-insult treatment with cytidine diphosphate-choline (CDP-choline, or citicoline) affects serum levels of the angiogenesis inhibitor angiostatin and neurospecific proteins as markers of brain damage in patients with cerebral ischemia associated with atrial fibrillation. …”
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VASCULAR-1 and VASCULAR-2 as a New Potential Angiogenesis and Endothelial Dysfunction Markers in Peripheral Arterial Disease by Radosław Wieczór MD, PhD, Danuta Rość MD, PhD, Anna Maria Wieczór MSc, Arleta Kulwas MD, PhD

“…The quotient of concentrations concerning the key proangiogenic factor, that is, the vascular endothelial growth factor (VEGF-A) and the angiogenesis inhibitor, namely, its soluble receptors (sVEGFR-1 or sVEGFR-2), seems to reflect increased hypoxia and intensity of compensation angiogenesis. …”
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In Vitro and In Vivo Antiangiogenic Activity of Caged Polyprenylated Xanthones Isolated from Garcinia hanburyi Hook. f. by Jianhong Yang, Shichao He, Shucai Li, Ronghong Zhang, Aihua Peng, Lijuan Chen

“…Taken together, these findings strongly suggest that xanthone 7 might be a novel angiogenesis inhibitor.…”
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Synthesis, anti-angiogenic activity and prediction toxicity of (E)-3-(3-methoxyphenyl) propenoic acid by Juni Ekowati, Kholis Amalia Nofianti, Maya Nurwartanti Yunita, Iwan Sahrial Hamid, Fitria Dwiningrum, Darwin Ryan Ramadhan, Ghinalya Chalbi Ananda

“…Conclusion: (E)-3-(3-methoxyphenyl)propenoic acid can be obtained through Knovenagel reaction using microwave irradiation and it has potential as anti-angiogenesis inhibitor with low toxicity. …”
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Capillary growth and regression in skeletal muscle by Hidemi Fujino, Hiroyo Kondo, Fumiko Nagatomo, Akihiko Ishihara

“…Thrombospondin-1 (TSP-1) was shown to be an angiogenesis inhibitor. A balance between pro- and anti-angiogenic factors tightly modulates capillary regression or growth. …”
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The Utilization of Bevacizumab in Patients with Advanced Ovarian Cancer: A Systematic Review of the Mechanisms and Effects by Chih-Lin Mao, Kok-Min Seow, Kuo-Hu Chen

“…Currently, many studies have put emphases on anti-angiogenetic medication, such as bevacizumab, the first and most investigated angiogenesis inhibitor that can exert anti-neoplastic effects. …”
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Thrombomodulin is upregulated in the kidneys of women with pre-eclampsia by Cleo C. L. van Aanhold, Manon Bos, Katrina M. Mirabito Colafella, Marie-Louise P. van der Hoorn, Ron Wolterbeek, Jan A. Bruijn, Kitty W. M. Bloemenkamp, Anton H. van den Meiracker, A. H. Jan Danser, Hans J. Baelde

“…We set out to investigate whether thrombomodulin expression is decreased in the kidneys of women with pre-eclampsia and rats exposed to an angiogenesis inhibitor. Thrombomodulin expression was examined using immunohistochemistry and qPCR in renal autopsy tissues collected from 11 pre-eclamptic women, 22 pregnant controls and 11 hypertensive non-pregnant women. …”
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Durable efficacy of anlotinib in a patient with advanced thymic squamous cell carcinoma after multiline chemotherapy and apatinib: A case report and literature review by Ran Zuo, Cuicui Zhang, Li Lin, Zhaoting Meng, Yajie Wang, Yudong Su, Mihray Abudurazik, Ye Du, Peng Chen

“…Herein we report a case of an advanced thymic squamous cell carcinoma patient harboring EGFR exon 20 insertion who had previously received multiline therapy, including chemotherapy, radiotherapy as well as antiangiogenic therapy. Also as an angiogenesis inhibitor, anotinib had controlled his mediastinal mass after failure of the apatinib treatment. …”
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Functions of Thrombospondin-1 in the Tumor Microenvironment by Sukhbir Kaur, Steven M. Bronson, Dipasmita Pal-Nath, Thomas W. Miller, David R. Soto-Pantoja, David D. Roberts

“…The identification of thrombospondin-1 as an angiogenesis inhibitor in 1990 prompted interest in its role in cancer biology and potential as a therapeutic target. …”
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Effects of Genistein on Common Kidney Diseases by Qianwen Peng, Yuanyuan Li, Jia Shang, Haitao Huang, Yiming Zhang, Yueming Ding, Yipei Liang, Zhenxing Xie, Chaoran Chen

“…Genistein is also an angiogenesis inhibitor and an antioxidant. Genistein has effects on kidney cells, some of the kidney’s physiological functions, and a variety of kidney diseases. …”
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Sorafenib-Loaded Nanoparticles Based on Biodegradable Dendritic Polymers for Enhanced Therapy of Hepatocellular Carcinoma by Li Z, Ye L, Liu J, Lian D, Li X

“…Zihuang Li,1 Ling Ye,2 Jingwen Liu,1 Daizheng Lian,1 Xianming Li1 1Department of Radiation Oncology, The Second Clinical Medical College of Jinan University, Shenzhen Municipal People’s Hospital, Shenzhen 518020, People’s Republic of China; 2Department of Oncology, The First Affiliated Hospital of Jinan University, Guangzhou 510632, People’s Republic of ChinaCorrespondence: Zihuang Li; Xianming LiDepartment of Radiation Oncology, The Second Clinical Medical College of Jinan University, Shenzhen Municipal People’s Hospital, Shenzhen 518020, People’s Republic of ChinaTel +86 755 22942428Email li.zihuang@szhospital.com; li.xianming@szhospital.comPurpose: In spite of its enhanced efficacy and reduced side effects in clinical hepatocellular carcinoma (HCC) therapy, the therapeutic efficacy of antitumor angiogenesis inhibitor sorafenib (SFB) is still restricted due to short in vivo half-life and drug resistance. …”
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Tyrosine kinase inhibitor SU6668 represses chondrosarcoma growth via antiangiogenesis <it>in vivo</it> by Huber Peter E, Ewerbeck Volker, Gebhard Martha-Maria, Bertl Elisabeth, Abdollahi Amir, Klenke Frank M, Sckell Axel

“…The experimental data obtained provide rationale to further develop the strategy of the use of the angiogenesis inhibitor SU6668 in the treatment of chondrosarcomas in addition to established therapies such as surgery.…”
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EZH2 Methyltransferase Regulates Neuroinflammation and Neuropathic Pain by Han-Rong Weng, Kyle Taing, Lawrence Chen, Angela Penney

“…Genes suppressed by EZH2 include suppressor of cytokine signaling 3 (SOCS3), nuclear factor (erythroid-derived 2)-like-2 factor (NrF2), miR-29b-3p, miR-146a-5p, and brain-specific angiogenesis inhibitor 1 (BAI1). Pro-inflammatory mediators facilitate neuronal activation along pain-signaling pathways by sensitizing nociceptors in the periphery, as well as enhancing excitatory synaptic activities and suppressing inhibitory synaptic activities in the CNS. …”
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GTP cyclohydrolase I/BH4 pathway protects EPCs via suppressing oxidative stress and thrombospondin-1 in salt-sensitive hypertension by Xie, H, Zhou, S, Chen, D, Channon, K, Su, D, Chen, A

“…Secreted thrombospondin-1 (TSP-1; a potent angiogenesis inhibitor) from EPCs was elevated in WT DOCA-salt and hph-1 but not DOCA-salt Tg-GCH mice. …”

GTP cyclohydrolase I/BH4 pathway protects EPCs via suppressing oxidative stress and thrombospondin-1 in salt-sensitive hypertension. by Xie, H, Zhou, S, Chen, D, Channon, K, Su, D, Chen, A

“…Secreted thrombospondin-1 (TSP-1; a potent angiogenesis inhibitor) from EPCs was elevated in WT DOCA-salt and hph-1 but not DOCA-salt Tg-GCH mice. …”