Albendazole repurposing on VEGFR-2 for possible anticancer application: In-silico analysis by Nikita Maruti Gaikwad, Pravin Digambar Chaudhari, Karimunnisa Sameer Shaikh, Somdatta Yashwant Chaudhari, Rasha Mohammed Saleem, Mohammad Algahtani, Ahmed E. Altyar, Ghadeer M. Albadrani, Mohamed Kamel, Mohamed M. Abdel-Daim

“…Therefore, the current work suggests the role of Albendazole as a potent angiogenesis inhibitor as ascertained by its potential interaction with VEGFR-2. …”
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Characteristics of Somatic Status and Individual Biochemical Markers in Patients with Retinal Vein Occlusion by I. V. Zlobin, T. N. Iureva, Yu. V. Kursakova

“…Retinal vein occlusion is one of the most severe vascular lesions of the organ of vision, usually accompanied by somatic pathology.The aim of the study was to study the somatic status and individual biochemical markers in patients with retinal vein occlusion and comparison in groups opposing the effectiveness of anti-VEGF therapy.Methods. 84 patients with macular edema were examined on the background of retinal vein occlusion, who underwent intravitreal injections of an angiogenesis inhibitor for therapeutic purposes. Further, depending on the effectiveness of treatment, the patients were divided into 2 groups, in which a retrospective comparative analysis of somatic status and laboratory data was performed.Results. …”
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Simultaneous Administration of Bevacizumab with Bee-Pollen Extract-Loaded Hybrid Protein Hydrogel NPs Is a Promising Targeted Strategy against Cancer Cells by Nemany A. N. Hanafy, Eman Ali Bakr Eltonouby, Elsayed I. Salim, Magdy E. Mahfouz, Stefano Leporatti, Ezar H. Hafez

“…It was the first specifically considered angiogenesis inhibitor and it has now become the normative first-line therapy for advanced non-small-cell lung cancer (NSCLC). …”
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Mapping and targeting of C1ql1-expressing cells in the mouse by Shayan Moghimyfiroozabad, Maëla A. Paul, Séverine M. Sigoillot, Fekrije Selimi

“…This secreted protein interacts with Brain-specific Angiogenesis Inhibitor 3, BAI3/ADGRB3, and controls synapse formation and maintenance. …”
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Inhibition of Angiogenesis: A Novel Effect of Zataria Multiflora by Amir Hossein Norooznezhad, Maryam Keshavarz, Fatemeh Norooznezhad, Kamran Mansouri

“…Z.multiflora could be introduced as a significant angiogenesis inhibitor for angiogenesis-dependent diseases in further complementary studies.…”
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PEDF inhibits LPS-induced acute lung injury in rats and promotes lung epithelial cell survival by upregulating PPAR-γ by Lei Xu, Yifei Chen, Shoujie Feng, Zeyan Liu, Ying Ye, Ranran Zhou, Lijun Liu

“…Pigment epithelium-derived factor (PEDF) is an angiogenesis inhibitor and a potential anti-inflammatory factor. …”
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Intravitreal Ranibizumab for Treatment of Posttraumatic Choroidal Neovascularization: a Case Report by A. N. Kulikov, A. Yu. Kuznetsova, N. A. Nekrash, D. S. Maltsev

“…An analysis of the case of applying a course of fibrinolytic therapy and one intravitreal injection of an angiogenesis inhibitor in a patient with traumatic rupture of the choroid complicated by choroidal neovascularization (CNV) is presented. …”
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Citicoline affects serum angiostatin and neurospecific protein levels in patients with atrial fibrillation and ischemic stroke by A. A. Tykhomyrov, Yu. S. Kushnir, V. S. Nedzvetsky, T. V. Grinenko, O. V. Kuryata

“…The present study was undertaken to examine whether post-insult treatment with cytidine diphosphate-choline (CDP-choline, or citicoline) affects serum levels of the angiogenesis inhibitor angiostatin and neurospecific proteins as markers of brain damage in patients with cerebral ischemia associated with atrial fibrillation. …”
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Synthesis, anti-angiogenic activity and prediction toxicity of (E)-3-(3-methoxyphenyl) propenoic acid by Juni Ekowati, Kholis Amalia Nofianti, Maya Nurwartanti Yunita, Iwan Sahrial Hamid, Fitria Dwiningrum, Darwin Ryan Ramadhan, Ghinalya Chalbi Ananda

“…Conclusion: (E)-3-(3-methoxyphenyl)propenoic acid can be obtained through Knovenagel reaction using microwave irradiation and it has potential as anti-angiogenesis inhibitor with low toxicity. …”
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The Utilization of Bevacizumab in Patients with Advanced Ovarian Cancer: A Systematic Review of the Mechanisms and Effects by Chih-Lin Mao, Kok-Min Seow, Kuo-Hu Chen

“…Currently, many studies have put emphases on anti-angiogenetic medication, such as bevacizumab, the first and most investigated angiogenesis inhibitor that can exert anti-neoplastic effects. …”
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Functions of Thrombospondin-1 in the Tumor Microenvironment by Sukhbir Kaur, Steven M. Bronson, Dipasmita Pal-Nath, Thomas W. Miller, David R. Soto-Pantoja, David D. Roberts

“…The identification of thrombospondin-1 as an angiogenesis inhibitor in 1990 prompted interest in its role in cancer biology and potential as a therapeutic target. …”
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Effects of Genistein on Common Kidney Diseases by Qianwen Peng, Yuanyuan Li, Jia Shang, Haitao Huang, Yiming Zhang, Yueming Ding, Yipei Liang, Zhenxing Xie, Chaoran Chen

“…Genistein is also an angiogenesis inhibitor and an antioxidant. Genistein has effects on kidney cells, some of the kidney’s physiological functions, and a variety of kidney diseases. …”
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EZH2 Methyltransferase Regulates Neuroinflammation and Neuropathic Pain by Han-Rong Weng, Kyle Taing, Lawrence Chen, Angela Penney

“…Genes suppressed by EZH2 include suppressor of cytokine signaling 3 (SOCS3), nuclear factor (erythroid-derived 2)-like-2 factor (NrF2), miR-29b-3p, miR-146a-5p, and brain-specific angiogenesis inhibitor 1 (BAI1). Pro-inflammatory mediators facilitate neuronal activation along pain-signaling pathways by sensitizing nociceptors in the periphery, as well as enhancing excitatory synaptic activities and suppressing inhibitory synaptic activities in the CNS. …”
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GTP cyclohydrolase I/BH4 pathway protects EPCs via suppressing oxidative stress and thrombospondin-1 in salt-sensitive hypertension by Xie, H, Zhou, S, Chen, D, Channon, K, Su, D, Chen, A

“…Secreted thrombospondin-1 (TSP-1; a potent angiogenesis inhibitor) from EPCs was elevated in WT DOCA-salt and hph-1 but not DOCA-salt Tg-GCH mice. …”

GTP cyclohydrolase I/BH4 pathway protects EPCs via suppressing oxidative stress and thrombospondin-1 in salt-sensitive hypertension. by Xie, H, Zhou, S, Chen, D, Channon, K, Su, D, Chen, A

“…Secreted thrombospondin-1 (TSP-1; a potent angiogenesis inhibitor) from EPCs was elevated in WT DOCA-salt and hph-1 but not DOCA-salt Tg-GCH mice. …”

Randomized, placebo-controlled, phase III study of first-line oxaliplatin-based chemotherapy plus PTK787/ZK 222584, an oral vascular endothelial growth factor receptor inhibitor, i... by Hecht, JR, Trarbach, T, Hainsworth, J, Major, P, Jäger, E, Wolff, R, Lloyd-Salvant, K, Bodoky, G, Pendergrass, K, Berg, W, Chen, B, Jalava, T, Meinhardt, G, Laurent, D, Lebwohl, D, Kerr, D

“… PURPOSE: PTK787/ZK 222584 (PTK/ZK; vatalanib), an orally active, multitargeted angiogenesis inhibitor, has shown tolerability and promising activity in early-phase studies, which led to a phase III trial in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4). …”

Serum angiostatin levels in diabetic patients with heart failure taking oral antidiabetic therapy or basal insulin and its clinical significance by Birol Yildiz, Ismail Erturk, Galip Buyukturan, Bilgin Bahadir Basgoz, Ramazan Acar, Kenan Saglam

“…After the discovery of a natural angiogenesis inhibitor, angiostatin in the ethiopathogenesis of retinopathy and nephropathy, which are frequent complications of diabetes, several successful clinical trials have been made. …”
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Combining an adenovirus encoding human endostatin and PD‐1 blockade enhanced antitumor immune activity by Yaomei Tian, Qieyue Hu, Rui Zhang, Bailing Zhou, Daoyuan Xie, Yuanda Wang, Li Yang

“…Endostatin, an angiogenesis inhibitor, has been widely used as an antiangiogenic therapy for cancer. …”
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Deglycosylation Increases the Aggregation and Angiogenic Properties of Mutant Tissue Inhibitor of Metalloproteinase 3 Protein: Implications for Sorsby Fundus Dystrophy by Jian Hua Qi, Bela Anand-Apte

“…We have previously reported that wild-type TIMP3 is an endogenous angiogenesis inhibitor that inhibits Vascular Endothelial Growth Factor (VEGF)-mediated signaling in endothelial cells. …”
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Modeling the atrophy of retinal pigment epithelium by N. V. Neroeva, V. V. Neroev, P. A. Ilyukhin, A. G. Karmokova, O. A. Losanova, M. V. Ryabina, A. M. Maybogin

“…Histological analysis revealed a more aggressive action of 0.9% sodium chloride solution on the retina and the choroid as compared with the model obtained with a similarly delivered subretinal angiogenesis inhibitor. Conclusion. The obtained experimental models may be useful in investigating various types of RPE atrophy, including those arising from the use of angiogenesis inhibitors.…”
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