Effects of Combined Admistration of Imatinib and Sorafenib in a Murine Model of Liver Fibrosis by Antonio Pesce, Rosella Ciurleo, Alessia Bramanti, Eliana Concetta Armeli Iapichino, Maria Cristina Petralia, Gaetano Giuseppe Magro, Paolo Fagone, Placido Bramanti, Ferdinando Nicoletti, Katia Mangano

“…For this purpose, we have studied the effects of the PDGF inhibitor imatinib and the angiogenesis inhibitor sorafenib, administered alone or in combination, in reducing the progression of the fibrogenetic process in a pre-clinical model of liver damage induced in mice by repeated administration of Concanavalin A (ConA), resembling long-tern autoimmune hepatitis. …”
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Preclinical anti‐angiogenic and anti‐cancer activities of BAY1143269 in glioblastoma via targeting oncogenic protein expression by Weifeng Wan, Xin Zhang, Changren Huang, Ligang Chen, Xiaobo Yang, Kunyang Bao, Tangming Peng

“…We identified BAY1143269 as an angiogenesis inhibitor, by in vitro and in vivo glioblastoma angiogenesis models. …”
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Impact of DICER1 and DROSHA on the Angiogenic Capacity of Human Endothelial Cells by Heike Braun, Michael Hauke, Anne Ripperger, Christian Ihling, Matthew Fuszard, Robert Eckenstaler, Ralf A. Benndorf

“…Consistent with these observations, global proteomic analyses showed that knockdown of DICER1 or DROSHA only moderately altered HUVEC protein expression profiles but additively reduced, for example, expression of the angiogenesis inhibitor thrombospondin-1. In conclusion, global reduction of miRNA biogenesis by knockdown of DICER1 or DROSHA does not inhibit the angiogenic capacity of HUVEC. …”
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A retrospective study on the efficacy and safety of Endostar with chemotherapy in EGFR-TKI-resistant NSCLC by Bing Han, Yanrong Kang, Haiji Wang, Jian Wang, Rong Shen, Shuai Liu, Lu Lu, Zhigang Sun, Nan Zhang

“…Abstract Background Endostar is a strong angiogenesis inhibitor that is effective in treating non-small cell lung cancer (NSCLC), but the effect of Endostar in the treatment of patients with EGFR-TKI-resistant NSCLC remains unclear. …”
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A randomized two arm phase III study in patients post radical resection of liver metastases of colorectal cancer to investigate bevacizumab in combination with capecitabine plus ox... by Schouten Sander B, van der Sijp Joost RM, Tollenaar Rob AEM, Verheul Henk M, Dalesio Otilia, Bergman Andre M, Voest Emile E, Snoeren Nikol, Rinkes Inne, van Hillegersberg R

“…This study aims to achieve an improved disease free survival for patients after resection or resection combined with RFA of colorectal liver metastases by adding the angiogenesis inhibitor bevacizumab to an adjuvant regimen of CAPOX.…”
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AFLIBERCEPT IN TREATMENT OF RESISTANT POLYPOID CHOROIDAL VASCULOPATHY: SHORT-TERM RESULTS by E. K. Pedanova, A. V. Doga, A. M. Mayorova, I. M. Gorshkov, A. A. Voskresenskaya

“…In its turn, the angiogenesis inhibitor Aflibercept with a relatively greater affinity for VEGF-A molecules had already demonstrated its efficacy in previously untreated patients with PCV.Purpose. …”
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Development of an invasion score based on metastasis-related pathway activity profiles for identifying invasive molecular subtypes of lung adenocarcinoma by Tao Han, Yafeng Liu, Jiawei Zhou, Jianqiang Guo, Yingru Xing, Jun Xie, Ying Bai, Jing Wu, Dong Hu

“…In addition, CMap showed that purvalanol-a, angiogenesis-inhibitor, and masitinib have potential therapeutic effects in the high IRGS group. …”
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BAI1 localizes AMPA receptors at the cochlear afferent post-synaptic density and is essential for hearing by Adam J. Carlton, Jing-Yi Jeng, Fiorella C. Grandi, Francesca De Faveri, Ana E. Amariutei, Lara De Tomasi, Andrew O’Connor, Stuart L. Johnson, David N. Furness, Steve D.M. Brown, Federico Ceriani, Michael R. Bowl, Mirna Mustapha, Walter Marcotti

“…Here, we demonstrate that brain-specific angiogenesis inhibitor 1 (BAI1) is required for the clustering of AMPA receptors GluR2–4 (glutamate receptors 2–4) at the PSD. …”
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Comparison of the Efficacy and Safety of Transarterial Chemoembolization with or without Lenvatinib for Unresectable Hepatocellular Carcinoma: A Retrospective Propensity Score&ndas... by Chen YX, Zhang JX, Zhou CG, Liu J, Liu S, Shi HB, Zu QQ

“…Yu-Xing Chen,1,* Jin-Xing Zhang,1,* Chun-Gao Zhou,1 Jin Liu,2 Sheng Liu,1 Hai-Bin Shi,1 Qing-Quan Zu1 1Department of Interventional Radiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, People’s Republic of China; 2Department of Clinical Medicine Research Institution, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qing-Quan Zu, Department of Interventional Radiology, The First Affiliated Hospital with Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, 210029, People’s Republic of China, Tel +86-25-68306316 ; +86-13913807470, Fax +86-25-83724440, Email zuqingquan@njmu.edu.cnBackground: Combination of angiogenesis inhibitor may achieve better therapeutic synergistic efficacy, considering of tumor hypoxia and promoted angiogenesis after transarterial chemoembolization (TACE). …”
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Comparison of the effectiveness of various protocols for the transition to aflibercept with tachyphylaxis for ranibizumab in patients with neovascular AMD by A. N. Kulikov, S. V. Sosnovsky, N. A. Gribanov, R. D. Berezin, V. V. Volkov, V. F. Danilichev

“…Expanding the range of angiogenesis inhibitors allows the creation of treatment regimens with a change in the drug to increase the effectiveness of treatment. …”
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Nano-Sized Extracellular Vesicles Secreted from GATA-4 Modified Mesenchymal Stem Cells Promote Angiogenesis by Delivering Let-7 miRNAs by Min Gong, Min Wang, Jie Xu, Bin Yu, Yi-Gang Wang, Min Liu, Muhammad Ashraf, Meifeng Xu

“…The transfer of exosomal let-7 miRs into HUVECs was recorded with an accompanied down-regulation of thrombospondin-1 (THBS1) expression, a major endogenous angiogenesis inhibitor. The loss-and-gain of function studies of let-7 miRs showed that let-7f knockdown significantly decreased EV^GATA-4-mediated vascularization inside Matrigel plugs. …”
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Canstatin represses glioma growth by inhibiting formation of VM-like structures by Ma Yuqiang, Wu Tao, Zhou Houjie, He Guilu, Li Yifei, Wang Bocheng, Guo Qiang, Chen Baodong, Li Weiping

“…Canstatin was first identified as an endogenous angiogenesis inhibitor. In the present study, the inhibitory effect of canstatin on VM formation was evaluated. …”
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Anti-Angiogenic Effect of Orally Available Pemetrexed for Metronomic Chemotherapy by Ruby Maharjan, Rudra Pangeni, Saurav Kumar Jha, Jeong Uk Choi, Kwan-Young Chang, Young Kweon Choi, Jin Woo Park, Youngro Byun

“…In addition, PMX/DCK-OP enhanced the release of an endogenous angiogenesis inhibitor, thrombospondin-1 (TSP-1), into both the blood circulation and the tumor microenvironment. …”
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Role of Immune Checkpoint Inhibitor Therapy in Advanced EGFR-Mutant Non-Small Cell Lung Cancer by Nathaniel Wiest, Umair Majeed, Karan Seegobin, Yujie Zhao, Yanyan Lou, Rami Manochakian

“…Nonetheless, combination therapies including dual-ICI blockade and ICI, chemotherapy, and angiogenesis inhibitor combinations are areas of active study with some intriguing signals in preliminary studies. …”
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The role of microRNA-325-3p as a critical player in cell death in NSCs and astrocytes by Yukyeong Lee, Yukyeong Lee, Yukyeong Lee, Seung-Won Lee, Seung-Won Lee, Dahee Jeong, Hye Jeong Lee, Kinarm Ko, Kinarm Ko

“…Furthermore, we showed that microRNA-325-3p is a regulator of apoptosis by targeting brain-specific angiogenesis inhibitor (BAI1), which is a receptor for apoptotic cells and expressed in the brain and cultured astrocytes. …”
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Endometrial Carcinoma: Immune Microenvironment and Emerging Treatments in Immuno-Oncology by Sandrine Rousset-Rouviere, Philippe Rochigneux, Anne-Sophie Chrétien, Stéphane Fattori, Laurent Gorvel, Magali Provansal, Eric Lambaudie, Daniel Olive, Renaud Sabatier

“…Similar, encouraging results were obtained for MMR proficient (MMRp) cases treated with a combination of pembrolizumab and the angiogenesis inhibitor lenvatinib. Approvals have, thus, been obtained or are underway for EC with immune checkpoint inhibitors (ICI) used as monotherapy, and in combination with antiangiogenic agents. …”
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Case Report: Brainstem angiocentric glioma presenting in a toddler child–diagnostic and therapeutic challenges by Zita Reisz, Bence Laszlo Radics, Peter Nemes, Ross Laxton, Laszlo Kaizer, Krisztina Mita Gabor, Timea Novak, Pal Barzo, Safa Al-Sarraj, Istvan Bodi

“…The patient has been initially treated with angiogenesis inhibitor and mTOR inhibitor, and now he is receiving palliative vinblastine. …”
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Shikonin Causes an Apoptotic Effect on Human Kidney Cancer Cells through Ras/MAPK and PI3K/AKT Pathways by József Király, Erzsébet Szabó, Petra Fodor, Zsolt Fejes, Béla Nagy, Éva Juhász, Anna Vass, Mahua Choudhury, Gábor Kónya, Gábor Halmos, Zsuzsanna Szabó

“…(1) Background: Shikonin, the main ingredient in Chinese herbal medicine, is described as a novel angiogenesis inhibitor, and its anticancer effects have already been studied. …”
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Fumagillin Attenuates Spinal Angiogenesis, Neuroinflammation, and Pain in Neuropathic Rats after Chronic Constriction Injury by Zhi-Hong Wen, Shi-Ying Huang, Hsiao-Mei Kuo, Chao-Ting Chen, Nan-Fu Chen, Wu-Fu Chen, Kuan-Hao Tsui, Hsin-Tzu Liu, Chun-Sung Sung

“…Our results suggest that angiogenesis inhibitor treatment suppresses peripheral neuropathy-induced central angiogenesis, neuroinflammation, astrocyte activation, and neuropathic pain.…”
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Application of endostatin using nonviral gene delivery toward the regeneration of articular cartilage by Jeng, Lily

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