Antidepressant Effect of Optogenetic Stimulation of the Medial Prefrontal Cortex by Covington III, Herbert E., Lobo, Mary Kay, Maze, Ian, Vialou, Vincent, Hyman, James M., Zaman, Samir, LaPlant, Quincey C., Mouzon, Ezekiel, Ghose, Subroto, Tamminga, Carol A., Neve, Rachael L., Deisseroth, Karl, Nestler, Eric J.

“…These results indicate that the activity of the mPFC is a key determinant of depression-like behavior, as well as antidepressant responses.…”
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Strategies for managing sexual dysfunction induced by antidepressant medication. by Rudkin, L, Taylor, M, Hawton, K

“… BACKGROUND: Sexual dysfunction (including altered desire, orgasmic dysfunction, erectile and ejaculatory problems) is a relatively common side effect of antidepressant medication. These sexual side effects may compromise a person's lifestyle and result in a lack of compliance with the prescribed antidepressant to the detriment of the person's mental health. …”

Neuropharmacological studies of antidepressant action on brain dopamine systems by Ainsworth, K, Ainsworth, Kerri

Subjects:

Antidepressants for bipolar depression - Dr. Gijsman and colleagues reply by Gijsman, H, Geddes, J, Rendell, J, Goodwin, G, Nolen, W

A cognitive neuropsychological model of antidepressant drug action. by Pringle, A, Browning, M, Cowen, P, Harmer, C

“…The psychological mechanisms by which antidepressant drugs act to improve mood remain underspecified. …”

ANTIDEPRESSANT AGENTS AND REVERSAL OF DIURNAL ACTIVITY CYCLES IN RAT by Baltzer, V, Weiskrantz, L

A cognitive neuropsychological model of antidepressant drug action. by Pringle, A, Browning, M, Cowen, P, Harmer, C

“…The psychological mechanisms by which antidepressant drugs act to improve mood remain underspecified. …”

Profitable failure: antidepressant drugs and the triumph of flawed experiments by McGoey, L

“…Drawing on an analysis of Irving Kirsch and colleagues’ controversial 2008 article in PLoS [Public Library of Science] Medicine on the efficacy of SSRI antidepressant drugs such as Prozac, I examine flaws within the methodologies of randomized controlled trials (RCTs) that have made it difficult for regulators, clinicians and patients to determine the therapeutic value of this class of drug. …”

Strategies for managing sexual dysfunction induced by antidepressant medication by Rudkin, L, Taylor, M, Hawton, K

Antidepressants are not an effective adjunct to mood stabilisers for bipolar depression. by Rao, C, Devanga, A, Geddes, J

Do Antidepressants Alter Emotional Processing in PTSD? Reply by Harmer, C, Goodwin, G, Cowen, P

A role for 5-HT in the action of antidepressant drugs. by Cowen, P

“…However, there is presently no firm evidence that any of these changes are necessary for the clinical efficacy of antidepressant drugs. The best evidence that 5-HT neurons may be involved in mediating antidepressant effects is the antidepressant activity of selective 5-HT uptake blockers.…”

Antidepressant medicines for the elderly: are we using them appropriately? by Amar, K, Wilcock, G

“…We monitored antidepressant prescriptions to elderly patients over the age of 60 years admitted to a teaching hospital over a 3-months period. …”

Strategies for managing sexual dysfunction induced by antidepressant medication. by Taylor, M, Rudkin, L, Bullemor-Day, P, Lubin, J, Chukwujekwu, C, Hawton, K

“… BACKGROUND: Sexual dysfunction (including altered sexual desire, orgasmic and ejaculatory dysfunction, erectile and other problems) is a relatively common side effect of antidepressant medication. These sexual side effects may compromise a person's lifestyle and result in a lack of compliance with the prescribed antidepressant to the detriment of the person's mental health. …”

Role of surface activity in mechanism of actions of tricyclic antidepressants by Nagappa, A.N., Kole, P.L., Pandi, P.V., Shanmukha, I., Girish, K., Mishra, R.P.K.

“…The role of surface activity has been studied in the mechanism of action of tricyclic antidepressants (TCAs). TCAs have been shown to generate liquid membranes in series with a supporting membrane by the virtue of their amphiphillicity. …”
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A comparative study of personality aspects of females with depression using the antidepressant medications: selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs) by Saeed Pournaghash tehrani, Ladan Fathi, Sorya Etemadi

“…The previous studies have shown that antidepressant medications affect these neurotransmitters, and subsequently lead to some variations in the temperamental aspects of personality, particularly the aspects that underlie depression. …”
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Inhibition of Microglial GSK3β Activity Is Common to Different Kinds of Antidepressants: A Proposal for an In Vitro Screen to Detect Novel Antidepressant Principles by Hans O. Kalkman

“…Unfortunately, the present antidepressants often are insufficiently effective, whilst the discovery of more effective antidepressants has been extremely sluggish. …”
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Use of amitriptyline, bupropion and agomelatine in the treatment of non-depressive disorders: a review of mechanisms and therapeutic indications by Piotr Czerniak, Julia Buszek, Michał Medygrał, Przemysław Koszuta, Małgorzata Dydoń-Pikor, Katarzyna Pajdak-Gicala, Maciej Kawecki, Adrianna Antoszewska, Weronika Bargiel, Sylwia Buszek

Subjects: “…antidepressants…”
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Antidepressant efficacy of low-frequency repetitive transcranial magnetic stimulation in antidepressant-nonresponding bipolar depression: a single-blind randomized sham-controlled trial by Arthur D. P. Mak, Sebastiaan F. W. Neggers, Owen N. W. Leung, Winnie C. W. Chu, Jenny Y. M. Ho, Idy W. Y. Chou, Sandra S. M. Chan, Linda C. W. Lam, Sing Lee

“…Abstract Background To examine the antidepressant efficacy and response predictors of R-DLPFC-LF rTMS for antidepressant-nonresponding BD. …”
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Study protocol for the antidepressant advisor (ADeSS): a decision support system for antidepressant treatment for depression in UK primary care: a feasibility study by Allan H Young, Kimberley Goldsmith, Mark Ashworth, Ewan Carr, Phillippa Harrison, Diede Fennema, Barbara Barrett, Roland Zahn

“…Introduction The Antidepressant Advisor Study is a feasibility trial of a computerised decision-support tool which uses an algorithm to provide antidepressant treatment guidance for general practitioners (GPs) in the UK primary care service. …”
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