Epigenetic mechanisms of rapid-acting antidepressants by Antonio Inserra, Antonella Campanale, Tamim Rezai, Patrizia Romualdi, Tiziana Rubino

“…Abstract Background Rapid-acting antidepressants (RAADs), including dissociative anesthetics, psychedelics, and empathogens, elicit rapid and sustained therapeutic improvements in psychiatric disorders by purportedly modulating neuroplasticity, neurotransmission, and immunity. …”
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Is Autophagy Involved in the Diverse Effects of Antidepressants? by Theo Rein

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Neuroplasticity and the next wave of antidepressant strategies. by Shawn eHayley, Darcy eLitteljohn

“…We particularly focus on the NMDA antagonist, ketamine, which already has well documented rapid antidepressant effects, and the trophic cytokine, erythropoietin, which we propose as a potential adjunctive antidepressant agent.…”
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Antidepressants, bioenhancements, and the ethics of self-respect by Hoffman, Virginia Anne

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Antidepressant Actions of Histone Deacetylase Inhibitors by Haggarty, Stephen J., Covington III, Herbert E., Maze, Ian, LaPlant, Quincey C., Vialou, Vincent F., Ohnishi, Yoshinori N., Berton, Olivier, Fass, Daniel M., Renthal, William, Rush III, Augustus J., Wu, Emma Y., Ghose, Subroto, Krishnan, Vaishnav, Russo, Scott J., Tamminga, Carol, Nestler, Eric J.

“…Together, these findings provide new insight into the underlying molecular mechanisms of depression and antidepressant action, and support the antidepressant potential of HDAC inhibitors and perhaps other agents that act at the level of chromatin structure.…”
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Ketamine Antidepressant : Breakthrough or Potential Hazard? by Tan, Teck Boon, Gunasekaran, Nandhakumar

“…Ketamine has emerged in the West as a promising antidepressant. Its use in depression therapy raises important safety and security questions.…”
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Molecular and cellular mechanisms of antidepressant action. by Sharp, T

“…A long-standing theory is that brain monoamine signalling is critically involved in the mechanisms of antidepressant drug treatment. Theories on the nature of these mechanisms commenced with ideas developed in the 1960s that the drugs act simply by increasing monoamine availability in the synapse. …”

Testing the neurocognitive model of antidepressant treatment by Warren, M

“…The neurocognitive model of antidepressant treatment action states that antidepressants work by producing relatively immediate positive shifts in emotional processing, which translate into clinical improvement with time. …”

Antidepressants and benzodiazepines for panic disorder in adults by Bighelli, I, Trespidi, C, Castellazzi, M, Cipriani, A, Furukawa, T, Girlanda, F, Guaiana, G, Koesters, M, Barbui, C

“…Amongst pharmacological agents, antidepressants and benzodiazepines are the mainstay of treatment for panic disorder. …”

"Wish bias" in antidepressant drug trials? by Barbui, C, Cipriani, A, Brambilla, P, Hotopf, M

“…The present study investigated whether the outcome of randomized clinical trials studying fluoxetine favored fluoxetine, where this was the experimental agent, and favored comparator antidepressants in trials where fluoxetine was the reference agent. …”

Antidepressants: current concepts of mode of action. by Cowen, P

“…Repeated administration of antidepressant drugs to rodents produces adaptive changes in noradrenaline and 5-hydroxytryptamine pathways in the brain. …”

HOW IMPORTANT IS PLACEBO IN ANTIDEPRESSANT TRIALS? by Cipriani, A

Cost-effectiveness, cost-utility and the budget impact of antidepressants versus preventive cognitive therapy with or without tapering of antidepressants by Nicola S. Klein, Ben F. M. Wijnen, Joran Lokkerbol, Erik Buskens, Hermien J. Elgersma, Gerard D. van Rijsbergen, Christien Slofstra, Johan Ormel, Jack Dekker, Peter J. de Jong, Willem A. Nolen, Aart H. Schene, Steven D. Hollon, Huibert Burger, Claudi L. H. Bockting

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Making the best use of available evidence: the case of new generation antidepressants: a response to: are all antidepressants equal? by Barbui, C, Cipriani, A, Furukawa, T, Salanti, G, Higgins, J, Churchill, R, Watanabe, N, Nakagawa, A, Omori, I, Geddes, J

Why do antidepressants take so long to work? A cognitive neuropsychological model of antidepressant drug action. by Harmer, C, Goodwin, G, Cowen, P

“… BACKGROUND: The neuropharmacological actions of antidepressants are well characterised but our understanding of how these changes translate into improved mood are still emerging. …”

Pharmacogenomic overlap between antidepressant treatment response in major depression & antidepressant associated treatment emergent mania in bipolar disorder by Nicolas A. Nuñez, Brandon J. Coombes, Lindsay Melhuish Beaupre, Aysegul Ozerdem, Manuel Gardea Resendez, Francisco Romo-Nava, David J. Bond, Marin Veldic, Balwinder Singh, Katherine M. Moore, Hannah K. Betcher, Simon Kung, Miguel L. Prieto, Manuel Fuentes, Mete Ercis, Alessandro Miola, Jorge A. Sanchez Ruiz, Gregory Jenkins, Anthony Batzler, Jonathan G. Leung, Alfredo Cuellar-Barboza, Susannah J. Tye, Susan L. McElroy, Joanna M. Biernacka, Mark A. Frye

“…This study explored the relationship between antidepressant response in MDD and antidepressant-associated treatment emergent mania (TEM) in BD. …”
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The epidemiology of antidepressant use in South Korea: Does short-term antidepressant use affect the relapse and recurrence of depressive episodes? by Min Ji Kim, Namwoo Kim, Daun Shin, Sang Jin Rhee, C Hyung Keun Park, Hyeyoung Kim, Sung Joon Cho, Jae Won Lee, Eun Young Kim, Boram Yang, Yong Min Ahn

“…BACKGROUND:The duration of antidepressant use affects the treatment of depression. …”
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Antidepressants and Psychology : Talk Therapy vs. Medication / by Docalavich, Heather, author 622713

Subjects: “…Antidepressants…”

Hippocampal Neurogenesis, Depressive Disorders, and Antidepressant Therapy by Eleni Paizanis, Michel Hamon, Laurence Lanfumey

“…In particular, the stimulation of hippocampal neurogenesis by all types of antidepressant drugs supports the view that neuroplastic phenomena are involved in the physiopathology of depression and underlie—at least partly—antidepressant therapy.…”
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Comparative pharmacoeconomical analysis of modern antidepressants in monotherapy by A. E. Cheberda, D. Yu. Belousov, S. K. Zyryanov

“…Compare the cost effectiveness and budget impact of vortioxetine in monotherapy of depressive disorders with several other important antidepressants using pharmacoeconomic methods within context of Russian healthcare. …”
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