Showing 301 - 320 results of 376 for search '"antigenic drift"', query time: 0.15s Refine Results
  1. 301

    Clinical and molecular epidemiology of influenza viruses from Romanian patients hospitalized during the 2019/20 season. by Victor Daniel Miron, Leontina Bănică, Oana Săndulescu, Simona Paraschiv, Marius Surleac, Dragoș Florea, Ovidiu Vlaicu, Petre Milu, Anca Streinu-Cercel, Anuta Bilașco, Dan Oțelea, Daniela Pițigoi, Adrian Streinu-Cercel, Anca Cristina Drăgănescu

    Published 2021-01-01
    “…Two main mechanisms contribute to the continuous evolution of influenza viruses: accumulation of mutations in the hemagglutinin and neuraminidase genes (antigenic drift) and genetic re-assortments (antigenic shift). …”
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  2. 302

    Avian Influenza in Wild Birds and Poultry: Dissemination Pathways, Monitoring Methods, and Virus Ecology by Artem Blagodatski, Kseniya Trutneva, Olga Glazova, Olga Mityaeva, Liudmila Shevkova, Evgenii Kegeles, Nikita Onyanov, Kseniia Fede, Anna Maznina, Elena Khavina, Seon-Ju Yeo, Hyun Park, Pavel Volchkov

    Published 2021-05-01
    “…Migratory birds, especially waterfowl, are a natural reservoir of the avian influenza virus; they carry and exchange different virus strains along their migration routes, leading to antigenic drift and antigenic shift, which results in the emergence of novel HPAI viruses. …”
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  3. 303

    Fcγ Receptors Contribute to the Antiviral Properties of Influenza Virus Neuraminidase-Specific Antibodies by E. R. Job, T. Ysenbaert, A. Smet, A. Van Hecke, L. Meuris, H. Kleanthous, X. Saelens, T. U. Vogel

    Published 2019-10-01
    “…IMPORTANCE There is a pressing need for next-generation influenza vaccine strategies that are better able to manage antigenic drift and the cocirculation of multiple drift variants and that consistently improve vaccine effectiveness. …”
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  4. 304

    Novel recombinant avian infectious bronchitis viruses from chickens in Korea, 2019–2021 by Hyun-Jin Kim, Hyuk-Chae Lee, Andrew Y. Cho, Yun-Jeong Choi, Heesu Lee, Dong-Hun Lee, Chang-Seon Song, Chang-Seon Song

    Published 2023-02-01
    “…Infectious bronchitis virus (IBV) has evolved through various mutation mechanisms, including antigenic drift and recombination. Four genotypic lineages of IBVs including GI-15, GI-16, GI-19, and GVI-1 have been reported in Korea. …”
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  5. 305

    Improvement influenza vaccine immune responses with traditional Chinese medicine and its active ingredients by Danping Zhao, Xiuhong Chen, Linyuan Wang, Jianjun Zhang, Ruilin Lv, Lingyun Tan, Yawen Chen, Ran Tao, Xinyu Li, Yan Chen, Wei He, Jing He

    Published 2023-03-01
    “…The current influenza vaccines are unable to provide effective protection in many cases, like influenza viruses strain antigenic drift or shift, and the influenza continues to cause significant annual morbidity and mortality. …”
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    Article
  6. 306

    Evolution and Divergence of H3N8 Equine Influenza Viruses Circulating in the United Kingdom from 2013 to 2015 by Adam Rash, Rachel Morton, Alana Woodward, Olivia Maes, John McCauley, Neil Bryant, Debra Elton

    Published 2017-02-01
    “…Like other influenza A viruses, they undergo antigenic drift, highlighting the importance of both surveillance and virus characterisation in order for vaccine strains to be kept up to date. …”
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  7. 307

    Newly Designed Poxviral Promoters to Improve Immunogenicity and Efficacy of MVA-NP Candidate Vaccines against Lethal Influenza Virus Infection in Mice by Martin C. Langenmayer, Anna-Theresa Luelf-Averhoff, Lisa Marr, Sylvia Jany, Astrid Freudenstein, Silvia Adam-Neumair, Alina Tscherne, Robert Fux, Juan J. Rojas, Andreas Blutke, Gerd Sutter, Asisa Volz

    Published 2023-06-01
    “…Due to the high variability in seasonal IAV triggered by antigenic drift, annual vaccination is necessary, highlighting the need for a more broadly protective vaccine against IAV. …”
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  8. 308

    Repositioning Drugs on Human Influenza A Viruses Based on a Novel Nuclear Norm Minimization Method by Hang Liang, Li Zhang, Lina Wang, Man Gao, Xiangfeng Meng, Mengyao Li, Junhui Liu, Wei Li, Fanzheng Meng

    Published 2021-01-01
    “…There have been several big influenza pandemics that have caused millions of human deaths in history, and the threat of influenza viruses to public health is still serious nowadays due to the frequent antigenic drift and antigenic shift events. However, only few effective anti-flu drugs have been developed to date. …”
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  9. 309
  10. 310

    In-vitro assessment of differential cytokine gene expression in response to infections with Egyptian classic and variant strains of highly pathogenic H5N1 avian influenza virus by A.A. Samy, M.I. El-Enbaawy, A.A. El-Sanousi, S.A. Abd El-Wanes, A.M. Ammar, H. Hikono, T. Saito

    Published 2015-06-01
    “…In Egypt, two distinct genetic groups of HPAI H5N1 viruses are co-circulating: classic 2.2.1/C sub-clade and antigenic drift variant 2.2.1.1 clade isolated from vaccinated poultry flocks. …”
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  11. 311

    Determinants of Glycan Receptor Specificity of H2N2 Influenza A Virus Hemagglutinin by Viswanathan, Karthik, Koh, Xiaoying, Chandrasekaran, Aarthi, Pappas, Claudia, Raman, Rahul, Srinivasan, Aravind, Tumpey, Terrence M., Sasisekharan, Ram, Shriver, Zachary H.

    Published 2011
    “…Strains of H2 subtype still continue to circulate in birds and occasionally pigs and could be reintroduced into the human population through antigenic drift or shift. Such an event is a potential global health concern because of the waning population immunity to H2 hemagglutinin (HA). …”
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  12. 312

    Formulation and testing of a liposomal-based vaccine for cancer and influenza by Wallis, J

    Published 2020
    “…Despite influenza (flu) vaccines being available since the 1940s' they have had restricted success due to flu proteins being subject to a high rate of antigenic drift and shift. However, many groups have reported conserved regions of the viral proteins with low immunogenicity. …”
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  13. 313

    Influenza Antigens NP and M2 Confer Cross Protection to BALB/c Mice against Lethal Challenge with H1N1, Pandemic H1N1 or H5N1 Influenza A Viruses by Nutan Mytle, Sonja Leyrer, Jon R. Inglefield, Andrea M. Harris, Thomas E. Hickey, Jacob Minang, Hang Lu, Zhidong Ma, Hanné Andersen, Nathan D. Grubaugh, Tina Guina, Mario H. Skiadopoulos, Michael J. Lacy

    Published 2021-08-01
    “…Influenza hemagglutinin (HA) is considered a major protective antigen of seasonal influenza vaccine but antigenic drift of HA necessitates annual immunizations using new circulating HA versions. …”
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    Article
  14. 314

    Phylogenomic analysis uncovers a 9-year variation of Uganda influenza type-A strains from the WHO-recommended vaccines and other Africa strains by Grace Nabakooza, D. Collins Owuor, Zaydah R. de Laurent, Ronald Galiwango, Nicholas Owor, John T. Kayiwa, Daudi Jjingo, Charles N. Agoti, D. James Nokes, David P. Kateete, John M. Kitayimbwa, Simon D. W. Frost, Julius J. Lutwama

    Published 2023-04-01
    “…Africa forms part of the global influenza ecology with high viral genetic diversity, progressive antigenic drift, and local transmissions. For a continent with inadequate health resources and where social distancing is unsustainable, vaccination is the best option. …”
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  15. 315

    Broad and Protective Influenza B Virus Neuraminidase Antibodies in Humans after Vaccination and their Clonal Persistence as Plasma Cells by Michael S. Piepenbrink, Aitor Nogales, Madhubanti Basu, Christopher F. Fucile, Jane L. Liesveld, Michael C. Keefer, Alexander F. Rosenberg, Luis Martinez-Sobrido, James J. Kobie

    Published 2019-04-01
    “…Due to the propensity of influenza virus for antigenic drift and shift and its tendency to elicit predominantly strain-specific antibodies, humanity remains susceptible to waves of new strains of seasonal viruses and is at risk from viruses with pandemic potential for which limited or no immunity may exist. …”
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  16. 316

    Emerging Novel GII.P16 Noroviruses Associated with Multiple Capsid Genotypes by Leslie Barclay, Jennifer L. Cannon, Mary E. Wikswo, Annie R. Phillips, Hannah Browne, Anna M. Montmayeur, Roman L. Tatusov, Rachel M. Burke, Aron J. Hall, Jan Vinjé

    Published 2019-06-01
    “…Noroviruses evolve by antigenic drift and recombination, which occurs most frequently at the junction between the non-structural and structural protein coding genomic regions. …”
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  17. 317

    Human Influenza A Virus Hemagglutinin Glycan Evolution Follows a Temporal Pattern to a Glycan Limit by Meghan O. Altman, Matthew Angel, Ivan Košík, Nídia S. Trovão, Seth J. Zost, James S. Gibbs, Lorenzo Casalino, Rommie E. Amaro, Scott E. Hensley, Martha I. Nelson, Jonathan W. Yewdell

    Published 2019-04-01
    “…ABSTRACT Human antibody-based immunity to influenza A virus is limited by antigenic drift resulting from amino acid substitutions in the hemagglutinin (HA) head domain. …”
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  18. 318

    An Orf-Virus (ORFV)-Based Vector Expressing a Consensus H1 Hemagglutinin Provides Protection against Diverse Swine Influenza Viruses by Gabriela Mansano do Nascimento, Dina Bugybayeva, Veerupaxagouda Patil, Jennifer Schrock, Ganesh Yadagiri, Gourapura J. Renukaradhya, Diego G. Diel

    Published 2023-04-01
    “…Influenza A viruses (IAV-S) belonging to the H1 subtype are endemic in swine worldwide. Antigenic drift and antigenic shift lead to a substantial antigenic diversity in circulating IAV-S strains. …”
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  19. 319

    Nanobody engineering for SARS-CoV-2 neutralization and detection by Liina Hannula, Suvi Kuivanen, Jonathan Lasham, Ravi Kant, Lauri Kareinen, Mariia Bogacheva, Tomas Strandin, Tarja Sironen, Jussi Hepojoki, Vivek Sharma, Petri Saviranta, Anja Kipar, Olli Vapalahti, Juha T. Huiskonen, Ilona Rissanen

    Published 2024-04-01
    “…Despite simultaneous binding to distinct epitopes, Beta and Omicron variants were more resistant to neutralization by the multimodular nanobodies, which highlights the importance of accounting for antigenic drift in the design of biologics. To further explore the applications of nanobody engineering in outbreak management, we present an assay based on fusions of nanobodies with fragments of NanoLuc luciferase that can detect sub-nanomolar quantities of the SARS-CoV-2 spike protein in a single step. …”
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  20. 320

    A Broad and Potent H1-Specific Human Monoclonal Antibody Produced in Plants Prevents Influenza Virus Infection and Transmission in Guinea Pigs by Jun-Gyu Park, Chengjin Ye, Michael S. Piepenbrink, Aitor Nogales, Haifeng Wang, Michael Shuen, Ashley J. Meyers, Luis Martinez-Sobrido, James J. Kobie

    Published 2020-02-01
    “…Although seasonal influenza vaccines block most predominant influenza types and subtypes, humans still remain vulnerable to waves of seasonal and new potential pandemic influenza viruses for which no immunity may exist because of viral antigenic drift and/or shift. Previously, we described a human monoclonal antibody (hMAb), KPF1, which was produced in human embryonic kidney 293T cells (KPF1-HEK) with broad and potent neutralizing activity against H1N1 influenza A viruses (IAV) in vitro, and prophylactic and therapeutic activities in vivo. …”
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