NS1 and PA-X of H1N1/09 influenza virus act in a concerted manner to manipulate the innate immune response of porcine respiratory epithelial cells by Robin Avanthay, Robin Avanthay, Robin Avanthay, Obdulio Garcia-Nicolas, Obdulio Garcia-Nicolas, Gert Zimmer, Gert Zimmer, Artur Summerfield, Artur Summerfield

“…In addition, LAIV are expected to trigger stronger T-cell responses that may protect against a broader range of antigen-drifted viruses. However, the development of LAIV is challenging since a proper balance between immunogenicity and safety has to be reached. …”
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Decreased serologic response in vaccinated military recruits during 2011 correspond to genetic drift in concurrent circulating pandemic A/H1N1 viruses. by Dennis J Faix, Anthony W Hawksworth, Christopher A Myers, Christian J Hansen, Ryan G Ortiguerra, Rebecca Halpin, David Wentworth, Laura A Pacha, Erica G Schwartz, Shawn M S Garcia, Angelia A Eick-Cost, Christopher D Clagett, Surender Khurana, Hana Golding, Patrick J Blair

“…We hypothesize that antigen drift in circulating pH1N1 viruses contributed to reduce vaccine effectiveness at Fort Jackson. …”
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Robust immunity to influenza vaccination in haematopoietic stem cell transplant recipients following reconstitution of humoral and adaptive immunity by Wuji Zhang, Louise C Rowntree, Ramona Muttucumaru, Timon Damelang, Malet Aban, Aeron C Hurt, Maria Auladell, Robyn Esterbauer, Bruce Wines, Mark Hogarth, Stephen J Turner, Adam K Wheatley, Stephen J Kent, Sushrut Patil, Sharon Avery, Orla Morrissey, Amy W Chung, Marios Koutsakos, Thi HO Nguyen, Allen C Cheng, Tom C Kotsimbos, Katherine Kedzierska

“…Strikingly, 40% of HSCT recipients had markedly higher antibody responses towards A/H3N2 vaccine strain than healthy controls and showed cross‐reactivity to antigenically drifted A/H3N2 strains by antibody landscape analysis. …”
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Safety, efficacy, and immunogenicity of an inactivated influenza vaccine in healthy adults: a randomized, placebo-controlled trial over two influenza seasons by Bouveret Nancy, Balser John, Keyserling Harry L, Gaglani Manjusha J, Jackson Lisa A, Fries Louis, Treanor John J

“…Vaccination is the major strategy for influenza prevention; however, because antigenically drifted influenza A and B viruses circulate annually, influenza vaccines must be updated to provide protection against the predicted prevalent strains for the next influenza season. …”
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A broad-spectrum vaccine candidate against H5 viruses bearing different sub-clade 2.3.4.4 HA genes by Yuancheng Zhang, Pengfei Cui, Jianzhong Shi, Xianying Zeng, Yongping Jiang, Yuan Chen, Jie Zhang, Congcong Wang, Yan Wang, Guobin Tian, Hualan Chen, Huihui Kong, Guohua Deng

“…H5-Re11 + 3 serum has better cross-reactivity than sera generated with other 2.3.4.4 vaccines, and H5-Re11 + 3 vaccine provided 100% protection of chickens against antigenically drifted H5 viruses from various 2.3.4.4 antigenic groups. …”
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