Effects of aqueous ozone pasteurization on S. typhimurium inactivation and qualitative attributes of chokanan mango (Mangifera indica L.) fruit juice by Mohd Supian, Nur Amira

“…typhimurium inactivation and retention of physicochemical and antioxidant properties of various concentration ratios of Chokanan mango juice diluted with distilled water (DW); 100MJ:0DW, 75MJ:25DW, and 50MJ:50DW. …”
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Impact of sugar and acid adulteration on safety of honey produced by Apis mellifera Linnaeus and Heterotrigona itama cockerell bees by Fakhlaei, Rafieh

“…Honey possesses various pharmacological properties and health benefits such as anti-inflammatory, antioxidant, anti-cancer activities. Thus, honey is prone to be adulterated through inappropriate labelling and fake mixing with cheap and low-quality honey, sugars, and other substances. …”
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Pouteria campechiana pulp ethanol-water extract as a bioactive ingredient for topical delivery of oil-in-water nanoemulsion by Che Marzuki, Nur Haziqah

“…The resultant Pc extract showed a percentage 2,2-diphenyl-1-picrylhydrazyl (DPPH) inhibition at 82.91%, IC50 of 2.344 mg/mL, ferric reducing antioxidant power (FRAP) value of 836.30±30.60 μmol/100 g DW, and total flavonoid content (TFC) of 813.29 mg QE/100 g. …”
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Cigarette smoke exposure impairs β-cell function through activation of oxidative stress and ceramide accumulation by Xin Tong, Zunaira Chaudhry, Chih-Chun Lee, Robert N. Bone, Sukrati Kanojia, Judith Maddatu, Paul Sohn, Staci A. Weaver, Morgan A. Robertson, Irina Petrache, Carmella Evans-Molina, Tatsuyoshi Kono

“…Treatment with the antioxidant N-acetylcysteine markedly attenuated the effects of CSE on ceramide levels, restored β-cell function and survival, and increased cyclin D2 expression, while also reducing activation of β-cell ER and oxidative stress. …”
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Trehalose Attenuates Oxidative Stress and Endoplasmic Reticulum Stress-Mediated Apoptosis in IPEC-J2 Cells Subjected to Heat Stress by Fan Mo, Xu Zhou, Mengting Yang, Leyi Chen, Zhining Tang, Chong Wang, Yanjun Cui

“…This study was carried out to investigate the effects of trehalose (Tre) on antioxidant capacity, endoplasmic reticulum stress (ERS) response and apoptosis of heat-stressed intestinal porcine epithelial cells (IPEC-J2). …”
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Handelin alleviates cachexia‐ and aging‐induced skeletal muscle atrophy by improving protein homeostasis and inhibiting inflammation by Hui‐Jie Zhang, Ben‐Hui Wang, Xiang Wang, Chun‐Ping Huang, Si‐Man Xu, Jia‐Li Wang, Tian‐E Huang, Wan‐Li Xiao, Xiao‐Li Tian, Xin‐Qiang Lan, Qi‐Quan Wang, Yang Xiang

“…In the tibialis anterior muscle of aged mice, handelin upregulated mRNA levels of Igf1 (P < 0.01), anti‐inflammatory cytokine Il10 (P < 0.01), mitochondrial biogenesis genes (P < 0.05) and antioxidant‐related enzymes (P < 0.05) and strengthened Sod and Cat enzyme activity (P < 0.05). …”
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Post-traumatic administration of the p53 inactivator pifithrin-α oxygen analogue reduces hippocampal neuronal loss and improves cognitive deficits after experimental traumatic brai... by Ling-Yu Yang, Nigel H. Greig, Ya-Ni Huang, Tsung-Hsun Hsieh, David Tweedie, Qian-Sheng Yu, Barry J. Hoffer, Yu Luo, Yu-Chieh Kao, Jia-Yi Wang

“…Our data suggest that PFT-α and especially PFT-α (O) significantly reduce hippocampal neuronal degeneration, and ameliorate neurological and cognitive deficits in vivo via antiapoptotic and antioxidative properties.…”
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Optimizing dietary rumen-degradable starch to rumen-degradable protein ratio improves lactation performance and nitrogen utilization efficiency in mid-lactating Holstein dairy cows by Panliang Chen, Panliang Chen, Yan Li, Yan Li, Meimei Wang, Meimei Wang, Meimei Wang, Yizhao Shen, Yizhao Shen, Mingchao Liu, Mingchao Liu, Hongjian Xu, Hongjian Xu, Ning Ma, Ning Ma, Yufeng Cao, Yufeng Cao, Qiufeng Li, Qiufeng Li, Mahmoud M. Abdelsattar, Zhiyuan Wang, Zhiyuan Wang, Zihan Huo, Zihan Huo, Shuai Ren, Shuai Ren, Linqi Hu, Linqi Hu, Jie Liu, Jie Liu, Yanxia Gao, Yanxia Gao, Yanxia Gao, Yanxia Gao, Jianguo Li, Jianguo Li, Jianguo Li, Jianguo Li

“…The medium SPR group exhibited a lower milk somatic cell count and a higher blood total antioxidant capacity compared to other groups (p &lt; 0.05). …”
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Overexpression of thioredoxin‐2 attenuates age‐related muscle loss by suppressing mitochondrial oxidative stress and apoptosis by Huibin Tang, Michael Kim, Myung Lee, Kellie Baumann, Francesca Olguin, Hao He, Yoyo Wang, Bowen Jiang, Shuhuan Fang, Jinguo Zhu, Kun Wang, Hui Xia, Yang Gao, Harrison B. Konsker, Emmanuel A. Fatodu, Marco Quarta, Justin Blonigan, Thomas A. Rando, Joseph B. Shrager

“…We tested this concept in age‐dependent muscle atrophy by genetically overexpressing the mitochondrial antioxidant thioredoxin‐2 (TXN2). Methods We tested the functional role of TXN2 using ageing (n = 7–10 per group) and denervation (n = 3 per group) models in a transgenic mouse line that overexpresses TXN2. …”
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Oligosaccharides isolated from Rehmannia glutinosa protect LPS-induced intestinal inflammation and barrier injury in mice by Xiao Li, Xiao Li, Rong Gui, Rong Gui, Xuefang Wang, Xuefang Wang, Erjuan Ning, Erjuan Ning, Lixian Zhang, Lixian Zhang, Yi Fan, Yi Fan, Ling Chen, Ling Chen, Liqin Yu, Liqin Yu, Jie Zhu, Jie Zhu, Zhining Li, Zhining Li, Lei Wei, Lei Wei, Wei Wang, Wei Wang, Zihong Li, Zihong Li, Yue Wei, Yue Wei, Xuebing Wang

“…The association between intestinal microorganisms and SCFAs, occludins, digestive enzymes, inflammatory factor contents, and antioxidant indexes was also analyzed.ResultsRGO significantly increased the weight, pancreatic index, thymus index, and colon length of mice compared with the model group. …”
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Innate immunity of vascular smooth muscle cells contributes to two-wave inflammation in atherosclerosis, twin-peak inflammation in aortic aneurysms and trans-differentiation potent... by Qiaoxi Yang, Qiaoxi Yang, Fatma Saaoud, Yifan Lu, Yujiang Pu, Keman Xu, Ying Shao, Xiaohua Jiang, Xiaohua Jiang, Sheng Wu, Ling Yang, Ying Tian, Xiaolei Liu, Avrum Gillespie, Jin Jun Luo, Xinghua Mindy Shi, Huaqing Zhao, Laisel Martinez, Roberto Vazquez-Padron, Hong Wang, Xiaofeng Yang, Xiaofeng Yang

“…MethodsTo determine the roles of innate immunity in VSMC and aortic pathologies, we performed transcriptome analyses on aortas from ApoE–/– angiotensin II (Ang II)-induced aortic aneurysm (AAA) time course, and ApoE–/– atherosclerosis time course, as well as VSMCs stimulated with danger-associated molecular patterns (DAMPs).ResultsWe made significant findings: 1) 95% and 45% of the upregulated innate immune pathways (UIIPs, based on data of 1226 innate immune genes) in ApoE–/– Ang II-induced AAA at 7 days were different from that of 14 and 28 days, respectively; and AAA showed twin peaks of UIIPs with a major peak at 7 days and a minor peak at 28 days; 2) all the UIIPs in ApoE–/– atherosclerosis at 6 weeks were different from that of 32 and 78 weeks (two waves); 3) analyses of additional 12 lists of innate immune-related genes with 1325 cytokine and chemokine genes, 2022 plasma membrane protein genes, 373 clusters of differentiation (CD) marker genes, 280 nuclear membrane protein genes, 1425 nucleoli protein genes, 6750 nucleoplasm protein genes, 1496 transcription factors (TFs) including 15 pioneer TFs, 164 histone modification enzymes, 102 oxidative cell death genes, 68 necrotic cell death genes, and 47 efferocytosis genes confirmed two-wave inflammation in atherosclerosis and twin-peak inflammation in AAA; 4) DAMPs-stimulated VSMCs were innate immune cells as judged by the upregulation of innate immune genes and genes from 12 additional lists; 5) DAMPs-stimulated VSMCs increased trans-differentiation potential by upregulating not only some of 82 markers of 7 VSMC-plastic cell types, including fibroblast, osteogenic, myofibroblast, macrophage, adipocyte, foam cell, and mesenchymal cell, but also 18 new cell types (out of 79 human cell types with 8065 cell markers); 6) analysis of gene deficient transcriptomes indicated that the antioxidant transcription factor NRF2 suppresses, however, the other five inflammatory transcription factors and master regulators, including AHR, NF-KB, NOX (ROS enzyme), PERK, and SET7 promote the upregulation of twelve lists of innate immune genes in atherosclerosis, AAA, and DAMP-stimulated VSMCs; and 7) both SET7 and trained tolerance-promoting metabolite itaconate contributed to twin-peak upregulation of cytokines in AAA. …”
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Revealing the developmental characterization of rumen microbiome and its host in newly received cattle during receiving period contributes to formulating precise nutritional strate... by Yanjiao Li, Kang Mao, Yitian Zang, Guwei Lu, Qinghua Qiu, Kehui Ouyang, Xianghui Zhao, Xiaozhen Song, Lanjiao Xu, Huan Liang, Mingren Qu

“…Results The levels of serum hormones (COR and ACTH), and pro-inflammatory factors (IL-1β, TNF-α, and IL-6) were highest at day 16, and lowest at day 30 after arrival. Meanwhile, the antioxidant capacity (SOD, GSH-Px, and T-AOC) was significantly decreased at day 16 and increased at day 30 after arrival. …”
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Biochemical–molecular–genetic biomarkers in the tear film, aqueous humor, and blood of primary open-angle glaucoma patients by Maria D. Pinazo-Durán, Maria D. Pinazo-Durán, Maria D. Pinazo-Durán, Vicente Zanón-Moreno, Vicente Zanón-Moreno, Carolina García–Villanueva, Alessio Martucci, Cristina Peris-Martínez, Cristina Peris-Martínez, Jorge Vila-Arteaga, Jose J. García-Medina, Jose J. García-Medina, Jose J. García-Medina, Jose J. García-Medina, Irene Andrés–Blasco, Irene Andrés–Blasco, Irene Andrés–Blasco, Alex Gallego–Martínez, Alex Gallego–Martínez, Carlo Nucci, Julian García–Feijoo

“…Malondialdehyde (MDA), nitric oxide (NO), interleuquin (IL)-6, endothelin-1 (ET-1), and 5 hydroxyindolacetic acid (5-HIAA), displayed significantly higher levels in the POAG patients vs. the CG (p &lt; 0.001). Total antioxidant capacity (TAC), brain derived neurotrophic factor (BDNF), 5-hydroxy tryptamine (5-HT), solute carrier family 23-nucleobase transporters-member 2 (SLC23A2) gene, and the glutathione peroxidase 4 (GPX4) gene, showed significantly lower levelsin the POAG patients than in the CG (p &lt; 0.001). …”
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Relationship between lipoprotein concentrations and short-term and 1-year mortality in intensive care unit septic patients: results from the HIGHSEPS study by Sébastien Tanaka, Jules Stern, Donia Bouzid, Tiphaine Robert, Monique Dehoux, Aurélie Snauwaert, Nathalie Zappella, Maxime Cournot, Brice Lortat-Jacob, Pascal Augustin, Enora Atchade, Alexy Tran-Dinh, Olivier Meilhac, Philippe Montravers

“…Abstract Background High-density lipoproteins (HDLs), particles characterized by their reverse cholesterol transport function, display pleiotropic properties, including anti-inflammatory and antioxidant functions. Moreover, all lipoproteins (HDLs but also low-density lipoproteins (LDLs)) neutralize lipopolysaccharides, leading to increased bacterial clearance. …”
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Dexmedetomidine Mitigated NLRP3-Mediated Neuroinflammation via the Ubiquitin-Autophagy Pathway to Improve Perioperative Neurocognitive Disorder in Mice by Lieliang Zhang, Lieliang Zhang, Fan Xiao, Fan Xiao, Jing Zhang, Jing Zhang, Xifeng Wang, Xifeng Wang, Jun Ying, Jun Ying, Gen Wei, Gen Wei, Shoulin Chen, Shoulin Chen, Xiangfei Huang, Xiangfei Huang, Wen Yu, Wen Yu, Xing Liu, Xing Liu, Qingcui Zheng, Qingcui Zheng, Guohai Xu, Guohai Xu, Shuchun Yu, Shuchun Yu, Fuzhou Hua, Fuzhou Hua

“…Dexmedetomidine (DEX), an α2 adrenergic receptor agonist has been shown to have antioxidant and anti-inflammatory activities. The present study showed that DEX reduced the production of cleaved caspase1 (CASP1) and destroyed the NLRP3–PYD And CARD Domain Containing (PYCARD)–CASP1 complex assembly, thereby reducing the secretion of IL-1β interleukin beta (IL-1β). …”
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Intracisternal administration of tanshinone IIA-loaded nanoparticles leads to reduced tissue injury and functional deficits in a porcine model of ischemic stroke by Elizabeth S. Waters, Erin E. Kaiser, Xueyuan Yang, Madison M. Fagan, Kelly M. Scheulin, Julie H. Jeon, Soo K. Shin, Holly A. Kinder, Anil Kumar, Simon R. Platt, Kylee J. Duberstein, Hea Jin Park, Jin Xie, Franklin D. West

“…Results: Tan IIA-NP treated neural stem cells showed a reduction in SOD activity in in vitro assays demonstrating antioxidative effects. Ischemic stroke pigs treated with Tan IIA-NPs showed reduced hemispheric swelling when compared to vehicle only treated pigs (7.85 ± 1.41 vs. 16.83 ± 0.62%), consequent midline shift (MLS) (1.72 ± 0.07 vs. 2.91 ± 0.36 mm), and ischemic lesion volumes (9.54 ± 5.06 vs. 12.01 ± 0.17 cm3) when compared to vehicle-only treated pigs. …”
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Enhanced Resistance to <i>Sclerotinia sclerotiorum</i> in <i>Brassica rapa</i> by Activating Host Immunity through Exogenous <i>Verticillium dahliae</i> Aspf2-like Protein (VDAL) T... by Shufang Jiang, Weiwei Zheng, Zewei Li, Jingru Tan, Meifang Wu, Xinyuan Li, Seung-Beom Hong, Jianyu Deng, Zhujun Zhu, Yunxiang Zang

“…The results showed that foliar application of VDAL significantly reduced the plaque area on leaves inoculated with <i>S. sclerotiorum</i>. It also enhanced antioxidant capacity by increasing activities of superoxide dismutase (SOD), peroxidase (POD), peroxidase (APX), glutathione reductase (GR), protoporphyrinogen oxidase (PPO), and defense-related enzymes β-1,3-glucanase and chitinase during the infection periods. …”
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MyD88 deficiency ameliorates weight loss caused by intestinal oxidative injury in an autophagy‐dependent mechanism by Ming Qi, Simeng Liao, Jing Wang, Yuankun Deng, Andong Zha, Yirui Shao, Zhijuan Cui, Tongxing Song, Yulong Tang, Bie Tan, Yulong Yin

“…Notably, there is a marked decrease in reactive oxygen species in MyD88‐deficient IECs during PQ exposure (~70% reduction), which are consistent with high activity of antioxidative enzymes (~83% increment) (P < 0.001). Intestinal ablation of MyD88 inhibits mTOR signalling, and further phosphorylates p53 proteins during PQ exposure, which eventually promotes intestinal autophagy (~74% increment) (P < 0.01). …”
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FOXC1 promotes HCC proliferation and metastasis by Upregulating DNMT3B to induce DNA Hypermethylation of CTH promoter by Zhuoying Lin, Wenjie Huang, Qin He, Dongxiao Li, Zhihui Wang, Yangyang Feng, Danfei Liu, Tongyue Zhang, Yijun Wang, Meng Xie, Xiaoyu Ji, Mengyu Sun, Dean Tian, Limin Xia

“…Moreover, low levels of ROS induced by N-acetylcysteine (NAC) which is an antioxidant inhibited the cell proliferation, migration, and invasion abilities mediated by FOXC1 overexpression, whereas high levels of ROS induced by L-Buthionine-sulfoximine (BSO) rescued the suppression results mediated by FOXC1 knockdown. …”
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Investigation of dose-dependent effects of berberine against renal ischemia/reperfusion injury in experimental diabetic rats by Meltem Kumaş, Mukaddes Eşrefoğlu, Ersin Karataş, Nurcihan Duymaç, Songül Kanbay, Ilyas Samet Ergün, Mehmet Üyüklü, Abdurrahim Koçyiğit

“…To date, numerous antidiabetic and antioxidant agents have been used for treatment of the disease-related changes. …”
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