A novel technology for in vivo detection of cell type-specific neural connection with AQP1-encoding rAAV2-retro vector and metal-free MRI by Ning Zheng, Mei Li, Yang Wu, Challika Kaewborisuth, Zhen Li, Zhu Gui, Jinfeng Wu, Aoling Cai, Kangguang Lin, Kuan-Pin Su, Hongbing Xiang, Xuebi Tian, Anne Manyande, Fuqiang Xu, Jie Wang

“…The recombinant adeno-associated virus (rAAV) with retrograde ability, the rAAV2-retro, encoding the human water channel aquaporin 1 (AQP1) MRI reporter gene was generated to label neural connections. …”
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A novel and low-toxic peptide DR3penA alleviates pulmonary fibrosis by regulating the MAPK/miR-23b-5p/AQP5 signaling axis by Dan Wang, Bochuan Deng, Lu Cheng, Jieru Li, Jiao Zhang, Xiang Zhang, Xiaomin Guo, Tiantian Yan, Xin Yue, Yingying An, Bangzhi Zhang, Wenle Yang, Junqiu Xie, Rui Wang

“…A mechanistic study revealed that DR3penA increased the expression of aquaporin 5 (AQP5) by inhibiting the upregulation of miR-23b-5p and the mitogen-activated protein kinase (MAPK) pathway, indicating that DR3penA may alleviate PF by regulating MAPK/miR-23b-5p/AQP5. …”
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Regional spinal cord volumes and pain profiles in AQP4-IgG + NMOSD and MOGAD by Susanna Asseyer, Susanna Asseyer, Susanna Asseyer, Ofir Zmira, Ofir Zmira, Ofir Zmira, Ofir Zmira, Laura Busse, Barak Pflantzer, Barak Pflantzer, Patrick Schindler, Patrick Schindler, Patrick Schindler, Tanja Schmitz-Hübsch, Tanja Schmitz-Hübsch, Tanja Schmitz-Hübsch, Friedemann Paul, Friedemann Paul, Friedemann Paul, Claudia Chien, Claudia Chien, Claudia Chien

“…ObjectiveAquaporin-4-antibody-seropositive (AQP4-IgG+) Neuromyelitis Optica Spectrum Disorder (NMOSD) and Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disorder (MOGAD) are relapsing neuroinflammatory diseases, frequently leading to chronic pain. …”
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Differentiated pattern of complement system activation between MOG-IgG-associated disease and AQP4-IgG-positive neuromyelitis optica spectrum disorder by Eun Bin Cho, Eun Bin Cho, Ju-Hong Min, Ju-Hong Min, Ju-Hong Min, Patrick Waters, Miyoung Jeon, Miyoung Jeon, Eun-Seon Ju, Eun-Seon Ju, Ho Jin Kim, Su-Hyun Kim, Ha Young Shin, Sa-Yoon Kang, Young-Min Lim, Sun-Young Oh, Hye Lim Lee, Eunhee Sohn, Sang-Soo Lee, Jeeyoung Oh, Sunyoung Kim, So-Young Huh, Joong-Yang Cho, Jin Myoung Seok, Byung-Jo Kim, Byoung Joon Kim, Byoung Joon Kim

“…BackgroundMyelin oligodendrocyte glycoprotein antibody (MOG) immunoglobulin G (IgG)-associated disease (MOGAD) has clinical and pathophysiological features that are similar to but distinct from those of aquaporin-4 antibody (AQP4-IgG)-positive neuromyelitis optica spectrum disorders (AQP4-NMOSD). …”
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Golgi localization of SARS-CoV-2 spike protein and interaction with furin in cerebral COVID-19 microangiopathy: a clue to the central nervous system involvement? by Susana Boluda, Karima Mokhtari, Bruno Mégarbane, Djillali Annane, Bertrand Mathon, Albert Cao, Clovis Adam, Alexandre Androuin, Franck Bielle, Guy Brochier, Frédéric Charlotte, Lydia Chougar, Khalid Hamid El Hachimi, Marc Eloit, Stéphane Haïk, Dominique Hervé, Amal Kasri, Valentin Leducq, Stéphane Lehéricy, Etienne Levavasseur, Christian Lobsiger, Geoffroy Lorin de La Grandmaison, Isabelle Malet, Isabelle Malissin, Stéphane Marot, Serge Marty, Philippe Pérot, Isabelle Plu, Annick Prigent, Lev Stimmer, Marie-Claude Potier, Anne-Geneviève Marcelin, Benoît Delatour, Charles Duyckaerts, Danielle Seilhean

“…This COVID-19 associated cerebral microangiopathy (CCM) was characterized by perivascular changes: arterioles were surrounded by vacuolized tissue, clustered macrophages, large axonal swellings and a crown arrangement of aquaporin-4 immunoreactivity. There was evidence of blood-brain-barrier leakage. …”
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Rare variants and HLA haplotypes associated in patients with neuromyelitis optica spectrum disorders by Inna Tabansky, Inna Tabansky, Inna Tabansky, Inna Tabansky, Inna Tabansky, Inna Tabansky, Akemi J. Tanaka, Jiayao Wang, Jiayao Wang, Guanglan Zhang, Irena Dujmovic, Irena Dujmovic, Simone Mader, Simone Mader, Venkatesh Jeganathan, Tracey DeAngelis, Michael Funaro, Michael Funaro, Michael Funaro, Michael Funaro, Michael Funaro, Asaff Harel, Mark Messina, Mark Messina, Mark Messina, Mark Messina, Mark Messina, Maya Shabbir, Vishaan Nursey, William DeGouvia, William DeGouvia, William DeGouvia, William DeGouvia, William DeGouvia, Micheline Laurent, Micheline Laurent, Micheline Laurent, Micheline Laurent, Micheline Laurent, Karen Blitz, Peter Jindra, Mark Gudesblatt, Regeneron Genetics Center, Alejandra King, Jelena Drulovic, Edmond Yunis, Vladimir Brusic, Yufeng Shen, Derin B. Keskin, Derin B. Keskin, Souhel Najjar, Joel N. H. Stern, Joel N. H. Stern, Joel N. H. Stern, Joel N. H. Stern, Joel N. H. Stern

“…Many NMOSD patients have antibodies to Aquaporin-4 (AQP4). Prior studies show associations of NMOSD with individual Human Leukocyte Antigen (HLA) alleles and with mutations in the complement pathway and potassium channels. …”
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A Novel Model of Mixed Vascular Dementia Incorporating Hypertension in a Rat Model of Alzheimer’s Disease by Paul Denver, Heather D’Adamo, Heather D’Adamo, Heather D’Adamo, Shuxin Hu, Shuxin Hu, Shuxin Hu, Xiaohong Zuo, Xiaohong Zuo, Xiaohong Zuo, Cansheng Zhu, Cansheng Zhu, Chihiro Okuma, Chihiro Okuma, Peter Kim, Peter Kim, Peter Kim, Daniel Castro, Daniel Castro, Mychica R. Jones, Mychica R. Jones, Carmen Leal, Carmen Leal, Carmen Leal, Marisa Mekkittikul, Marisa Mekkittikul, Marisa Mekkittikul, Elham Ghadishah, Elham Ghadishah, Elham Ghadishah, Bruce Teter, Bruce Teter, Harry V. Vinters, Harry V. Vinters, Gregory Michael Cole, Gregory Michael Cole, Gregory Michael Cole, Gregory Michael Cole, Sally A. Frautschy, Sally A. Frautschy, Sally A. Frautschy, Sally A. Frautschy

“…Evidence for vascular pathology included a change in the distribution of astrocytic end-foot protein aquaporin-4, normally distributed in microvessels, but in SHRSP/FAD rats largely dissociated from vessels, appearing disorganized or redistributed into neuropil. …”
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Lateral geniculate nucleus volume changes after optic neuritis in neuromyelitis optica: A longitudinal study by Athina Papadopoulou, Frederike C. Oertel, Claudia Chien, Joseph Kuchling, Hanna G. Zimmermann, Nadja Siebert, Seyedamirhosein Motamedi, Marcus D' Souza, Susanna Asseyer, Judith Bellmann-Strobl, Klemens Ruprecht, M. Mallar Chakravarty, Michael Scheel, Stefano Magon, Jens Wuerfel, Friedemann Paul, Alexander U. Brandt

“…Methods: Twenty-nine patients with aquaporin 4-IgG seropositive NMOSD (age: 47.8 ± 14.6 years (y), female: n = 27, history of ON (NMO-ON): n = 17, median time since ON: 3[1.2–12.1]y) and 18 healthy controls (HC; age: 39.3 ± 15.8y; female: n = 13) were included. …”
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MRI Patterns Distinguish AQP4 Antibody Positive Neuromyelitis Optica Spectrum Disorder From Multiple Sclerosis by Laura Clarke, Simon Arnett, Wajih Bukhari, Elham Khalilidehkordi, Sofia Jimenez Sanchez, Cullen O'Gorman, Jing Sun, Kerri M. Prain, Mark Woodhall, Roger Silvestrini, Christine S. Bundell, David A. Abernethy, Sandeep Bhuta, Stefan Blum, Mike Boggild, Karyn Boundy, Bruce J. Brew, Wallace Brownlee, Helmut Butzkueven, William M. Carroll, Cella Chen, Alan Coulthard, Russell C. Dale, Chandi Das, Marzena J. Fabis-Pedrini, David Gillis, Simon Hawke, Robert Heard, Andrew P. D. Henderson, Saman Heshmat, Suzanne Hodgkinson, Trevor J. Kilpatrick, John King, Christopher Kneebone, Andrew J. Kornberg, Jeannette Lechner-Scott, Ming-Wei Lin, Christopher Lynch, Richard A. L. Macdonell, Deborah F. Mason, Pamela A. McCombe, Jennifer Pereira, John D. Pollard, Sudarshini Ramanathan, Sudarshini Ramanathan, Stephen W. Reddel, Cameron P. Shaw, Judith M. Spies, James Stankovich, Ian Sutton, Steve Vucic, Michael Walsh, Richard C. Wong, Eppie M. Yiu, Michael H. Barnett, Allan G. K. Kermode, Mark P. Marriott, John D. E. Parratt, Mark Slee, Bruce V. Taylor, Ernest Willoughby, Fabienne Brilot, Fabienne Brilot, Angela Vincent, Patrick Waters, Simon A. Broadley, Simon A. Broadley

“…NMOSD and MS MRI lesions were identified and defined through a literature search. Aquaporin-4 (AQP4) antibody positive NMOSD cases and age- and sex-matched MS cases were collected. …”
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Exploring three PIPs and three TIPs of grapevine for transport of water and atypical substrates through heterologous expression in aqy-null yeast. by Farzana Sabir, Maria José Leandro, Ana Paula Martins, Maria C Loureiro-Dias, Teresa F Moura, Graça Soveral, Catarina Prista

“…Aquaporins are membrane channels that facilitate the transport of water and other small molecules across the cellular membranes. …”
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Confronting Secondary Metabolites with Water Uptake and Transport in Plants under Abiotic Stress by Juan Nicolas-Espinosa, Paula Garcia-Ibañez, Alvaro Lopez-Zaplana, Lucia Yepes-Molina, Lorena Albaladejo-Marico, Micaela Carvajal

“…Furthermore, their relation with water uptake and transport mediated through aquaporins is reviewed. In this way, the increases of phenolic compounds and glucosinolate synthesis have been related to primary responses to abiotic stress and induction of resistance. …”
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Porous organic cages as synthetic water channels by Yi Di Yuan, Jinqiao Dong, Jie Liu, Daohui Zhao, Hui Wu, Wei Zhou, Hui Xian Gan, Yen Wah Tong, Jianwen Jiang, Dan Zhao

“…Replicating the performance of protein water channels (aquaporins) in artificial one-dimensional channels are often synthetically challenging. …”
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Action Mode of Gut Motility, Fluid and Electrolyte Transport in Chronic Constipation by Qi Zhao, Yan-Yan Chen, Ding-Qiao Xu, Shi-Jun Yue, Rui-Jia Fu, Jie Yang, Li-Ming Xing, Yu-Ping Tang

“…The occurrence of constipation is inherently connected to disorders of gut motility as well as fluid and electrolyte transport, which involve the nervous system, endocrine signaling, the gastrointestinal microbiota, ion channels, and aquaporins. The mechanisms of action and application of the main drugs are summarized; a better understanding of ion channels and aquaporins may be helpful for new drug development. …”
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Mild salt stress conditions induce different responses in root hydraulic conductivity of phaseolus vulgaris over-time. by Monica Calvo-Polanco, Beatriz Sánchez-Romera, Ricardo Aroca

“…Although its regulation has been commonly attributed to aquaporins activity, osmotic adjustment and the toxic effect of Na+ and Cl- have also a main role in the whole process. …”
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The physiological role of fat body and muscle tissues in response to cold stress in the tropical cockroach Gromphadorhina coquereliana. by Szymon Chowański, Jan Lubawy, Ewelina Paluch-Lubawa, Marta Spochacz, Grzegorz Rosiński, Małgorzata Słocińska

“…On the other hand, there were lower levels of aquaporins in both tissues following exposure to cold. …”
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Membrane Vesicles for Nanoencapsulated Sulforaphane Increased Their Anti-Inflammatory Role on an In Vitro Human Macrophage Model by Lucía Yepes-Molina, María Isabel Pérez-Jiménez, María Martínez-Esparza, José A. Teruel, Antonio J. Ruiz-Alcaraz, Pilar García-Peñarrubia, Micaela Carvajal

“…On the one hand, the release of SFN from membrane vesicles was modeled in vitro, and two release phases were stabilized, one faster and the other slower due to the interaction between SFN and membrane proteins, such as aquaporins. Furthermore, the anti-inflammatory action of sulforaphane-loaded membrane vesicles was demonstrated, as a decrease in interleukins crucial for the development of inflammation, such as TNF-α, IL-1β and IL-6, was observed. …”
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Foliar Mineral Treatments for The Reduction of Melon (<i>Cucumis melo</i> L.) Fruit Cracking by Alvaro Lopez-Zaplana, Gloria Bárzana, Agatha Agudelo, Micaela Carvajal

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Neuron-Derived Exosome Proteins May Contribute to Progression From Repetitive Mild Traumatic Brain Injuries to Chronic Traumatic Encephalopathy by Edward J. Goetzl, Aurélie Ledreux, Ann-Charlotte Granholm, Fanny M. Elahi, Laura Goetzl, Jade Hiramoto, Dimitrios Kapogiannis

“…Of the many proteins that are loaded into neuron-derived exosomes (NDEs) from damaged neurons after acute TBI, the levels of prion cellular protein (PRPc), coagulation factor XIII (XIIIa), synaptogyrin-3, IL-6, and aquaporins remain elevated for months. Prolonged heightened expression of aquaporins and IL-6 may account for the persistent central nervous system edema and inflammation of CTE. …”
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5-Aminolevulinic Acid Pretreatment Mitigates Drought and Salt Stresses in Poplar Plants by Zhiyin Jiao, Shuo Han, Xiao Yu, Mengbo Huang, Conglong Lian, Chao Liu, Weilun Yin, Xinli Xia

“…In addition, our results showed that ALA might mediate Na⁺ transporter and aquaporins activity, thereby increasing the salt tolerance of poplar.…”
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Bioactive peptides from broccoli stems strongly enhance regenerative keratinocytes by stimulating controlled proliferation by Juan Nicolas-Espinosa, Lucía Yepes-Molina, Micaela Carvajal

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