Malaria. by Ashley, E, Mcgready, R, Proux, S, Nosten, F

“…The treatment must be initiated without delay preferably with an artemisinin containing regimen. Uncomplicated malaria can be treated with oral drugs while severe infections will be hospitalized and treated with injectables. …”

Reply to Hastings, et al., and Meshnick. by Pyae Phyo, A, Ashley, E, Anderson, T, Carrara, V, Woodrow, C, White, N, Nosten, F

“…A response to the comments of Professor Meshnik and Dr Hastings on the paper "Phyo, A.P., et al., Declining Efficacy of Artemisinin Combination Therapy Against P. Falciparum Malaria on the Thai–Myanmar Border (2003–2013): The Role of Parasite Genetic Factors. …”

Antimalarial drug resistance by White, N

“…Resistance has emerged to all classes of antimalarial drugs except the artemisinins and is responsible for a recent increase in malaria-related mortality, particularly in Africa. …”

Quantification of the antimalarial piperaquine in plasma. by Tarning, J, Lindegardh, N

“…Piperaquine is an antimalarial drug that was extensively used in China during the 1980s and has recently received renewed interest as a partner drug in artemisinin-based combination therapy. Despite extensive use, the first bioanalytical method was published in 2003. …”

An Analytical Evaluation Of In Vitro Drug-Drug Interaction Studies For Fixed Artesunate Combination Therapy by Jayaraj, Vanessa Shalini Daniel

“…In light of this, the WHO has recommended artemisinin combination therapy such as artesunate-mefloquine and artesunate-amodiaquine as first line treatment for uncomplicated falciparum malaria especially in regions harbouring the most resistant isolates. …”
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Efficacy and safety of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in mainland Tanzania, 2019 by Billy E. Ngasala, Mercy G. Chiduo, Bruno P. Mmbando, Filbert T. Francis, Samwel Bushukatale, Twilumba Makene, Celine I. Mandara, Deus S. Ishengoma, Erasmus Kamugisha, Maimuna Ahmed, Muhidin K. Mahende, Reginald A. Kavishe, Florida Muro, Fabrizio Molteni, Erik Reaves, Chonge Kitojo, George Greer, Ssanyu Nyinondi, Bilal Kabula, Shabbir Lalji, Frank Chacky, Ritha J. Njau, Marian Warsame, Ally Mohamed

“…Abstract Background Artemisinin-based combination therapy (ACT) has been a major contributor to the substantial reductions in global malaria morbidity and mortality over the last decade. …”
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Efficacy and safety of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in mainland Tanzania, 2018 by Billy Ngasala, Mercy G. Chiduo, Samwel Bushukatale, Bruno P. Mmbando, Twilumba Makene, Erasmus Kamugisha, Maimuna Ahmed, Celine I. Mandara, Filbert Francis, Muhidin K. Mahende, Reginald A. Kavishe, Florida Muro, Deus S. Ishengoma, Renata Mandike, Fabrizio Molteni, Frank Chacky, Chonge Kitojo, George Greer, Dunstan Bishanga, Jasmine Chadewa, Ritha Njau, Marian Warsame, Bilali Kabula, Ssanyu S. Nyinondi, Erik Reaves, Ally Mohamed

“…Abstract Background The use of artemisinin-based combination therapy (ACT) is recommended by the World Health Organization for the treatment of uncomplicated falciparum malaria. …”
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CHSY1 promotes CD8+ T cell exhaustion through activation of succinate metabolism pathway leading to colorectal cancer liver metastasis based on CRISPR/Cas9 screening by Guangshun Sun, Siqi Zhao, Zhongguo Fan, Yuliang Wang, Hanyuan Liu, Hengsong Cao, Guoqiang Sun, Tian Huang, Hongzhou Cai, Hong Pan, Dawei Rong, Yun Gao, Weiwei Tang

“…PLGA-loaded Artemisinin and ICG probe reduced liver metastasis and increased the efficiency of anti-PD1 treatment in CRC. …”
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The impact of targeted malaria elimination with mass drug administrations on falciparum malaria in Southeast Asia: a cluster randomised trial by Von Seidlein, L, Peto, TJ, Landier, J, Nguyen, T-N, Tripura, R, Phommasone, K, Pongvongsa, T, Lwin, KM, Keereecharoen, L, Kajeechiwa, L, Thwin, MM, Parker, DM, Wiladphaingern, J, Nosten, S, Proux, S, Corbel, V, Tuong-Vy, N, Phuc-Nhi, TL, Son, DH, Huong-Thu, PN, Tuyen, NTK, Tien, NT, Dong, LT, Hue, DV, Quang, HH, Nguon, C, Davoeung, C, Rekol, H, Adhikari, B, Henriques, G, Phongmany, P, Suangkanarat, P, Jeeyapant, A, Vihokhern, B, Van Der Pluijm, RW, Lubell, Y, White, LJ, Aguas, R, Promnarate, C, Sirithiranont, P, Malleret, B, Rénia, L, Onsjö, C, Chan, XH, Chalk, J, Miotto, O, Patumrat, K, Chotivanich, K, Hanboonkunupakarn, B, Jittmala, P, Kaehler, N, Cheah, PY, Pell, C, Dhorda, M, Imwong, M, Snounou, G, Mukaka, M, Peerawaranun, P, Lee, SJ, Simpson, JA, Pukrittayakamee, S, Singhasivanon, P, Grobusch, MP, Cobelens, F, Smithuis, F, Newton, PN, Thwaites, GE, Day, NPJ, Mayxay, M, Hien, TT, Nosten, FH, Dondorp, AM, White, NJ

“…Of 221 participants with subclinical P. falciparum infections who participated in MDA and could be followed up, 207 (94%) cleared their infections, including 9 of 10 with artemisinin- and piperaquine-resistant infections. The DP MDAs were well tolerated; 6 severe adverse events were detected during the follow-up period, but none was attributable to the intervention. …”

7,8,15,16-tetraoxa-dispiro[5.2.5.2]hexadecane-3-carboxylic acid derivatives and their antimalarial activity by BOGDAN SOLAJA, WILBUR K. MILHOUS, DEJAN OPSENICA, NATASA TERZIC, IGOR OPSENICA

“…The obtained tetraoxanes showed pronounced antimalarial activity against P. falciparum chloroquine resistant W2 and chloroquine susceptible D6 strains, with N-(2-dimethylamino)ethyl-7,8,15,16-tetraoxa-dispiro[5.2.5.2] hexadecane-3-carboxamide being as active as artemisinin.…”
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Clinical status and implications of antimalarial drug resistance. by Winstanley, P, Ward, SA, Snow, R

“…Affordable options include chloroquine plus sulfadoxine-pyrimethamine (SP), amodiaquine (alone or in combination with SP) and chlorproguanil-dapsone. Artemisinin combination therapy may offer considerable advantages over alternative therapies, but its introduction faces considerable logistic difficulty.…”

Efficacy and safety of artemether-lumefantrine compared with quinine in pregnant women with uncomplicated Plasmodium falciparum malaria: an open-label, randomised, non-inferiority... by Piola, P, Nabasumba, C, Turyakira, E, Dhorda, M, Lindegardh, N, Nyehangane, D, Snounou, G, Ashley, E, Mcgready, R, Nosten, F, Guerin, P

“…In 2006, WHO recommended use of artemisinin-based combination treatments during the second or third trimesters, but data on efficacy and safety in Africa were scarce. …”

Chinese medicine in East Africa: an intimacy with strangers by Hsu, E

“…Rather than taking recourse to the ‘placebo effect’, the author explains through the spatialities and materialities of the medical procedures provided why - apart from purchasing the Chinese antimalarial called Artemisinin - locals would try out their ‘alternatively modern’ formulas for treating a wide range of post-colonial disorders and seek their sexual enhancement medicines.…”

Protective efficacy of malaria case management and intermittent preventive treatment for preventing malaria mortality in children: a systematic review for the Lives Saved Tool by Steketee Richard W, Eisele Thomas P, Thwing Julie

“…New advances in antimalarials have improved their efficacy of treating uncomplicated and severe malaria. Artemisinin-based combination therapies (ACTs) for uncomplicated <it>Plasmodium falciparum</it> malaria and parenteral or rectal artemisinin or quinine for severe malaria syndromes have been shown to be very effective for the treatment of malaria in children. …”
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Structural Modelling Prediction of Recombinant <i>Plasmodium falciparum</i> K13-F446I and K13-C580Y Gene by AlphaFold Method and Heterologous Expression in <i>Spodoptera frugiperda... by He Yan, Jun Feng, Min Chen

“…However, the function of Pfk13 and the structural alterations associated with artemisinin resistance mutations remain unknown. Herein, we screened two proteins, namely Pfk13-F446I and Pfk13-C580Y, which are closely associated with artemisinin, for structural prediction analysis. …”
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Celastrol targeting Nedd4 reduces Nrf2-mediated oxidative stress in astrocytes after ischemic stroke by Zexuan Hong, Jun Cao, Dandan Liu, Maozhu Liu, Mengyuan Chen, Fanning Zeng, Zaisheng Qin, Jigang Wang, Tao Tao

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Transmission blocking activity of a standardized neem (<it>Azadirachta indica</it>) seed extract on the rodent malaria parasite <it>Plasmodium berghei </it>in its vector <it>Anophe... by Esposito Fulvio, Pasqualini Luciano, Lupidi Giulio, Yerbanga Rakiswendé S, Lucantoni Leonardo, Habluetzel Annette

“…<p>Abstract</p> <p>Background</p> <p>The wide use of gametocytocidal artemisinin-based combination therapy (ACT) lead to a reduction of <it>Plasmodium falciparum </it>transmission in several African endemic settings. …”
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Effects of Mixed Allelochemicals on the Growth of <i>Microcystis aeruginosa</i>, Microcystin Production, Extracellular Polymeric Substances, and Water Quality by Ping Ouyang, Chao Wang, Peifang Wang, Xiaorong Gan, Xun Wang, Chaohui Yang

“…The obtained results demonstrated that artemisinin, nonanoic acid, malonic acid, and ethyl acetate inhibited algal growth more efficiently than D-menthol and lactic acid. …”
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Distinct evolution of type I glutamine synthetase in Plasmodium and its species-specific requirement by Sourav Ghosh, Rajib Kundu, Manjunatha Chandana, Rahul Das, Aditya Anand, Subhashree Beura, Ruchir Chandrakant Bobde, Vishal Jain, Sowmya Ramakant Prabhu, Prativa Kumari Behera, Akshaya Kumar Mohanty, Mahabala Chakrapani, Kapaettu Satyamoorthy, Amol Ratnakar Suryawanshi, Anshuman Dixit, Govindarajan Padmanaban, Viswanathan Arun Nagaraj

“…Targeting PfGS affects asparagine levels and inhibits protein synthesis through eIF2α phosphorylation leading to parasite death. Exposure of artemisinin-resistant Pf parasites to MSO and PPT inhibits the emergence of viable parasites upon artemisinin treatment.…”
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Cytoprotective autophagy as a pro-survival strategy in ART-resistant malaria parasites by Deepika Kannan, Nishant Joshi, Sonal Gupta, Soumya Pati, Souvik Bhattacharjee, Gordon Langsley, Shailja Singh

“…Abstract Despite several initiatives to subside the global malaria burden, the spread of artemisinin-resistant parasites poses a big threat to malaria elimination. …”
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