Targeted deep amplicon sequencing of kelch 13 and cytochrome b in Plasmodium falciparum isolates from an endemic African country using the Malaria Resistance Surveillance (MaRS) pr... by Mariangela L’Episcopia, Julia Kelley, Dhruviben Patel, Sarah Schmedes, Shashidahar Ravishankar, Michela Menegon, Edvige Perrotti, Abduselam M. Nurahmed, Albadawi A. Talha, Bakri Y. Nour, Naomi Lucchi, Carlo Severini, Eldin Talundzic

“…Results Spanning the full-length k13 gene, seven non-synonymous single nucleotide polymorphisms (SNPs) were found (K189N, K189T, E208K, D281V, E401Q, R622I and T535M), of which none have been associated with artemisinin resistance. No mutations were found in cytochrome b. …”
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Adverse effects of falciparum and vivax malaria and the safety of antimalarial treatment in early pregnancy: A population-based study by McGready, R, Wiladphaingern, J, Ashley, E, Rijken, M, Boel, M, Paw, M, Pimanpanarak, M, Mu, O, Nosten, F, Lee, S, Singhasivanon, P, White, N, Simpson, J

“…Prospective studies should now be done to assess the safety and efficacy of artemisinin combination treatments in early pregnancy. …”

Genetic markers associated with dihydroartemisinin–piperaquine failure in Plasmodium falciparum malaria in Cambodia: a genotype-phenotype association study by Kwiatkowski, D, Amato, R, Lim, P, Miotto, O, Amaratunga, C, Dek, D, Pearson, R, Almagro-Garcia, J, Neal, A, Sreng, S, Suon, S, Drury, E, Jyothi, D, Stalker, J, Fairhurst, R

“… <h4>Background</h4> <p>As the prevalence of artemisinin-resistant Plasmodium falciparum malaria increases in the Greater Mekong Subregion (GMS), emerging resistance to partner drugs in artemisinin combination therapies (ACTs) seriously threatens global efforts to treat and eliminate this disease. …”

Synthesizing the quality of study methodology and evidence to support guidelines for optimal treatment of falciparum malaria in pregnancy by Saito, M

“…Based on limited evidence, WHO has recommended quinine (with clindamycin, if available) for first-trimester and artemisinin-based combination therapy (ACT) for second- and third-trimester women since 2015. …”

Adverse effects of falciparum and vivax malaria and the safety of antimalarial treatment in early pregnancy: a population-based study. by Mcgready, R, Lee, S, Wiladphaingern, J, Ashley, E, Rijken, M, Boel, M, Simpson, J, Paw, M, Pimanpanarak, M, Mu, O, Singhasivanon, P, White, N, Nosten, F

“…Prospective studies should now be done to assess the safety and efficacy of artemisinin combination treatments in early pregnancy.…”

Malaria on the Guiana Shield: a review of the situation in French Guiana by Lise Musset, Stéphane Pelleau, Romain Girod, Vanessa Ardillon, Luisiane Carvalho, Isabelle Dusfour, Margarete SM Gomes, Félix Djossou, Eric Legrand

“…In a climate of growing concern that Plasmodium falciparum may be developing a drug resistance to artemisinin derivatives in the Guiana Shield, this review details our current knowledge of malaria and control strategy in one part of the Shield, French Guiana. …”
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Effect of Antimalarial Drugs on Plasmodia Cell-Free Protein Synthesis by Ana Ferreras, Ledia Triana, Erlinda Sánchez, Flor Herrera

“…A cell-free system from Plasmodium falciparum able to translate endogenous mRNA was used to determine the effect of artemisinin, chloroquine and primaquine on the protein synthesis mechanism of the parasite. …”
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Malaria-Infected Mice Are Cured by a Single Low Dose of a New Silylamide Trioxane Plus Mefloquine by Theresa A. Shapiro, Gary H. Posner, Nirbhay Kumar, Bryan T. Mott, Vandana Singhal, Lauren E. Woodard

“…Three thermally and hydrolytically stable silylamide trioxanes have been prepared from the natural trioxane artemisinin in only five simple chemical steps and in at least 56% overall yield. …”
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Treatment of malaria (lecture) by A. F. Popov

“…Unlike previous years, the new treatment is supplemented with artemisinin-based combination therapy – ACT, where two or more anti-malarial drug have multidirectional mechanism of action on P. falciparum. …”
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7&#946;-Hydroxyartemisinin by Mitchell A. Avery, John S. Williamson, Yunshan Wu, Bo Liu, Paulo B. Carvalho

“…Crystals of the title compound [systematic name: (3R,6R,7S,8aR,9R,12aR)-7-hydroxy-3,6,9-trimethyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one], C15H22O6, were obtained from microbial transformation of artemisinin by a culture of Cunninghamella elegans. …”
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Corrigendum: Identification and metabolomic characterization of potent anti-MRSA phloroglucinol derivatives from Dryopteris crassi rhizoma Nakai (Polypodiaceae) by Sumana Bhowmick, Sumana Bhowmick, Manfred Beckmann, Jianying Shen, Luis A. J. Mur

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South-Eastern Asia by Paris, D, White, N

“…The emergence and spread of artemisinin-resistant malaria and multidrug resistant (MDR) TB and the widespread use of poor quality anti-infective drugs emanating from this region all pose serious global risks. …”

Antimalarial drug quality: Methods to detect suspect drugs by Kaur, H, Green, MD, Hostetler, D, Fernández, F, Newton, P

“…The emergence of resistance to the artemisinin derivatives in Asia bodes ill for malaria control in Africa, and strenuous efforts are needed to improve the quality of the world's supply of antimalarials. …”

Mechanistic engineering of celastrol liposomes induces ferroptosis and apoptosis by directly targeting VDAC2 in hepatocellular carcinoma by Piao Luo, Qian Zhang, Shuo Shen, Yehai An, Lixia Yuan, Yin-Kwan Wong, Sizhe Huang, Shaohui Huang, Jingnan Huang, Guangqing Cheng, Jiahang Tian, Yu Chen, Xiaoyong Zhang, Weiguang Li, Songqi He, Jigang Wang, Qingfeng Du

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Malaria: new developments in treatment and prevention. by Newton, P, White, N

“…Resistance to the cheap, most commonly used antimalarials continues to spread alarmingly and could outpace drug development. The artemisinin derivatives have had an important clinical impact both on the treatment of resistant falciparum malaria and on the incidence of disease in low-transmission areas. …”

Anticancer agents against malaria: time to revisit? by Nzila, A, Okombo, J, Becker, R, Chilengi, R, Lang, T, Niehues, T

“…The emergence of artemisinin resistance could adversely impact the current strategy for malaria treatment; thus, new drugs are urgently needed. …”

Dihydroartemisinin-piperaquine rescue treatment of multidrug-resistant Plasmodium falciparum malaria in pregnancy: a preliminary report. by Rijken, M, Mcgready, R, Boel, M, Barends, M, Proux, S, Pimanpanarak, M, Singhasivanon, P, Nosten, F

“…Dihydroartemisinin-piperaquine (DHA-PPQ) is a promising new artemisinin combination treatment. There are no published data on the intentional use of the drug in pregnancy. …”

Induction of Artesunate Resistance in Plasmodium falciparum 3D7 Strain Using Intermittent Exposure Method and Comparing P.fk13 Sequence between Susceptible and Resistant Strains by Sahar Barati, Afsaneh Motevalli Haghi, Mehdi Nateghpour, Zahra Zamani, Sadegh Khodaveisi, Soudabeh Etemadi

“… Background: Resistance to artemisinin has threatened major achievements in malaria control, more investigations is needed about resistant strains and related genes. …”
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Dealing with indeterminate outcomes in antimalarial drug efficacy trials: a comparison between complete case analysis, multiple imputation and inverse probability weighting by Prabin Dahal, Kasia Stepniewska, Philippe J. Guerin, Umberto D’Alessandro, Ric N. Price, Julie A. Simpson

“…Methods 3369 study participants from the multicentre study (4ABC trial) with molecularly defined parasitic recurrence treated with three artemisinin-based combination therapies were used to represent a complete dataset. …”
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Private sector availability and affordability of under 5 malaria health commodities in selected states in Nigeria and the Federal Capital Territory by Kunle Rotimi, Babatunde Fagbemi, Ademola Joshua Itiola, Taiwo Ibinaiye, Adaeze Aidenagbon, Chrysantus Dabes, Ahmed Aminu Biambo, Azuka Iwegbu, Sarah Onabajo, Chibuzo Oguoma, Olusola Oresanya

“…However, when the cost of testing and treatment with artemisinin-based combination therapies (ACTs) was assessed, testing and treatment with dihydroartemisinin/piperaquine were unaffordable as the they cost more than 1.5 times the daily wage of the least-paid government worker. …”
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