Electrocardiographic monitoring in severe falciparum malaria. by Bethell, D, Phuong, P, Phuong, C, Nosten, F, Waller, D, Davis, T, Day, N, Crawley, J, Brewster, D, Pukrittayakamee, S, White, N

“…Furthermore, no abnormality was detected which could have resulted from the often large doses of quinine, chloroquine or the artemisinin derivatives used for treatment. These results suggest that the heart is remarkably resilient even in the face of heavy parasite sequestration and other vital organ dysfunction, and that deaths from cardiac arrhythmias in severe malaria are rare. …”

Malaria in children. by Crawley, J, Chu, C, Mtove, G, Nosten, F

“…Coverage with existing control methods (ie, vector control and artemisinin-based combination therapy) is increasing, and, in some Asian and African countries, childhood morbidity and mortality from malaria caused by Plasmodium falciparum are starting to decline. …”

A comparison of oral artesunate and artemether antimalarial bioactivities in acute falciparum malaria. by Suputtamongkol, Y, Newton, P, Angus, B, Teja-Isavadharm, P, Keeratithakul, D, Rasameesoraj, M, Pukrittayakamee, S, White, N

“… AIMS: Artesunate and artemether are the two most widely used artemisinin derivatives in the treatment of uncomplicated Plasmodium falciparum malaria, but there is little information on their comparative pharmacokinetics. …”

The role of anti-malarial drugs in eliminating malaria. by White, N

“…Mature Plasmodium falciparum gametocytes are more drug resistant and affected only by artemisinins and 8-aminoquinolines. The key operational question now is whether primaquine should be added to artemisinin combination treatments for the treatment of falciparum malaria to reduce further the transmissibility of the treated infection. …”

The role of early detection and treatment in malaria elimination by Nosten, F, Landier, J, Parker, D, Thu, A, Carrara, V, Lwin, K, Bonnington, C, Pukrittayakamee, S, Delmas, G

“…The main focus of a MP is to provide uninterrupted and rapid access to rapid diagnostic tests (RDTs) and artemisinin-based combination therapy (ACT) too all inhabitants of a village. …”

Monitoring parasite diversity for malaria elimination in sub-Saharan Africa. by Ghansah, A, Amenga-Etego, L, Amambua-Ngwa, A, Andagalu, B, Apinjoh, T, Bouyou-Akotet, M, Cornelius, V, Golassa, L, Andrianaranjaka, V, Ishengoma, D, Johnson, K, Kamau, E, Maïga-Ascofaré, O, Mumba, D, Tindana, P, Tshefu-Kitoto, A, Randrianarivelojosia, M, William, Y, Kwiatkowski, D, Djimde, A

“…Of current concern is the recently reported emergence of resistance to the front-line drug, artemisinin, in South-East Asia in Plasmodium falciparum, which calls for preemptive surveillance of the African parasite population for genetic markers of emerging drug resistance. …”

Trends in antimalarial drug use in Africa. by Flegg, J, Metcalf, C, Gharbi, M, Venkatesan, M, Shewchuk, T, Hopkins Sibley, C, Guerin, P

“…In East Africa SP drug use was strongly correlated to resistance. If artemisinin resistance spreads to, or emerges in, Africa this methodology will be a valuable tool to estimate actual drug use and its impact on changes in drug efficacy.…”

Feasibility of home management using ACT for childhood malaria episodes in an urban setting by Nsagha DS, Elat JBN, Ndong PAB, Tata PN, Tayong MN, Pokem F, Wankah CC

“…The purpose of this study was to determine community perception and the treatment response to episodes of childhood malaria in an urban setting prior to implementation of home management using artemisinin-based combination therapy (ACT).Methods: This qualitative exploratory study on the home management of malaria in urban children under 5 years of age used 15 focus group discussions and 20 in-depth interviews in various categories of caregivers of children under 5 years. …”
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TRIM56-mediated production of type I interferon inhibits intracellular replication of Rickettsia rickettsii by Ruxi Cheng, Chunyu Zhou, Mingliang Zhao, Shan Zhang, Weiqiang Wan, Yonghui Yu, Bohai Wen, Jun Jiao, Xiaolu Xiong, Qin Xu, Xuan OuYang

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Protocol for a cluster randomised placebo-controlled trial of adjunctive ivermectin mass drug administration for malaria control on the Bijagós Archipelago of Guinea-Bissau: the MA... by David Mabey, John Bradley, Amabelia Rodrigues, Chris Drakeley, Eunice Teixeira da Silva, Hristina Vasileva, Umberto d'Alessandro, Cesario Martins, Robert T Jones, James G Logan, Harry Hutchins, Elizabeth Pretorius, Mamadou Ousmane Ndiath, Harouna dit Massire Soumare, Ernesto Jose Nante, Hannah Slater, Anna R Last

“…Mass drug administration (MDA) of artemisinin-based combination therapy (ACT) is capable of reducing malaria transmission where coverage of control interventions is already high, though the impact is short-lived. …”
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Application of economic analysis to evaluate various infectious diseases in Vietnam by Phuong, T

“…</p> <p>Increasing resistance of <em>Plasmodium falciparum</em> malaria to <em>artemisinin</em> is posing a major threat to the global effort to eliminate malaria. …”

Biotechnology : research, technology and applications / by Richter, Felix W.

National-scale simulation of human movement in a spatially coupled individual-based model of malaria in Burkina Faso by Robert J. Zupko, Tran Dang Nguyen, Amy Wesolowski, Jaline Gerardin, Maciej F. Boni

“…Abstract Malaria due to the Plasmodium falciparum parasite remains a threat to human health despite eradication efforts and the development of anti-malarial treatments, such as artemisinin combination therapies. Human movement and migration have been linked to the propagation of malaria on national scales, highlighting the need for the incorporation of human movement in modeling efforts. …”
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Plasmodial Kinase Inhibitors Targeting Malaria: Recent Developments by Romain Mustière, Patrice Vanelle, Nicolas Primas

“…Recent progress in reducing malaria cases and ensuing deaths is threatened by factors like mutations that induce resistance to artemisinin derivatives. Multiple drugs are currently in clinical trials for malaria treatment, including some with novel mechanisms of action. …”
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Severe falciparum malaria with hypophosphataemia and presumed hypophosphatemia induced rhabdomyolysis: a case report by M Perera, V Samarawickrama, K Lokuketagoda, K Thirumavalawan

“…He was started on IV artesunate followed by artemisinin based combination therapy orally to which he responded. …”
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Biological Activity of Selected Natural and Synthetic Terpenoid Lactones by Alicja K. Surowiak, Lucyna Balcerzak, Stanisław Lochyński, Daniel J. Strub

“…Moreover, one terpenoid lactone, artemisinin, is used as a drug against malaria. Because of these abilities, there is constant interest in new terpenoid lactones that are both isolated and synthesized, and their biological activities have been verified. …”
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Efficacy of six-dose regimen of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria, three years after its introduction into Ethiopia by Kefyalew T., Animut A., Tamene T., Jima D., Hailemariam A., Legesse M.

“…A significant increase in the mean of haemoglobin level was observed on day 28 posttreatment (11.4 g/dL on day 0 vs 12.3 g/dL on day 28, p < 0.05). Thus, artemisinin-based combination therapies (ACTs) seem to mitigate not only the problem of drug resistance malaria but also the transmission of the disease. …”
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Combination therapy for malaria in Africa: hype or hope? by Peter B. Bloland, Mary Ettling, Sylvia Meek

“…Observations in South-East Asia on combination therapy with artemisinin derivatives and mefloquine indicate that the development of resistance to both components is slowed down. …”
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Purification and characterization of putative RNA binding protein from plasmodium falciparum by Cho, Samuel Jia Sheng

“…Not only has quinoline resistance become widespread around the world, disconcertingly, artemisinin resistance is also emerging in parts of Southeast Asia. …”
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An evaluation of rectal artesunate for the pre-hospital management of severe malaria by Angus, BJ

“…There is a concern that the administration of a single dose of artesunate without adequate follow up therapy may encourage the emergence of artemisinin resistance.</p> <p><strong>Expert opinion</strong> Artesunate is an essential drug and RAS is a very useful, potentially lifesaving formulation designed to be quickly administered in remote areas to severely unwell children by non-medical personnel. …”