The Search for New Drugs from Higher Plants by Kurt Hostettmann, Andrew Marston

“…Recently introduced plant-derived drugs include paclitaxel from Taxus (Taxaceae) species for the treatment of cancers, artemisinin for malaria therapy and the alkaloid galanthamine for the management of Alzheimer's disease. …”
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USING OF Agrobacterium-MEDIATED TRANSFORMATION FOR THE BIOTECHNOLOGICAL IMPROVEMENT OF COMPOSITAE PLANTS. ІІ. SYNTHESIS OF BIOACTIVE COMPOUNDS IN TRANSGENIC PLANTS AND «HAIRY» ROOT... by N. A. Matvieieva

“…The article presents data on the results of genetic transformation of Cichorium intybus, Lactuca sativa, Artemisia annua, Artemisia vulgaris, Calendula officinalis, Withania somnifera and other Compositae plants as well as studies on the artemisinin, flavonoids, polyphenols, fructans and other compounds accumulation in transgenic plants and roots. …”
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Mechanism and Prospect of Gastrodin in Osteoporosis, Bone Regeneration, and Osseointegration by Yi Li, Fenglan Li

“…In addition, we speculated on the potential mechanisms of gastrodin against osteoporosis, by affecting actin filament polymerization, renin–angiotensin system (RAS) and ferroptosis, and proposed that the potential combination of gastrodin with Mg²⁺, angiotensin type 2 receptor blockers or artemisinin may greatly inhibit osteoporosis. The purpose of this review is to provide a reference for more in-depth research and application of gastrodin in the treatment of osteoporosis and implant osseointegration in the future.…”
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Optimization and inhibition of the adherent ability of Plasmodium falciparum-infected erythrocytes by Heidi Smith, Ian Crandall, Jacques Prudhomme, Irwin Sherman

“…Antimalarials (chloroquine, quinacrine, mefloquine, artemisinin), on the other hand, affected adherence in an indirect fashion i.e. since cytoadherence is due, in part to the presence of knobs on the surface of the infected erythrocyte, and knob formation is dependent on intracellular parasite growth, when plasmodial development is inhibited so is knob production, and consequently adherence is ablated.…”
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Fault-Tolerant Quantum Algorithm for Symmetry-Adapted Perturbation Theory by Cristian L. Cortes, Matthias Loipersberger, Robert M. Parrish, Sam Morley-Short, William Pol, Sukin Sim, Mark Steudtner, Christofer S. Tautermann, Matthias Degroote, Nikolaj Moll, Raffaele Santagati, Michael Streif

“…Finally, we perform the resource estimation for a heme and artemisinin complex as a representative large-scale system encountered in drug design, highlighting the performance of our algorithm in this new benchmark study and discussing possible bottlenecks that may be improved in future work.…”
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Dried blood spots: a robust tool for malaria surveillance in countries targeting elimination by Minu Nain, Abhinav Sinha, Amit Sharma

“…In India, malaria cases have reduced significantly over the past decade but to achieve malaria elimination by 2030, country-wide DBS-based screening should be conducted to identify the presence of molecular markers of artemisinin resistance and to study parasite reservoirs in asymptomatic populations. …”
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The global pipeline of new medicines for the control and elimination of malaria by Anthony Melinda P, Burrows Jeremy N, Duparc Stephan, JMoehrle Joerg, Wells Timothy NC

“…<p>Abstract</p> <p>Over the past decade, there has been a transformation in the portfolio of medicines to combat malaria. New fixed-dose artemisinin combination therapy is available, with four different types having received approval from Stringent Regulatory Authorities or the World Health Organization (WHO). …”
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A thirty one year old man with co-infection of malaria and dengue by B. Rathypriya, S. Maathury, M. C. Wickramasinghe, J. Indrakumar

“…Antimalarial treatment was started with intravenous artesunate, followed by artemisinin based combination therapy. The patient’s fever improved with 24 hours of treatment and thereafter he recovered completely. …”
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Pharmacovigilance of antimalarial treatment in Africa: is it possible? by Staedke Sarah G, Talisuna Ambrose O, D'Alessandro Umberto

“…Many African countries have simultaneously adopted artemisinin derivative based combination therapy (ACT) as first-line treatment for uncomplicated malaria, offering an opportunity to assess the safety of these drugs when used widely. …”
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Population pharmacokinetics and pharmacodynamics of piperaquine in children with uncomplicated falciparum malaria. by Tarning, J, Zongo, I, Somé, F, Rouamba, N, Parikh, S, Rosenthal, P, Hanpithakpong, W, Jongrak, N, Day, N, White, N, Nosten, F, Ouedraogo, J, Lindegardh, N

“…Dihydroartemisinin-piperaquine is being increasingly used as a first-line artemisinin combination treatment for malaria. The aim of this study was to describe the pharmacokinetic and pharmacodynamic properties of piperaquine in 236 children with uncomplicated falciparum malaria in Burkina Faso. …”

A high throughput screen for next-generation leads targeting malaria parasite transmission by Delves, MJ, Miguel-Blanco, C, Matthews, H, Molina, I, Ruecker, A, Yahiya, S, Straschil, U, Abraham, M, León, ML, Fischer, OJ, Rueda-Zubiaurre, A, Brandt, JR, Cortés, Á, Barnard, A, Fuchter, MJ, Calderón, F, Winzeler, EA, Sinden, RE, Herreros, E, Gamo, FJ, Baum, J

“…Spread of parasite resistance to artemisinin threatens current frontline antimalarial therapies, highlighting the need for new drugs with alternative modes of action. …”

A high-content phenotypic screen reveals the disruptive potency of quinacrine and 3',4'-dichlorobenzamil on the digestive vacuole of Plasmodium falciparum. by Lee, Y, Goh, A, Ch'ng, J, Nosten, F, Preiser, P, Pervaiz, S, Yadav, S, Tan, K

“…Quinacrine was effective at inhibiting field isolates in a 48-h reinvasion assay regardless of artemisinin clearance status. We therefore present as proof of concept a phenotypic screening method with the potential to provide mechanistic insights to the activity of antimalarial drugs.…”

Artesunate versus artemether in combination with mefloquine for the treatment of multidrug-resistant falciparum malaria. by Price, R, Nosten, F, Luxemburger, C, Kham, A, Brockman, A, Chongsuphajaisiddhi, T, White, N

“…There was no significant adverse effect attributable to the artemisinin derivatives. Fever and parasite clearance times with mefloquine alone were significantly longer (P &lt; 0.001). …”

A systematic overview of published antimalarial drug trials. by Myint, H, Tipmanee, P, Nosten, F, Day, N, Pukrittayakamee, S, Looareesuwan, S, White, N

“…Chloroquine was given to over half the patients in antimalarial drug trials (n = 53552) compared with artemisinin derivatives (n = 12463), mefloquine-sulphadoxine-pyrimethamine (n = 9153), mefloquine (n = 5546) and sulphadoxine-pyrimethamine (n = 5909). …”

The management of patients with severe malaria. by Day, N, Dondorp, A

“…The antimalarial treatment of severe disease is being transformed by the development and deployment of the water-soluble artemisinin derivative artesunate. Parenteral artesunate is now the treatment of choice in low-transmission areas and in the 2nd and 3rd trimesters of pregnancy, and research is underway into whether it should replace quinine as the treatment of choice in African children. …”

The pathogenesis of Plasmodium falciparum malaria in humans: insights from splenic physiology. by Buffet, P, Safeukui, I, Deplaine, G, Brousse, V, Prendki, V, Thellier, M, Turner, G, Mercereau-Puijalon, O

“…The spleen-specific pitting function accounts for a large fraction of parasite clearance in artemisinin-treated patients. RBC loss contributes to malarial anemia, a clinical form associated with subacute progression, frequent splenomegaly, and relatively low parasitemia. …”

Chemotherapeutic strategies for reducing transmission of Plasmodium vivax malaria. by Douglas, N, John, G, von Seidlein, L, Anstey, N, Price, R

“…Given the spread of chloroquine-resistant P. vivax strains, the artemisinin combination therapies dihydroartemisinin + piperaquine and artesunate + mefloquine are currently the most assured means of preventing P. vivax recrudescence. …”

Malaria: severe, life-threatening. by Sheehy, S, Angus, B

“…CONCLUSIONS: In this systematic review we present information relating to the effectiveness and safety of the following interventions: dexamethasone, exchange blood transfusion, initial blood transfusion, intramuscular artemether, intravenous and intramuscular artesunate, intravenous and intramuscular dihydroartemisinin, quinine, and rectal/intravenous/intramuscular artemisinin and its derivatives.…”

Combined chloroquine, sulfadoxine/pyrimethamine and primaquine against Plasmodium falciparum in Central Java, Indonesia. by Lederman, E, Maguire, J, Sumawinata, I, Chand, K, Elyazar, I, Estiana, L, Sismadi, P, Bangs, M, Baird, J

“…Combining CQ with other drugs, like SP, may provide an affordable, available and effective option where artemisinin-combined therapies (ACT) are not licensed or are unavailable. …”

The mechanisms of parasite clearance after antimalarial treatment of Plasmodium falciparum malaria. by Chotivanich, K, Udomsangpetch, R, Dondorp, A, Williams, T, Angus, B, Simpson, J, Pukrittayakamee, S, Looareesuwan, S, Newbold, C, White, N

“…Rapid malaria parasite clearance after treatment with artemisinin derivatives results mainly from the extraction of drug-affected parasites from host erythrocytes-presumably by the spleen. …”