Initial evidence of reduction of malaria cases and deaths in Rwanda and Ethiopia due to rapid scale-up of malaria prevention and treatment by Gausi Khoti, Jima Daddi, Bekele Worku, Medin Ambachew, Karema Corine, Were Wilson, Aregawi Maru, Otten Mac, Komatsu Ryuichi, Korenromp Eline, Low-Beer Daniel, Grabowsky Mark

“…To have an initial estimate of the impact of these efforts, time trends in health facility records were evaluated in selected districts in Ethiopia and Rwanda, where long-lasting insecticidal nets (LLIN) and artemisinin-based combination therapy (ACT) had been distributed nationwide by 2007.…”
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Introducing rapid diagnostic tests for malaria to drug shops in Uganda: a cluster-randomized controlled trial by Jessica Cohen, Günther Fink, Kathleen Maloney, Katrina Berg, Matthew Jordan, Theodore Svoronos, Flavia Aber, William Dickens

“…The probability that artemisinin combination therapy was bought increased by a statistically insignificant 5.48% (P = 0.574). …”
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Variation in CYP2A6 Activity and Personalized Medicine by Julie-Anne Tanner, Rachel F. Tyndale

“…The gene that encodes the CYP2A6 enzyme is highly polymorphic, resulting in extensive interindividual variation in CYP2A6 enzyme activity and the rate of metabolism of nicotine and other CYP2A6 substrates including cotinine, tegafur, letrozole, efavirenz, valproic acid, pilocarpine, artemisinin, artesunate, SM-12502, caffeine, and tyrosol. …”
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Averting a malaria disaster in Africa: where does the buck stop? by Christopher J.M. Whitty, Richard Allan, Virginia Wiseman, Sam Ochola, Maria Veronicah Nakyanzi-Mugisha, Benjamin Vonhm, Mahemba Mwita, Constantin Miaka, Aggrey Oloo, Zul Premji, Craig Burgess, Theonest K. Mutabingwa

“…However, the current cost of combination therapy, and especially that of artemisinin combination therapy (ACT), is potentially a serious drawback, even if a significant part of its cost is passed on to the end-user. …”
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Changing patterns of malaria during 1996-2010 in an area of moderate transmission in Southern Senegal by Vaillant Michel T, Agnamey Patrice, Badiane Malick, Cisse Moustafa, Brasseur Philippe, Olliaro Piero L

“…Temporally, this coincides with deploying artemisinin combinations on parasitological confirmation, but other contributing causes are unclear.…”
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Comparative Study of Pharmaceutical, Herbal Medicine, and Low-Value Alternating Electromagnetic Radiation as Anti-Malaria Treatment by Abayomi Alade

“…Pharmaceutical interventions, specifically artemisinin-based combination therapies (ACTs), have long been the mainstay of malaria treatment due to their proven efficacy in eliminating Plasmodium parasites. …”
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<it>In vitro </it>activity of pyronaridine against <it>Plasmodium falciparum </it>and comparative evaluation of anti-malarial drug susceptibility assays by Pongratz Peter, Kurth Florian, Bélard Sabine, Mordmüller Benjamin, Kremsner Peter G, Ramharter Michael

“…</p> <p>Conclusion</p> <p>Pyronaridine is highly active in chloroquine-resistant parasites and seems a promising partner drug for artemisinin-based combination therapy in Africa.</p>…”
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Phosphatidylinositol 3-phosphate and Hsp70 protect Plasmodium falciparum from heat-induced cell death by Lu, Kuan-Yi, Pasaje, Charisse Flerida A, Srivastava, Tamanna, Loiselle, David R, Niles, Jacquin C, Derbyshire, Emily

“…Phosphatidylinositol 3-phosphate (PI(3)P) levels in Plasmodium falciparum correlate with tolerance to cellular stresses caused by artemisinin and environmental factors. However, PI(3)P function during the Plasmodium stress response was unknown. …”
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In vivo and in vitro activities and ADME-Tox profile of a quinolizidine-modified 4-aminoquinoline: A potent Anti-P. falciparum and anti-P. vivax blood-stage antimalarial by Basilico, N, Parapini, S, Sparatore, A, Romeo, S, Misiano, P, Vivas, L, Yardley, V, Croft, S, Habluetzel, A, Lucantoni, L, Renia, L, Russell, B, Suwanarusk, R, Nosten, F, Dondio, G, Bigogno, C, Jabes, D, Taramelli, D

“…Low toxicity and additivity with artemisinin derivatives were also demonstrated in vitro. …”

How much fat is necessary to optimize lumefantrine oral bioavailability? by Ashley, E, Stepniewska, K, Lindegårdh, N, Annerberg, A, Kham, A, Brockman, A, Singhasivanon, P, White, N, Nosten, F

“… BACKGROUND: Artemether-lumefantrine (AL) is the only fixed, artemisinin-based combination antimalarial drug which is registered internationally and deployed on a large scale. …”

Smartphones for community health in rural Cambodia: A feasibility study by Ngor, P, White, L, Chalk, J, Lubell, Y, Favede, C, Cheah, P, Nguon, C, Ly, P, Maude, R, Sovannaroth, S, Day, N, Dunachie, S

“… <h4>Background</h4> <p>Village Malaria Workers (VMWs) are lay people trained to provide a valuable role in frontline testing and treatment of malaria in rural villages in Cambodia. Emergence of artemisinin-resistant malaria highlights the essential role of such VMWs in surveillance and early treatment of malaria. …”

Study protocol: an open-label individually randomised controlled trial to assess the efficacy of artemether-lumefantrine prophylaxis for malaria among forest goers in Cambodia by Maude, RJ, Tripura, R, Ean, M, Sokha, M, Peto, TJ, Callery, JJ, Imwong, M, Vongpromek, R, Tarning, J, Mukaka, M, Waithira, N, Soviet, O, von Seidlein, L, Sovannaroth, S

“…The primary objective is to compare the efficacy of the artemisinin combination therapy AL versus a multivitamin preparation as defined by the 28-day PCR parasite positivity rate and incidence of confirmed clinical malaria of any species. …”

Neuropsychiatric adverse effects of mefloquine - What do we know and what should we do? by Nosten, F, van Vugt, M

“…Mefloquine, if possible in combination with an artemisinin derivative, is the only efficacious treatment left for uncomplicated but highly multidrug-resistant P. falciparum infections encountered in some areas. …”

Similar efficacy and tolerability of double-dose chloroquine and artemether-lumefantrine for treatment of Plasmodium falciparum infection in Guinea-Bissau: a randomized trial. by Ursing, J, Kofoed, P, Rodrigues, A, Blessborn, D, Thoft-Nielsen, R, Björkman, A, Rombo, L

“…High-dose chloroquine treatment regimes should be further evaluated with the aim of assessing chloroquine as a potential partner drug to artemisinin derivatives. Clinical trials registration. …”

An interactive application for malaria elimination transmission and costing in the Asia-Pacific by Celhay, OJ, Silal, SP, Maude, RJ, Gran Mercado, CE, Shretta, R, White, LJ

“…The emergence and spread of artemisinin drug resistance in the Greater Mekong Subregion makes elimination urgent and strategic for the global goal of malaria eradication. …”

Changes in malaria parasite drug resistance in an endemic population over a 25-year period with resulting genomic evidence of selection. by Nwakanma, D, Duffy, C, Amambua-Ngwa, A, Oriero, E, Bojang, K, Pinder, M, Drakeley, C, Sutherland, C, Milligan, P, Macinnis, B, Kwiatkowski, D, Clark, T, Greenwood, B, Conway, D

“…This covered a period before antimalarial resistance was detected locally, through subsequent failure of multiple drugs until introduction of artemisinin combination therapy. We separately performed genome-wide sequence analysis of 52 clinical isolates from 2008 to prospect for loci under recent directional selection. …”

Malaria control by commodities without practical malariology by Baird, J

“…Since 2005, tens of billions of dollars mobilized new commodities to control malaria: point-of-care diagnostics, effective artemisinin-based treatments, and longer-lasting insecticide treated bed nets. …”

Artesunate versus artemether for the treatment of recrudescent multidrug-resistant falciparum malaria. by Price, R, van Vugt, M, Nosten, F, Luxemburger, C, Brockman, A, Phaipun, L, Chongsuphajaisiddhi, T, White, N

“…Overall, these data suggest that the two oral artemisinin derivatives are safe, highly effective, and result in equivalent therapeutic responses in the treatment of drug-resistant falciparum malaria.…”

Gametocyte carriage in an era of changing malaria epidemiology: A 19-year analysis of a malaria longitudinal cohort by Muthui, M, Mogeni, P, Mwai, K, Nyundo, C, Macharia, A, Williams, TN, Nyangweso, G, Wambua, J, Mwanga, D, Marsh, K, Bejon, P, Kapulu, M

“…The prevalence of asexual parasites and of gametocyte carriage declined over time, and after 2006, when artemisinin combination therapy (ACT) was introduced, recent episodes of clinical malaria ceased to be a predictor of gametocyte carriage.…”

Smartphones for community health in rural Cambodia: A feasibility study by Ngor, P, White, L, Chalk, J, Lubell, Y, Favede, C, Cheah, P, Nguon, C, Ly, P, Maude, R, Sovannaroth, S, Day, N, Dunachie, S

“… <h4>Background</h4> <p>Village Malaria Workers (VMWs) are lay people trained to provide a valuable role in frontline testing and treatment of malaria in rural villages in Cambodia. Emergence of artemisinin-resistant malaria highlights the essential role of such VMWs in surveillance and early treatment of malaria. …”