Histone methyltransferase inhibitors: orally bioavailable, fast acting molecules with activity against different human malaria species. by Malmquist, N, Sundriyal, S, Caron, J, Chen, P, Witkowski, B, Menard, D, Suwanarusk, R, Renia, L, Nosten, F, Jiménez-Díaz, M, Angulo-Barturen, I, Martínez, MS, Ferrer, S, Sanz, L, Gamo, F, Wittlin, S, Duffy, S, Avery, V, Ruecker, A, Delves, M, Sinden, R, Fuchter, M, Scherf, A

“…BIX-01294 and TM2-115 displayed potent in vitro activity with IC50 values <50 nM against drug sensitive laboratory strains and multi-drug resistant field isolates including artemisinin refractory P. falciparum isolates. Activity against ex vivo clinical isolates of both P. falciparum and P. vivax were similar with potencies of 300-400 nM. …”

Probability of emergence of antimalarial resistance in different stages of the parasite life cycle. by Pongtavornpinyo, W, Hastings, I, Dondorp, A, White, L, Maude, R, Saralamba, S, Day, N, White, N, Boni, M

“…Antimalarial drug resistance is a major threat to malaria control and directly related to trends in malaria attributable mortality. Artemisinin combination therapies (ACT) are now recommended worldwide as first line treatment for uncomplicated malaria, and losing them to resistance would be a disaster for malaria control. …”

Safety and efficacy of dihydroartemisinin/piperaquine (Artekin) for the treatment of uncomplicated Plasmodium falciparum malaria in Rwandan children. by Karema, C, Fanello, C, van Overmeir, C, van Geertruyden, J, van Doren, W, Ngamije, D, D'Alessandro, U

“…In Rwanda, amodiaquine+sulfadoxine/pyrimethamine (AQ+SP) is the current first-line treatment for malaria, introduced in 2001 as an interim strategy before the future deployment of an artemisinin-based combination treatment (ACT). Dihydroartemisinin/piperaquine (DHA-PQP) is a new co-formulated and well tolerated ACT increasingly used in Southeast Asia where it has proved to be highly effective against Plasmodium falciparum malaria. …”

Complex polymorphisms in the Plasmodium falciparum multidrug resistance protein 2 gene and its contribution to antimalarial response. by Veiga, M, Veiga, M, Osório, N, Ferreira, P, Franzén, O, Dahlstrom, S, Lum, J, Nosten, F, Gil, J

“…We also investigated the potential association of the identified Pfmrp2 polymorphisms with altered in vitro susceptibility to several antimalarials used in artemisinin-based combination therapy and with parasite clearance time. …”

Recent advances in understanding apicomplexan parasites [version 1; referees: 2 approved] by Frank Seeber, Svenja Steinfelder

“…Plasmodium falciparum causes malaria, and thus the recent emergence of resistance against the currently used drug combinations based on artemisinin has been of major interest for the scientific community. …”
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The Alleviation of LPS-Induced Murine Acute Lung Injury by GSH-Mediated PEGylated Artesunate Prodrugs by Dan-Li Hao, Ya-Jie Wang, Jia-Ying Yang, Ran Xie, Ling-Yu Jia, Jin-Tang Cheng, Hai Ma, Ji-Xiang Tian, Shan-Shan Guo, Ting Liu, Feng Sui, Yu Zhao, Yan-Jun Chen, Qing-He Zhao

“…Artesunate (ART), a derivative of artemisinin, has been reported to have anti-inflammatory effects. …”
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Acceptance, availability, and feasibility of RTS, S/AS01 malaria vaccine: A review by Hassan Mumtaz, Abdullah Nadeem, Wajeeha Bilal, Farrukh Ansar, Saira Saleem, Qaisar Ali Khan, Tamara Tango, Christopher Farkouh, Naod F. Belay, Ravina Verma, Matthew Farkouh, Muhammad Saqib

“…The number of malaria‐related fatalities has drastically decreased because of artemisinin‐based pharmacological regimens. Methods Two independent researchers did a comprehensive literature search using PubMed/MEDLINE and Google Scholar from its inception to September 2022. …”
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Accelerating the understanding of Aspergillus terreus: Epidemiology, physiology, immunology and advances by Raman Thakur, Sonia Kumari Shishodia, Ananya Sharma, Arjun Chauhan, Sumanpreet Kaur, Jata Shankar

“…The exploration of epidemiology, morphological transitions, immunopathology, and novel treatment approaches such as new antifungal drugs (PC945, olorofim) and combinational therapy using antifungal drugs and phytochemicals (Phytochemicals: quercetin, shikonin, artemisinin), also using immunotherapies to modulate immune response has resulted in better outcomes. …”
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Resistance to Antimalarial Monotherapy Is Cyclic by Rachel Weitzman, Ortal Calfon-Peretz, Trishna Saha, Naamah Bloch, Karin Ben Zaken, Avi Rosenfeld, Moshe Amitay, Abraham O. Samson

“…The antimalarial drugs that exhibit cyclic resistance are quinine, chloroquine, mefloquine, amodiaquine, artesunate, artemether, sulfadoxine, doxycycline, halofantrine, piperaquine, pyrimethamine, atovaquone, artemisinin, and dihydroartemisinin. Exceptionally, the resistance of the two latter drugs can also correlate with a linear rise. …”
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Potential Plant-Based New Antiplasmodial Agent Used in Papua Island, Indonesia by Raden Bayu Indradi, Muhaimin Muhaimin, Melisa Intan Barliana, Alfi Khatib

“…The World Health Organization recently reported that artemisinin partial resistance, which was defined as delayed parasite clearance, was detected in Southeast Asia, particularly in the Greater Mekong subregion, and in Africa, particularly in Rwanda and Uganda. …”
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The Effects of Frequent Therapeutic Administration of Artesunate-amodiaquine and Artemether-lumefantrine on Haematological Markers in BALB/c Mice by David Audu, Olufunmilayo Ajoke Idowu, Vinood B Patel, Musa Fakilahyel Mshelbwala, Adewumi Babatunde Idowu

“…Artemisinin Combination Therapy (ACT) is readily available in malaria-endemic nations, leading to repeated drug usage by undiagnosed persons. …”
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Synergistic antimalarial treatment of Plasmodium berghei infection in mice with dihydroartemisinin and Gymnema inodorum leaf extract by Sakaewan Ounjaijean, Voravuth Somsak

“…The rise of resistance to most antimalarial medicines has been a serious hurdle to effective treatment. Artemisinin-based combination therapies (ACTs) are currently the most effective antimalarial medication. …”
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Applications of Sesquiterpene Lactones: A Review of Some Potential Success Cases by Laila Moujir, Oliver Callies, Pedro M. C. Sousa, Farukh Sharopov, Ana M. L. Seca

“…Sesquiterpene lactones, a vast range of terpenoids isolated from Asteraceae species, exhibit a broad spectrum of biological effects and several of them are already commercially available, such as artemisinin. Here the most recent and impactful results of in vivo, preclinical and clinical studies involving a selection of ten sesquiterpene lactones (alantolactone, arglabin, costunolide, cynaropicrin, helenalin, inuviscolide, lactucin, parthenolide, thapsigargin and tomentosin) are presented and discussed, along with some of their derivatives. …”
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Potential of nanoformulations in malaria treatment by Janaina Braga Chaves, Bianca Portugal Tavares de Moraes, Stela Regina Ferrarini, Francisco Noé da Fonseca, Adriana Ribeiro Silva, Cassiano Felippe Gonçalves-de-Albuquerque, Cassiano Felippe Gonçalves-de-Albuquerque

“…Current treatments include single drugs such as chloroquine, lumefantrine, primaquine, or in combination with artemisinin or its derivatives. Resistance to antimalarial drugs has increased; therefore, there is an urgent need to diversify therapeutic approaches. …”
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In vitro and in vivo antiplasmodial evaluation of sugar-modified nucleoside analogues by Miklós Bege, Vigyasa Singh, Neha Sharma, Nóra Debreczeni, Ilona Bereczki, Poonam, Pál Herczegh, Brijesh Rathi, Shailja Singh, Anikó Borbás

“…The establishment of Pf resistance to most existing antimalarial therapies has complicated the problem, and the emergence of resistance to artemisinin derivatives is even more concerning. It is increasingly difficult to cure malaria patients due to the limited availability of effective antimalarial drugs, resulting in an urgent need for more efficacious and affordable treatments to eradicate this disease. …”
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Quantitative Refocused INEPT Method Based on Simulated Annealing Optimization by CHEN Lei, LIU Hongbing, LIU Huili, WANG Liying

“…The above methods were validated using model compounds such as artemisinin and simvastatin, and the relative standard deviations of the quantitative integrals with Case I delay set were 1.6% and 3.3%, respectively. …”
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Investigating antimalarial drug interactions of emetine dihydrochloride hydrate using CalcuSyn-based interactivity calculations. by Holly Matthews, Jon Deakin, May Rajab, Maryam Idris-Usman, Niroshini J Nirmalan

“…The widespread introduction of artemisinin-based combination therapy has contributed to recent reductions in malaria mortality. …”
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Current Status and De Novo Synthesis of Anti-Tumor Alkaloids in <i>Nicotiana</i> by Md. Ahsan Habib, Md. Mobinul Islam, Md. Mukul Islam, Md. Mohidul Hasan, Kwang-Hyun Baek

“…Creating new or shunting of existing biosynthesis pathways in different species of Nicotiana resulted in de novo or increased synthesis of different anti-tumor molecules or their derivatives or precursors including Taxadiane (~22.5 µg/g), Artemisinin (~120 μg/g), Parthenolide (~2.05 ng/g), Costunolide (~60 ng/g), Etoposide (~1 mg/g), Crocin (~400 µg/g), Catharanthine (~60 ng/g), Tabersonine (~10 ng/g), Strictosidine (~0.23 mg/g), etc. …”
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Assessing emergence risk of double-resistant and triple-resistant genotypes of Plasmodium falciparum by Eric Zhewen Li, Tran Dang Nguyen, Thu Nguyen-Anh Tran, Robert J. Zupko, Maciej F. Boni

“…Until novel therapies become available, the mainstay of antimalarial treatment will continue to be artemisinin-based combination therapy (ACT). Deployment of different ACTs can be optimized to minimize evolutionary pressure for drug resistance by deploying them as a set of co-equal multiple first-line therapies (MFT) rather than rotating therapies in and out of use. …”
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Dihydroartemisinin Reduces Irradiation-Induced Mitophagy and Radioresistance in Lung Cancer A549 Cells via CIRBP Inhibition by Shunlong Wu, Zhaodong Li, Haiyu Li, Kui Liao

“…Recent studies have shown that dihydroartemisinin (DHA), a derivative of artemisinin, can increase the sensitivity to treatment in multiple types of cancer, including lung cancer. …”
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