Retail sector distribution chains for malaria treatment in the developing world: a review of the literature by Hanson Kara G, Patouillard Edith, Goodman Catherine A

“…These are important limitations in the advent of the Affordable Medicine Facility for Malaria, which aims to increase consumer access to artemisinin-based combination therapy (ACT), through a subsidy introduced at the top of the distribution chain. …”
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Increased access to care and appropriateness of treatment at private sector drug shops with integrated management of malaria, pneumonia and diarrhoea: a quasi-experimental study in... by Phyllis Awor, Henry Wamani, Thorkild Tylleskar, George Jagoe, Stefan Peterson

“…From the household survey, the prevalence ratio of the intervention effect on use of RDTs was 3.2 (1.9-5.4); Artemisinin Combination Therapy for malaria was 0.74 (0.65-0.84), and ORS/zinc for diarrhoea was 2.3 (1.2-4.7). …”
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Cell Culture Characterization of Prooxidative Chain-Transfer Agents as Novel Cytostatic Drugs by Victoria Heymans, Sascha Kunath, Parvana Hajieva, Bernd Moosmann

“…Prooxidative therapy is a well-established concept in infectiology and parasitology, in which prooxidative drugs like artemisinin and metronidazole play a pivotal clinical role. …”
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Safety of artemether-lumefantrine in pregnant women with malaria: results of a prospective cohort study in Zambia by Manyando Christine, Mkandawire Rhoda, Puma Lwipa, Sinkala Moses, Mpabalwani Evans, Njunju Eric, Gomes Melba, Ribeiro Isabela, Walter Verena, Virtanen Mailis, Schlienger Raymond, Cousin Marc, Chipimo Miriam, Sullivan Frank M

“…<p>Abstract</p> <p>Background</p> <p>Safety data regarding exposure to artemisinin-based combination therapy in pregnancy are limited. …”
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Extracellular vesicles in pancreatic cancer immune escape: Emerging roles and mechanisms by Chunping Liu, Dongyue He, Longmei Li, Shihui Zhang, Lei Wang, Zhijin Fan, Yichao Wang

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Development of ELISA-based methods to measure the anti-malarial drug chloroquine in plasma and in pharmaceutical formulations by Ronn Anita, Bygbjerg Ib C, Recke Camilla, Hoegberg Lotte C, Alifrangis Michael, Khalil Insaf F, Koch Claus

“…The methodology has been exploited to develop monoclonal antibodies for the drugs used in artemisinin-based combination therapy (ACT).</p>…”
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Cost-effectiveness of malaria diagnostic methods in sub-Saharan Africa in an era of combination therapy by Samuel Shillcutt, Chantal Morel, Catherine Goodman, Paul Coleman, David Bell, Christopher JM Whitty, A Mills

“…Costs and effects encompassed those for both patients positive on RDT (assuming artemisinin-based combination therapy) and febrile patients negative on RDT (assuming antibiotic treatment). …”
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Interrogation of Streptomyces avermitilis for efficient production of avermectins by Jinsong Chen, Mei Liu, Xueting Liu, Jin Miao, Chengzhang Fu, Heyong Gao, Rolf Müller, Qing Zhang, Lixin Zhang

“…The 2015 Nobel Prize in Physiology or Medicine has been awarded to avermectins and artemisinin, respectively. Avermectins produced by Streptomyces avermitilis are excellent anthelmintic and potential antibiotic agents. …”
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Commercial drugs containing flavonoids are active in mice with malaria and in vitro against chloroquine-resistant Plasmodium falciparum by Julia Penna-Coutinho, Anna CC Aguiar, Antoniana Ursine Krettli/

“…BACKGROUND The main strategy to control human malaria still relies on specific drug treatment, limited now by Plasmodium falciparum-resistant parasites, including that against artemisinin derivatives. Despite the large number of active compounds described in the literature, few of them reached full development against human malaria. …”
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Malaria in Dielmo, a Senegal village: Is its elimination possible after seven years of implementation of long-lasting insecticide-treated nets? by Amélé Nyedzie Wotodjo, Souleymane Doucoure, Jean Gaudart, Nafissatou Diagne, Fatoumata Diene Sarr, Ngor Faye, Adama Tall, Didier Raoult, Cheikh Sokhna

“…The malaria burden has decreased significantly in recent years in Africa through the widespread use of artemisinin-based combination therapy (ACT) and long-lasting insecticide-treated nets (LLINs). …”
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A mitochondria-targeting dihydroartemisinin derivative as a reactive oxygen species -based immunogenic cell death inducer by Hong-Yang Zhao, Kun-Heng Li, Dan-Dan Wang, Zhi-Li Zhang, Zi-Jian Xu, Ming-Hui Qi, Shi-Wen Huang

“…These results indicate that T-D is an excellent ROS-based ICD inducer with the specific function of trigging vigorous ROS in mitochondria and sets an example for incorporating artemisinin-based drugs into the ICD field.…”
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Finding parasites and finding challenges: improved diagnostic access and trends in reported malaria and anti-malarial drug use in Livingstone district, Zambia by Masaninga Freddie, Sekeseke-Chinyama Masela, Malambo Thindo, Moonga Hawela, Babaniyi Olusegun, Counihan Helen, Bell David

“…Reported malaria mortality declined to zero in the year to September 2009, and all-cause mortality declined. Consumption of artemisinin-based combination therapy (ACT) dropped dramatically, but remained above reported malaria, declining from 12,550 courses dispensed by the district office in the quarter prior to RDT implementation to an average of 822 per quarter over the last year. …”
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Malaria in Indonesia: current treatment approaches, future strategies, and potential herbal interventions by Tina Christina L. Tobing, Wahrianto, Eka Saputri, Nasywa Inayah Wafa, Putri Daffa Zulfianti, Lidwina Iswari Sihaloho, Annisa Rabbiatul Husna, Devia Salsabila, Fito Hansen Hotasi Silalahi, Alex Insandus Sitohang, Aysiah Sabrina, Atika Darayani Hasyati Harianja, Silvyani Agustilova Barus, Salwa Sabina, Annisa Aulia Rahma, Adrian Joshua Velaro, Khairunnisa Khairunnnisa, Emil Salim, Fahrul Nurkolis, Rony Abdi Syahputra

“…Contemporary treatment approaches predominantly rely on Artemisinin-based Combination Therapy (ACT). However, the emergence of drug resistance, coupled with environmental and demographic factors, presents ongoing challenges. …”
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PHENOLIC CONTENT OF ARTEMISIA ANNUA L. FROM NATURAL HABITATS IN REPUBLIC OF MOLDOVA by Camelia Paula STEFANACHE, Oana-Crina BUJOR, Radu NECULA, Doina DANILA, Nina CIOCARLAN, Veaceslav GHENDOV, Christoph CARLEN, Xavier SIMONNET

“…Phenolic extracts were obtained by methanol extraction of the residual plant material resulted from artemisinin separation. The phenolic compounds were identified and quantified by TLC and HPLC-DAD analyses, respectively. …”
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The Kelch13 compartment contains highly divergent vesicle trafficking proteins in malaria parasites. by Sabine Schmidt, Jan Stephan Wichers-Misterek, Hannah Michaela Behrens, Jakob Birnbaum, Isabelle G Henshall, Jana Dröge, Ernst Jonscher, Sven Flemming, Carolina Castro-Peña, Paolo Mesén-Ramírez, Tobias Spielmann

“…Single amino acid changes in the parasite protein Kelch13 (K13) result in reduced susceptibility of P. falciparum parasites to artemisinin and its derivatives (ART). Recent work indicated that K13 and other proteins co-localising with K13 (K13 compartment proteins) are involved in the endocytic uptake of host cell cytosol (HCCU) and that a reduction in HCCU results in reduced susceptibility to ART. …”
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Study of Clinical Profile of Patients with Malarial Fever admitted in a Tertiary Care Centre by Gaurav Uday Ghurye, Nirmala Umesh Sawant, Vijaykumar Bhagwan Barge

“…Multidrug therapy like artemisinin combination therapy has more response in complicated and non-responding cases.…”
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Artesunate + amodiaquine versus artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in the Colombian Pacific region: a noninferiority trial by Fernando De la Hoz Restrepo, Alexandra Porras Ramírez, Alejandro Rico Mendoza, Freddy Córdoba, Diana Patricia Rojas

“…INTRODUCTION: In Colombia, there are no published studies for the treatment of uncomplicated Plasmodium falciparum malaria comparing artemisinin combination therapies. Hence, it is intended to demonstrate the non-inferior efficacy/safety profiles of artesunate + amodiaquine versus artemether-lumefantrine treatments. …”
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Clinical and Laboratory Features of Travel-associated Malaria: A University Hospital Experience by İlkay BOZKURT, Meltem KARSLIOĞLU, Şaban ESEN

“…The most commonly used anti-malarial drugs were artemisinin derivatives. Conclusion: Before visiting malaria-endemic regions it is essential to obtain information about preventive measures and chemoprophylaxis. …”
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Electrocardiographic study in Ghanaian children with uncomplicated malaria, treated with artesunate-amodiaquine or artemether-lumefantrine by Adjei George O, Oduro-Boatey Collins, Rodrigues Onike P, Hoegberg Lotte C, Alifrangis Michael, Kurtzhals Jorgen A, Goka Bamenla Q

“…These findings, although reassuring, may imply that non-amodiaquine based artemisinin combination therapy may be preferable for malaria treatment in patients who are otherwise at risk of cardiac effects.…”
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A qualitative study of health workers' perspectives on malaria case identification and management among pregnant women in Savelugu Municipality, Ghana. by Martin Nyaaba Adokiya, Michael Boah, Solomon Abotiba Atinbire, Felix Achana, Joyce Aputere Ndago, David Abatanie Kanligi, Zakaria Abotiyire, Cheryl A Moyer

“…When malaria is confirmed in pregnancy, quinine is used for first trimester treatment, while Artemisinin-based Combination Therapies are prescribed after the first trimester. …”
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