Computational biology and in vitro studies for anticipating cancer-related molecular targets of sweet wormwood (Artemisia annua) by Hend Dawood, Ismail Celik, Reham S. Ibrahim

“…Results Network pharmacology-based analysis showed that the hit Artemisia annua constituents related to cancer targets were 3-(2-methylpropanoyl)-4-cadinene-3,11-diol, artemisinin G, O-(2-propenal) coniferaldehyde, (2-glyceryl)-O-coniferaldehyde and arteamisinin III, whereas the main cancer allied targets were NFKB1, MAP2K1 and AR. …”
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Leukocyte Profile of Mice Infected with Plasmodium berghei and Treated with Aqueous Extract of Strychnos Ligustrina and Its Combination with Dihydroartemisinin Piperaquine Phosphat... by Umi Cahyaningsih, Siti Sa'diah, Wasrin Syafii, Rita Kartika Sari, Arifin Budiman Nugraha

“…Natural compounds are alternative ways as an antimalarial compound that are applied for the artemisinin combination. The aim of this study was to determine the effect of a combination of S. ligustrina extract and DHP on the differential leukocytes percentages. …”
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Oral Administration of Artemisone for the Treatment of Schistosomiasis: Formulation Challenges and In Vivo Efficacy by Johanna Zech, Daniel Gold, Nadeen Salaymeh, Netanel Cohen Sasson, Ithai Rabinowitch, Jacob Golenser, Karsten Mäder

“…Artemisone is an innovative artemisinin derivative with applications in the treatment of malaria, schistosomiasis and other diseases. …”
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Real-time imaging of the intracellular glutathione redox potential in the malaria parasite Plasmodium falciparum. by Denis Kasozi, Franziska Mohring, Stefan Rahlfs, Andreas J Meyer, Katja Becker

“…In contrast, quinoline and artemisinin-based antimalarial drugs showed strong effects on the parasites' EGSH after longer incubation times (24 h). …”
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Biosynthesis Investigations of Terpenoid, Alkaloid, and Flavonoid Antimicrobial Agents Derived from Medicinal Plants by Wenqian Huang, Yingxia Wang, Weisheng Tian, Xiaoxue Cui, Pengfei Tu, Jun Li, Shepo Shi, Xiao Liu

“…In this review, we discuss the biosynthesis investigations of terpenoid, alkaloid, and flavonoid antimicrobial agents—using artemisinin and oleanolic acid (terpenoids), berberine and colchicine (alkaloids), and baicalin (flavonoids) as examples—around their antimicrobial action mechanisms, biosynthesis pathway elucidation, key enzyme identification, and heterologous production, in order to provide useful hints for plant-derived antimicrobial agent discovery and development.…”
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In Vitro Effect on <i>Plasmodium falciparum</i> and In Vivo Effect on <i>Plasmodium berghei</i> of Annomaal<i>,</i> an Oily Fraction Obtained from the Seeds of <i>Annona squamosa</... by Sampada S. Sawant, Satish Y. Gabhe, Kamalinder K. Singh

“…The increasing threat of drug resistance to available artemisinin-based therapy warrants an urgent need to develop new antimalarial drugs that are safer, more effective, and have a novel mode of action. …”
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Isolation and characterization of three new monoterpene synthases from Artemisia annua by Ju-Xin eRuan, Jian-Xu eLi, Xin eFang, Ling-Jian eWang, Wen-Li eHu, Xiao-Ya eChen, Changqing eYang

“…Artemisia annua, an annual herb used in traditional Chinese medicine, produces a wealth of monoterpenes and sesquiterpenes, including the well-known sesquiterpene lactone artemisinin, an active ingredient in the treatment for malaria. …”
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Expression and purification of active shikimate dehydrogenase from Plasmodium falciparum by BRUNO G. DALLA VECCHIA MORALES, JOSEPH ALBERT M. EVARISTO, GEORGE A.R. DE OLIVEIRA, ANA FIDELINA G. GARAY, JORGE JAVIER A.R. DIAZ, ANDRELISSE ARRUDA, SORAYA S. PEREIRA, FERNANDO B. ZANCHI

“…Abstract Plasmodium falciparum is known to cause severe malaria, current treatment consists in artemisinin-based combination therapy, but resistance can lead to treatment failure. …”
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Geostatistical modelling of malaria indicator survey data to assess the effects of interventions on the geographical distribution of malaria prevalence in children less than 5 year... by Julius Ssempiira, Betty Nambuusi, John Kissa, Bosco Agaba, Fredrick Makumbi, Simon Kasasa, Penelope Vounatsou

“…However, no effect was observed for Artemisinin Combination-based Therapies (ACTs). Environmental factors, namely, land cover, rainfall, day and night land surface temperature, and area type were significantly associated with malaria prevalence. …”
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Therapeutic efficacy of sulfadoxine-pyrimethamine, amodiaquine and the sulfadoxine-pyrimethamine-amodiaquine combination against uncomplicated Plasmodium falciparum malaria in youn... by Basco Leonardo K., Same-Ekobo Albert, Ngane Vincent Foumane, Ndounga Mathieu, Metoh Theresia, Ringwald Pascal, Soula Georges

“…CONCLUSION: SP+AQ can be recommended as a temporary means of slowing the spread of multidrug resistance in Plasmodium falciparum in Africa while the introduction of other combinations, including artemisinin derivatives, is awaited.…”
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Treatment of malaria restricted to laboratory-confirmed cases: a prospective cohort study in Ugandan children by Staedke Sarah, Nzarubara Bridget, Clark Tamara D, Njama-Meya Denise, Kamya Moses R, Dorsey Grant

“…However, with the introduction of new artemisinin-based combination therapy (ACT), presumptive treatment becomes economically and clinically less acceptable.…”
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Transmission dynamics of co-endemic Plasmodium vivax and P. falciparum in Ethiopia and prevalence of antimalarial resistant genotypes. by Eugenia Lo, Elizabeth Hemming-Schroeder, Delenasaw Yewhalaw, Jennifer Nguyen, Estifanos Kebede, Endalew Zemene, Sisay Getachew, Kora Tushune, Daibin Zhong, Guofa Zhou, Beyene Petros, Guiyun Yan

“…Nevertheless, no mutation was detected in pfK13 that relates to artemisinin resistance. In P. vivax, while sequences of pvcrt-o were highly conserved and less than 5% of the samples showed pvmdr duplications, over 50% of the samples had pvmdr1 976F mutation. …”
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Relative effects of climate factors and malaria control interventions on changes of parasitaemia risk in Burkina Faso from 2014 to 2017/2018 by Nafissatou Traoré, Taru Singhal, Ourohiré Millogo, Ali Sié, Jürg Utzinger, Penelope Vounatsou

“…The use of ITNs was related to the decline at national and regional level, but coverage with artemisinin-based combination therapy only at regional level. …”
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Cyclic Organic Peroxides as New Fungicides against Phytopathogenic Fungi by Ivan A. Yaremenko, Peter S. Radulov, Yulia Yu. Belyakova, Dmitrii I. Fomenkov, Vera A. Vil’, Maria A. Kuznetsova, Valentina N. Demidova, Alexei P. Glinushkin, Alexander O. Terent’ev

“…The discovery of the antimalarial activity of the peroxide natural product Artemisinin, an achievement that was recently recognized with the Nobel Prize, has brought organic peroxides into the medicinal and agrochemistry. …”
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Spatiotemporal formation of glands in plants is modulated by MYB-like transcription factors by Jiang Chang, Shurong Wu, Ting You, Jianfeng Wang, Bingjing Sun, Bojun Xu, Xiaochun Xu, Yaping Zhang, Shuang Wu

“…Abstract About one third of vascular plants develop glandular trichomes, which produce defensive compounds that repel herbivores and act as a natural biofactory for important pharmaceuticals such as artemisinin and cannabinoids. However, only a few regulators of glandular structures have been characterized so far. …”
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Escalating <it>Plasmodium falciparum </it>antifolate drug resistance mutations in Macha, rural Zambia by Rouse Petrica, Sikalima Jay, Chishimba Sandra, Mkulama Mtawa AP, Thuma Philip E, Mharakurwa Sungano

“…<p>Abstract</p> <p>Background</p> <p>In Zambia the first-line treatment for uncomplicated malaria is artemisinin combination therapy (ACT), with artemether-lumefantrine currently being used. …”
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Malaria prevalence and incidence in an isolated, meso-endemic area of Mozambique by Jacques Derek Charlwood, Erzelia V.E. Tomás, Mauro Bragança, Nelson Cuamba, Michael Alifrangis, Michelle Stanton

“…Currently available control strategies include long-lasting insecticidal bednets impregnated with pyrethroid insecticides (LLINs), rapid diagnostic tests (RDTs) for diagnosis and artemisinin based combination therapy (ACT) for treatment and these were applied on the peninsula. …”
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Machine learning in TCM with natural products and molecules: current status and future perspectives by Suya Ma, Jinlei Liu, Wenhua Li, Yongmei Liu, Xiaoshan Hui, Peirong Qu, Zhilin Jiang, Jun Li, Jie Wang

“…Natural products and their effective agents such as artemisinin and paclitaxel have saved millions of lives worldwide. …”
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The Chemical and Pharmacological Research Progress on a Kind of Chinese Herbal Medicine, <i>Fructus Malvae</i> by Xiaoyu Li, Xianglei Wang, Menglu Zhao, He Zhang, Chao Liu

“…Furthermore, the discovery of artemisinin in <i>Artemisia annua</i> has reduced the incidence of malaria all over the world. …”
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Metabolites from Marine Sponges and Their Potential to Treat Malarial Protozoan Parasites Infection: A Systematic Review by Anna Caroline Campos Aguiar, Julia Risso Parisi, Renata Neves Granito, Lorena Ramos Freitas de Sousa, Ana Cláudia Muniz Renno, Marcos Leoni Gazarini

“…Malaria is an infectious disease caused by protozoan parasites of the <i>Plasmodium</i> genus through the bite of female Anopheles mosquitoes, affecting 228 million people and causing 415 thousand deaths in 2018. Artemisinin-based combination therapies (ACTs) are the most recommended treatment for malaria; however, the emergence of multidrug resistance has unfortunately limited their effects and challenged the field. …”
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