Use of a health worker-targeted smartphone app to support quality malaria RDT implementation in Busia County, Kenya: A feasibility and acceptability study. by Malia Skjefte, Shawna Cooper, Stephen Poyer, Christopher Lourenço, Sam Smedinghoff, Brett Keller, Tonny Wambua, Christine Oduor, Sasha Frade, Wycliffe Waweru

“…During 154 encounters (3.5% of all encounters) a health worker dispensed an artemisinin-based combination therapy (ACT) to their patient even with a negative mRDT readout. …”
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Anti-CMV therapy, what next? A systematic review by Claire Gourin, Sophie Alain, Sophie Alain, Sébastien Hantz, Sébastien Hantz

“…Molecules with a direct action against HCMV include brincidofovir, cyclopropavir and anti-terminase benzimidazole analogs. Artemisinin derivatives, quercetin and baicalein, and anti-cyclooxygenase-2 are derived from natural molecules and are generally used for different indications. …”
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Status of the Multidrug Resistance-1 Gene of Plasmodium falciparum in Four Malaria Epidemiological Strata, Two Decades after the Abolition of Chloroquine as First-Line Treatment fo... by David Denis Sofeu-Feugaing, Fabrice Nkengeh Ajonglefac, Marcel Nyuylam Moyeh, Tobias Obejum Apinjoh, Marianne Elodie Essende, Gilchrist Destin Talla Kouam, Stephen Mbigha Ghogomu

“…Chloroquine (CQ) was widely used in Cameroon for decades, but its declining clinical efficacy due to resistance prompted health authorities in 2004 to resort to artemisinin-based combination therapy (ACT) as the first-line treatment for uncomplicated malaria. …”
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Metabolomic analysis and antibacterial and antioxidant activities of three species of Artemisia plants in Tibet by Xinyu Liu, Renzengwangdui, Shiyu Tang, Yiru Zhu, Meng Wang, Binqian Cao, Jinglong Wang, Baoyu Zhao, Hao Lu

“…Differentially identified compounds included flavonoids, phenolic acids, artemisinins and coumarin. A. annua contained the highest relative content of artemisinin among three Artemisia. …”
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Impact of two anti-malaria drugs (artequin and chloroquine) on some hematological parameters in wistar rats by Princewill Ikechukwu Ugwu, Ugochukwu Bond Anyaehie, Amogechukwu Onyinye Ugwu, Ofem Effiong Ofem

“…Background: Artequin (AQ) and other Artemisinin-based therapies have replaced chloroquine (CQ) as the preferred treatment for uncomplicated Plasmodium falciparum malaria, due to the resistance of the parasite to CQ. …”
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Review of the clinical pharmacokinetics of artesunate and its active metabolite dihydroartemisinin following intravenous, intramuscular, oral or rectal administration by Shin Chang-Sik, Jung Donald, Borghini-Fuhrer Isabelle, Duparc Stephan, Morris Carrie A, Fleckenstein Lawrence

“…<p>Abstract</p> <p>Artesunate (AS) is a clinically versatile artemisinin derivative utilized for the treatment of mild to severe malaria infection. …”
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Deciphering the Plasmodium epitranscriptome as a mechanism of translational control by Sinha, Ameya

“…Additionally, we quantified tRNA modification levels in the parasites that were exposed to oxidative stressors like hydrogen peroxide, sodium hypochlorite and anti-malarials like artemisinin and chloroquine. The work presented here holds potential for several avenues of new discovery. …”
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Genetic modulators of Plasmodium falciparum parasites asexual fitness and resistance to clinical and preclinical compounds by Hong, Davin

“…M343L mutation, however, did not confer resistance to artemisinin partner drugs lumefantrine or mefloquine, while pm2/3 amplification augmented resistance phenotype to preclinical compound MMV675939. …”
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Potential roles of tRNA modifications in the human malaria parasite plasmodium falciparum by Ng, Chee Sheng

“…In parallel, we examined the involvement of tRNA modifications in stress-induced translational control by treating the parasites with IC20-90 doses of hydrogen peroxide, artemisinin and chloroquine. Hierarchical clustering and principal component analysis distinguished signature tRNA modifications reprogramming patterns induced by different stresses, implying stress-specific translational control mechanism for survival response. …”
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DNA damage regulation and its role in drug-related phenotypes in the malaria parasites by Gupta, Devendra Kumar, Patra, Alok Tanala, Zhu, Lei, Gupta, Archana Patkar, Bozdech, Zbynek

“…We also showed that acetylation at H3K9, H4K8, and H3K56 play a role in the direct and indirect response to DNA damage induced by an alkylating agent, methyl methanesulphonate (MMS). Artemisinin, the first line antimalarial chemotherapeutics elicits a similar response compared to MMS which suggests its activity as a DNA damaging agent. …”
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Effectiveness of artemether-lumefantrine provided by community health workers in under-five children with uncomplicated malaria in rural Tanzania: an open label prospective study. by Ngasala, B, Malmberg, M, Carlsson, A, Ferreira, P, Petzold, MG, Blessborn, D, Bergqvist, Y, Gil, J, Premji, Z, Mårtensson, A

“…However, limited data are available on the effectiveness of using artemisinin-based combination therapy (ACT) within the HMM strategy. …”

Spread of anti-malarial drug resistance: mathematical model with implications for ACT drug policies. by Pongtavornpinyo, W, Yeung, S, Hastings, I, Dondorp, A, Day, N, White, N

“… BACKGROUND: Most malaria-endemic countries are implementing a change in anti-malarial drug policy to artemisinin-based combination therapy (ACT). The impact of different drug choices and implementation strategies is uncertain. …”

Estimating the number of paediatric fevers associated with malaria infection presenting to Africa's public health sector in 2007 by Gething, P, Kirui, V, Alegana, V, Okiro, E, Noor, A, Snow, R

“…Background: As international efforts to increase the coverage of artemisinin-based combination therapy in public health sectors gather pace, concerns have been raised regarding their continued indiscriminate presumptive use for treating all childhood fevers. …”

Semimechanistic pharmacokinetic and pharmacodynamic modeling of piperaquine in a volunteer infection study with Plasmodium falciparum blood-stage malaria by Wattanakul, T, Baker, M, Mohrle, J, McWhinney, B, Hoglund, RM, McCarthy, JS, Tarning, J

“…Dihydroartemisinin-piperaquine is a recommended first-line artemisinin combination therapy for Plasmodium falciparum malaria. …”

Implementation of field detection devices for antimalarial quality screening in Lao PDR-A cost-effectiveness analysis by Luangasanatip, N, Khonputsa, P, Caillet, C, Vickers, S, Zambrzycki, S, Fernández, FM, Newton, PN, Lubell, Y

“…We evaluated the cost-effectiveness of introducing such devices in post-market surveillance in pharmacies in Laos, conservatively focusing on their outcome in detecting SF artemisinin-based combination therapies (ACTs). We simulated the deployment of six portable screening devices: two handheld near-infrared [MicroPHAZIR RX, NIR-S-G1], two handheld Raman [Progeny, TruScan RM]; one portable mid-infrared [4500a FTIR] spectrometers, and single-use disposable paper analytical devices [PADs]. …”

Estimating the number of paediatric fevers associated with malaria infection presenting to Africa's public health sector in 2007. by Gething, P, Kirui, VC, Alegana, V, Okiro, E, Noor, A, Snow, R

“… BACKGROUND: As international efforts to increase the coverage of artemisinin-based combination therapy in public health sectors gather pace, concerns have been raised regarding their continued indiscriminate presumptive use for treating all childhood fevers. …”

Changes in the treatment responses to artesunate-mefloquine on the northwestern border of Thailand during 13 years of continuous deployment by Carrara, V, Zwang, J, Ashley, E, Barends, M, McGready, R, Phaiphun, L, Proux, S, van Vugt, M, Hutagalung, R, Lwin, K, Phyo, A, Nosten, F, Stepniewska, K, Preechapornkul, P, Imwong, M, Pukrittayakamee, S, Singhasivanon, P, White, N, Price, R, Brockman, A, Anderson, T

“…Background: Artemisinin combination treatments (ACT) are recommended as first line treatment for falciparum malaria throughout the malaria affected world. …”

Community engagement and the social context of targeted malaria treatment: a qualitative study in Kayin (Karen) State, Myanmar by Sahan, K, Pell, C, Smithuis, F, Phyo, A, Maung, S, Indrasuta, C, Dondorp, A, White, N, Day, N, von Seidlein, L, Cheah, P

“…<p>BACKGROUND: The spread of artemisinin-resistance in Plasmodium falciparum is a threat to current global malaria control initiatives. …”

Quantifying and valuing community health worker time in improving access to malaria diagnosis and treatment by Castellani, J, Mihaylova, B, Ajayi, I, Siribié, M, Nsungwa-Sabiiti, J, Afonne, C, Sermé, L, Balyeku, A, Kabarungi, V, Kyaligonza, J, Evers, S, Paulus, A, Petzold, M, Singlovic, J, Gomes, M

“…<br/><br/> Methods: In Burkina Faso, Nigeria and Uganda, CHWs were trained to assess and manage febrile patients in keeping with Integrated Management of Childhood Illness recommendations to use rapid diagnostic tests, artemisinin-based combination therapy and rectal artesunate for malaria treatment. …”

Dihydroartemisinin-piperaquine treatment of multidrug resistant falciparum and vivax malaria in pregnancy by Poespoprodjo, JR, Fobia, W, Kenangalem, E, Lampah, D, Sugiarto, P, Tjitra, E, Anstey, N, Price, R

“…Background Artemisinin combination therapy (ACT) is recommended for the treatment of multidrug resistant malaria in the second and third trimesters of pregnancy, but the experience with ACTs is limited. …”