Safety and tolerability of adjunctive rosiglitazone treatment for children with uncomplicated malaria by Rosauro Varo, Valerie M. Crowley, Antonio Sitoe, Lola Madrid, Lena Serghides, Rubao Bila, Helio Mucavele, Alfredo Mayor, Quique Bassat, Kevin C. Kain

“…The study was a prospective, randomized, double-blind, placebo-controlled, phase IIa trial of rosiglitazone (0.045 mg/kg/dose) twice daily for 4 days versus placebo as adjunctive treatment in addition to Mozambican standard of care (artemisinin combination therapy Coartem®) in children with uncomplicated malaria. …”
Get full text

Investigating the Presence of Falsified and Poor-Quality Fixed-Dose Combination Artemether-Lumefantrine Pharmaceutical Dosage Forms in Kumasi, Ghana by Simon Nyarko, Kwabena Ofori-Kwakye, Raphael Johnson, Noble Kuntworbe, Denis Dekugmen Yar

“…Artemether-lumefantrine (AL) is a highly effective and commonly used Artemisinin-based Combination Therapy (ACT) for treating uncomplicated malaria caused by Plasmodium falciparum, including drug-resistant strains. …”
Get full text

Identification and metabolomic characterization of potent anti-MRSA phloroglucinol derivatives from Dryopteris crassirhizoma Nakai (Polypodiaceae) by Sumana Bhowmick, Sumana Bhowmick, Manfred Beckmann, Jianying Shen, Luis A. J. Mur

Get full text

Zinc-metal–organic frameworks with tunable UV diffuse-reflectance as sunscreens by Jisheng Xiao, Haishan Li, Wanling Zhao, Chengyuan Cai, Tingting You, Zhenyu Wang, Mengling Wang, Feng Zeng, Jinmei Cheng, Jiaxin Li, Xiaopin Duan

Get full text

Planetary Health and Traditional Medicine: A Potential Synergistic Approach to Tackle Antimicrobial Resistance by Iyiola Olatunji Oladunjoye, Yusuf Amuda Tajudeen, Habeebullah Jayeola Oladipo, Mona Said El-Sherbini

“…Examples include the recent discovery of Artemisinin, a highly active antimalarial drug derived from <i>Artemisia annua</i>, and the discovery of Taxol, an active chemotherapeutic drug derived from the bark of the Pacific yew, <i>Taxus brevifolia</i>. …”
Get full text

MYC2: A Master Switch for Plant Physiological Processes and Specialized Metabolite Synthesis by Lei Luo, Ying Wang, Lu Qiu, Xingpei Han, Yaqian Zhu, Lulu Liu, Mingwu Man, Fuguang Li, Maozhi Ren, Yadi Xing

“…Based on our understanding of the mechanism underlying the regulation of specialized metabolite synthesis in plants by the transcription factor MYC2, the use of synthetic biology approaches to design MYC2-driven chassis cells for the synthesis of specialized metabolites with high medicinal value, such as paclitaxel, vincristine, and artemisinin, seems to be a promising strategy. In this review, the regulatory role of MYC2 in JA signal transduction of plants to biotic and abiotic stresses, plant growth, development and specialized metabolite synthesis is described in detail, which will provide valuable reference for the use of MYC2 molecular switches to regulate plant specialized metabolite biosynthesis.…”
Get full text

Effectiveness of artemether-lumefantrine provided by community health workers in under-five children with uncomplicated malaria in rural Tanzania: an open label prospective study by Blessborn Daniel, Petzold Max G, Ferreira Pedro E, Carlsson Anja M, Malmberg Maja, Ngasala Billy E, Bergqvist Yngve, Gil José P, Premji Zul, Mårtensson Andreas

“…However, limited data are available on the effectiveness of using artemisinin-based combination therapy (ACT) within the HMM strategy. …”
Get full text

Are rapid diagnostic tests more accurate in diagnosis of <it>plasmodium falciparum </it>malaria compared to microscopy at rural health centres? by Magnussen Pascal, Batwala Vincent, Nuwaha Fred

“…<p>Abstract</p> <p>Background</p> <p>Prompt, accurate diagnosis and treatment with artemisinin combination therapy remains vital to current malaria control. …”
Get full text

Establishment and evaluation of glucose-modified nanocomposite liposomes for the treatment of cerebral malaria by Ya Tian, Zhongyuan Zheng, Xi Wang, Shuzhi Liu, Liwei Gu, Jing Mu, Xiaojun Zheng, Yujie Li, Shuo Shen

“…About 627,000 patients died of malaria in 2020. Currently, artemisinin and its derivatives are the front-line drugs used for the treatment of cerebral malaria. …”
Get full text

Comparison of intermittent screening (using ultra-sensitive malaria rapid diagnostic test) and treatment (using a newly registered antimalarial pyronaridine-artesunate—PYRAMAX®) to... by Vivi Maketa, Japhet Kabalu, Melissa Kabena, Flory Luzolo, Hypolite Muhindo-Mavoko, Henk D. F. H. Schallig, Kassoum Kayentao, Petra F. Mens, Pascal Lutumba, Halidou Tinto

“…As an alternative, the intermittent screening and treatment for pregnancy (ISTp) aims at a monthly screening of pregnant women, preferably by using very sensitive tests such as ultrasensitive rapid diagnostic tests (us-RDTs) and the treatment of positive cases with artemisinin-based combination therapy (ACT) regardless of the presence of symptoms. …”
Get full text

Dietary phytochemicals: As a potential natural source for treatment of Alzheimer's Disease by Zhuo Ren, Haixia Yang, Chenhui Zhu, Daidi Fan, Jianjun Deng

“…In this study, several representatives’ dietary phytochemicals with anti-AD effect, including resveratrol, lycopene, gallic acid, berberine, ginsenoside Rg1, pseudoginsenoside-F11, ginsenoside Rh2, artemisinin, and torularhodin were selected from the published data over the last 10 years and their potential molecular mechanisms and clinical applications reviewed in the treatment of AD.…”
Get full text

Assessment of the performance and challenges in the implementation of the test, treat and track (T3) strategy for malaria control among children under-five years in Ghana by Margaret Kweku, Joyce B. Der, William K. Blankson, Haruna M. Salisu, Francis Arizie, Sorengmen A. Ziema, Jonathan M. Gmanyami, Fortress Y. Aku, Martin Adjuik

“…<h4>Background</h4> The World Health Organization recommended the Test, Treat and Track (T3) strategy for malaria control that, every suspected malaria case should be tested prior to treatment with Artemisinin-based combination therapy (ACT) and tracked. …”
Get full text

Efficacy of antimalarial herbal medicines used by communities in malaria affected regions globally: a protocol for systematic review and evidence and gap map by Nakalembe Loyce, Robert Apunyo, Alison Annet Kinengyere, Moses Ocan, Ekwaro A Obuku, Kevin Ouma Ojiambo

“…Introduction With the rising resistance to artemisinin-based combination treatments, there is a need to hasten the discovery and development of newer antimalarial agents. …”
Get full text

<i>Artemisia annua</i> Growing Wild in Romania—A Metabolite Profile Approach to Target a Drug Delivery System Based on Magnetite Nanoparticles by Adina-Elena Segneanu, Catalin Nicolae Marin, Ioan Ovidiu-Florin Ghirlea, Catalin Vladut Ionut Feier, Cornelia Muntean, Ioan Grozescu

“…Various studies focused on artemisinin and its derivates for their antiparasitic and antitumoral effects. …”
Get full text

Correction: Successful treatment with doxycycline monotherapy for human infection with Babesia venatorum (Babesiidae, Sporozoa) in China: a case report and proposal for a clinical... by Lei Huang, Yi Sun, Dan‑Dan Huo, Ming Xu, Luo‑Yuan Xia, Ning Yang, Wei Hong, Lin Huang, Wei‑Min Nie, Ru‑He Liao, Ming‑Zhu Zhang, Dai‑Yun Zhu, Yan Li, He‑Cheng Ma, Xin Zhang, Yong‑Gang Li, Xin‑An Huang, Jing‑Yuan Wang, Wu‑Chun Cao, Fu‑Sheng Wang, Jia‑Fu Jiang

Get full text

Impact of school-based malaria case management on school attendance, health and education outcomes: a cluster randomised trial in southern Malawi by Katherine E Halliday, Stefan S Witek-McManus, Austin Mtali, Andrew Bauleni, Saidi Ndau, Emmanuel Phondiwa, Doreen Ali, Virginia Kachigunda, John H Sande, Mpumulo Jawati, Allison Verney, Tiyese Chimuna, David Melody, Helen Moestue, Natalie Roschnik, Simon J Brooker, Don P Mathanga

“…The intervention, implemented in 29 randomly selected schools, provided malaria rapid diagnostic tests and artemisinin-based combination therapy to diagnose and treat uncomplicated malaria as part of basic first aid kits known as ‘Learner Treatment Kits’ (LTK). …”
Get full text

Anti-malarial market and policy surveys in sub-Saharan Africa by Sevcsik Ann-Marie, Boakye Isaac, Amuasi John, Diap Graciela, Pecoul Bernard

“…<p>Abstract</p> <p>At a recent meeting (Sept 18, 2009) in which reasons for the limited access to artemisinin-based combination therapy (ACT) in sub-Saharan Africa were discussed, policy and market surveys on anti-malarial drug availability and accessibility in Burundi and Sierra Leone were presented in a highly interactive brainstorming session among key stakeholders across private, public, and not-for-profit sectors. …”
Get full text

Dihydroartemisinin ameliorates innate inflammatory response induced by Streptococcus suis-derived muramidase-released protein via inactivation of TLR4-dependent NF-κB signaling by Yun Ji, Kaiji Sun, Ying Yang, Zhenlong Wu

“…Dihydroartemisinin (DhA) is an artemisinin derivative with potential anti-inflammatory activity. …”
Get full text

Molecular markers of dihydroartemisinin-piperaquine resistance in northwestern Thailand by Khine Nwe Win, Khajohnpong Manopwisedjaroen, Kanit Phumchuea, Chayanut Suansomjit, Kesinee Chotivanich, Saranath Lawpoolsri, Liwang Cui, Jetsumon Sattabongkot, Wang Nguitragool

“…Results Among the samples whose kelch13 were successfully sequenced, approximately half (31/55; 56%) had mutation associated with artemisinin resistance, including G533S (23/55; 42%), C580Y (6/55; 11%), and G538V (2/55; 4%). …”
Get full text

The evolution of pyrimethamine resistant <it>dhfr </it>in <it>Plasmodium falciparum </it>of south-eastern Tanzania: comparing selection under SP alone <it>vs </it>SP+artesunate com... by Mshinda Hassan, Kachur Patrick S, Abdullah Salim, Mutayoba Ben M, Pearce Richard J, Malisa Allen L, Bloland Peter, Roper Cally

“…<p>Abstract</p> <p>Background</p> <p>Sulphadoxine-pyrimethamine (SP) resistance is now widespread throughout east and southern Africa and artemisinin compounds in combination with synthetic drugs (ACT) are recommended as replacement treatments by the World Health Organization (WHO). …”
Get full text